Bifidobacterium breve CCFM1078 regulates bone development in growing BALB/c mice via gut microbiota and metabolites to balance bone formation and resorption

作     者：Bowen Li Mengfan Ding Xiaoming Liu Haiqin Chen Jianxin Zhao R.Paul Ross Catherine Stanton Shilong Jiang Wei Chen Bo Yang 

作者机构：State Key Laboratory of Food Science and Technology， Jiangnan University School of Food Science and Technology， Jiangnan University International Joint Research Center for Probiotics & Gut Health， Jiangnan University APC Microbiome Ireland， University College Cork Teagasc Food Research Centre Nutrition and Metabolism Research Division， Innovation Center， Heilongjiang Feihe Dairy Co.， Ltd. PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development National Engineering Research Center for Functional Food， Jiangnan University 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康(英文))

年 卷 期：2024年

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083201[工学-食品科学] 

基　　金：supported by the National Key R&D Program of China (2021YFD2100700) National Natural Science Foundation of China (32021005) 111 project (BP0719028) and Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province 

摘      要：This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c mice. Newborn BALB/c mice were assigned to the control group (administration saline) and the CCFM1078 group (administration B. breve CCFM1078， 3 × 109CFU/day) in 3-， 4-， and 5-week tests. All the groups have male and female distinctions. Our findings demonstrate that B. breve CCFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites (hexadecanamide， linoleoyl ethanolamide， and palmitoyl ethanolamide)， the genes and proteins expression related to the GH/IGF-1 axis and Gs/PKA/CREB signaling pathways， as well as downstream osteogenic and osteoclastic differentiation factors. The effects of B. breve CCFM1078 were different with age and gender dependent. This finding suggests B. breve CCFM1078 may have potential applications in regulating bone metabolism in the growth period population.