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Melanoma of the rectum: A rare entity

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World Journal of Gastroenterology 2008年第10期14卷 1633-1635页

作者： PM van Schaik MF Ernst HA Meijer K Bosscha jeroen bosch hospital Department of Surgery 's-Hertogenbosch 5211 The Netherlands jeroen bosch hospital Department of Pathology 's-Hertogenbosch 5211 The Netherlands

A 41-year-old man presented with a 6-mo history of changed defecation and rectal bleeding. A 3-cm polypoid tumor of the lower rectum was found at rectosigmoidos- copy, which proved to be a leiomyosarcoma upon biopsy. Dissemination studies did not show any metastases. He was underwent to an abdomino-perineal resection (APR). Histopathology of the specimen showed a melanoma (S-100 stain positive). Two years after the resection, me- tastases in the abdomen and right lung were found. He died one and half years later. Primary anorectal melano- ma is a rare and very aggressive disorder. According to current data, one should always perform a S-100 stain when anorectal sarcoma is suspected. A positive S-100 stain suggests the tumour to be most likely a melanoma. Subsequently, thorough dissemination studies need to be performed. Depending on the outcome of the dissemina- tion studies, a surgical resection has to be performed. Nowadays, a sphincter-saving local excision combined with adjuvant loco-regional radiotherapy should be pre- ferred in case of small tumors. The same loco-regional control is achieved with less "loss of function" compared to non-sphincter saving surgery. Only in the case of large and obstructing tumors an abdomino-perineal resection is the treatment of choice.

关键词：黑素瘤直肠腹-会阴切除术肿瘤治疗

Pelvic sepsis after stapled hemorrhoidopexy

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World Journal of Gastroenterology 2008年第38期14卷 5924-5926页

作者： Remco JA van Wensen Maarten H van Leuken Koop Bosscha Department of Surgery Jeroen Bosch Hospital Nieuwstraat 34 ' s-Hertogenbosch 5211 NL Netherlands Department of Radiology jeroen bosch hospital Nieuwstraat 34 's-Hertogenbosch 5211 NL Netherlands

Stapled hemorrhoidopexy is a surgical procedure used worldwide for the treatment of grade Ⅲ and Ⅳ hemorrhoids in all age groups. However, life-threatening complications occur occasionally. The following case report describes the development of pelvic sepsis after stapled hemorrhoidopexy. A literature review of techniques used to manage major septic complications after stapled hemorrhoidopexy was performed. There is no standardized treatment currently available. Stapled hemorrhoidopexy is a safe, effective and time-efficient procedure in the hands of experienced colorectal surgeons.

关键词：痔疮脓毒病外科治疗消化道疾病

Phase Ⅱ study of docetaxel,cisplatin and capecitabine as preoperative chemotherapy in resectable gastric cancer

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World Journal of Gastrointestinal Surgery 2016年第10期8卷 706-712页

作者： Anneriet E Dassen Nienke Bernards Valery EPP Lemmens Yes AJ van de Wouw Koop Bosscha Geert-Jan Creemers Hans JFM Pruijt Department of Gastro-intestinal Surgery and Surgical Oncology Jeroen Bosch Hospital Department of Oncology Catharina Hospital Comprehensive Cancer South (IKZ) Eindhoven Cancer Registry Department of Public Health Erasmus MC University Department of Oncology Vie Curi Hospital Department of Oncology Jeroen Bosch Hospital

AIM To investigate the feasibility of preoperative docetaxel,cisplatin and capecitabine(DCC) in patients with resectable gastric *** Patients with resectable gastric cancer fulfilling the inclusion criteria,were treated with 4 cycles of docetaxel(60 mg/m2),cisplatin(60 mg/m2) and capecitabine(1.875 mg/m2 orally on day 1-14,two daily doses) repeated every three weeks,followed by *** end point was the feasibility and toxicity/safety profile of DCC,secondary endpoints were pathological complete resection rate and pathological complete response(p CR) *** All of the patients(51) were assessable for the feasibility and safety of the *** entire preoperative regimen was completed by 68.6% of the *** Ⅲ/Ⅳ febrile neutropenia occurred in 10% of all *** patients died due to treatment related toxicity(5.9%),one of them(also) because of refusing further treatment for *** the 45 patients who were evaluable for secondary endpoints,four developed metastatic disease and 76.5% received a curative *** 3 patients a p CR was seen(5.9%),two patients underwent a R1 resection(3.9%).CONCLUSION Four courses of DCC as a preoperative regimen for patients with primarily resectable gastric cancer is highly *** high occurrence of febrile neutropenia is of *** decrease the occurrence of febrile neutropenia the prophylactic use of granulocyte colonystimulating factor(G-CSF) should be explored.A curative resection rate of 76.5% is *** use of DCC without G-CSF support as preoperative regimen in resectable gastric cancer is debatable.

关键词： Gastric cancer Preoperative chemotherapy Docetaxel Capecitabine

Low dose oral haloperidol does not prolong QTc interval in older acutely hospitalised adults： a subanalysis of a randomised double-blind placebo-controlled study

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Journal of Geriatric Cardiology 2018年第6期15卷 401-407页

作者： Edmee JM Schrijver Maaike Verstraaten Peter M van de Ven Pierre M Bet Astrid M van Strien Carel de Cock Prabath WB Nanayakkara on behalf of all HARPOON Investigators Department of Internal Medicine VU University Medical Centre Amsterdam the Netherlands Department of Cardiology VU University Medical Centre Amsterdam the Netherlands Department of Epidemiology and Biostatistics VU University Medical Centre the Netherlands Department of Clinical Pharmacology and Pharmacy VU University Medical Centre the Netherlands Department of Geriatric Medicine Jeroen Bosch Hospital s-Hertogenbosch the Netherlands

BackgroundHaloperidol 是经常规定的大多数为谵妄症状抑制精神。 QTc 延伸的风险经常提起担心，尽管 QTc 间隔上的 haloperidol 的效果还没在 randomised 被调查了一个 randomised 双窗帘的控制安慰剂的改正剂量 *** subanalysis 控... 详细信息

BackgroundHaloperidol 是经常规定的大多数为谵妄症状抑制精神。 QTc 延伸的风险经常提起担心，尽管 QTc 间隔上的 haloperidol 的效果还没在 randomised 被调查了一个 randomised 双窗帘的控制安慰剂的改正剂量 *** subanalysis 控制安慰剂的学习被进行评估预防 haloperidol 的效果 1 mg 或安慰剂 1 mg 口头上地两次每日( 14 剂量的最大值)在 QTc 上，在病人的间隔变老 70 年并且在上。床边， 12 铅 ECG 被记录在前，在期间并且在一个星期干预时期以后。自动 QTc 大小除了 QT 和 RR 间隔的用手的大小被获得，为治疗使失明地位。用手的大小被改正(QTc ) 使用 Bazett (QTc-B ) ， Framingham (QTc-Fa ) ， Fridericia (QTc-Fi ) 和霍奇斯(QTc-H ) 方法。混合模型分析在在收到 haloperidol 和 72 个病人的 *** 记录的病人之间的 QTc 的纵的路线为差别习惯于测试(haloperidol n = 38 ) 被分析， 45.8% 男性。中部(范围)白天 4 上的 haloperidol 浆液集中是 0.71 ( 0.32-1.82 )溜????????????????????????????????????????????????

关键词：低剂量学习控制窗帘成年人 ECG 模型分析最大值

麻醉技术对结肠癌患者术后生存期的影响:文献综述

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Gastroenterology Report 2016年第1期4卷 30-34,I0002页

作者： F.jeroen Vogelaar Daan J.Lips Frank R.C.van Dorsten Valery E.Lemmens Koop Bosscha Department of Surgery Jeroen Bosch Hospital‘s-Hertogenboschthe Netherlands Department of Surgery VieCuri Medical CentreVenlothe Netherlands Department of Anaesthesiology Jeroen Bosch Hospital‘s-Hertogenboschthe Netherlands Department of Research Netherlands Cancer Registry/Comprehensive Cancer Organisation The NetherlandsEindhoventhe Netherlands Department of Public Health Erasmus MC University Medical CentreRotterdamthe Netherlands

对于潜在可根治的结肠癌,手术切除是核心治疗方式。尽管肉眼看不见,但大多数患者术中都会残留一些癌细胞。而手术本身所引起的免疫抑制也会影响到肿瘤复发和术后生存。相较于阿片类麻醉剂,区域阻滞麻醉或椎管内麻醉(如硬膜外麻醉)或可... 详细信息

对于潜在可根治的结肠癌,手术切除是核心治疗方式。尽管肉眼看不见,但大多数患者术中都会残留一些癌细胞。而手术本身所引起的免疫抑制也会影响到肿瘤复发和术后生存。相较于阿片类麻醉剂,区域阻滞麻醉或椎管内麻醉(如硬膜外麻醉)或可通过减少应激和降低阿片类麻醉剂的用量,减轻对免疫功能的抑制作用。研究显示,区域阻滞麻醉可降低乳腺癌和前列腺癌的复发率,从而印证了这一假设。然而对于结肠癌,相关研究结果却不尽一致。本文对所有探讨硬膜外麻醉与结肠癌手术患者生存相关性的研究进行了综述。

关键词：结肠癌硬膜外麻醉免疫抑制生存

在疑诊阑尾炎病人的诊断流程中进行强制性影像检查能够减少医疗费用并降低不必要的手术率

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国际医学放射学杂志 2015年第4期 395-396页

作者： M.J.Lahaye D.M.J.Lambregts E.Mutsaers B.A.B.Essers S.Breukink V.C.Cappendijk 高丽珍 Department of Radiology Jeroen Bosch Hospital's Hertogenbosch

摘要目的评估对疑似阑尾炎病人进行强制性影像检查能否有效减少不必要的手术和医疗费用。方法 2010年荷兰建立指南建议对临床疑诊阑尾炎进行术前强制性影像检

关键词：阑尾炎病人影像检查医疗费用手术率强制性

An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

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Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-Ha Jeong Jarno Hiemstra Patrick V.Blokzijl Rebeca Damian-Ferrara Danilo Martins dos Santos Jéssica H.L.da Fonseca Min-Ho Kang Jihyun Kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez jeroen Leijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

Cytomegalovirus in inflammatory bowel disease： Asystematic review

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World Journal of Gastroenterology 2016年第3期22卷 1321-1330页

作者： Tessa EH Römkens Geert J Bulte Loes HC Nissen Joost PH Drenth Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Centre6500 HB NijmegenThe Netherlands Department of Gastroenterology and Hepatology Jeroen Bosch Hospital5200 ME HertogenboschThe Netherlands

AIM: To identify definitions of cytomegalovirus(CMV) infection and intestinal disease, in inflammatory bowel disease(IBD), to determine the prevalence associated with these ***: We conducted a systematic review and interrogated Pub Med, EMBASE and Cochrane for literature on prevalence and diagnostics of CMV infection and intestinal disease in IBD patients. As medical headings we used "cytomegalovirus" OR "CMV" OR "cytomegalo virus" AND "inflammatory bowel disease" OR "IBD" OR "ulcerative colitis" OR "colitis ulcerosa" OR "Crohn's disease". Both Me SH-terms and free searches were performed. We included all types of English-language(clinical) trials concerning diagnostics and prevalence of CMV in ***: The search strategy identified 924 citations, and 52 articles were eligible for inclusion. We identified 21 different definitions for CMV infection, 8 definitions for CMV intestinal disease and 3 definitions for CMV reactivation. Prevalence numbers depend on used definition, studied population and region. The highest prevalence for CMV infection was found when using positive serum PCR as a definition, whereas for CMV intestinal disease this applies to the use of tissue PCR > 10 copies/mg tissue. Most patients with CMV infection and intestinal disease had steroid refractory disease and came from East ***: We detected multiple different definitions used for CMV infection and intestinal disease in IBD patients, which has an effect on prevalence numbers and eventually on outcome in different trials.

关键词： Inflammatory bowel disease Cytomegalovirus Ulcerative colitis Crohn's disease Systematicreview

Single-port laparoscopic cholecystectomy vs standard laparoscopic cholecystectomy:A non-randomized,agematched single center trial

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World Journal of Gastrointestinal Surgery 2015年第8期7卷 145-151页

作者： Yoen TK van der Linden Koop Bosscha Hubert A Prins Daniel J Lips Department of Surgery Jeroen Bosch Hospital

AIM: To compare the safety of single-port laparoscopic cholecystectomies with standard four-port ***: Between January 2011 and December 2012 datas were gathered from 100 consecutive patients who received a single-port cholecystectomy. Patient baseline characteristics of all 100 single-port cholecystectomies were collected(body mass index, age, etc.) in a database. This group was compared with 100 age-matched patients who underwent a conventional laparoscopic cholecystectomy in the same period. Retrospectively, per- and postoperative data were added. The two groups were compared to each other using independent t-tests and χ2-tests, P values below 0.05 were considered significantly ***: No differences were found between both groups regarding baseline characteristics. Operating time was significantly shorter in the total single-port group(42 min vs 62 min, P hospital stay, readmissions and mortality. CONCLUSION: Single-port laparoscopic cholecystectomy has the potential to be a safe technique with a low complication rate, short in-hospital stay and comparable operating time. Single-port cholecystectomy provides the patient an almost non-visible scar while preserving optimal quality of surgery. Further prospective studies are needed to prove the safety of the single-port technique.

关键词： Single-port Minimal invasive Laparoscopy Safety Fe