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牛痘相关激酶2在神经发育过程中小胶质细胞介导的突触消除中起重要作用

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神经损伤与功能重建 2019年第5期14卷 F0003-F0003页

作者： Lee J Lee S Ryu YJ Lee D Kim S Seo JY Oh E Paek SH Kim SU Ha CM Choi SY Kim KT 聂昊(编译) Division of Integrative Biosciences and Biotechnology Pohang University of Science and Technology Pohang Republic of Korea Department of Physiology Dental Research Institute Seoul National University School of Dentistry Seoul Republic of Korea Research Division and Brain Research Core Facilities of Korea Brain Research Institute Daegu Republic of Korea Department of Life Sciences Pohang University of Science and Technology Pohang Republic of Korea Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore Maryland Department of Neurosurgery Seoul National University College of Medicine Seoul South Korea University of British Columbia Vancouver British Columbia Canada 不详

在出生后的神经发育过程中,大脑神经回路的建立需要小胶质细胞消除过度的突触连接。小胶质细胞突触调节缺失已被证实与自闭症、精神分裂症和智力残疾等神经发育障碍有关。小胶质细胞中表达的牛痘相关激酶2(VRK2)可能可以激活突触消除的... 详细信息

在出生后的神经发育过程中,大脑神经回路的建立需要小胶质细胞消除过度的突触连接。小胶质细胞突触调节缺失已被证实与自闭症、精神分裂症和智力残疾等神经发育障碍有关。小胶质细胞中表达的牛痘相关激酶2(VRK2)可能可以激活突触消除的过程。在VRK2缺陷小鼠(VRK2KO)中,可以观察到小胶质细胞内突触前位点的减少。而且,在出生后第2周,VRK2KO小鼠的突触前位点和突出的数量都出现了异常增加。这些差异并没有持续到成年期。尽管突触数量的增加最终结局与正常小鼠无异,但成年VRK2KO小鼠在社交行为、情境恐惧记忆和空间记忆中表现出行为缺陷。

关键词：牛痘相关激酶2 小胶质细胞神经发育突触消除

Measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

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Chinese Physics C 2020年第2期44卷 1-12页

作者： F.Abudinén I.Adachi P.Ahlburg H.Aihara N.Akopov A.Aloisio F.Ameli L.Andricek N.Anh Ky D.M.Asner H.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu S.Baehr S.Bahinipati A.M.Bakich P.Bambade Sw.Banerjee S.Bansal V.Bansal M.Barrett J.Baudot A.Beaulieu J.Becker P.K.Behera J.V.Bennett E.Bernieri F.U.Bernlochner M.Bertemes M.Bessner S.Bettarini V.Bhardwaj F.Bianchi T.Bilka S.Bilokin D.Biswas G.Bonvicini A.Bozek M.Bračko P.Branchini N.Braun T.E.Browder A.Budano S.Bussino M.Campajola L.Cao G.Casarosa C.Cecchi D.Červenkov M.-C.Chang P.Chang R.Cheaib V.Chekelian Y.Q.Chen Y.-T.Chen B.G.Cheon K.Chilikin H.-E.Cho K.Cho S.Cho S.-K.Choi S.Choudhury D.Cinabro L.Corona L.M.Cremaldi S.Cunliffe T.Czank F.Dattola E.De La Cruz-Burelo G.De Nardo M.De Nuccio G.De Pietro R.de Sangro M.Destefanis S.Dey A.De Yta-Hernandez F.Di Capua S.Di Carlo J.Dingfelder Z.Doležal I.Domínguez Jiménez T.V.Dong K.Dort S.Dubey S.Duell S.Eidelman M.Eliachevitch T.Ferber D.Ferlewicz G.Finocchiaro S.Fiore A.Fodor F.Forti A.Frey B.G.Fulsom M.Gabriel E.Ganiev M.Garcia-Hernandez R.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich J.Gemmler T.Geßler R.Giordano A.Giri B.Gobbo R.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani D.Greenwald C.Hadjivasiliou S.Halder K.Hara T.Hara O.Hartbrich K.Hayasaka H.Hayashii C.Hearty M.T.Hedges I.Heredia de la Cruz M.Hernández Villanueva A.Hershenhorn T.Higuchi E.C.Hill H.Hirata M.Hoek S.Hollitt T.Hotta C.-L.Hsu Y.Hu K.Huang T.Iijima K.Inami G.Inguglia J.Irakkathil Jabbar A.Ishikawa R.Itoh M.Iwasaki Y.Iwasaki S.Iwata P.Jackson W.W.Jacobs D.E.Jaffe E.-J.Jang H.B.Jeon S.Jia Y.Jin C.Joo J.Kahn H.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki H.Kichimi C.Kiesling B.H.Kim C.-H.Kim D.Y.Kim S.-H.Kim Y.K.Kim Y.Kim T.D.Kimmel K.Kinoshita C.Kleinwort B.Knysh P.Kodyš T.Koga I.Komarov T.Konno S.Korpar D.Kotchetkov N.Kovalchuk T.M.G.Kraetzschmar P.Križan R.Kroeger J.F.Krohn P.Krokovny W.Kuehn T.Kuhr M.Kumar R.Kumar K.Kumara S.Kurz A.Kuzmin Y.-J.Kwon S.Lacaprara Y.-T.Lai C.La Licata K.Lalwani L.Lanceri J.S.Lange K.Lautenbach I.-S.Le Beihang University Beijing 100191 Brookhaven National Laboratory UptonNew York 11973 Budker Institute of Nuclear Physics SB RAS Novosibirsk 630090 Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional Mexico City 07360 Faculty of Mathematics and Physics Charles University12116 Prague Chiba University Chiba 263-8522 Consejo Nacional de Ciencia y Tecnología Mexico City 03940 Deutsches Elektronen–Synchrotron 22607 Hamburg Duke University DurhamNorth Carolina 27708 Earthquake Research Institute University of TokyoTokyo 113-0032 Forschungszentrum Jülich 52425 Jülich Department of Physics Fu Jen Catholic UniversityTaipei 24205 Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu University Gifu 501-1193 The Graduate University for Advanced Studies(SOKENDAI) Hayama 240-0193 Gyeongsang National University Jinju 52828 Department of Physics and Institute of Natural Sciences Hanyang UniversitySeoul 04763 High Energy Accelerator Research Organization(KEK) Tsukuba 305-0801 J-PARC Branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of Science Education and Research Mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology Hyderabad Telangana 502285 Indian Institute of Technology Madras Chennai 600036 Indiana University BloomingtonIndiana 47408 Institute for High Energy Physics Protvino 142281 Institute of High Energy Physics Vienna 1050 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(Canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de Fisica Corpuscular Paterna 46980 INFN Laboratori Nazionali di Frascati I-00044 Frascati INFN Sezione di Napoli I-80126 Napoli INFN Sezione di Padova I-35131 Padova INFN Sezione di Perugia I-06123 Perugia

From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

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提高针灸临床实践指南的实用性

英国医学杂志中文版 2022年第6期25卷 308-314页

作者：张誉清陆丽明许能贵汤小荣石啸双 Alonso Carrasco-Labra Holger Schiinemann 陈耀龙夏君陈光刘建平刘保延王吉耀 Amir Qaseem 景向红 Gordon Guyatt 赵宏(文/译) 郭丽花中国中医科学院广安门医院中加整合医学循证医学研究合作中心加拿大麦克马斯特大学健康研究方法、证据与影响学系中国中医科学院针灸研究所宁波诺丁汉大学宁波诺丁汉GRADE中心宁波315100 广州中医药大学华南针灸研究中心广东广州510006 Center for Integrative Global Oral Health School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA 兰州大学健康数据科学研究所世界卫生组织指南实施与知识转化合作中心 Lifespan and population Health School of Medicine University of NottinghamUK Harvard Medical School Harvard UniversityBostonUSA 北京中医药大学循证医学中心中国医学科学院复旦大学附属中山医院复旦大学循证医学中心 American college of Physicians PhiladelphiaPennsylvaniaUSA Department of Medicine Faculty of Health SciencesMcMaster UniversityHamiltonONCanada 深圳市罗湖区中医院针灸科广东深圳518004

针灸是应用最广泛的传统医学补充和替代疗法。根据世界卫生组织2019年的报告3,在调查的120个国家中,有113个国家在使用针灸疗法。除了注册针灸师以外,医师、护士以及整脊疗法医师有时也会提供针灸服务4。尽管针灸临床应用广泛,而且有大... 详细信息

针灸是应用最广泛的传统医学补充和替代疗法。根据世界卫生组织2019年的报告3,在调查的120个国家中,有113个国家在使用针灸疗法。除了注册针灸师以外,医师、护士以及整脊疗法医师有时也会提供针灸服务4。尽管针灸临床应用广泛,而且有大量的证据支持,但直到最近,现代医学组织在制订临床实践指南时,却很少形成与针灸相关的推荐意见。

关键词：临床实践指南针灸师传统医学整脊疗法针灸疗法推荐意见现代医学针灸临床应用

DIET AND dental CARIES

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Chinese Medical Journal 1932年第1期46卷 76-84页

作者： LESLIE G.KILBORN M.A. M.D.PH.D. Department of Physiology and Pharmacology College of Medicine and DentistryWest China Union UniversityChengtu.

I approach this subject with hesitancy,for it is one in which Ihave no first hand *** a few years ago I found that aphysiologist could not work day after day in close proximity to a pro-gressive dental clinic without becoming interested in various aspectsof the practical application of physiological knowledge to mouth *** of these subjects I have chosen as the subject of this *** the past two years a voluminous and most contradictoryliterature upon the subject has *** every possible,aswell as many a highly improbable dietary factor has been suggestedas the cause of tooth *** task of the reviewer is,therefore,not an easy ***(1)in a 1924 review of'The Etiology of dental Caries'stated that'more had been written and less is known of this disease

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Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease

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四川生理科学杂志 2020年第4期42卷 414-414页

作者： David B Beck From the National Human Genome Research Institute (D.B.B. A.K.O. W.P. N.B. D.L.R. D.O.C. K.M. P.H. S.R. L.X. H.O. M.N. A.J. R.S.L. N.D. J.J.C. M.C.V.M. D.N. B.D.S. W.A.G. S.M.B. I.A. D.L.K.) the National Institute of Arthritis and Musculoskeletal and Skin Diseases (M.A.F. K.A.S. S.N. W.L.T. S.G. C.C.-R. W.G. E.R. K.V.W. G.W. S.B. S.D. Z.D. R.A.C. M.J.K. M.G. P.C.G.) the National Institute of Dental and Craniofacial Research (J.C.C. A.J.A. A.W.) the Undiagnosed Diseases Program Common Fund Office of the Director (N.B. D.L.R. M.C.V.M. D.N. W.A.G.) the Hematology Branch National Heart Lung and Blood Institute (Z.W. B.P. E.M.G. F.G.-R. L.W.D. C.S.H. N.S.Y.) the National Institute of Allergy and Infectious Diseases (K.S.B.) the Laboratory of Pathology Center for Cancer Research National Cancer Institute (C.-C.R.L.) the National Institutes of Health (NIH) Intramural Sequencing Center National Human Genome Research Institute (J.M.) the Department of Laboratory Medicine (W.W. M.T. A.D.-F. K.R.C.) and the National Eye Institute (M.A.-A.) NIH Bethesda and GeneDx Gaithersburg (K.R.) — both in Maryland and the National Amyloidosis Centre Royal Free Hospital London NHS Foundation Trust and University College London London (D.R. H.J.L.) and the National Institute for Health Research–Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds Leeds (S.S.) — both in the United Kingdom.

Background:Adult-onset inflammatory syndromes often manifest with overlapping clinical *** in ubiquitin-related genes,previously implicated in autoinflammatory disease,may define new ***:We analyzed peripheral-blood exome sequence data independent of clinical phenotype and inheritance pattern to identify deleterious mutations in ubiquitin-related *** sequencing,immunoblotting,immunohistochemical testing,flow cytometry,and transcriptome and cytokine profiling were ***-Cas9-edited zebrafish were used as an in vivo model to assess gene function.

关键词： inflammatory clinical Adult

Andersen-Tawil综合征:新的钾通道突变和可能的表型变异

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 47-47页

作者： Davies N.P. Imbrici P. Fialho D. M.G.Hanna 陈海 Department of Molecular Neuroscience Institute of Neurology University College London Queen Square London WC1N 3BG United Kingdom.Dr

Objective: To evaluate clinical, genetic, and electrophysiologic features of patients with Andersen-Tawil syndrome (ATS) in the United Kingdom. Methods: Clinical and neurophysiologic evaluation was conducted of 11 families suspected to have ATS. Molecular genetic analysis of each proband was performed by direct DNA sequencing of the entire coding region of KCNJ2. Control samples were screened by direct DNA sequencing. The electrophysiologic consequences of several new mutations were studied in an oocyte expression system. Results: All 11 ATS families harbored pathogenic mutations in KCNJ2 with six mutations not previously reporte d. Some unusual clinical features including renal tubular defect, CNS involvemen t, and dental and phonation abnormalities were observed. Five mutations (T75M, D 78G, R82Q, L217P, and G300D) were expressed, all of which resulted in nonfunctio nal channels when expressed alone, and co-expression with wild-type (WT) KCNJ2 demonstrated a dominant negative effect. Conclusion: Six new disease-causing m utations in KCNJ2 were identified, one of which was in a PIP2 binding site. Mole cular expression studies indicated that five of the mutations exerted a dominant negative effect on the wild-type allele. KCNJ2 mutations are an important caus e of ATS in the UK.

关键词：综合征综合病症 Andersen-Tawil 电生理学生理电学

Human genetic and immunological determinants of critical COVID-19 pneumonia

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四川生理科学杂志 2021年第11期43卷 1947-1947页

作者： Qian Zhang St Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France University of Paris Imagine Institute Paris France Howard Hughes Medical Institute Paris France The Rockefeller University & Howard Hughes Medical Institute New York NY USA Necker Hospital for Sick Children & INSERM Paris France Department of Pediatrics Necker Hospital for Sick Children Paris France Cemil Taşcıoglu City Hospital Istanbul Turkey Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France Imagine Institute University of Paris Paris France Al Jalila Children’s Hospital Dubai United Arab Emirates San Raffaele Telethon Institute for Gene Therapy IRCCS Ospedale San Raffaele and Vita Salute San Raffaele University Milan Italy Hospices Civils de Lyon Lyon France Helix San Mateo CA USA Department of Intensive Care Medicine Critical Care Center CHU Lille Lille France Univ. Lille CNRS Inserm CHU Lille Institut Pasteur de Lille U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité deLille Lille France Shupyk National Medical Academy for Postgraduate Education Kiev Ukraine Department of Medical Microbiology University Medical Center Utrecht Utrecht The Netherlands Sidra Medicine Doha Qatar Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia Medellín Colombia School of Microbiology University of Antioquia Medellín Colombia IIBB-CSIC IDIBAPS Barcelona Spain Department of Immunology Second Faculty of Medicine Charles University University Hospital in Motol Prague Czech Republic Department of Immunology Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia Pulmonology Department Cliniques Universitaire

SARS-CoV-2 infection is benign in most individuals but,in-10%of cases,it triggers hypoxemic COVID-19 pneumonia,which becomes critical in-3%of *** ensuing risk of death(-1%)doubles every five years from childhood onward and is-1.5 times greater in men than in *** are the molecular and cellular determinants of critical COVID-19 pneumonia?Inborn errors of type I IFNs,including autosomal TLR3 and X-linked TLR7 deficiencies,are found in-1-5%of patients with critical pneumonia under 60 years old.

关键词： pneumonia critical cases

Single cell atlas of developing mouse dental germs reveals populations of CD24^(+)and Plac8^(+)odontogenic cells

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Science Bulletin 2022年第11期67卷 1154-1169页

作者： Yaofeng Wang Yifan Zhao Shubin Chen Xiaoming Chen Yanmei Zhang Hong Chen Yuansong Liao Jiashu Zhang Di Wu Hongxing Chu Hongying Huang Caixia Wu Shijuan Huang Huichao Xu Bei Jia Jie Liu Bo Feng Zhonghan Li Dajiang Qin Duanqing Pei Jinglei Cai Innovation Centre for Advanced Interdisciplinary Medicine The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510799China CAS Key Laboratory of Regenerative Biology GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Centre for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong KongChina Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China Guangdong Provincial People’s Hospital Ganzhou Hospital Ganzhou Municipal HospitalGanzhou 341099China State Key Laboratory of Oral Disease West China Hospital of StomatologyCenter of Growth Metabolism and AgingKey Laboratory of Bio-Resource and Eco-Environment of Ministry of EducationCollege of Life SciencesSichuan UniversityChengdu 610041China Department of Regeneration Medicine School of Pharmaceutical ScienceJilin UniversityChangchun 130012China Department of Periodontics and Implantology Stomatological HospitalSouthern Medical University(Guangdong Provincial Stomatological Hospital)Guangzhou 510515China Animal Center Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China The Center for Prenatal and Hereditary Disease Diagnosis Department of Obstetrics and GynecologyNanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Obstetrics and Gynecology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina Laboratory of Cell Fate Control School of Life SciencesWestlake UniversityHangzhou 310024China

The spatiotemporal relationships in high-resolution during odontogenesis remain poorly *** report a cell lineage and atlas of developing mouse *** performed a large-scale(92,688 cells)single cell RNA sequencing,tracing the cell trajectories during odontogenesis from embryonic days 10.5 to *** with an assay for transposase-accessible chromatin with high-throughput sequencing,our results suggest that mesenchymal cells show the specific transcriptome profiles to distinguish the tooth ***,we identified key gene regulatory networks in teeth and bone formation and uncovered spatiotemporal patterns of odontogenic mesenchymal ***24^(+)and Plac8^(+)cells from the mesenchyme at the bell stage were distributed in the upper half and preodontoblast layer of the dental papilla,respectively,which could individually induce nonodontogenic epithelia to form tooth-like ***,the Plac8^(+)tissue we discovered is the smallest piece with the most homogenous cells that could induce tooth regeneration to *** work reveals previously unknown heterogeneity and spatiotemporal patterns of tooth germs that may lead to tooth regeneration for regenerative dentistry.

关键词： Single cell RNA-seq dental germ development Spatiotemporal pattern Odontogenesis CD24^(+)odontogenic cells Plac8^(+)odontogenic cells