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Malnutrition predicts poor outcomes in diabetic COVID-19 patients in Huangshi,Hubei

The Journal of Biomedical Research 2022年第1期36卷 42-48页

作者： Jiao Chen Can Zhao Yingzi Huang Hao Wang Xiang Lu Wei Zhao Wei Gao Department of Intensive care Unit the Affiliated Sir Run Run Hospital of Nanjing Medical UniversityNanjingJiangsu 211100China Department of Geriatrics the Affiliated Sir Run Run Hospital of Nanjing Medical UniversityNanjingJiangsu 211100China key laboratory for Aging&Disease Nanjing Medical UniversityNanjingJiangsu 211166China jiangsu provincial key laboratory of critical care medicine Department of Critical Care MedicineZhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China.

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has spread throughout the world,which becomes a global public health *** prolongs its convalescence and has an adverse effect on its prognosis,especially in diabetic *** purpose of this study was to evaluate the prevalence and characteristics of undernourishment and to determine how it is related to the prognostic outcomes in the diabetic patients with coronavirus disease 2019(COVID-19).A retrospective,multicenter study was conducted in 85 diabetic COVID-19 patients from three hospitals in Hubei *** patients were assessed using the European Nutritional Risk Screening 2002(NRS-2002)and other nutritional assessments when *** them,35(41.18%)were at risk of malnutrition(NRS score≥3).Severe COVID-19 patients had a significantly lower level of serum albumin and prealbumin and higher NRS score than non-severe *** logistic regression analysis showed that serum prealbumin and NRS score increased the likelihood of progression into severe status(P<0.05).Meanwhile,single factor and multivariate analysis determined that grade of illness severity was an independent predictor for ***,prealbumin and NRS score could well predict severe status for COVID-19 *** malnutrition group(NRS score≥3)had more severe illness than the normal nutritional(NRS score<3)group(P<0.001),and had a longer length of in-hospital stay and higher *** is highly prevalent among COVID-19 patients with *** is associated with severely ill status and poor *** of nutritional status should be strengthened,especially the indicators of NRS-2002 and the level of serum prealbumin.

关键词： NRS-2002 malnutrition COVID-19 diabetes

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Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng Zheng Wang Zhou Ying Mo Biao Zheng Miaomiao Han Qin Zhong Wenwen Yang Peng Gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong Li Faqin Li Zhaoyi Chen Erwen Wu Xiaoxi Dai Danni Li Haojie An Shiyi Zeng Chunyan Wang Li Yang Cheng Long School of Life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of Life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong provincial key laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLD in glutamatergic neurons is largely ***,we first proposed involvement of CYLD in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male ***,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission

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Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan Sun Lulin Li Jian Luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation

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Circular RNAs:Diagnostic and Therapeutic Perspectives in CNS Diseases

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Current Medical Science 2023年第5期43卷 879-889页

作者： Ying BAI Hong-hong YAO jiangsu provincial key laboratory of critical care medicine Department of PharmacologySchool of MedicineSoutheast UniversityNanjing 210009China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Institute of Life Sciences Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210009China

Circular RNAs(circRNAs)are a class of regulatory non-coding RNAs characterized by the presence of covalently closed ends.A growing body of evidence suggests that circRNAs play important roles in physiology and *** particular,accumulating data on circRNA functions in various central nervous system(CNS)diseases and their correlations indicate that circRNAs are critical contributors to the onset and development of brain *** this review,we focus on the regulatory and functional roles of circRNAs in CNS diseases,highlighting their diagnostic and therapeutic potential,with the aim of providing new insights into CNS diseases.

关键词： circular RNAs brain central nervous system disease diagnosis therapy

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Fangji Fuling Decoction Alleviates Sepsis by Blocking MAPK14/FOXO3A Signaling Pathway

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Chinese Journal of Integrative medicine 2024年第3期30卷 230-242页

作者： WANG Yi CHEN Ming-qi DAI Lin-feng ZHANG Hai-dong WANG Xing Department of critical care medicine Changzhou Hospital of Traditional of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineChangzhouJiangsu Province213000China Department of critical care medicine Jiangsu Province Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing210029China

Objective:To examine the therapeutic effect of Fangji Fuling Decoction(FFD) on sepsis through network pharmacological analysis combined with in vitro and in vivo ***:A sepsis mouse model was constructed through intraperitoneal injection of 20 mg/kg lipopolysaccharide(LPS).RAW264.7 cells were stimulated by 250 ng/m L LPS to establish an in vitro cell *** pharmacology analysis identified the key molecular pathway associated with FFD in *** ectopic expression and depletion experiments,the effect of FFD on multiple organ damage in septic mice,as well as on cell proliferation and apoptosis in relation to the mitogen-activated protein kinase 14/Forkhead Box O 3A(MAPK14/FOXO3A) signaling pathway,was ***:FFD reduced organ damage and inflammation in LPS-induced septic mice and suppressed LPS-induced macrophage apoptosis and inflammation in vitro(P<0.05).Network pharmacology analysis showed that FFD could regulate the MAPK14/FOXO signaling pathway during *** confirmed by in vitro cell experiments,FFD inhibited the MAPK14 signaling pathway or FOXO3A expression to relieve LPS-induced macrophage apoptosis and inflammation(P<0.05).Furthermore,FFD inhibited the MAPK14/FOXO3A signaling pathway to inhibit LPS-induced macrophage apoptosis in the lung tissue of septic mice(P<0.05).Conclusion:FFD could ameliorate the LPS-induced inflammatory response in septic mice by inhibiting the MAPK14/FOXO3A signaling pathway.

关键词： sepsis Fangji Fuling Decoction mitogen-activated protein kinase 14/Forkhead Box O 3A signaling pathway inflammatory response apoptosis lung injury Chinese medicine

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Trends in point-of-care ultrasound protocols in the emergency department and intensive care unit:a review

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Emergency and critical care medicine 2023年第2期3卷 64-69页

作者： Xinhui Fan Yuan Bian Guoying Wang Weikang Liu Luyao Gao Yuhui Pan Shengchuan Cao Qiuhuan Yuan Shujian Wei Feng Xu Yuguo Chen Department of Emergency and Chest Pain Center Shandong Provincial Clinical Research Center for Emergency and Critical Care MedicineInstitute of Emergency and Critical Care Medicine of Shandong UniversityKey Laboratory of Emergency and Critical Care Medicine of Shandong ProvinceKey Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceQilu Hospital of Shandong UniversityJinanChina.

Together with the development of the focused assessment with sonography for trauma protocol for ultrasound in trauma patients,point-of-care ultrasound is widely used in the field of emergency and critical care *** have established several classic operating protocols for different diseases,such as acute respiratory failure,shock,and cardiac arrest,in the emergency department and intensive care *** further development in the portability and popularity of ultrasonic equipment,it is expected to be used as a new type of technology for physical examination,including inspection,palpation,percussion,auscultation,and insonation,which will improve the clinical medicine practice in the future.

关键词： Auscultation and insonation Inspection Palpation Percussion Point-of-care ultrasound Protocol Seven-point and nineplane protocol

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Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach

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Signal Transduction and Targeted Therapy 2022年第8期7卷 3054-3068页

作者： Xiaoyan Zhang Shan Li Haihua Luo Shuyue He Huangda Yang Lei Li Tian Tian Qizheng Han Jiacong Ye Chenyang Huang Aihua Liu Yong Jiang Guangdong provincial key laboratory of Proteomics State Key Laboratory of Organ Failure ResearchDepartment of PathophysiologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Respiratory and critical care medicine Nanfang HospitalSouthern Medical UniversityGuangzhouChina

Effectively killing pathogenic bacteria is key for the treatment of *** various anti-infective drugs have been used for the treatment of sepsis,the therapeutic effect is largely limited by the lack of a specific bacterium-targeting delivery *** study aimed to develop antibacterial peptides that specifically target pathogenic bacteria for the treatment of *** lethal bacterial strain Escherichia coli MSI001 was isolated from mice of a cecal ligation and puncture(CLP)model and was used as a target to screen bacterial binding heptapeptides through an integrative bioinformatics approach based on phage display technology and high-throughput sequencing(HTS).Heptapeptides binding to *** MSI001 with high affinity were acquired after normalization by the heptapeptide frequency of the library.A representative heptapeptide VTKLGSL(VTK)was selected for fusion with the antibacterial peptide LL-37 to construct the specific-targeting antibacterial peptide *** found that,in comparison with LL37,VTK-LL37 showed prominent bacteriostatic activity and an inhibitive effect on biofilm formation in *** vivo experiments demonstrated that VTK-LL37 significantly inhibited bacterial growth,reduced HMGB1 expression,alleviated lesions of vital organs and improved the survival of mice subjected to CLP ***,membrane DEGP and DEGQ were identified as VTKbinding proteins by proteomic *** study provides a novel strategy for targeted pathogen killing,which is helpful for the treatment of sepsis in the era of precise medicine.

关键词： inhibited organs strain

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Synthesis, Crystal Structure and Anti-lung Cancer Activity of a New Dy(Ⅱ) Complex

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Chinese Journal of Structural Chemistry 2017年第4期36卷 609-613页

作者：韩婧韩利梅邵松军夏婧范红 Department of Respiratory medicine and critical care medicine West China Hospital Sichuan University Department of Respiratory medicine and critical care medicine Institute of Respiratory Disease Guizhou Provincial People's Hospital Department of Respiratory medicine The Second Affiliated Hospital of Xinjiang Medical University Nursing School of Guizhou provincial People's Hospital

A new Dy-based coordination polymer, namely {[Dy（cptpy）_2（H_2O）_2]（TPT）（Cl）}_n（1, Hcptpy = 4-（4-carboxyphenyl）-4,2？：6？,4？？-terpyridine, TPT = 2,4,6-tri（4-pyridyl）-1,3,5-triazine, DMA = N,N-dimethylacetamide） has been solvothermally synthesized by the reactions of DyCl_3, Hcptpy and TPT in a mixture solvent of DMA and H_2O. Single-crystal X-ray structural analysis reveals that 1 is a 1D linear chain coordination polymer with quadrangle channels which are occupied by the TPT ligands. The compound has been characterized by singe-crystal analyses, thermogravimetry analyses and powder X-ray diffraction measurements. The antitumor activity of compound 1 and its corresponding organic ligands Hcptpy and TPT were then investigated against four human lung cancer cell lines（NCI-H460, Calu-3, A549 and NCI-H292） by MTT assay. It was found that compared with Hcptpy and TPT, compound 1 exerted rather potent activity against all of these cell lines.

关键词： coordination polymers 1D linear chain lung cancer

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Myocardial injury caused by Amanita pseudoporphyria Hongo

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World Journal of Emergency medicine 2024年第5期15卷 401-403页

作者： Junliang Xiao Chengliang Liao Xiquan Yan Xiaotong Han Maiying Fan Department of Emergency medicine the First Affi liated Hospital of Hunan Normal University(People's Hospital of Hunan Province)Changsha 410005China Clinical Research Center For Emergency and critical care in Hunan Province Changsha 410005China Hunan provincial Institute of Emergency medicine Changsha 410005China Hunan provincial key laboratory of Emergency and critical care Metabonomics Changsha 410005China

Amanita pseudoporphyria Hongo(APH)is a toxic mushroom containing Amanita toxin that is notably associated with liver and kidney function impairment.[1]Acute myocardial infarction(AMI)is a severe stage of coronary heart disease that can cause sudden death and is the leading cause of mortality and morbidity across the world.[2]The incidence rate of myocardial injury caused by accidental ingestion of APH is very *** this study,we aimed to report 11 patients who had varying degrees of myocardial injury,reduced heart function,and even cardiac arrest after accidental ingestion of APH.

关键词： mortality injury coronary

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