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Potential underlying genetic associations between keratoconus and diabetes mellitus

Advances in Ophthalmology Practice and Research 2021年第1期1卷 15-31页

作者： Kristin M.Ates Amy J.Estes Yutao Liu Department of Cellular Biology and Anatomy Medical College of GeorgiaAugusta UniversityAugustaGAUSA Department of Ophthalmology Medical College of GeorgiaAugusta UniversityAugustaGAUSA james and jean culver vision discovery institute Medical College of GeorgiaAugusta UniversityAugustaGAUSA Center for Biotechnology and Genomic Medicine Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Background:Keratoconus(KC)is the most common ectatic corneal disease,characterized by significantly localized thinning of the corneal ***,environmental,hormonal,and metabolic factors contribute to the pathogenesis of ***,multiple comorbidities,such as diabetes mellitus,may affect the risk of *** Text:Patients with diabetes mellitus(DM)have been reported to have lower risk of developing KC by way of increased endogenous collagen crosslinking in response to chronic ***,this remains a debated topic as other studies have suggested either a positive association or no association between DM and *** gain further insight into the underlying genetic components of these two diseases,we reviewed candidate genes associated with KC and central corneal thickness in the *** then explored how these genes may be regulated similarly or differentially under hyperglycemic conditions and the role they play in the systemic complications associated with ***:Our comprehensive review of potential genetic factors underlying KC and DM provides a direction for future studies to further determine the genetic etiology of KC and how it is influenced by systemic diseases such as diabetes.

关键词： Keratoconus Genetics Diabetes Collagen crosslinking Oxidative stress

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