Low dose oral haloperidol does not prolong QTc interval in older acutely hospitalised adults： a subanalysis of a randomised double-blind placebo-controlled study

作     者：Edmee JM Schrijver Maaike Verstraaten Peter M van de Ven Pierre M Bet Astrid M van Strien Carel de Cock Prabath WB Nanayakkara on behalf of all HARPOON Investigators 

作者机构：Department of Internal Medicine VU University Medical Centre Amsterdam the Netherlands Department of Cardiology VU University Medical Centre Amsterdam the Netherlands Department of Epidemiology and Biostatistics VU University Medical Centre the Netherlands Department of Clinical Pharmacology and Pharmacy VU University Medical Centre the Netherlands Department of Geriatric Medicine Jeroen Bosch Hospital s-Hertogenbosch the Netherlands 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2018年第15卷第6期

页      面：401-407页

核心收录：

学科分类：0711[理学-系统科学] 0832[工学-食品科学与工程（可授工学、农学学位）] 07[理学] 081104[工学-模式识别与智能系统] 08[工学] 0811[工学-控制科学与工程] 071102[理学-系统分析与集成] 081103[工学-系统工程] 083203[工学-农产品加工及贮藏工程] 

主　　题：Haloperidol Prolongation QTc interval The aged 

摘      要：Background Haloperidol is the most frequently prescribed antipsycbotic for delirium symptoms. The risk of QTc prolongation often raises concerns, although the effect of haloperidol on QTc interval has not yet been investigated in a randomised placebo-controlled fixed-dose study. Methods A subanalysis of a randomised double-blind placebo-controlled study was conducted to evaluate the effect of prophylactic haloperidol 1 mg or placebo 1 mg orally twice-daily （maximum of 14 doses） on QTc interval in patients aged 70 years and over. Bedside, 12-lead ECGs were recorded before, during and after the one-week intervention period. Automatic QTc measurements were ob- tained in addition to manual measurements of QT and RR intervals, blinded for treatment status. Manual measurements were corrected （QTc） using Bazett （QTc-B）, Framingham （QTc-Fa）, Fridericia （QTc-Fi） and Hodges （QTc-H） methods. Mixed model analyses were used to test for differences in longitudinal course of QTc between patients receiving haloperidol and placebo. Results ECG recordings of 72 patients （haloperidol n = 38） were analysed, 45.8% male. Median （range） haloperidol serum concentration on day 4 was 0.71 （0.32-1.82） μg/L （n = 23）. Longitudinal course of mean QTc did not significantly differ between treatment arms for any of the automatic or manually derived QTc values. Conclusions Low dose oral haloperidol did not result in QTc prolongation in older acutely hospitalised patients. Results may not be generalizable to patients with existing ECG abnormalities such as atrial fibrillation.