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Conservative treatment for anal incontinence

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Gastroenterology Report 2014年第2期2卷 85-91页

作者： dan Carter Department of Gastroenterology Chaim Sheba Medical CenterIsrael

Anal incontinence(AI)in adults is a troublesome condition that negatively impacts upon quality of life and results in significant embarrassment and social *** conservative management of AI is the first step and targets symptomatic *** reported significant improvement with conservative treatments for AI is close to 25%and involves prescribed changes in lifestyle habits,a reduced intake of foods that may cause or aggravate diarrhea or rectal urgency,and the use of specific anti-diarrheal *** use of a mechanical barrier in the form of an anal plug and the outcomes and principles of pelvic kinesitherapies and biofeedback options are *** review discusses a gastroenterologist’s approach towards conservative therapy in patients referred with anal incontinence.

关键词： anal incontinence loperamide biofeedback

Evaluation of an Orthodontic Adhesive with Combined Primer and Composite

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Open Journal of Stomatology 2018年第6期8卷 205-216页

作者： Yoav Shapinko Iro Eleftheriadi Tamar Brosh Lihi Adler-Abramovich Moshe Davidovitch Tatiana Sella-Tunis Rachel Sarig Nir Shpack Department of Orthodontics The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University Tel Aviv Israel Department of Oral Biology The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University Tel Aviv Israel dan David Center for Human Evolution and Bio-History Research Sackler Faculty of Medicine The Steinhardt Museum of Natural History Tel Aviv University Tel Aviv Israel

Objectives: To investigate the efficacy of a new orthodontic bonding system that incorporates the primer solution in the adhesive. Materials and Methods: 90 anterior bovine teeth were divided in three groups: in Group I, brackets were bonded with Transbond XT system, in Group II with GC Ortho Connect which incorporates the primer in the adhesive, and in Group III, a single layer of primer was applied on the teeth before bonding the brackets with GC Ortho Connect. After a 24-hour latency period, Shear Bond Strength (SBS) and Adhesive Remnant Index (ARI) were measured. In cases with remnants left mainly on the bracket base, energy dispersive X-ray (EDX) spectrometry was performed in order to determine the presence of calcium particles. Selected cases were examined with Scanning Electron Microscopy (SEM) analysis and in nanometer scale with a confocal visible light microscope (μsurf revolver, NanoFocus AG, Germany). Results: The mean SBS values were 7.25 ± 0.58 MPa for Group I, 6.57 ± 0.50 MPa for Group II and 7.33 ± 0.56 MPa for Group III. These differences were not statistically significant (p = 0.562). ARI evaluation showed that the debonding failure happened more frequently within the adhesive interface in Group II, whereas this occurred more often at the tooth-adhesive interface in Group III. However, statistical analysis of the ARI scores showed no significant difference in adhesive remnants among the three groups (p = 0.078). Conclusion: The GC Ortho Connect bonding system can be efficiently used for orthodontic bonding. Adding a layer of primer appears to slightly increase the SBS while causing less adhesive to remain on enamel from which brackets were debonded.

关键词： Orthodontic Adhesive Shear Bond Strength Adhesive Remnant Index

Adjuvant chemotherapy after radical cystectomy:Do all patients who need chemotherapy after surgery actually receive it?

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Current Urology 2023年第2期17卷 109-112页

作者： Roy Croock Jonathan Modai Yuval Avda Igal Shpunt Morad Jaber Yamit Peretz Yaniv Shilo dan Leibovici Department of Urology Kaplan Medical CenterRehovotIsrael

Background:Compliance with the guideline recommendations for neoadjuvant chemotherapyin patients with muscle-invasive bladder cancer is *** adjuvant chemotherapy approach has the advantage of pathology-based decision-making,allowing for patient *** addition,radical surgery is not delayed and treatment-related toxicity does not impair surgical *** proportion of patients who completed chemotherapy after cystectomy among those who were fit and in need of treatment were *** reasons for not completing adjuvant chemotherapy were *** and methods:We retrospectively evaluated all patients who had undergone radical cystectomy at our center over thelast 7 *** for adjuvant chemotherapy included pathological T>2,any node+,or surgical margin *** patients who were fit for chemotherapy before surgery were included in the ***:Of the 52 patients with muscle-invasive bladder cancer,14 received neoadjuvant chemotherapy or unfit for chemotherapy were *** the remaining 38 patients,14(37%)had bladder-confined cancers and did not require additional *** the 24 patients who needed chemotherapy and were fit to receive it,8 patients completed treatment(33%),and 3 discontinued treatment due to *** patients(50%)declined chemotherapy,whereas 1 patient became unfit for chemotherapy after ***:While the adjuvant chemotherapy approach could save unnecessary treatment in 37%of patients,two-thirds of those who needed chemotherapy did not complete *** refusal was the primary reason for not receiving treatment.

关键词： Adjuvant chemotherapy Muscle-invasive bladder cancer Neoadjuvant chemotherapy

Microstructure and properties of LZQT600-3 HCCDIBs for plunger pump cylinder

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China Foundry 2024年第2期21卷 197-204页

作者： Chun-jie Xu Yuan-ying Jin Dong Ma Zhen Zhao Jia-wei Qi Shang Sui Xiang-quan Wu Can Guo Zhong-ming Zhang Yong-hui Liu dan Shechtman School of Materials Science and Engineering Xi'an University of TechnologyXi'an 710048China Xi'an Shechtman Nobel Prize New Materials Institute Xi'an 710048China Tongchuan Huazhu Precision Technology Co. Ltd.Tongchuan 727100ShaanxiChina Faculty of Materials Science and Engineering Technion-Israel Insititue of TechnologyHaifa 3200003Israel

It is important to improve the comprehensive performance of the ductile iron bars(DIBs)for the cylinder block of the extra high pressure hydraulic plunger pump and accelerate the industrial *** this work,the LZQT600-3 DIBs with the diameter of 145 mm were prepared by the horizontal continuous casting(HCC)process,that is,LZQT600-3 *** microstructure and room temperature tensile properties of different sections[left-edge(surface layer),left-1/2R(left half of the radius),and the center of the HCCDIBs]were *** results show that the spheroidization of LZQT600-3 HCCDIBs matrix from the left-edge,left-1/2R to the center is at nodulizing grade II and *** the cooling rate gradually decreases from surface to the center of the HCCIBs,the number of spheroidized graphite is gradually reduced,the size is gradually increased,the shape factor is decreased,and the pearlite content and lamellate spacing are *** the horizontal direction of the section,the hardness of the material is distributed symmetrically around the center of the *** the vertical direction,the hardness distribution in the center of the HCCDIBs is asymmetrical due to the gravity during the solidification ***,the microstructure in the lower part of the section solidifies relatively *** left-edge has the best tensile mechanical properties,and the ultimate tensile strength,yield tensile strength and elongation are 597.3 MPa,418.5 MPa and 9.6%,*** tensile fracture belongs to the ductile-brittle hybrid *** comprehensive performances of LZQT600-3 HCCDIBs meet the actual application requirements of ultra-high pressure hydraulic plunger pump cylinder.

关键词： horizontal continuous casting(HCC) nodular cast iron ductile iron bars microstructure mechanical properties

Free-standing microscale photonic lantern spatial mode(De-)multiplexer fabricated using 3D nanoprinting

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Light(Science & Applications) 2024年第6期13卷 1170-1185页

作者： Yoav dana Yehudit Garcia Aleksei Kukin Lauren Dallachiesa Sterenn Guerrier Nicolas K.Fontaine dan M.Marom Institute of Applied Physics Hebrew University of JerusalemJerusalemIsrael Nokia Bell Labs 600 Mountain AveNew ProvidenceNJ07974USA

Photonic lantern(PL)spatial multiplexers show great promise for a range of applications,such as future high-capacity mode division multiplexing(MDM)optical communication networks and free-space optical *** enable efficient conversion between multiple single-mode(SM)sources and a multimode(MM)waveguide of the same *** multiplexers operate by facilitating adiabatic transitions between the SM arrayed space and the single MM ***,current fabrication methods are forcing the size of these devices to multi-millimeters,making integration with micro-scale photonic systems quite *** advent of 3D micro and nano printing techniques enables the fabrication of freestanding photonic structures with a high refractive index contrast(photopolymer-air).In this work we present the design,fabrication,and characterization of a 6-mode mixing,375µm long PL that enables the conversion between six single-mode inputs and a single six-mode *** PL was designed using a genetic algorithm based inverse design approach and fabricated directly on a 7-core fiber using a commercial two-photon polymerization-based 3D printer and a *** the waveguides exhibit high index contrast,low insertion loss(−2.6 dB),polarization dependent(−0.2 dB)and mode dependent loss(−4.4 dB)were measured.

关键词： mode enable printing

Separate But not Equal:Stressors in the Work of Arab Teachers in israel

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Psychology Research 2020年第10期10卷 395-409页

作者： Yaffa Buskila Tarek Suliman dan Buskila Ismael Abu Saad Orot israel College of Education RehovotIsrael Ben-Gurion University of the Negev Beer ShevaIsrael

Teaching is a stressful profession characterizing the work of *** Neoliberal reforms have added a further burden on teachers’work,increasing stress at work and resulting in negative health,occupational and economic *** aims of the study were to examine the perceptions of stress factors among Arab teachers in israel,and the relationship between Arab teachers’stress factors by types of school(elementary,middle school,and high school)and *** factors were measured by using an instrument developed by Ablin et al.(2010).Three hundred forty-two public school Arab teachers participated in the study,of whom 230 were female and 112 were *** hundred twenty-five worked in elementary schools,78 in middle schools,and 130 in high *** most stressful factors among Arab teachers were“busy schedule and lack of flexibility”,“the student composition of the class”,and“conflicting requirements between school assignments and home responsibilities”.Significant statistical differences were found between teachers’stress factors by gender and school *** teachers rated stress factors“the student composition of the class”and“conflicting requirements between school assignments and home responsibilities”higher than male *** teachers rated stress factors“student parents”,“lack of proper physical conditions”,and“requirement to teach a subject other than one’s specialty”higher than high school *** school teachers rated stress factors“school management”,“general supervisor”,and“requirement to teach a subject other than one’s specialty”higher than primary school *** leading stressor in this study is a result of educational disparities between Jews and *** formally purports to embrace the liberal responsibility of providing educational and development opportunities to all of its citizens,enabling them to actualize their full potential as human beings.

关键词： stressors in schools Arab teachers equality,israel

Effect of the transcutaneous electrical stimulation system on esophageal-acid exposure in patients non-responsive to once-daily proton-pump inhibitor:proof-of-concept study

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Gastroenterology Report 2021年第4期9卷 323-328,I0002页

作者： Ram Dickman Sigal Levy Tsachi Tsadok Perets Maor Hazani-Pauker Doron Boltin Hemda Schmilovitz-Weiss Issa Nidal Matan Siterman dan Carter Ronnie Fass Rachel Gingold-Belfer Department of Gastroenterology Rabin Medical CenterBeilinson CampusesPetah Tikva and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Statistics Education Unit Academic College of Tel Aviv-YafoTel Aviv-YafoIsrael Department of Surgery B Rabin Medical CenterHasharon CampusPetah Tikva and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Division of Gastroenterology and Hepatology Chaim Sheba Medical CenterRamat Gan and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Division of Gastroenterology and Hepatology Metrohealth Medical CenterClevelandOHUSA

Background:Gastroesophageal reflux disease(GERD)is a common ***,≤35%of GERD patients fail the standard dose of proton-pump-inhibitor(PPI)*** to the high prevalence and low satisfaction rate with treatment failure,there is an unmet need for new *** aim was to evaluate whether the use of the transcutaneous electrical stimulation system(TESS)can reduce esophageal-acid exposure in GERD patients unresponsive to standard-dose ***:We enrolled 10 patients suffering from heartburn and regurgitation with an abnormal esophageal-acid exposure(off PPIs)who failed standard-dose *** the placement of a wireless esophageal pH capsule,all patients were treated with *** primary end point was the reduction in the baseline(pretreatment)24-hour percent total time pH<4 and/or DeMeester score by 50%.Results:Seven GERD patients(five females and two males,aged 49.3610.1 years)completed the *** baseline,the mean percent total time pH<4 was *** TESS,the mean percent total time pH<4 dropped to 5.563.4,4.562.6,3.762.9,and 4.462.5 on Days 1,2,3,and 4,*** baseline,the mean DeMeester score was *** TESS,the mean DeMeester score dropped to 15.869.2,13.266.8,11.269.4,and 12.066.8 on Days 1,2,3,and 4,***:TESS is a safe and potentially effective modality in reducing esophageal-acid exposure in GERD patients unresponsive to standard-dose PPI.A larger and prospective controlled study is needed to verify these preliminary results.

关键词： gastroesophageal reflux disease transcutaneous electrical stimulation system proton-pump inhibitor

Hif-1α/Hsf1/Hsp70 signaling pathway regulates redox homeostasis and apoptosis in large yellow croaker(Larimichthys crocea)under environmental hypoxia

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Zoological Research 2021年第6期42卷 746-760页

作者： Sheng-Yu Luo Jing-Qian Wang Cheng Liu Xin-Ming Gao Yi-Bo Zhang Jie Ding Cong-Cong Hou Jun-Quan Zhu Bao Lou Wei-Liang Shen Xiong-Fei Wu Chun-dan Zhang Dao-Jun Tang Key Laboratory of Applied Marine Biotechnology by the Ministry of Education School of Marine SciencesNingbo UniversityNingboZhejiang 315211China Zhejiang Academy of Agricultural Sciences HangzhouZhejiang 310021China State Key Laboratory of Large Yellow Croaker Breeding Ningbo Academy of Oceanology and FisheryNingboZhejiang 315012China

Oxygen is an essential molecule for animal respiration,growth,and *** in terrestrial environments,contamination and climate change have led to the frequent occurrence of hypoxia in aquatic environments,thus impacting aquatic animal ***,the adaptative mechanisms underlying fish responses to environmental hypoxia remain largely ***,we used large yellow croaker(Larimichthys crocea)and large yellow croaker fry(LYCF)cells to investigate the roles of the Hif-1α/Hsf1/Hsp70 signaling pathway in the regulation of cellular redox homeostasis,and *** confirmed that hypoxia induced the expression of Hif-1α,Hsf1,and Hsp70 in vivo and in *** Hsp70 knockdown/overexpression indicated that Hsp70 was required for maintaining redox homeostasis and resisting oxidative stress in LYCF cells under hypoxic ***70 inhibited caspase-dependent intrinsic apoptosis by maintaining normal mitochondrial membrane potential,enhancing Bcl-2 mRNA and protein expression,inhibiting Bax and caspase3 mRNA expression,and suppressing caspase-3 and caspase-9 ***70 suppressed caspaseindependent intrinsic apoptosis by inhibiting nuclear translocation of apoptosis-inducing factor(AIF)and disturbed extrinsic apoptosis by inactivating *** knockdown/overexpression of Hif-1αand dual-luciferase reporter assay indicated that Hif-1αactivated the Hsf1 DNA promoter and enhanced Hsf1 mRNA ***1 enhanced Hsp70 mRNA transcription in a similar *** summary,the Hif-1α/Hsf1/Hsp70 signaling pathway plays an important role in regulating redox homeostasis and anti-apoptosis in *** under hypoxic stress.

关键词： Hypoxia Larimichthys crocea Apoptosis Redox homeostasis Hif-1α/Hsf1/Hsp70

Enhanced strength-ductility synergy in a wire and arc additively manufactured Mg alloy via tuning interlayer dwell time

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Journal of Magnesium and Alloys 2023年第12期11卷 4696-4709页

作者： Dong Ma Chunjie Xu Shang Sui Jun Tian Can Guo Xiangquan Wu Zhongming Zhang dan Shechtman Sergei Remennik School of Materials Science and Engineering Xi’an University of TechnologyXi’anShaanxi 710048China Xi’an Shechtman Nobel Prize New Materials Institute Xi’an 710048China Xi’an Key Laboratory of Advanced Magnesium Alloy Additive Manufacturing and Precision Forming Xi’anShaanxi 710048China Department of Materials Science and Engineering Technion-Israel Institute of TechnologyHaifa 32000Israel Center for Nanoscience&Nanotechnology Hebrew University of JerusalemEdmond J.Safra CampusJerusalem 91904Israel MGM Nobel Prize New Materials Co. LtdTongchuan 727100China

Strength-ductility trade-off is a common issue in Mg alloys. This work proposed that a synergistic enhancement of strength and ductility could be achieved through tuning interlayer dwell time(IDT) in the wire and arc additive manufacturing(WAAM) process of Mg *** thermal couples were used to monitor the thermal history during the WAAM process. Additionally, the effect of different IDTs on the microstructure characteristics and resultant mechanical properties of WAAM-processed Mg alloy thin-wall were investigated. The results showed that the stable temperature of the thin-wall component could reach 290 ℃ at IDT=0s, indicating that the thermal accumulation effect was remarkable. Consequently, unimodal coarse grains with an average size of 39.6 μm were generated, and the resultant room-temperature tensile property was poor. With the IDT extended to 60s, the thermal input and thermal dissipation reached a balance, and the stable temperature was only 170 ℃, closing to the initial temperature of the substrate. A refined grain structure with bimodal size distribution was obtained. The remelting zone had fine grains with the size of 15.2 μm, while the arc zone owned coarse grains with the size of 24.5 μ*** alternatively distributed coarse and fine grains lead to the elimination of strength-ductility trade-off. The ultimate tensile strength and elongation of the samples at IDT=60s are increased by 20.6 and 75.0% of those samples at IDT=0s, respectively. The findings will facilitate the development of additive manufacturing processes for advanced Mg alloys.

关键词： Wire arc additive manufacturing Interlayer dwell time Strength-ductility Magnesium alloys