检索结果-南通市图书馆

Non-coding RNAs in exercise immunology:A systematic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第3期13卷 311-338,I0002页

作者： Mona Kotewitsch Melina Heimer Boris Schmitz Frank C.Mooren Department of Rehabilitation Sciences Faculty of HealthUniversity of Witten/HerdeckeWitten 58455Germany DRV clinic Konigsfeld Center for Medical RehabilitationEnnepetal 58256Germany

Regular physical exercise has been recognized as a potent modulator of immune function,with its effects including enhanced immune surveillance,reduced inflammation,and improved overall *** strong evidence exists that physical exercise affects the specific expression and activity of non-coding RNAs(ncRNAs)also involved in immune system regulation,heterogeneity in individual study designs and analyzed exercise protocols exists,and a condensed list of functional,exercise-dependent ncRNAs with known targets in the immune system is missing from the literature.A systematic review and qualitative analysis was used to identify and categorize ncRNAs participating in immune modulation by physical *** combined approaches were used:(a)a systematic literature search for“ncRNA and exercise immunology”,(b)and a database search for microRNAs(miRNAs)(miRTarBase and DIANA-Tarbase v8)aligned with known target genes in the immune system based on the Reactome database,combined with a systematic literature search for“ncRNA and exercise”.Literature searches were based on PubMed,Web of Science,and SPORTDiscus;and miRNA databases were filtered for targets validated by in vitro experimental *** were eligible if they reported on exercise-based interventions in healthy *** duplicate removal,95 studies were included reporting on 164 miRNAs,which were used for the qualitative *** studies reporting on long-noncoding RNAs(lncRNAs)or circular RNAs were also *** were analyzed using ordering tables that included exercise modality(endurance/resistance exercise),acute or chronic interventions,as well as the consistency in reported change between *** criteria were defined as“validated”with 100%of≥3 independent studies showing identical direction of regulation,“plausible”(≥80%),or“suggestive”(≥70%).For resistance exercise,upregulation of miR-206 was validated while downregulation of miR-133a appeared *** endurance exer

关键词： Immune system Inflammation MicroRNA ncRNA Physical exercise

Interactivity software tools for teaching in ophthalmology

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Annals of Eye Science 2024年第1期9卷 10-23页

作者： Jesús Barrio-Barrio Department of Ophthalmology Navarra University Clinic HospitalNavarra Institute for Health ResearchIdiSNAPamplonaSpain

The use of interactive audience software,such as audience response systems(ARS),in medical education has become increasingly popular in recent *** technology allows instructors to engage students in real time,encouraging active participation and promoting effective *** benefits of interactive audience software in medical education include increased student engagement,promotion of active learning,and enhanced learning ***,there are also several challenges to its implementation,including technical difficulties,careful planning and preparation,over-reliance on technology,and ethical concerns related to privacy and data *** cost of implementing interactive audience software may also be a barrier for some *** paper specifically reviews six interactive software platforms,including Socrative,Quizizz,Pear Deck,Slido,Wooclap and *** platforms allow for real-time assessment of student understanding,feedback,and *** also enable instructors to adjust their teaching strategies based on student responses and ***,interactive audience software has shown great potential to enhance learning and engagement in medical *** is important for instructors to carefully consider the benefits and challenges of its *** the cost of implementing interactive audience software may be a barrier for some institutions,there are free and low-cost options available.

关键词： Interactive audience software mobile software audience response systems(ARS) medical education

Diagnostic tools for fecal incontinence: Scoring systems are the crucial first step

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第6期30卷 516-522页

作者： Peter Liptak Martin Duricek Peter Banovcin clinic of Internal Medicine-Gastroenterology University Hospital in MartinJessenius Faculty of Medicine in MartinComenius UniversityMartin 03601Slovakia

The main aim of this editorial is to comment on the recent article published by Garg et al in the World Journal of Gastroenterology 2023;29:*** original research presents a new scoring system for fecal *** incontinence is a chronic disease with a severe impact on the quality of life of the *** social stigmatization often leads to significant underreporting of the condition even during visits to a specialist and could lead to further misman-agement or non-existent management of the *** important fact is that patients are often unable to describe their condition when not asked precisely defined *** problem is partially resolved by scoring *** scoring systems are commonly used;however,each of them has their *** example,the absence of different kinds of leakage besides flatus and stool could further lead to underscoring the incontinence ***,there has long been a call for a more precise scoring *** correct identification of the presence and severity of fecal incontinence is paramount for further diagnostic approach and for choosing the appropriate therapy *** editorial describes fecal incontinence,its effect on quality of life in general and further evaluates the diagnostic approach with a particular focus on symptom scoring systems and their implications for clinical practice.

关键词： Incontinence Fecal Scoring system Questionary Quality of life

Ratio of Gravitational Force to Electric Force from Empirical Equations in Terms of the Cosmic Microwave Background Temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Physics 2024年第5期15卷 674-689页

作者： Tomofumi Miyashita Miyashita clinic Osaka Japan

Previously, we presented several empirical equations using the cosmic microwave background (CMB) temperature. Next, we propose an empirical equation for the fine-structure constant. Considering the compatibility among these empirical equations, the CMB temperature (Tc) and gravitational constant (G) were calculated to be 2.726312 K and 6.673778 × 10−11 m3∙kg−1∙s−2, respectively. Every equation could be explained in terms of the Compton length of an electron (λe), the Compton length of a proton (λp) and a. Furthermore, every equation could also be explained in terms of Avogadro’s number and the number of electrons in 1 C. However, the ratio of the gravitational force to the electric force cannot be uniquely determined when the unit of the Planck constant (Js) is changed. In this study, we showed that every equation can be described in terms of Planck constant. From the assumption of minimum mass, the ratio of gravitational force to electric force could be elucidated.

关键词： Ratio of Gravitational Force to Electric Force Minimum Mass Temperature of the Cosmic Microwave Background

Correspondence Principle for Empirical Equations in Terms of the Cosmic Microwave Background Temperature with Solid-State Ionics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Physics 2024年第1期15卷 51-63页

作者： Tomofumi Miyashita Miyashita clinic Osaka Japan

Previously, we presented several empirical equations using the cosmic microwave background (CMB) temperature that were mathematically connected. Next, we proposed an empirical equation for the fine-structure constant. Considering the compatibility among these empirical equations, the CMB temperature (Tc) and gravitational constant (G) were calculated to be 2.726312 K and 6.673778 × 10-11 m3·kg-1·s-2, respectively. Every equation can be explained in terms of the Compton length of an electron (λe), the Compton length of a proton (λp) and α. However, these equations are difficult to follow. Using the correspondence principle with the thermodynamic principles in solid-state ionics, we propose a canonical ensemble to explain these equations in this report. For this purpose, we show that every equation can be explained in terms of Avogadro’s number and the number of electrons in 1 C.

关键词： Temperature of the Cosmic Microwave Background

Algorithms for Empirical Equations in Terms of the Cosmic Microwave Background Temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Physics 2024年第10期15卷 1567-1585页

作者： Tomofumi Miyashita Miyashita clinic Osaka Japan

Previously, we presented several empirical equations using the cosmic microwave background (CMB) temperature. Next, we propose an empirical equation for the fine-structure constant. Considering the compatibility among these empirical equations, the CMB temperature (Tc) and gravitational constant (G) were calculated to be 2.726312 K and 6.673778 × 10−11 m3∙kg−1∙s−2, respectively. Every equation can be explained numerically in terms of the Compton length of an electron (λe), the Compton length of a proton (λp) and α. Furthermore, every equation can also be explained in terms of the Avogadro number and the number of electrons at 1 C. We show that every equation can be described in terms of the Planck constant. Then, the ratio of the gravitational force to the electric force can be uniquely determined with the assumption of minimum mass. In this report, we describe the algorithms used to explain these equations in detail. Thus, there are no dimension mismatch problems.

关键词： Temperature of the Cosmic Microwave Background Minimum Mass The Ratio of Gravitational Force to Electric Force Dimension Analysis Redefinition Method Fine Structure Constant

Testosterone replacement therapy and vascular thromboembolic events: a systematic review and meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2024年第2期26卷 144-154页

作者： Rossella Cannarella Carmelo Gusmano Claudia Leanza Vincenzo Garofalo Andrea Crafa Federica Barbagallo Rosita A Condorelli Sandro La Vignera Aldo E Calogero Department of clinical and Experimental Medicine University of CataniaCatania 95123Italy Glickman Urological&Kidney Institute Cleveland Clinic FoundationClevelandOH44195USA

To evaluate the relationship between testosterone replacement therapy(TRT)and arterial and/or venous thrombosis in patients with pre-treatment total testosterone(TT)<12 nmol I^(-1),we performed a meta-analysis following the Population Intervention Comparison Outcome ***:men with TT<12 nmol I^(-1) or clear mention of hypogonadism in the inclusion criteria of patients;intervention:TRT;comparison:placebo or no therapy;outcomes:arterial thrombotic events(stroke,myocardial infarction[MI],upper limbs,and lower limbs),VTE(deep vein thrombosis[DVT],portal vein thrombosis,splenic thrombosis,and pulmonary embolism),and mortality.A total of 2423 abstracts were assessed for ***-four studies,including 14 randomized controlled trials(RCTs),were finally included,with a total of 4027 and 310288 hypotestosteronemic male patients,from RCTs and from observational studies,*** on RCT-derived data,TRT did not influence the risk of arterial thrombosis(odds ratio[OR]=1.27,95%confidence interval[CI]:0.47-3.43,P=0.64),stroke(OR=1.34,95%CI:0.09-18.97,P=0.83),MI(OR=0.51,95%CI:0.11-2.31,P=0.39),VTE(OR=1.42,95%CI:0.22-9.03,P=0.71),pulmonary embolism(OR=1.38,95%CI:0.27-7.04,P=0.70),and mortality(OR=0.70,95%CI:0.20-2.38,P=0.56).Meanwhile,when only observational studies are considered,a significant reduction in the risk of developing arterial thrombotic events,Ml,venous thromboembolism,and mortality was *** risk for DVT remains uncertain,due to the paucity of RCT-based *** in men with TT<12 nmol I^(-1) is safe from the risk of adverse cardiovascular *** studies specifically assessing the risk of DVT in men on TRT are needed.

关键词： hypogonadism testosterone testosterone replacement therapy thromboembolism thrombosis TRT

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Effects of Transjugular Intrahepatic Portosystemic Shunt on Renal and Pulmonary Function in Hepatic Decompensation with and without Hepatorenal and Hepatopulmonary Syndromes:A Review

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of clinical and Translational Hepatology 2024年第9期12卷 780-791页

作者： Ahmed H.Abdelwahed Moataz Aboeldahb George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Department of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA

Cirrhosis is often characterized by decreased liver function,ranging from a compensated,typically asymptomatic phase to a decompensated phase characterized by the appearance of ascites or variceal bleeding,and ultimately hepatorenal syndrome(HRS)or hepatopulmonary syndrome(HPS).The latter two complications are associated with a poor prognosis and limited treatment *** cases of ascites or variceal bleeding resistant to medical therapy,transjugular intrahepatic portosystemic shunt(TIPS)is effective and *** blood by TIPS diverts portal blood to the systemic circulation,potentially increasing systemic blood volume and benefiting renal ***,TIPS could also divert nitric oxide to the systemic circulation,potentially worsening systemic hypotension and perfusion,which could be detrimental to renal *** evidence indicates that TIPS often improves renal function in patients with portal hypertension,with or without *** studies have shown persistently decreased renal function after ***,these data are insufficient to support a recommendation for the use of TIPS specifically for *** patients without pre-existing HPS,TIPS does not appear to significantly affect pulmonary gas *** of TIPS in HPS have been inconsistent;some studies have shown improvement,but effects were *** studies have shown a persistent decline in pulmonary function after *** evidence supports the need for large randomized controlled trials to investigate the beneficial effects of TIPS for *** pulmonary function data are less clear regarding TIPS for *** aim of the current report was to review the literature regarding the effects of TIPS on renal and pulmonary function in hepatic decompensation,with or without the development of HRS or HPS.

关键词： Cirrhosis Hepatorenal syndrome Hepatopulmonary syndrome Transjugular intrahepatic portosystemic shunt