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Significance of oxidative stress and antioxidant capacity tests as biomarkers of premature ovarian insufficiency: A case control study

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World Journal of Clinical Cases 2024年第3期12卷 479-487页

作者： Kaoru Kakinuma Toshiyuki Kakinuma Department of Obstetrics and Gynecology International University of Health and Welfare HospitalTochigi 329-2763Japan graduate school of Medicine International University of Health and WelfareTokyo 107-8402Japan

BACKGROUND Premature ovarian insufficiency(POI)is a condition that causes secondary amenorrhea owing to ovarian hypofunction at an early *** follicular depletion results in intractable infertility,thereby considerably reducing the quality of life of *** the continuum in weakened ovarian function,progressing from incipient ovarian failure(IOF)to transitional ovarian failure and further to POI,it is necessary to develop biomarkers for predicting *** oxidative stress states in IOF and POI were comprehensively evaluated via oxidative stress[diacron-reactive oxygen metabolites(d-ROMs)]test and anti-oxidant capacity[biological antioxidant potential(BAP)].METHODS Females presenting with secondary amenorrhea over 4 mo and a follicle stimulating hormone level of>40 mIU/mL were categorized into the POI *** presenting with a normal menstrual cycle and a follicle stimulating hormone level of>10.2 mIU/mL were categorized into the IOF *** females without ovarian hypofunction were categorized into the control *** females aged<40 years who visited our hospital from January 2021 to June 2022,we recruited 11 patients into both POI and IOF *** the potential antioxidant capacity,the relative oxidative stress index(BAP/d-ROMs×100)was calculated,and the oxidative stress defense system was comprehensively *** d-ROMs were significantly higher in the POI and IOF groups than in the control group,(478.2±58.7 ***,434.5±60.6 ***,and 341.1±35.1 ***,respectively)(*** is equivalent to 0.08 mg/dL of hydrogen peroxide).However,no significant difference was found between the POI and IOF *** BAP,no significant difference was found between the control,IOF,and POI groups(2078.5±157.4μmol/L,2116.2±240.2μmol/L,and 2029.0±186.4μmol/L,respectively).The oxidative stress index was significantly higher in the POI and IOF groups than in the control group(23.7±3.3,20.7±3.6,and 16.5±2.1,respectively).However,no signifi

关键词： Premature ovarian insufficiency Oxidative stress Diacron-reactive oxygen metabolites test Biological antioxidant potential Infertility Biomarker

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A large-scale cold plasma jet: generation mechanism and application effect

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Plasma Science and Technology 2024年第4期26卷 1-8页

作者：崔伟胜张若兵 Shenzhen international graduate school Tsinghua UniversityShenzhen 518055People’s Republic of China

Atmospheric pressure cold plasma jets(APCPJs) typically exhibit a slender, conical structure,which imposes limitations on their application for surface modification due to the restricted treatment area. In this paper, we introduce a novel plasma jet morphology known as the large-scale cold plasma jet(LSCPJ), characterized by the presence of both a central conical plasma jet and a peripheral trumpet-like diffuse plasma jet. The experimental investigations have identified the factors influencing the conical and the trumpet-like diffuse plasma jet, and theoretical simulations have shed light on the role of the flow field and the electric field in shaping the formation of the LSCPJ. It is proved that, under conditions of elevated helium concentration, the distributions of impurity gas particles and the electric field jointly determine the plasma jet’s morphology. High-speed ICCD camera images confirm the dynamic behavior of plasma bullets in LSCPJ, which is consistent with the theoretical analysis. Finally, it is demonstrated that when applied to the surface treatment of silicone rubber, LSCPJ can achieve a treatment area over 28 times larger than that of APCPJ under equivalent conditions. This paper uncovers the crucial role of impurity gases and electric fields in shaping plasma jet morphology and opens up the possibility of efficiently diversifying plasma jet generation effects through external electromagnetic fields. These insights hold the promise of reducing the generation cost of plasma jets and expanding their applications across various industrial sectors.

关键词： diffuse plasma jet flow field electric field surface treatment

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Recent progress about transmission electron microscopy characterizations on lithium-ion batteries

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Journal of Energy Chemistry 2024年第8期95卷 39-56,I0002页

作者： Yihang Liu Qiuyun Li Ziqiang Wang Institute of Materials Research Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518000GuangdongChina

With the rapid development of portable electronics,new energy vehicles,and smart grids,ion batteries are becoming one of the most widely used energy storage devices,while the safety concern of ion batteries has always been an urgent problem to be *** develop a safety-guaranteed battery,the characterization of the internal structure is indispensable,where electron microscopy plays a crucial *** on this,this paper summarizes the application of transmission electron microscopy(TEM)in battery safety,further concludes and analyzes the aspects of dendrite growth and solid electrolyte interface(SEI)formation that affect the safety of ion batteries,and emphasizes the importance of electron microscopy in battery safety research and the potential of these techniques to promote the future development of this *** advanced electron microscopy techniques and their prospects are also discussed.

关键词： Electron microscopy characterizations Lithium-ion batteries Dendrites SEI

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Targeted therapeutic effects of oral magnetically driven pectin nanoparticles containing chlorogenic acid on colon cancer

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Particuology 2024年第1期84卷 53-59页

作者： Huatai Zhu Limei Zhang Fujia Kou Jingyang Zhao Jiandu Lei Jing He Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing100083China Institute of Biopharmaceutical and health Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China

Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent ***,the unique and complex structure of the gastrointestinal tract is still an obstacle to the safe delivery of drugs targeting sites in colon ***,we designed magnetically driven dual-targeted oral colonic nanoparticles loaded with chlorogenic acid using pectin and oleic acid-modified iron oxide(Fe3O4@OA).Specific degradation of pectin by pectinase produced by colonic flora and magnetic fields applied to the colon confers specific targeting of nanoparticles to the *** order to overcome the challenge of preparing magnetically driven nanoparticles with small and homogeneous particle sizes by a single conventional method,we developed the combined ultrasound-emulsification *** average particle size of the prepared nanoparticles was 81.04±1.02 nm,which showed good drug release in the simulated colonic *** vitro anticancer studies,the drug-loaded nanoparticles possess an obvious toxicity and apoptosis-inducing ability against cancer ***,the hemolysis results demonstrated the safety of the nanoplatform(PET/CGA/Fe_(3)O_(4)@OA).This work holds broad prospects as a new treatment modality for colon cancer.

关键词： Pectin Chlorogenic acid Ultrasound-emulsion Magnetically driven Colon cancer Colon targeted

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Editorial for the Special Issue on Emerging Technology and Advanced Application of Nondestructive Detection for Power Equipment

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Chinese Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei H. Li S. Tianjin university China Tsinghua Shenzhen international graduate school China Lanzhou Jiaotong university China

The rapid development of clean and renewable energy technologies represented by wind and solar energy,as well as the continuous growth of load demand,have put forward higher requirements for the safe operation of the power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,which cannot meet the reliability requirements of power systems in the new *** detection is an essential technical method in industrial development,which can detect and evaluate the defect and damage status of in-service equipment,key components,and materials without damaging the object.

关键词： service Application operation

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Density-based ship detection in SAR images:Extension to a self-similarity perspective

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Chinese Journal of Aeronautics 2024年第3期37卷 168-180页

作者： Xueqian WANG Gang LI Zhizhuo JIANG Yu LIU You HE Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Shenzhen international graduate school Tsinghua UniversityShenzhen 518055China

Nonlocal self-similarity is an important property of Synthetic Aperture Radar(SAR)images to characterize the repetitiveness of features embodied by SAR images within nonlocal areas and has been used for enhancement of SAR *** SAR ship detectors often independently handle small sub-images cropped from a large marine SAR image and do not exploit the nonlocal self-similarity *** this paper,we propose a new ship detector from the perspective of nonlocal self-similarity in SAR images to improve the ship detection performance,basically including three stages:prescreening,intra-cue calculation,and inter-cue *** the prescreening stage,we design a new Histogram-based Density(HD)feature to rapidly select candidate sub-images potentially containing ship targets from a large SAR *** the intra-cue calculation stage,target cues within a single candidate sub-image are *** the inter-cue calculation stage,thanks to the nonlocal self-similarity among different candidate sub-images in terms of density features,we innovatively extract a weighted superpixel-HD map to obtain accumulated intracues across all the candidate ***,for each candidate sub-image,we fuse its inter-cue and intra-cue to obtain final detection *** results based on real SAR images show that our newly proposed method provides a better target-to-clutter contrast and ship detection performance than those of other state-of-the-art detection approaches.

关键词： Ship detection Synthetic aperture radar(SAR) Density Self-similarity Histogram

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Considerations of advanced aqueous batteries recycling:A perspective

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Journal of Energy Chemistry 2024年第6期93卷 46-54,I0002页

作者： Yun Zhao Yuqiong Kang Hao Du Feiyu Kang Baohua Li Institute of Materials Research Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055GuangdongChina

*** Battery technology,serving as a basis for a rechargeable society,has developed rapidly over a century[1].The progress can be roughly divided into three stages,with the initial two mainly focusing on aqueous battery *** to 1859,research primarily focused on the conceptualization of batteries and the development of primary(non-rechargeable)cells[2].In the subsequent150 years,rechargeable battery technology emerged。

关键词： battery Battery primarily

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Multiple-dimensioned defect engineering for graphite felt electrode of vanadium redox flow battery

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Carbon Energy 2024年第2期6卷 143-153页

作者： Yingqiao Jiang Yinhui Wang Gang Cheng Yuehua Li Lei Dai Jing Zhu Wei Meng Jingyu Xi Ling Wang Zhangxing He school of Chemical Engineering North China University of Science and TechnologyTangshanChina Tsinghua Shenzhen international graduate school Institute of Materials ResearchTsinghua UniversityShenzhenChina

The scarcity of wettability,insufficient active sites,and low surface area of graphite felt(GF)have long been suppressing the performance of vanadium redox flow batteries(VRFBs).Herein,an ultra-homogeneous multipledimensioned defect,including nano-scale etching and atomic-scale N,O codoping,was used to modify GF by the molten salt ***_(4)Cl and KClO_(3) were added simultaneously to the system to obtain porous N/O co-doped electrode(GF/ON),where KClO_(3) was used to ultra-homogeneously etch,and O-functionalize electrode,and NH4Cl was used as N dopant,***/ON presents better electrochemical catalysis for VO_(2)+/VO_(2)+ and V3+/V2+ reactions than only O-functionalized electrodes(GF/O)and *** enhanced electrochemical properties are attributed to an increase in active sites,surface area,and wettability,as well as the synergistic effect of N and O,which is also supported by the density functional theory ***,the cell using GF/ON shows higher discharge capacity,energy efficiency,and stability for cycling performance than the pristine cell at 140 mA cm^(−2) for 200 ***,the energy efficiency of the modified cell is increased by 9.7% from 55.2% for the pristine cell at 260 mA cm^(−2).Such an ultra-homogeneous etching with N and O co-doping through“boiling”molten salt medium provides an effective and practical application potential way to prepare superior electrodes for VRFB.

关键词： graphite felt molten salt N O co-doping ultra-homogeneous etching vanadium redox flow battery

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Design strategies for rechargeable aqueous metal-ion batteries

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Science China Chemistry 2024年第1期67卷 165-190页

作者： Yang Li Xin Zhao Yifu Gao Yichen Ding Zhichun Si Liubing Dong Dong Zhou Feiyu Kang Tsinghua Shenzhen international graduate school Tsinghua UniversityShenzhen 518055China College of Chemistry and Materials Science Jinan UniversityGuangzhou 511443China

Rechargeable aqueous metal-ion batteries(AMBs)have attracted extensive scientific and commercial interest due to their potential for cost-effective,highly safe,and scalable stationary energy ***,their limited output voltage,inadequate energy density,and poor reversibility of ambiguous electrode reactions in aqueous electrolytes strongly limit their practical *** review aims to elucidate the challenges of existing AMBs from the material design to whole device *** summarize the emerging electrochemistry,fundamental properties,and key issues in interfacial behaviors of various classes of prevailing AMBs,including aqueous alkali metal-ion batteries and multivalent-ion batteries,and present an appraisal of recent advances for addressing the performance ***,the progress of zinc-ion batteries is highlighted to provide a ubiquitous guideline for their commercialization in the grid-scale energy ***,we figure out the dominating general challenges for achieving high-performance AMBs,laying out a perspective for future breakthroughs.

关键词： aqueous metal-ion batteries aqueous alkali metal-ion batteries zinc-ion batteries interfacial behavior stationary energy storage

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Robust blind image watermarking based on interest points

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虚拟现实与智能硬件（中英文） 2024年第4期6卷 308-322页

作者： Zizhuo WANG Kun HU Chaoyangfan HUANG Zixuan HU Shuo YANG Xingjun WANG Tsinghua Shenzhen international graduate school Tsinghua UniversityShenzhen 518071China

Digital watermarking technology plays an essential role in the work of anti-counterfeiting and ***,image watermarking algorithms are weak against hybrid attacks,especially geometric attacks,such as cropping attacks,rotation attacks,*** propose a robust blind image watermarking algorithm that combines stable interest points and deep learning networks to improve the robustness of the watermarking algorithm ***,to extract more sparse and stable interest points,we use the Superpoint algorithm for generation and design two steps to perform the screening *** first keep the points with the highest possibility in a given region to ensure the sparsity of the points and then filter the robust interest points by hybrid attacks to ensure high *** message is embedded in sub-blocks centered on stable interest points using a deep learning-based *** kinds of attacks and simulated noise are added to the adversarial training to guarantee the robustness of embedded *** use the ConvNext network for watermark extraction and determine the division threshold based on the decoded values of the unembedded *** extensive experimental results,we demonstrate that our proposed algorithm can improve the accuracy of the network in extracting information while ensuring high invisibility between the embedded image and the original cover *** with previous SOTA work reveals that our algorithm can achieve better visual and numerical results on hybrid and geometric attacks.

关键词： Blind watermarking Robust region selection Geometric distortion Deep learning

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