Potential underlying genetic associations between keratoconus and diabetes mellitus

作     者：Kristin M.Ates Amy J.Estes Yutao Liu 

作者机构：Department of Cellular Biology and AnatomyMedical College of GeorgiaAugusta UniversityAugustaGAUSA Department of OphthalmologyMedical College of GeorgiaAugusta UniversityAugustaGAUSA James and Jean Culver Vision Discovery InstituteMedical College of GeorgiaAugusta UniversityAugustaGAUSA Center for Biotechnology and Genomic MedicineMedical College of GeorgiaAugusta UniversityAugustaGAUSA 

出 版 物：《Advances in Ophthalmology Practice and Research》 (眼科实践与研究新进展（英文）)

年 卷 期：2021年第1卷第1期

页      面：15-31页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Institutes of Health[grant numbers R01EY023242,R21EY028671,and P30EY031631] the startup fund from the Medical College of Georgia at Augusta University,Augusta,GA,USA 

主　　题：Keratoconus Genetics Diabetes Collagen crosslinking Oxidative stress 

摘      要：Background:Keratoconus(KC)is the most common ectatic corneal disease,characterized by significantly localized thinning of the corneal ***,environmental,hormonal,and metabolic factors contribute to the pathogenesis of ***,multiple comorbidities,such as diabetes mellitus,may affect the risk of *** Text:Patients with diabetes mellitus(DM)have been reported to have lower risk of developing KC by way of increased endogenous collagen crosslinking in response to chronic ***,this remains a debated topic as other studies have suggested either a positive association or no association between DM and *** gain further insight into the underlying genetic components of these two diseases,we reviewed candidate genes associated with KC and central corneal thickness in the *** then explored how these genes may be regulated similarly or differentially under hyperglycemic conditions and the role they play in the systemic complications associated with ***:Our comprehensive review of potential genetic factors underlying KC and DM provides a direction for future studies to further determine the genetic etiology of KC and how it is influenced by systemic diseases such as diabetes.