Infant feces-derived Bifidobacterium breve CCFM1078 inhibits the occurrence of rheumatoid cachexia by IRS1/PI3K/Akt signaling pathway
作者机构：State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University Department of Rheumatology， Jiangnan University Medical Center International Joint Research Center for Probiotics & Gut Health， Jiangnan University APC Microbiome Ireland， University College Cork Teagasc Food Research Centre National Engineering Research Center for Functional Food， Jiangnan University
出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康(英文))
年 卷 期：2024年
核心收录：
学科分类：1002[医学-临床医学] 08[工学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 10[医学]
基 金：supported by the National Natural Science Foundation of China (32021005) 111 project (BP0719028) the Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
摘 要：This study aimed to investigate the effects of infant feces-derived Bifidobacterium breve CCFM1078 on rheumatoid cachexia （RC）. Twenty-four female Wistar rats were assigned to three groups: CON group （normal saline by gavage）， CIA group （collagen-induced arthritis， normal saline by gavage）， and CCFM1078 group (collagen-induced arthritis， 3×109CFU/rat/day B breve CCFM1078 gavage). The results demonstrated that B. breve CCFM1078 not only improved skeletal muscle function in CIA rats， but also modulated the gut microbiota， skeletal muscle metabolism and hormone levels， reduced inflammation in the knee joint and skeletal muscles， decreased activity of the NF-κB inflammatory signaling pathway， enhanced the IRS1/PI3K/Akt signaling pathway， promoted skeletal muscle differentiation， and maintained skeletal muscle fiber diameter， consequently slowing down the progression of RC. These findings suggested that B. breve CCFM1078 may have a beneficial role as part of a dietary intervention for RC， enhancing overall therapeutic effects.
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