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Phylogenetic and Comparative Genomic Analysis of Lactobacillus fermentum Strains and the Key Genes Related to their Intestinal Anti-Inflammatory Effects

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Engineering 2022年第10期17卷 170-182页

作者： Yan Zhao Chengcheng Zhang Leilei Yu Fengwei Tian Jianxin Zhao Hao Zhang Wei Chen Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering research Centre for Functional Food Jiangnan UniversityWuxi 214122China international joint research Laboratory for probiotics Jiangnan UniversityWuxi 214122China Beijing Innovation Centre of Food Nutrition and Human Health Beijing Technology and Business UniversityBeijing 100048China

Emerging evidence shows that some Lactobacillus fermentum(***)strains can contribute to the prevention and treatment of ulcerative colitis(UC).In this study,105 isolates of *** strains were separated from fecal samples of populations in different regions in China and their draft genomes were ***-genomic and phylogenetic characterizations of these strains and four model strains(*** 3872,CECT5716,IF03956,and VRI003)were *** analysis ind icated that there was no significant adaptive evolution between the genomes of *** strains and the geographical location,sex,ethnicity,and age of the *** *** strains(FWXBH115,FGDLZR121,and FXJCJ61)from different branches of the phylogenetic tree and strain type *** CECT5716 were selected and their anti-inflammatory and immune modulatory activities in a dextran sulphate sodium(DSS)-induced colitis mouse model were further *** *** FXJCJ61 and CECT5716 significantly alleviated UC by reducing all colitis-associated histological indices,maintaining mucosal integrity,and stimulating replenishment of short-chain fatty acids(SCFAs),while the other two strains failed to offer similar *** anti-inflammato ry mechanisms of *** FXJCJ61 and CECT5716 were related to the inhibition of nuclear factor kappa-B(NF-κB)signaling pathway activation and enhancement of interleukin 10(IL-10)*** genomic analysis of these strains identified candidate genes that may contribute to the anti-inflammatory effects of specific *** strains.

关键词： Lactobacillus fermentum Ulcerative colitis Anti-inflammation Phylogenetic analysis Comparative genomic analysis

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Effects of vegetarian diet-associated nutrients on gut microbiota and intestinal physiology

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Food Science and Human Wellness 2022年第2期11卷 208-217页

作者： Wei Xiao Qingsong Zhang Leilei Yu Fengwei Tian Wei Chen Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China international joint research Laboratory for probiotics at jiangnan university Wuxi 214122 China National Engineering research Center for Functional Food Jiangnan UniversityWuxi 214122China Beijing Innovation Center of Food Nutrition and Human Health Beijing Technology and Business University(BTBU)Beijing 100048China

People are increasingly aware of the role of vegetarian diets in modulating human gut microbial abundance and intestinal physiology.A plant-based diet is thought to benefit host health by contributing to establish a diverse and stable *** addition,microbe-derived metabolites of specific nutrients known to be abundant in vegetarian diets(such as indigestible carbohydrates,arginine,and others) are important to promote effective intestinal immune responses,maintain intestinal barrier function,and protect against *** review explores the characteristics of the gut microbiome formed by vegetarian diets and the effects of diet-associated nutrients on intestinal microbial *** interactions between the microbe-derived metabolites of vegetarian diet-associated nutrients and intestinal physiology are also discussed.

关键词： Vegetarian diet Gut microbiota Microbial metabolites Intestinal physiology

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Lactobacillus plantarum CCFM8610 Alleviates Irritable Bowel Syndrome and Prevents Gut Microbiota Dysbiosis:A Randomized,Double-Blind,Placebo-Controlled,Pilot Clinical Trial

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Engineering 2021年第3期7卷 376-385页

作者： Yang Liu Xinjie Yu Leilei Yu Fengwei Tian Jianxin Zhao Hao Zhang Long Qian Qun Wang Zhengqing Xue Qixiao Zhai Wei Chen State Key Laboratory of Food Science and Technology Jjiangnan UniversityWixi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China Hwa Chong Institution(College) Singapore 269734Singapore international joint research laborutory for probiotics jiangnan university Wuxi 214122 China National Engineering research Center for Functional Food Jjiangnan UniversityWuxdi 214122China Wiuxi Translational Medicine research Center and Jiangsu Translatianal Medicine research Institute Wuxi Branch Wixi 214122China (Yangzhou)Institute of Food Biotechnology Jiangnan UniversityYangzhou 225004China The Tinghu People's Hospital Yancheng 224002China Beijing Advanced Innnovation Center for Food Nutrition and Human Health Beijing Technology and Rasiness Univesity(BTBU)Bejing 100048China

Irritable bowel syndrome with diarrhea(IBS-D)is chronic intestinal dysfunction with diarrhea and othercomplicated clinical symptoms,and it has a great impact on the daily life and mental state of *** studies have reported that ingestion of probiotics can significantly alleviate a variety of *** pupose of this study was to investigate the IBS-D-alleviating effects of a probiotic strain,lactobacillus plantarum(***)CCFM8610,with multiple health-promoting *** studywas a 12-week,randomized,double-blind,placebo-controlled,pilot clinical ***-five patientswere randomly assigned to receive the placebo,oligosaccharides,or *** CCFM8610(1×10^(10) colony-forming units(CFU)per day),with a 2-week run-in period,an 8-week intervention period,anda 2-week follow-up observation *** patients'clinical symptoms and quality of life were exam-ined by the IBS symptom severity scale(IBS-SsS)and the IlBS quality of life scale(IBS-QOL).Changes ingut microbiota composition and diversity were measured at the end of the intervention *** oraladministration of *** CCFM8610 significantly decreased the IBS-SSS and IBS-QOL scores,reduced IBS-D symptom severity,recovered gut microbiota diversity,decreased the relative abundanceof bloating-related genus Methanobrevibacter,and increased the relative abundance of butyric acid-producing genera,including Anaerostipes,Anaerotruncus,Bifidobacterium,Butyricimonas,*** findings suggest that ingestion of *** CCFM8610 can significantly alleviate clinical symptoms and gut microbiota dysbiosis in IBS-D *** IBS-D-alleviating effect of ***-tarum CCFM8610 may be related to theincrease in the relative abundance of butyric acid-producing genera in the intestine.

关键词： Lactobacillus plantarum Irritable bowelsyndrome Gut microbiota Butyric acid Clinical trial

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Infant feces-derived Bifidobacterium breve CCFM1078 inhibits the occurrence of rheumatoid cachexia by IRS1/PI3K/Akt signaling pathway

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Food Science and Human Wellness 2024年

作者： Bowen Li Mengfan Ding Chen Chi Guoxun Shi Xiaoming Liu Jianxin Zhao Paul Ross Catherine Stanton Wei Chen Bo Yang State Key Laboratory of Food Science and Resources， jiangnan university School of Food Science and Technology， jiangnan university Department of Rheumatology， jiangnan university Medical Center international joint research Center for probiotics & Gut Health， jiangnan university APC Microbiome Ireland， university College Cork Teagasc Food research Centre National Engineering research Center for Functional Food， jiangnan university

This study aimed to investigate the effects of infant feces-derived Bifidobacterium breve CCFM1078 on rheumatoid cachexia （RC）. Twenty-four female Wistar rats were assigned to three groups: CON group （normal saline by gavage）， CIA group （collagen-induced arthritis， normal saline by gavage）， and CCFM1078 group (collagen-induced arthritis， 3×109CFU/rat/day B breve CCFM1078 gavage). The results demonstrated that B. breve CCFM1078 not only improved skeletal muscle function in CIA rats， but also modulated the gut microbiota， skeletal muscle metabolism and hormone levels， reduced inflammation in the knee joint and skeletal muscles， decreased activity of the NF-κB inflammatory signaling pathway， enhanced the IRS1/PI3K/Akt signaling pathway， promoted skeletal muscle differentiation， and maintained skeletal muscle fiber diameter， consequently slowing down the progression of RC. These findings suggested that B. breve CCFM1078 may have a beneficial role as part of a dietary intervention for RC， enhancing overall therapeutic effects.

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Limosilactobacillus mucosae FZJTZ26M3 prevents NAFLD in mice through modulation of lipid metabolism and gut microbiota dysbiosis

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Food Science and Human Wellness 2024年第3期13卷 1589-1601页

作者： Danting Dang Bowen Li Mengfan Ding RPaul Ross Catherine Stanton Jianxin Zhao Bo Yang Wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China international joint research Center for probiotics&Gut Health Jiangnan UniversityWuxi 214122China APC Microbiome Ireland University College CorkCork T12 YT20Ireland Teagasc Food research Centre MooreparkFermoyCork T12 YT20Ireland National Engineering research Center for Functional Food Jiangnan UniversityWuxi 214122China

Lactobacillus are considered promising therapeutic methods for nonalcoholic fatty liver disease(NAFLD).The effects of two strains of Ltmosilactobacillus mucosae on NAFLD were investigated in this ***-old male C57BL/6J mice were divided into 4 groups(n=8 per group,Control,Model,FZJTZ26M3,FGSYC17L3).*** FZJTZ26M3 reduced the mice 's body weight,liver weight,and adipose tissue weight after 12 weeks of *** to serum analysis,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol significantly decreased after *** FZJTZ26M3 *** pathology showed that *** FZJTZ26M3 was effective to ameliorate lipid deposition in NAFLD ***,the expression of the gene related to lipid metabolism in the liver and adipose tissue was analyzed,and the results indicated that *** FZJTZ26M3 could alleviate NAFLD by regulating lipid ***,the results of 16S rRNA gene sequencing revealed a drop in the relative abundance of Ruminococcaceae,which is linked to inflammation,but the relative abundance of a potential probiotic Akkermansia significantly increased after *** FZJTZ26M3 ***,*** FZJTZ26M3 could be a candidate to prevent NAFLD.

关键词： Limosilactobacillus mucosae Nonalcoholic fatty liver disease(NAFLD) Probiotic Lipid metabolism Gut microbiota

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Bifidobacterium breve CCFM1078 regulates bone development in growing BALB/c mice via gut microbiota and metabolites to balance bone formation and resorption

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Food Science and Human Wellness 2024年

作者： Bowen Li Mengfan Ding Xiaoming Liu Haiqin Chen Jianxin Zhao R.Paul Ross Catherine Stanton Shilong Jiang Wei Chen Bo Yang State Key Laboratory of Food Science and Technology， jiangnan university School of Food Science and Technology， jiangnan university international joint research Center for probiotics & Gut Health， jiangnan university APC Microbiome Ireland， university College Cork Teagasc Food research Centre Nutrition and Metabolism research Division， Innovation Center， Heilongjiang Feihe Dairy Co.， Ltd. PKUHSC-China Feihe joint research Institute of Nutrition and Healthy Lifespan Development National Engineering research Center for Functional Food， jiangnan university

This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c mice. Newborn BALB/c mice were assigned to the control group (administration saline) and the CCFM1078 group (administration B. breve CCFM1078， 3 × 109CFU/day) in 3-， 4-， and 5-week tests. All the groups have male and female distinctions. Our findings demonstrate that B. breve CCFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites (hexadecanamide， linoleoyl ethanolamide， and palmitoyl ethanolamide)， the genes and proteins expression related to the GH/IGF-1 axis and Gs/PKA/CREB signaling pathways， as well as downstream osteogenic and osteoclastic differentiation factors. The effects of B. breve CCFM1078 were different with age and gender dependent. This finding suggests B. breve CCFM1078 may have potential applications in regulating bone metabolism in the growth period population.

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Bifidobacterium longum subsp. infantis CCFM1269 promotes intestinal barrier and release of IFN-β through TLR4-TRIF dependent way in growing mice

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Food Science and Human Wellness 2024年

作者： Mengfan Ding Bo Yang Bowen Li Haiqin Chen Renqiang Yu R.Paul Ross Catherine Stanton Shilong Jiang Jianxin Zhao Wei Chen State Key Laboratory of Food Science and Resources， jiangnan university School of Food Science and Technology， jiangnan university international joint research Center for probiotics & Gut Health， jiangnan university Department of Neonatology， Wuxi Maternity and Child Health Care Hospital， Affiliated Women's Hospital of jiangnan university APC Microbiome Ireland， university College Cork Teagasc Food research Centre Nutrition and Metabolism research Division， Innovation Center， Heilongjiang Feihe Dairy Co.， Ltd. PKUHSC-China Feihe joint research Institute of Nutrition and Healthy Lifespan Development National Engineering research Center for Functional Food， jiangnan university

Bifidobacterium longum subsp. infantis is a commensal bacterium that predominates in the infant gut， playing a critical role in both preventing foreign infections and facilitating immune development. This study aimed to explore the effects of B. longum subsp. infantis supplementation on interferon-beta (IFN-β) secretion and intestinal barrier improvement in growing mice. Female and male mice were orally administered either saline or B. longum subsp. infantis CCFM1269 or I5TI (1 × 109CFU/mice per day， n = 8) from 1-week-age until 3-， 4-， and 5-week-age. RNA sequencing analysis revealed that CCFM1269 exhibited potential antiviral capacity through increasing 2’-5’ oligoadenylate synthetase (OAS). Additionally， CCFM1269 supplementation significantly increased colonic IFN-β levels which combined with OAS in 3-week-old female and male mice by activating the TLR4-TRIF-dependent signaling pathway. However， this effect was not observed in 4- and 5-week-old mice. Furthermore， both CCFM1269 were found to modulate the gut microbiota composition and enhance the intestinal barrier function in 3-， 4-， and 5-week-old mice. In summary， the results of this study suggested that B. longum subsp. infantis CCFM1269 promoting intestinal barrier and releasing IFN-β in growing mice was in a strain-specific and time-dependent manner.

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Protective effects of Bifi dobacterium breve on imiquimod-induced psoriasis in mice through secondary bile acid production and FXR-TLR4/NF-κB pathway

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Food Science and Human Wellness 2024年第6期13卷 3447-3460页

作者： Xinqi Chen Yang Chen Catherine Stanton RPaul Ross Jianxin Zhao Bo Yang Wei Chen State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China international joint research Center for probiotics&Gut Health Jiangnan UniversityWuxi 214122China APC Microbiome Ireland University College CorkCork T12 YT20Ireland Teagasc Food research Centre Cork T12 YT20Ireland National Engineering research Center for Functional Food Jiangnan UniversityWuxi 214122China

This study aimed to evaluate the effects of Bifi dobacterium breve CCFM683 on psoriasis and to investigate the underlying *** CCFM683 significantly ameliorated psoriasis in mice as well as elevated the deoxycholic acid(DCA)and lithocholic acid(LCA)in the colon compared with those of the imiquimod(IMQ)-treated ***,*** CCFM683 increased the relative abundance of DCA-producing Lachnoclostridium and diminished the harmful Desulfovibrio and Prevotellaceae ***,the farnesoid X receptor(FXR)in the skin was activated and the expression of the Toll-like receptor 4(TLR4)/nuclear factor kappa-B(NF-κB)pathway was inhibited,and the downstream interleukin(IL)-17 and tumor necrosis factor(TNF)-αwere downregulated whereas IL-10 was ***,the subsequent hyperproliferation of keratinocytes and the dysfunction of the epidermal barrier were *** conclusion,CCFM683 administration ameliorated IMQ-induced psoriasis via modulating gut microbiota,promoting the DCA production,regulating the FXR-TLR4/NF-κB pathway,diminishing proinflammatory cytokines,and regulating keratinocytes and epidermal *** findings may be conducive to elucidating the mechanism for probiotics to ameliorate psoriasis and to promote its clinical trials in skin disease.

关键词： Psoriasis Bifi dobacterium breve Gut microbiota Secondary bile acids FXR-TLR4/NF-κB pathway

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Hyaluronic acid modulates gut microbiota and metabolites relieving inflammation:A molecular weight-dependent study

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Science Bulletin 2024年第17期69卷 2683-2687页

作者： Chuan Zhang Botao Wang Leilei Yu Ruohan Zhao Qingsong Zhang Chengcheng Zhang Shumao Cui Jianxin Zhao Arjan Narbad Wei Chen Fengwei Tian Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122 China School of Food Science and Technology Jiangnan UniversityWuxi 214122 China Bloomage Biotechnology Co. Ltd.Jinan 250000 China international joint research Laboratory for probiotics Jiangnan UniversityWuxi 214122 China Gut Health and Microbiome Institute Strategic Programme Quadram Institute BioscienceNorwich NR47UAUK

Hyaluronic acid(HA),a linear glycosaminoglycan polymer,is an inherent carbon source for gut microbiota and is capable of mitigating host inflammation by modulating gut *** length of hyaluronan can range from an oligomer to an extremely long-form up to millions of Daltons,and its biological functions depend on its molecular mass[1,2].Presently,the precise mechanisms through which HA of varying molecular weights alleviates inflammation by modulating the gut microbiota remain unclear[3].

关键词： inflammation precise weights

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Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders

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Engineering 2020年第4期6卷 415-423页

作者： Wanqiang Wu Qingmin Kong Peijun Tian Qixiao Zhai Gang Wang Xiaoming Liu Jianxin Zhao Hao Zhang Yuan Kun Lee Wei Chen a State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering research Center for Functional Food Wuxi 214122China international joint research Laboratory for probiotics Jiangnan UniversityWuxi 214122China Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Technology and Business UniversityBeijing 100048China

It is well known that the gut microbiota plays an extremely important role in modulating host physiological functions such as immunity and metabolic *** recent years,accumulated evidence has revealed that the gut microbiota can regulate the functions of the central nervous system(CNS)through the gut-brain axis,which provides a novel insight into the interactions between the gut and *** review focuses on the molecular mechanism of the crosstalk between the gut microbiota and the brain via the gut-brain axis,and on the onset and development of neurological disorders triggered by gut microbiota *** topics are followed by a critical analysis of potential intervention strategies targeting gut microbiota dysbiosis,including the use of probiotics,prebiotics,synbiotics,and *** research on the microbiota-gut-brain axis is still in its relative infancy,clarifying the molecular mechanism that underlies how the gut microbiota regulates neurological functions not only holds the promise of revealing potentially novel pathogeneses of neurological disorders,but also may lead to the development of potential diagnosis biomarkers and intervention strategies targeting microbiota dysbiosis for neurological disorders.

关键词： Gut microbiota Gut-brain axis Neurological disorders Intervention strategies

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