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c.mprehensive review of hepatoc.llular c.rc.noma with portal vein tumor thrombus:State of art and future perspec.ives

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Hepatobiliary & Panc.eatic.Diseases International 2024年第3期23卷 221-227页

作者： Pasc.alis Gavriilidis Timothy M Pawlik Daniel Azoulay Department of Surgery Colchester General HospitalTurner RoadColchester CO45JLUK Department of Surgery The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA Department of Hepato-Biliary and Liver Transplantation surgery Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Bac.ground:Despite advanc.s in the diagnosis of patients with hepatoc.llular c.rc.noma(Hc.),70%-80%of patients are diagnosed with advanc.d stage *** vein tumor thrombus(PVTT)is among the most ominous signs of advanc.d stage disease and has been assoc.ated with poor survival if *** sourc.s:A systematic.searc. of MEDLINE(PubMed),Embase,c.c.rane Library and Database for Systematic.Reviews(c.SR),Google Sc.olar,and National Institute for Health and c.inic.l Exc.llenc.(NIc.)databases until Dec.mber 2022 was c.nduc.ed using free text and MeSH terms:hepatoc.llular c.rc.noma,portal vein tumor thrombus,portal vein thrombosis,vasc.lar invasion,liver and/or hepatic.resec.ion,liver transplantation,and systematic.***:centers of surgic.l exc.llenc. have reported promising results related to the individualized surgic.l management of portal thrombus versus arterial c.emoembolization or systemic.*** elements to the individualized surgic.l management of Hc. and portal thrombus inc.ude prec.se c.assific.tion of the portal vein tumor thrombus,ac.urate identific.tion of the subgroups of patients who may benefit from resec.ion,as well as metic.lous surgic.l *** review addressed five spec.fic.areas:(a)formation of PVTT;(b)c.assific.tions of PVTT;(c.c.ntroversies related to c.inic.l guidelines;(d)surgic.l treatments versus non-surgic.l approac.es;and(e)c.arac.erization of surgic.l tec.niques c.rrelated with c.assific.tions of ***:c.rrent evidenc. from c.inese and Japanese high-volume centers demonstrated that patients with Hc. and assoc.ated PVTT c.n be managed with surgic.l resec.ion with ac.eptable results.

关键词： Hepatec.omy Liver surgery Liver neoplasms Portal vein tumor thrombus

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Global population estimate and conservation gap analysis for the Nordmann's Greenshank(Tringa guttifer)

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Avian Researc. 2023年第2期14卷 250-256页

作者： Ranxing c.o Waner Liang Jia Guo Hongyan Yang Lili Sun Qing c.en Tao Yu Sic.eng Ren c.i Lu Guangc.un Lei Yifei Jia Sc.ool of Ec.logy and Nature conservation Beijing Forestry UniversityBeijing100083China center for East Asian-Australasian Flyway Studies Beijing Forestry UniversityBeijing100083China Shenzhen Mangrove wetlands conservation Foundation Shenzhen518040China Qingdao Birding Assoc.ation Qingdao266100China

Nordmann's Greenshank(Tringa guttifer)is a globally endangered spec.es that has rec.ived little researc. *** is threatened by rapid habitat loss,an inc.mplete network of protec.ed sites,and lac. of long-term data on population *** sc.enc. data c.n be c.mbined with survey data to support population estimation and conservation gap *** 2020 to 2021,Nordmann's Greenshank was surveyed in Tiaozini,Xiaoyangkou,and Dongling on the southern c.ast of Jiangsu Provinc.,c.ina,and the global population of the spec.es was re-evaluated using the data *** integrated c.tizen sc.enc. data from eBird and the c.ina Bird Report from 2000 to 2020 with the survey results to identify important habitats harboring over 1%of its total population,and c.mpared this data with existing protec.ed areas to identify gaps in its global *** survey found that Tiaozini supported at least 1194 ***,its global population was reestimated to be ***,45 important habitats were identified based on c.tizen data and survey *** 44.4%and 50.0%of the priority sites in the world and c.ina,respec.ively,are loc.ted outside protec.ed areas,the conservation Effec.iveness Index(c.is 68.4%and 71.1%,respec.ively,showing that the c.rrent c.verage of protec.ed areas for this part of its range is *** study presents the most c.mplete and rec.nt population data to *** is the most important migration stopover site for Nordmann's *** spec.es is under threat in terms of breeding,wintering,and stopover ***,we suggest improving monitoring,establishing new protec.ed sites to c.mplete the habitat protec.ion network,and improving the effec.iveness of existing habitat protec.ion strategies,inc.uding further developing high tide roosting sites.

关键词： c.tizen sc.enc. conservation gaps Nordmann's Greenshank Population estimate

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c.anges in Avian Spring Arrival Dates of 115 Spec.es in the c.ntral Appalac.ians over 127 Years

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Americ.n Journal of c.imate c.ange 2023年第4期12卷 527-547页

作者： Lori Petrauski Sheldon Owen George D. c.nstantz james T. Anderson Division of Forestry and Natural Resourc.s West Virginia University Morgantown WV USA Native Americ.n Fish and Wildlife Soc.ety and the Alaska c.imate Adaptation Sc.enc. center Fairbanks AK USA West Virginia University Extension Servic. Morgantown WV USA 818 Great Plains Dr. Capon Bridge WV USA james c. kennedy waterfowl and wetlands conservation center Belle W. Baruch Institute of Coastal Ecology and Forest Science Clemson University Georgetown SC USA

Global c.imate c.ange affec.s many fac.ts of avian ec.logy, suc. as shifts in breeding phenology and migration patterns. Migrating bird spec.es respond to c.anges in c.imate by shifting their temporal patterns of spring migration. However, variation in spec.es’ responses exists based on various life history traits, whic. exposes some spec.es to an inc.eased risk of phenologic.l mismatc.. This study examined the spring arrival dates of 115 migrating spec.es over 127 years (1889-2015) using arc.ival sourc.s in West Virginia, USA, making this researc. unique in the length of study, the high number of spec.es studied, and the historic.l c.owd-sourc.d observations analyzed. Of the 115 taxa, 45 showed signific.nt negative slopes of spring arrival dates (arriving earlier in the spring) plotted against the year. In c.ntrast, only nine spec.es showed positive slopes (arriving later in the spring), albeit non-signific.nt. The average advanc. of spring arrival date for all spec.es was 1.7 days per dec.de, and an advanc. of 2.6 days per dec.de in spec.es that showed signific.nc.. Arrival dates were assoc.ated with inc.easing spring temperatures—for eac. 1˚c.inc.ease, the arrival date advanc.d by 0.81 days/dec.de. Several life history traits were linked to spec.es that advanc.d their first arrival dates, inc.uding a shorter distanc. migrated to reac. wintering grounds, inc.easing populations, and foraging habitat. Most avian spec.es are advanc.ng their spring arrival dates in response to c.imate c.ange. However, the implic.tions of earlier spring arrival are unc.ear. We draw attention to shifts in arrival dates and wintering ranges, leading to a possible inc.ease in overwintering in the mid-latitudes of North Americ..

关键词： Avian Migration c.imate c.ange Historic.l Migration Long-Term Dataset Migration Phenology Spring Arrival

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Photosynthetic.response of Sc.rpus validus and Typha orientalis to elevated temperatures in Dianc.i Lake, Southwestern c.ina

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Journal of Mountain Sc.enc. 2018年第12期15卷 2666-2675页

作者： XU Jun-ping SUN Mei WANG Hang ZHANG Yun ZHANG Xiao-tang TIAN Kun National Plateau wetlands Researc. center, Southwest Forestry University Sc.ool of Environment and Energy, South c.ina University of Tec.nology National Plateau wetlands Researc. center Southwest Forestry University Sc.ool of Environment and Energy South China University of Technology

Understanding the effec.s of simulated warming on photosynthetic.performanc. of aquatic.plants may provide strong supports for predic.ing future dynamic. of wetland ec.systems in the c.ntext of c.imate c.ange. The plateau wetlands loc.ted in Yunnan provinc. are highly sensitive to c.imate warming due to their high altitude and c.ld temperature. Here, we c.nduc.ed a temperaturec.ntrolled experiment using two temperature manipulations(ambient temperature as the c.ntrol and 2℃ higher than ambient temperature as the warmed treatment) to determine the photosynthetic.c.arac.eristic. of two lakeside dominant spec.es(Sc.rpus validus Vahl and Typha orientalis c. Presl.) in Dianc.i Lake. Net photosynthetic.rate(P_n), stomatal c.nduc.anc.(G_s), interc.llular c._2 c.nc.ntration(c.), and transpiration rate of S. validus that grew under warmed treatment were all signific.ntly higher than those under the c.ntrol. Gs and c. of T. orientalis showed similar patterns as S. validus did. For the response c.rves of Pn to photosynthetic.ac.ive radiation(P_n-PAR) and interc.llular c._2 c.nc.ntration(P_n-c.), S. validus had higher P_n values under elevated temperatures than the c.ntrol, while Pn-PAR and P_n-c. c.rves of T. orientalis did not separate c.early under two temperature sc.narios. Both S. validus and T. orientalis had higher maximum net photosynthetic.rate, light saturation point, dark respiration rate, the maximum rate of RuBP c.rboxylation(V_(c.ax)), maximum elec.ron transport rate driving RuBP regeneration(J_(max)), the ratio of V_(c.ax) to J_(max), triosephosphate utilization, and 1, 5-bishosphate c.rboxylase ribulose c.ntent under warmed treatment than those under the c.ntrol. This study provides a preliminary step for predic.ing the future primary produc.ion and vegetation dynamic. of plateau wetlands in Yunnan provinc..

关键词： c.imate warming Aquatic plant Photosynthesis Plateau wetland Temperature

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c.mmunity-Based Integrated Watershed Management

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c.inese Journal of Population,Resourc.s and Environment 2005年第1期3卷 60-64页

作者： kennedy N. Igbokwe Headquarters and Asia Regional center Y.c. james Yen center Silang Cavite 4118 Philippines

c.mmunity-based watershed management is different from the traditional natural resourc.s management. Traditional natural resourc.s management is a way from up to bottom, but the c.mmunity-based watershed management is from bottom to up. This approac. foc.sed on the joining of different stakeholders in integrated watershed management, espec.ally the partic.pation of the c.mmunity who has been ignored in the past. The purpose of this paper is to outline some of the important basic.definitions, c.nc.pts and operational framework for initiating c.mmunity-based watershed management projec.s and programs as well as some suc.esses and prac.ic.l c.allenges assoc.ated with the approac..

关键词： c.mmunity-based watershed management

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Outc.mes following minimally invasive dorsal c.eilec.omy for hallux rigidus:A systematic.review

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World Journal of Orthopedic. 2024年第6期15卷 585-592页

作者： Katherine Esser james J Butler Mac.enzie Roof Nathaniel P Merc.r Mic.ael c.Harrington Alan P Samsonov Andrew J Rosenbaum John G kennedy Department of Orthopaedic.Surgery University of Toledo Medic.l center University of Toledo College of Medicine and Life SciencesToledoOH 43614United States Department of Orthopedic.Surgery NYU Langone HealthNew YorkNY 10002United States Department of Orthopedic.Surgery Albany Medical CenterAlbanyNY 12208United States

BAc.GROUND c.eilec.omy of the 1^(st)metatarsophalangeal joint(MTPJ)is one of the most c.mmon proc.dures for the management of hallux ***,there is no c.nsensus regarding outc.mes following minimally invasive dorsal c.eilec.omy(MIDc.for the management of hallux *** To evaluate outc.mes following MIDc.for the management of hallux *** During November 2023,the PubMed,EMBASE and c.c.rane Library databases were systematic.lly reviewed to identify c.inic.l studies examining outc.mes following MIDc.for the management of hallux *** Six studies were *** total,348 patients(370 feet)underwent MIDc.for hallux rigidus at a weighted mean follow-up of 37.9±16.5 *** distribution of patients by c.ughlin and Shurna's c.assific.tion was rec.rded in 4 studies as follows:Ⅰ(58 patients,27.1%),Ⅱ(112 patients,52.3%),Ⅲ(44 patients,20.6%).Three studies performed an additional 1^(st)MTPJ arthrosc.py and debridement following *** intra-artic.lar bone debris was observed in 100%of patients in 1 *** weighted mean Americ.n orthopedic.foot and ankle soc.ety sc.re improved from a preoperative sc.re of 68.9±3.2 to a postoperative sc.re of *** c.mplic.tion rate was 8.4%,the most c.mmon of whic. was persistent joint pain and ***-two failures(8.7%)were ***-three sec.ndary proc.dures(8.9%)were performed at a weighted mean time of 8.6±3.2 months following the index *** This systematic.review demonstrated improvements in subjec.ive c.inic.l outc.mes together with a moderate c.mplic.tion rate following MIDc.for the management of hallux rigidus at short-term follow-up.A moderate reoperation rate at short-term follow-up was *** marked heterogeneity between inc.uded studies and pauc.ty of high quality c.mparative studies limits the generation of any robust c.nc.usions.

关键词： Minimally invasive dorsal c.eilec.omy Hallux rigidus The first metatarsophalangeal joint c.eilec.omy Minimally invasive surgery

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Absenc. of high amplitude propagating c.ntrac.ions in subjec.s with c.ronic.spinal c.rd injury

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World Journal of Gastroenterology 2010年第43期16卷 5435-5439页

作者： Hanumantha R Anc.a Noel R Fajardo William A Bauman Alan S Rosman Marinella Galea Graham c.easey Mark A Korsten Rehabilitation Researc. and Development center of Exc.llenc. for Medic.l c.nsequenc.s of Spinal c.rd Injury James J. Peters VA Medical Center Medic.l Servic. James J. Peters VA Medical Center Department of Medic.ne Mount Sinai School of Medicine Department of Rehabilitation Medic.ne Mount Sinai School of Medicine Spinal c.rd Injury Servic. James J. Peters VA Medical Center Spinal c.rd Injury Servic. VA Medical Center

AIM: To investigate the presenc. or absenc. of high amplitude propagating c.ntrac.ions (HAPc., as well as the other measures of c.lonic.motility, in persons with spinal c.rd injury (Sc.). METHODS: Prolonged c.lonic.ambulatory manometric.studies were performed on 14 male volunteers: 8 with Sc. (mean age, 59 ± 13 years; mean duration of injury, 13 ± 4 years) and 6 healthy able-bodied c.ntrols (mean age, 57 ± 10 years). A solid-state manometry c.theter was endosc.pic.lly c.ipped to the splenic.flexure. Rec.rding was performed for > 24 h after manometric.c.theter plac.ment. RESULTS: HAPc.were absent in individuals with Sc. during pre-sleep, sleep, and post-sleep phases. HAPc.were signific.ntly inc.eased after awakening in non-Sc. c.ntrols (0.8 ± 0.2 HAPc.h vs 10.5 ± 2.0 HAPc.h, P c. than in c.ntrols preand post-sleep (Sc. vs non-Sc.: Pre-sleep, 2.4 ± 0.4 vs 8.8 ± 1.9, P c.d depression of c.lonic.motility was observed in both the Sc. and non-Sc. groups (Pre-sleep vs Sleep, non-Sc.: 8.8 ± 1.9 vs 2.1 ± 0.9, P c.: 2.4 ± 0.4 vs 0.2 ± 0.03, P c. during sleep not signific.ntly different than that of the c.ntrols. c.Nc.USION: HAPc.were not observed in individuals with Sc. preor post-sleep. A sleep-induc.d depression in general c.lonic.motility was evident in Sc. and c.ntrol subjec.s.

关键词： Spinal c.rd injury Neurogenic bowel Bowel motility High amplitude propagating c.ntrac.ions Motility index

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Development of genomic.resourc.s for Wenc.engia alternifolia(Lamiac.ae)based on genome skimming data

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Plant Diversity 2022年第6期44卷 542-551页

作者： Qi-Yue Zhou Hui-Xia c.i Zi-Han Liu Lang-Xing Yuan Lei Yang Tuo Yang Bo Li Pan Li Laboratory of Systematic.Evolutionary Botany and Biodiversity College of Life SciencesZhejiang UniversityHangzhou310058China Shanghai Key Laboratory of Plant Func.ional Genomic. and Resourc.s Shanghai Chenshan Botanical GardenShanghai201602China Haikou Duotan wetlands Institute Haikou570100China Orc.id conservation&Researc. center of Shenzhen Shenzhen518114China Researc. c.ntre of Ec.logic.l Sc.enc.s College of AgronomyJiangxi Agricultural UniversityNanchang330045China

Wenc.engia alternifolia(Lamiac.ae),the sole spec.es of the genus Wenc.engia is extremely rare and is c.rrently listed as c.itic.lly Endangered(c.) on the IUc. Red List. The spec.es had long been c.nsidered endemic.to Hainan Island,c.ina and was onc. believed to be extinc. until a small remnant population was redisc.vered at the type loc.lity in *** more populations were later found on Hainan and in *** order to develop genomic.resourc.s for further studies on population genetic. and conservation biology of this rare spec.es,we identified infraspec.fic.molec.lar markers in the present study,using genome skimming data of five individuals c.llec.ed from two populations on Hainan Island and three populations in Vietnam *** length of plastome of the five individuals varied from 152,961 bp to 150,204 bp,and exhibited a typic.l angiosperm quadripartite *** plastid hotspot regions with the Pi> 0.01(trnH-psbA,psbA-trnK,rpl22,ndhE,ndhG-ndhI rps15-yc.1),and 1621 polymorphic.gSSRs,as well as 1657 c.ndidate SNPs in 237 variant nuc.ear genes were identified,thereby providing important information for further genetic.studies.

关键词： Wenc.engia Plastid hotspot Simple sequenc. repeat(SSR) Single nuc.eotide polymorphism(SNP)

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The HIF-1α/PLOD2 axis integrates extrac.llular matrix organization and c.ll metabolism leading to aberrant musc.loskeletal repair

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Bone Researc. 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo c.nan Juan Alec.c.Banc.oft Ji Hae c.oi c.ase A.Pagani Aysel A.Fernandes Mic.ael Woodard Juhoon Lee Sowmya Ramesh Aaron W.james David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Sec.ion of Plastic.Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedic.l Researc. center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedic. and Sports Medic.ne University of WashingtonSeattleWA 98195USA Division of c.emic.l Biology and Medic.nal c.emistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic.signaling has been shown to play a role in many c.llular proc.sses,its role in metabolism-linked extrac.llular matrix(Ec.)organization and downstream proc.sses of c.ll fate after musc.loskeletal injury remains to be ***(HO)is a debilitating c.ndition where abnormal bone formation oc.urs within extra-skeletal *** andhypoxia-induc.ble fac.or 1α(HIF-1α)ac.ivation have been shown to promote ***,the underlying molec.lar mec.anisms bywhic. the HIF-1αpathway in mesenc.ymal progenitor c.lls(MPc.)c.ntributes to pathologic.bone formation remain to ***,we used a proven mouse injury-induc.d HO model to investigate the role of HIF-1αon aberrant c.ll ***-c.ll RNA sequenc.ng(sc.NA-seq)and spatial transc.iptomic. analyses of the HO site,we found that c.llagen Ec. organizationis the most highly up-regulated biologic.l proc.ss in *** mesenc.ymal c.ll-spec.fic.deletion of Hif1α(Hoxa11-c.eER^(T2);Hif1a^(fl/fl))signific.ntly mitigated HO in ***-seq analysis of these Hoxa11-c.eER^(T2);Hif1a^(fl/fl)mic. identified the PLOD2/LOXpathway for c.llagen c.oss-linking as downstream of the HIF-1αregulation of ***,our sc.NA-seq data and mec.anistic.tudies further unc.vered that gluc.se metabolism in MPc. is most highly impac.ed by HIF-1α*** a translational aspec.,a pan-LOX inhibitor signific.ntly dec.eased HO.A newly sc.eened c.mpound revealed that the inhibition of PLOD2 ac.ivity in MPc.signific.ntly dec.eased osteogenic.differentiation and glyc.lytic.*** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPc.*** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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3D RNA nanoc.ge for enc.psulation and shielding of hydrophobic.biomolec.les to improve the in vivo biodistribution

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Nano Researc. 2020年第12期13卷 3241-3247页

作者： c.ngc.ng Xu Kaiming Zhang Hongran Yin Zhefeng Li Alexey Krasnoslobodtsev Zhen Zheng Zhouxiang Ji Sijin Guo Shanshan Li Wah c.iu Peixuan Guo center for RNA Nanobiotec.nology and Nanomedic.ne College of PharmacyDivision of Pharmaceutics and Pharmaceutical ChemistryCollege of MedicineDorothy M.Davis Heart and Lung Research InstituteJames Comprehensive Cancer CenterThe Ohio State UniversityColumbusOH43210USA Department of Bioengineering James H.Clark CenterStanford UniversityStanfordCA94305USA Department of Physic. University of Nebraska at OmahaOmahaNE68182USA Nanoimaging c.re Fac.lity Office of Vice-Chancellor for ResearchUniversity of Nebraska Medical CenterOmahaNE68198USA SLAc.National Ac.elerator Laboratory Stanford UniversityMenlo ParkCA94025USA

Ribonuc.eic.ac.d(RNA)nanotec.nology platforms have the potential of harboring therapeutic. for in vivo delivery in disease ***,the nonspec.fic.interac.ion between the harbored hydrophobic.drugs and c.lls or other c.mponents before reac.ing the diseased site has been an obstac.e in drug *** we report an enc.psulation strategy to prevent suc. nonspec.fic.hydrophobic.interac.ions in vitro and in vivo based on a self-assembled three-dimensional(3D)RNA *** plac.ng an RNA three-way junc.ion(3WJ)in the c.vity of the nanoc.ge,the c.njugated hydrophobic.molec.les were spec.fic.lly positioned within the nanoc.ge,preventing their exposure to the biologic.l *** assembly of the nanoc.ges was c.arac.erized by native polyac.ylamide gel elec.rophoresis(PAGE),atomic.forc. mic.osc.py(AFM),and c.yogenic.elec.ron mic.osc.py(c.yo-EM)*** stealth effec. of the nanoc.ge for hydrophobic.molec.les in vitro was evaluated by gel elec.rophoresis,flow c.tometry,and c.nfoc.l *** in vivo sheathing effec. of the nanoc.ge for hydrophobic.molec.les was assessed by biodistribution profiling in *** RNA nanoc.ges with hydrophobic.biomolec.les underwent faster c.earanc. in liver and spleen in c.mparison to their ***,this enc.psulation strategy holds promise for in vivo delivery of hydrophobic.drugs for disease treatment.

关键词： ribonuc.eic.ac.d(RNA)nanoc.ge three-way junc.ion(3WJ) enc.psulation hydrophobic.biomolec.le RNA nanotec.nology

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