检索结果-南通市图书馆

Food Science and Human Wellness 2024年

作者： Chi Chen Bowen Li Mengfan Ding Huizhen Li Jianxin Zhao R.Paul Ross Catherine Stanton Wei Chen Bo Yang State Key Laboratory of Food Science and Resources， jiangnan university School of Food Science and Technology， jiangnan university international joint research center for probiotics & gut health， jiangnan university APC Microbiome Ireland， university College Cork Teagasc Food research Centre， Moorepark National Engineering research center for Functional Food， jiangnan university

Irritable bowel syndrome-diarrhea （IBS-D） is a prevalent functional bowel disease severely impairs the quality of life of patients. Visceral hypersensitivity （VH） is the main symptom of IBS-D. probiotics have been found to effectively alleviate VH. In this study， neonatal maternal separation （NMS） was used to induce VH in 72 rats and investigated the effects of daily gavage of 3*109CFU of Lactobacillus and Bifidobacterium on alleviating the symptoms of IBS-D and behavioral interventions， as well as exploring potential mechanisms. The results demonstrated that Lactobacillus acidophilus and Bifidobacterium breve could alleviate the symptoms of IBS-D such as VH and increased frequency of bowel movements， as well as improving non-spatial memory in NMS rats. These effects were achieved by modulating the composition of gut microbiota and metabolites （including short-chain fatty acids， deoxycholic acid and adenosine）， and by regulating the expression of genes and proteins associated with the NGF/TrkA signaling pathway， tryptophan metabolism， and inflammatory factors in the hippocampus. This finding suggests that Lactobacillus acidophilus and Bifidobacterium breve have promising potential for the alleviation of IBS.

关键词：

Lactobacillus rhamnosus MP108 alleviates ulcerative colitis in mice by enhancing the intestinal barrier， inhibiting inflammation， and modulating gut microbiota

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Huizhen Li Yang Chen Huiting Fang Xinmei Guo Xuecong Liu Jianxin Zhao Wei Chen Bo Yang State Key Laboratory of Food Science and Resources， jiangnan university School of Food Science and Technology， jiangnan university Jinqiao Biotechnology Co.， Ltd. Huai'an， Jiangsu， China National Engineering research center for Functional Food， jiangnan university international joint research center for probiotics & gut health， jiangnan university

Ulcerative colitis (UC) is a long-term inflammatory disorder that has evolved into a worldwide challenge. The development of new therapies against UC is imperative as all current therapies for UC are flawed in some way. Thus， the present study aimed to assess the palliative effects of Lactobacillus rhamnosus MP108 on UC in mice and to explore its potential mechanisms. The results showed that L. rhamnosus MP108 ameliorated the symptoms of UC， including preventing body weight loss， DAI elevation， and colon shortening， and attenuated colonic pathological damage. L. rhamnosus MP108 dramatically increased the number of goblet cells， MUC2 level， and tight junction protein level in the colon and remarkably inhibited epithelial cell apoptosis， thereby strengthening the intestinal barrier. L. rhamnosus MP108 pronouncedly diminished pro-inflammatory cytokine levels and strikingly augmented anti-inflammatory cytokine levels， in turn suppressing inflammation. Furthermore， L. rhamnosus MP108 conspicuously boosted the proportion of short-chain fatty acids (SCFAs) producers in gut microbiota， contributing to increased levels of acetate and butyrate. Therefore， L. rhamnosus MP108 might alleviate UC via improving the intestinal barrier， inhibiting inflammation， and modulating intestinal microbiota.

关键词：

Limosilactobacillus mucosae FZJTZ26M3 prevents NAFLD in mice through modulation of lipid metabolism and gut microbiota dysbiosis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第3期13卷 1589-1601页

作者： Danting Dang Bowen Li Mengfan Ding RPaul Ross Catherine Stanton Jianxin Zhao Bo Yang Wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China international joint research center for probiotics&gut health Jiangnan UniversityWuxi 214122China APC Microbiome Ireland University College CorkCork T12 YT20Ireland Teagasc Food research Centre MooreparkFermoyCork T12 YT20Ireland National Engineering research center for Functional Food Jiangnan UniversityWuxi 214122China

Lactobacillus are considered promising therapeutic methods for nonalcoholic fatty liver disease(NAFLD).The effects of two strains of Ltmosilactobacillus mucosae on NAFLD were investigated in this ***-old male C57BL/6J mice were divided into 4 groups(n=8 per group,Control,Model,FZJTZ26M3,FGSYC17L3).*** FZJTZ26M3 reduced the mice 's body weight,liver weight,and adipose tissue weight after 12 weeks of *** to serum analysis,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol significantly decreased after *** FZJTZ26M3 *** pathology showed that *** FZJTZ26M3 was effective to ameliorate lipid deposition in NAFLD ***,the expression of the gene related to lipid metabolism in the liver and adipose tissue was analyzed,and the results indicated that *** FZJTZ26M3 could alleviate NAFLD by regulating lipid ***,the results of 16S rRNA gene sequencing revealed a drop in the relative abundance of Ruminococcaceae,which is linked to inflammation,but the relative abundance of a potential probiotic Akkermansia significantly increased after *** FZJTZ26M3 ***,*** FZJTZ26M3 could be a candidate to prevent NAFLD.

关键词： Limosilactobacillus mucosae Nonalcoholic fatty liver disease(NAFLD) Probiotic Lipid metabolism gut microbiota

维普期刊数据库

Bifidobacterium breve CCFM1078 regulates bone development in growing BALB/c mice via gut microbiota and metabolites to balance bone formation and resorption

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Bowen Li Mengfan Ding Xiaoming Liu Haiqin Chen Jianxin Zhao R.Paul Ross Catherine Stanton Shilong Jiang Wei Chen Bo Yang Nutrition and Metabolism research Division， Innovation center， Heilongjiang Feihe Dairy Co.， Ltd. National Engineering research center for Functional Food， jiangnan university State Key Laboratory of Food Science and Technology， jiangnan university PKUHSC-China Feihe joint research Institute of Nutrition and healthy Lifespan Development APC Microbiome Ireland， university College Cork School of Food Science and Technology， jiangnan university international joint research center for probiotics & gut health， jiangnan university Teagasc Food research Centre

This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c mice. Newborn BALB/c mice were assigned to the control group (administration saline) and the CCFM1078 group (administration B. breve CCFM1078， 3 × 109CFU/day) in 3-， 4-， and 5-week tests. All the groups have male and female distinctions. Our findings demonstrate that B. breve CCFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites (hexadecanamide， linoleoyl ethanolamide， and palmitoyl ethanolamide)， the genes and proteins expression related to the GH/IGF-1 axis and Gs/PKA/CREB signaling pathways， as well as downstream osteogenic and osteoclastic differentiation factors. The effects of B. breve CCFM1078 were different with age and gender dependent. This finding suggests B. breve CCFM1078 may have potential applications in regulating bone metabolism in the growth period population.

关键词：

Bifidobacterium longum subsp. infantis CCFM1269 promotes intestinal barrier and release of IFN-β through TLR4-TRIF dependent way in growing mice

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Mengfan Ding Bo Yang Bowen Li Haiqin Chen Renqiang Yu R.Paul Ross Catherine Stanton Shilong Jiang Jianxin Zhao Wei Chen State Key Laboratory of Food Science and Resources， jiangnan university Teagasc Food research Centre Nutrition and Metabolism research Division， Innovation center， Heilongjiang Feihe Dairy Co.， Ltd. Department of Neonatology， Wuxi Maternity and Child health Care Hospital， Affiliated Women's Hospital of jiangnan university National Engineering research center for Functional Food， jiangnan university School of Food Science and Technology， jiangnan university PKUHSC-China Feihe joint research Institute of Nutrition and healthy Lifespan Development international joint research center for probiotics & gut health， jiangnan university APC Microbiome Ireland， university College Cork

Bifidobacterium longum subsp. infantis is a commensal bacterium that predominates in the infant gut， playing a critical role in both preventing foreign infections and facilitating immune development. This study aimed to explore the effects of B. longum subsp. infantis supplementation on interferon-beta (IFN-β) secretion and intestinal barrier improvement in growing mice. Female and male mice were orally administered either saline or B. longum subsp. infantis CCFM1269 or I5TI (1 × 109CFU/mice per day， n = 8) from 1-week-age until 3-， 4-， and 5-week-age. RNA sequencing analysis revealed that CCFM1269 exhibited potential antiviral capacity through increasing 2’-5’ oligoadenylate synthetase (OAS). Additionally， CCFM1269 supplementation significantly increased colonic IFN-β levels which combined with OAS in 3-week-old female and male mice by activating the TLR4-TRIF-dependent signaling pathway. However， this effect was not observed in 4- and 5-week-old mice. Furthermore， both CCFM1269 were found to modulate the gut microbiota composition and enhance the intestinal barrier function in 3-， 4-， and 5-week-old mice. In summary， the results of this study suggested that B. longum subsp. infantis CCFM1269 promoting intestinal barrier and releasing IFN-β in growing mice was in a strain-specific and time-dependent manner.

关键词：

Aldehyde oxidase mediated enantioselective metabolic health risk of dinotefuran

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第6期67卷 2079-2091页

作者： Liwei Xu Xinxin Xu Hua Kuang Chuanlai Xu Xiaoling Wu State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi214122China international joint research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan UniversityWuxi214122China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityWuxi214122China

Chiral pollutants often pose significant differential environmental health *** this study,the biotransformation of chiral dinotefuran(DIN)and its enantioselective metabolic toxicity mechanisms have been systemically ***,reversedphase chromatography-high resolution mass spectrometry was developed to quantify the content of DIN R/S chiral enantiomer with pg level sensitivity,revealing a lower elimination rate constant(K_(e))of S-DIN(0.730 h^(-1))than R-DIN(0.746 h^(-1)).Secondly,the interaction mechanism between DIN metabolism and important endogenous bioactive molecules,such as aldehyde oxidase(AOX)and neurotransmitters,was *** DIN nitro-group was converted into a guanidine group by the reducing site of nearby flavin adenine dinucleotide(FAD)in AOX with the preferred higher affinity of ***,the endogenous tryptophan(Trp)aldehyde metabolic intermediate,5-hydroxyindoleacetaldehyde(5-HIAL),provides a persistent electron donor for DIN reduction via the oxidation-catalyzed site in AOX,resulting in remarkable up-regulation of monoamine neurotransmitters such as serotonin and ***,the higher level of neurotransmitters further mediated dysregulation of oxylipin homeostasis via the serotonergic pathway,where S-DIN exhibited more pronounced liver lipid damage and environmental health risk with the accumulated lipid biomarkers,oxidized triglyceride(OxTG)and oxidized sphingomyelin(OxSM).This study elucidates the AOX-mediated enantioselectivity metabolic pathway of DIN,providing a new analytical method for chiral pollutants and paves the way for their health risk assessments.

关键词： neonicotinoid dinotefuran enantiomer aldehyde oxidase metabolomics health risk

维普期刊数据库

同方期刊数据库

A multi-colloidal gold immunochromatography assay for rapid and simultaneous detection of 13 herbicides

在线全文

学校读者我要写书评

暂无评论

Nano research 2024年第9期17卷 8368-8376页

作者： Qianqian Lu Xinxin Xu Aihua Qu Liqiang Liu Yuzhe Li Maozhong Sun Chuanlai Xu Hua Kuang international joint research Laboratory for Biointerface and Biodetection and School of Food Science and TechnologyJiangnan UniversityWuxi 214122China China National center for Food Safety Risk Assessment Beijing 100021China

Herbicide residues in agricultural products can have adverse effects on the environment and human health,therefore,there is an urgent need to establish a sensitive,rapid,and wide-ranging detection *** this study,haptens of phenylurea herbicides(PUs)and sulfonylurea herbicides(SUs)were analyzed and designed based on computational simulation techniques,and two high-performance broad-spectrum monoclonal antibodies against PUs and SUs were *** this basis,a multi-colloidal gold immunochromatography assay(multi-CGIA)was developed to simultaneously detect 13 herbicides in *** visual limit of detection(vLOD)for PUs including diuron,chlortoluron,neburon,chlorbromuron,and linuron was 1-2μg/*** vLOD for SUs including metsulfuron methyl,ethametsulfuron-methyl,sulfometuron-methyl,tribenuron methyl,cinosulfuron,triasulfuron,chlorimuron-ethyl,and chlorsulfuron was 2-10μg/*** results of real sample determination indicated that the multi-CGIA is accurate,stable,and reliable,and adaptable to on-site preliminary screening of actual samples.

关键词： phenylurea herbicides sulfonylurea herbicides monoclonal antibody immunochromatographic assay wheat

Foodborne toxin Aflatoxin B_(1)induced glomerular podocyte inflammation through proteolysis of RelA,downregulation of miR-9 and CXCR4/TXNIP/NLRP3 pathway

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第4期13卷 2289-2309页

作者： Jie Zhang Shuang Yang Baocai Xu Zihui Qin Xinyi Guo Ben Wei Qinghua Wu Kamil Kuca Tushuai Li Wenda Wu School of Biology and Food Engineering Changshu Institute of TechnologySuzhou 215500China center for Clinical Mass Spectrometry School of Pharmaceutical SciencesSoochow UniversitySuzhou 215123China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China MOE joint international research Laboratory of Animal health and Food Safety College of Veterinary MedicineNanjing Agricultural UniversityNanjing 210095China Department of Chemistry Faculty of ScienceUniversity of Hradec KraloveHradec Kralove 50003Czech Republic College of Life Science Yangtze UniversityJingzhou 434025China Wuxi Medical College Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine research center and Jiangsu Translational Medicine research Institute Wuxi Branch Wuxi 214013China

Aflatoxin B_(1)(AFB_(1))is a naturally-occurring mycotoxin and recognized as the most toxic foodborne toxin,particularly causing damages to *** podocytes are terminally differentiated epithelial ***_(1)induces podocyte inflammation,proteinuria and renal *** the mechanism of AFB_(1)-induced podocyte inflammation and murine kidney dysfunction,we detected that AFB_(1)increased ubiquitindependent degradation of the transcription factor RelA through enhanced interaction of RelA with E3 ubiquitin ligase tripartite motif containing 7(TRIM7)in mouse podocyte clone-5(MPC-5)and mouse *** of RelA resulted in decreasing microRNA-9(miR-9)and activating the chemokine receptor 4(CXCR4),thioredoxin interacting protein(TXNIP),and NOD-like receptor pyrin domain-containing 3(NLRP3)signaling axis(CXCR4/TXNIP/NLRP3 pathway),leading to podocyte *** also determined that downregulation of miR-9 led to CXCR4 expression and the downstream TXNIP/NLRP3 pathway *** of miR-9 or deletion of CXCR4 suppressed AFB_(1)-induced CXCR4/TXNIP/NLRP3 pathway,resulting in alleviating podocyte inflammation and kidney *** findings indicated that ubiquitin-dependent proteolysis of RelA,downregulation of miR-9,and activation of CXCR4/TXNIP/NLRP3 pathway played an essential role in AFB_(1)-induced glomerular podocyte *** study revealed a novel mechanism,via RelA,for the control of AFB_(1)’s nephrotoxicity,leading to an effective protection of food safety and public health.

关键词： Aflatoxin B_(1) Podocyte inflammation miRNA-9 Chemokine(C-X-C motif)receptor 4 RelA ubiquitin-dependent degradation

维普期刊数据库

Bifidobacterium breve alleviates gut–liver-axis injury caused by high-fat diet and aflatoxin B1 in mice

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Yongli Ye Tingwei Wang Jian Ji Jiasheng Wang Yinzhi Zhang Xiulan Sun international joint Laboratory on Food Safety， Synergetic Innovation center of Food Safety and Quality Control， School of Food Science and Technology， jiangnan university School of Biological and Chemical Engineering， Zhejiang university of Science and Technology Yixing Institute of Food and Biotechnology Co.， Ltd. Department of Environmental health Science， College of Public health， university of Georgia

Aflatoxin B1(AFB1) is a common contaminant in cereals of global concern， and long-term low-dose exposure can adversely affect human health. Here， we showed that populations with dietary patterns characterized by high-fat diet (HFD) might have an increased risk of exposure to high levels of AFB1. Our data indicated that chronic exposure of AFB1 induced “gut-liver axis” injury in mice under HFD and normal diet (ND) patterns. AFB1 further aggravated hepatic and intestinal injury， and intestinal microbiota disruption in HFD mice. Bifidobacterium breve BAA-2849 intervention analysis showed that liver injury and lipid disorders caused by AFB1 exposure were alleviated by regulating the proportions of different gut microbes. We demonstrated through a mice model that the populations with a dietary pattern of HFD might be more susceptible to AFB1 exposure and adverse effects on the gut-liver axis， and the toxicity of AFB1 exposure can be alleviated by regulating the gut microbiota.

关键词：

Protective Effects of Bifidobacterium breve on IMQ-Induced Psoriasis in Mice through Secondary Bile Acid Production and FXR-TLR4/NF-κB Pathway

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2023年

作者： Xinqi Chen Yang Chen Catherine Stanton R.Paul Ross Jianxin Zhao Bo Yang Wei Chen National Engineering research center for Functional Food， jiangnan university School of Food Science and Technology， jiangnan university State Key Laboratory of Food Science and Technology， jiangnan university APC Microbiome Ireland， university College Cork Teagasc Food research Centre international joint research center for probiotics & gut health， jiangnan university

This study aimed to evaluate the effects of Bifidobacterium breve CCFM683 on psoriasis and to investigate the underlying mechanisms. Bifidobacterium breve CCFM683 significantly ameliorated psoriasis in mice as well as elevated the deoxycholic acid (DCA) and lithocholic acid (LCA) in the colon compared with those of the imiquimod-treated mice. Meanwhile， B. breve CCFM683 increased the relative abundance of DCA-producing Lachnoclostridium and diminished the harmful Desulfovibrio and Prevotellaceae UCG001. Additionally， the farnesoid X receptor (FXR) in the skin was activated and the expression of the TLR4/NF-κB pathway was inhibited， and the downstream IL-17 and TNF-α were downregulated whereas IL-10 was up-regulated . Moreover， the subsequent hyperproliferation of keratinocytes and the dysfunction of the epidermal barrier were improved. In conclusion， CCFM683 administration ameliorated IMQ-induced psoriasis via modulating gut microbiota， promoting the DCA production， regulating the FXR-TLR4/NF-κB pathway， diminishing proinflammatory cytokines， and regulating keratinocytes and epidermal barrier. These findings may be conducive to elucidating the mechanism for probiotics to ameliorate psoriasis and to promote its clinical trials in skin disease.

关键词：