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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 339-352页

作者： Yang Feng Wenhuan Chen Zheng Xu Weijun He Bin Jiang Fusheng Pan college of Materials Science and Engineering Chongqing UniversityChongqing400044China international Joint Laboratory for Light Alloys(Ministry of education) Chongqing UniversityChongqing400044China

AZ31/Mg3Y composites with a layer thickness of 100-200μm were fabricated by accumulated rolling bonding(ARB),which was followed by diffusion annealing at 300℃ for 0-32 h.An interface layer,containing numerous Al-Y precipitates,is formed in the Mg3Y layer that is adjacent to the interface as a result of Al diffusing from the AZ31 layers into the Mg3Y layers.The thickness of the interface layer gets increased and more precipitates are formed in the interface layer with the extension of the annealing time.The microhardness of the AZ31 and Mg3Y layer decreases firstly and then reaches a stable value,while the microhardness of the interface layer increases gradually with the extension of the annealing time.The AZ31/Mg3Y composites exhibit equivalent strength but increased ductility after diffusion annealing,in comparison to the as-rolled AZ31/Mg3Y composite.In addition,the AZ31/Mg3Y composites after annealing always present higher strength and ductility than AZ31/AZ31 composite,which was fabricated by the same process as that for the AZ31/Mg3Y composites.Hetero-deformation induced strengthening also plays an important role in the excellent strength and ductility of the annealed AZ31/Mg3Y composite.This study can provide a direction for improving the plasticity and strength of magnesium alloys synergistically.

关键词： AZ31/Mg3Y composite Accumulated rolling bonding Diffusion annealing Precipitates Strengthening

The risk of mpox importation and subsequent outbreak potential in Chinese mainland: a retrospective statistical modelling study

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Infectious Diseases of Poverty 2024年第1期13卷 63-73页

作者： Xiaowei Deng Yuyang Tian Junyi Zoul Juan Yang Kaiyuan Sun Hongjie Yu School of Public Health Key Laboratory of Public Health SafetyMinistry of EducationFudan UniversityShanghai 200032China Division of international Epidemiology and Population Studies Fogarty International CenterNational Institutes of HealthBethesdaMDUSA

Background The 2022-2023 mpox(monkeypox)outbreak has spread rapidly across multiple countries in the non-endemic region,mainly among men who have sex with men(MSM).In this study,we aimed to evaluate mpox's importation risk,border screening effectiveness and the risk of local outbreak in Chinese mainland.Methods We estimated the risk of mpox importation in Chinese mainland from April 14 to September 11,2022 using the number of reported mpox cases during this multi-country outbreak from Global.health and the international air-travel data from Official Aviation Guide.We constructed a probabilistic model to simulate the effectiveness of a border screening scenario during the mpox outbreak and a hypothetical scenario with less stringent quarantine requirement.And we further evaluated the mpox outbreak potential given that undetected mpox infections were introduced into men who have sex with men,considering different transmissibility,population immunity and population activity.Results We found that the reduced international air-travel volume and stringent border entry policy decreased about 94% and 69% mpox importations respectively.Under the quarantine policy,15-19% of imported infections would remain undetected.Once a case of mpox is introduced into active MSM population with almost no population immunity,the risk of triggering local transmission is estimated at 42%,and would rise to>95% with over six cases.Conclusions Our study demonstrates that the reduced international air-travel volume and stringent border entry policy during the COvID-19 pandemic reduced mpox importations prominently.However,the risk could be sub-stantially higher with the recovery of air-travel volume to pre-pandemic level.Mpox could emerge as a public health threat for Chinese mainland given its large MSM community.

关键词： Mpox(Monkeypox) Importation risk international air travel Statistical modelling Men who have sex with men

Optimizing 2D-metal contact in layered Tin-selenide via native oxide modulation

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Nano Research 2024年第4期17卷 3014-3020页

作者： Yue Zheng Qi You Zhentian Yin Jian Tang Ke Jiang Zihao Xie Henan Li Cheng Han Yumeng Shi international Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China college of Electronics and Information Engineering Shenzhen UniversityShenzhen 518060China

The discovery of two-dimensional(2D)semiconductor has opened up new avenues for the development of short-channel field-effect transistors(FETs)with desired electrical performance.Among them,orthorhombic tin-selenide(SnSe)has garnered increasing attention due to its potential applications in a variety of electronic,optoelectronic,and thermoelectric devices.However,the realization of high-performance SnSe FETs with low contact resistance(Rc)remains a challenge.Herein,we systematically investigate the contact of few-layer SnSe FETs through the modulation of native oxide on SnSe by using different metals.It is found that chromium(Cr)-contacted devices possess the best FET performance,such as electron mobility up to 606 cm^(2)/(V·s)at 78 K,current on/off ratio exceeding 1010,and saturation current of~550μA/μm,where a negligible Schottky barrier(SB)of~30 meV and a low contact resistance of~425Ωμm are achieved.X-ray photoelectron spectroscopy(XPS)and cross-sectional electron dispersive X-ray spectroscopy(EDX)results further reveal that the improved contact arises from the Cr-induced reduction of native oxide(SnOx)to Sn,which thins the tunneling barrier for efficient electron injection.Our findings provide a deep insight into the 2D-metal contact of SnSe and pave the way for its applications in future nanoelectronics.

关键词： few-layer SnSe field-effect transistors(FETs) Cr contact native oxide contact resistance(Rc) Schottky barrier(SB)

Embodying Deeply Held Values in education:Seeking a More Equitable World for Both Humans and Non-Humans

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ECNU Review of education 2024年第2期7卷 241-251页

作者：林静 Shue-kei Joanna Mok Virginia Gomes Department of Counseling Higher Education and Special EducationCollege of Education3214 Benjamin BuildingUniversity of MarylandCollege ParkMD20742USA

Highlights In this article,we contend that the bedrock of an equitable world lies in the profound recognition of love as the fundamental force permeating the cosmos.We believe that love is built into the essence of who we are.We posit that genuine progress toward an equitable world is elusive unless we place love,both for one another and for the natural world,at the core of our educational endeavors.

关键词： Embodied practices heart and spirit love and equity love as a cosmic force

Remote copper-catalyzed enantioselective substitution of yne-thiophene carbonates

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Science China Chemistry 2024年第4期67卷 1175-1180页

作者： Hao-Dong Qian Xiang Li Tingrui Yin Wei-Feng Qian Chunhui Zhao Cuiju Zhu Hao Xu CCNU-uOttawa Joint Research Centre Key Laboratory of Pesticides&Chemical Biology of Ministry of EducationInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China

Here,we describe a strategy for the copper-catalyzed asymmetric heteroarylation of yne-thiophene carbonates with indoles via remote substitution.The key to the success of this strategy lies in the design of the alkynyl group at the ortho-position of the heterocycle thiophene,enabling the formation of a triarylmethane moiety via very remote substitution.Thus,the concept of remote copper-catalyzed asymmetric transformation extends not only to yne-allylic esters but also to yne-aryl esters.The reaction readily provides a diverse array of chiral triarylmethanes with high efficiency,enantioselectivity,and excellent functional group compatibility.Moreover,facile follow-up transformations underscore their potential utility in the synthesis of various enantioenriched building blocks.Preliminary mechanistic studies support the plausibility of the remote substitution pathway.

关键词： remote substitution copper catalyst asymmetric catalysis triaryl methanes

Parental educational Expectations,Academic Pressure,and Adolescent Mental Health:An Empirical Study Based on CEPS Survey Data

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international Journal of Mental Health Promotion 2024年第2期26卷 93-103页

作者： Tao Xu Fangqiang Zuo Kai Zheng Department of Social Work College of International Education and Social DevelopmentZhejiang Normal UniversityJinhua321004China Department of Economics and international Trade School of EconomicsManagement&LawHubei Normal UniversityHuangshi435002China

Background:This study aimed to investigate the relationship between parental educational expectations and adolescent mental health problems,with academic pressure as a moderating variable.Methods:This study was based on the baseline data of the China education Panel Survey,which was collected within one school year during 2013–2014.It included 19,958 samples from seventh and ninth graders,who ranged from 11 to 18 years old.After removing missing values and conducting relevant data processing,the effective sample size for analysis was 16344.The OLS(Ordinary Least Squares)multiple linear regression analysis was used to examine the relationship between parental educational expectations,academic pressure,and adolescents’mental health problems.In addition,we established an interaction term between parents’educational expectations and academic pressure to investigate the moderating effect of academic stress.Results:The study found that adolescents whose parents had high educational expectations reported less mental health problems.(β=−0.195;peducational expectations and adolescents’mental health problems(β=0.082;peducational expectations had a close relationship with adolescents’mental health problems,and academic pressure moderated this relationship.For those adolescents with high levels of academic pressure,the association between high parental educational expectations and mental health problems became stronger.On the contrary,for those adolescents with low levels of academic pressure,the association between high parental educational expectations and mental health problems became weaker.These findings shed new light on how parental educational expectations affected adolescent mental health problems and had significant implications for their healthy de

关键词： Parental educational expectations academic pressure adolescent mental health problems

Orthogonal Combinatorial Raman Codes Enable Rapid High-Throughput-Out Library Screening of Cell-Targeting Ligands

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Research 2024年第1期2023卷 199-208页

作者： Yuchen Tang Xingxing Zheng Tingjuan Gao China Key Laboratory of Pesticide and Chemical Biology of Ministry of education College of ChemistryCentral China Normal UniversityWuhan 430079China

High-throughput assays play an important role in the fields of drug discovery,genetic analysis,and clinical diagnostics.Although super-capacity coding strategies may facilitate labeling and detecting large numbers of targets in a single assay,practically,the constructed large-capacity codes have to be decoded with complicated procedures or are lack of survivability under the required reaction conditions.This challenge results in either inaccurate or insufficient decoding outputs.Here,we identified chemical-resistant Raman compounds to build a combinatorial coding system for the high-throughput screening of cell-targeting ligands from a focused 8-mer cyclic peptide library.The accurate in situ decoding results proved the signal,synthetic,and functional orthogonality for this Raman coding strategy.The orthogonal Raman codes allowed for a rapid identification of 63 positive hits at one time,evidencing a high-throughput-out capability in the screening process.We anticipate this orthogonal Raman coding strategy being generalized to enable efficient high-throughput-out screening of more useful ligands for cell targeting and drug discovery.

关键词： enable throughput allowed

Biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

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Oncology Research 2024年第1期32卷 73-94页

作者： VIGNESH BALAJI E DIVYA RAMESH MANISHA CHUNGAN SHAJU AKSHARA KUMAR SAMYAK PANDEY RAKSHA NAYAK V.ALKA SRISHTI MUNJAL AMIR SALIMI K.SREEDHARA RANGANATH PAI SHANKAR M.BAKKANNAVAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human body.It is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological conditions.Also,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome source.Moreover,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological actions.There are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor cells.Once the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological response.Even though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic efficacy.So,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： Exosomes Physiology Cancer Therapeutics Challenges

Regioselective and asymmetric allylic alkylation of vinyl epoxides for the construction of allylic alcohols via synergistic catalysis

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Science China Chemistry 2024年第2期67卷 542-550页

作者： Min Chen Longqing Yang Yuzhen Li Yinhe Qu Guihua Pan Xiaoming Feng Xiaohua Liu Key Laboratory of Green Chemistry&Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengdu610064China

A highly efficient asymmetric allylic alkylation of cyclic and acyclic carbon nucleophiles with vinyl epoxides has been developed,which exhibits good functional group compatibility,high atomic and step economy.This protocol utilizes a strategy of synergistic catalysis with a chiral N,N'-dioxide/Ni~Ⅱ complex and an achiral Pd~0 catalyst,generating a series of multisubstituted allylic alcohols with a quaternary carbon stereocenter in high yield and excellent regio-,Z/E-and enantioselectivity under mild conditions.Further transformations of the product demonstrate the potential utility of this protocol in the synthesis of allyl alcohol derivatives and natural product analogues.Experimental studies revealed that the N,N′-dioxide/metal complexes play an important role in controlling the Z/E-and enantioselectivity.The density functional theory(DFT) calculations further demonstrated that multiple C–H···π interactions between the aromatic rings of the two substrates and the amide moiety in the ligand stabilized the dominant transition state.

关键词： asymmetric allylic alkylation synergistic catalysis vinyl epoxides allyl alcohol multiple weak interactions

Pure-high-even-order dispersion bound solitons complexes in ultra-fast fiber lasers

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Light(Science & Applications) 2024年第5期13卷 957-972页

作者： Ying Han Bo Gao Honglin Wen Chunyang Ma Jiayu Huo Yingying Li Luyao Zhou Qi Li Ge Wu Lie Liu college of Communication Engineering Jilin UniversityChangchun 130012China. Research Center of Circuits and Systems Peng Cheng LaboratoryShenzhen 518055China. international Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China. college of Electronic Science and Engineering Jilin UniversityChangchun 130012China

Temporal solitons have been the focus of much research due to their fascinating physical properties.These solitons can form bound states,which are fundamentally crucial modes in fiber laser and present striking analogies with their matter molecules counterparts,which means they have potential applications in large-capacity transmission and alloptical information storage.Although traditionally,second-order dispersion has been the dominant dispersion for conventional solitons,recent experimental and theoretical research has shown that pure-high-even-order dispersion(PHEOD)solitons with energy-width scaling can arise from the interaction of arbitrary negative-even-order dispersion and Kerr nonlinearity.Despite these advancements,research on the bound states of PHEOD solitons is currently nonexistent.In this study,we obtained PHEOD bound solitons in a fiber laser using an intra-cavity spectral pulse shaper for high-order dispersion management.Specifically,we experimentally demonstrate the existence of PHEOD solitons and PHEOD bound solitons with pure-quartic,-sextic,-octic,and-decic dispersion.Numerical simulations corroborate these experimental observations.Furthermore,vibrating phase PHEOD bound soliton pairs,sliding phase PHEOD bound soliton pairs,and hybrid phase PHEOD bound tri-soliton are discovered and characterized.These results broaden the fundamental understanding of solitons and show the universality of multi-soliton patterns.

关键词： dispersion solitons soliton