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Tissue optical clearing enhances efficacy of vascular targeted photodynamic therapy of mouse dorsal skin

Journal of Innovative Optical Health Sciences 2024年第2期17卷 67-78页

作者： Ying Liu Qiushi Wang Yidi Liu Ying Wang Haixia Qiu Dan Zhu Ying Gu Defu Chen School of optics and photonics Beijing Institute of TechnologyBeijing 100081P.R.China School of Medical Technology Beijing Institute of TechnologyBeijing 100081P.R.China Department of Laser Medicine First Medical Center of PLA General HospitalBeijing 100853P.R.China Britton Chance center for Biomedical photonics-MoE Key Laboratory for Biomedical photonics A duanced Biomedical Imaging FacilityWuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074HubeiP.R.China Precision Laser Medical Diagnosis and Treatment Innovation Unit Chinese A cademy of Medical SciencesBeijing 100000P.R.China

Vascular-targeted photodynamic therapy(V-PDT)is an effective treatment for port wine stains(PWS).However,repeated treatment is usually needed to achieve optimal treatment outcomes,possibly due to the limited treatment light penetration depth in the PWS *** optical clearing technique can increase light penetration in depth by reducing light *** study aimed to investigate the V-PDT in combination with an optical clearing agent(OCA)for the therapeutic enhancement of V-PDT in the rodent skinfold window chamber *** responses were closely monitored with laser speckle contrast imaging(LSCI),optical coherence tomography angiography,and stereo microscope before,during,and after the *** further quantitatively demonstrated the effects of V-PDT in combination with OCA on the blood flow and blood vessel size of skin *** combination of OCA and V-PDT resulted in significant vascular damage,including vasoconstriction and the reduction of blood *** results indicate the promising potential of OCA for enhancing V-PDT for treating vascular-related diseases,including PWS.

关键词： Vascular-targeted photodynamic therapy(V-PDT) optical clearing agent(OCA) treatment efficacy enhancement skin-fold window chamber port wine stains

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Full-parameter omnidirectional transformation optical devices

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National Science Review 2024年第3期11卷 92-99页

作者： Yuan Gao Yu Luo Jingjing Zhang Zhengjie Huang Bin Zheng Hongsheng Chen Dexin Ye Interdisciplinary center for Quantum Information State Key Laboratory of Extreme Photonics and InstrumentationZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang University School of Electrical and Electronic Engineering Nanyang Technological University CNRS-InternationalNTU-Thales research Alliance Nanyang Technological University Institute of Electromagnetic Space Southeast University State Key Laboratory of Millimeter Waves Southeast University International Joint Innovation center The Electromagnetics Academy at Zhejiang University Zhejiang University Key Laboratory of Advanced Micro/Nano Electronic Devices&Smart Systems of Zhejiang Jinhua Institute of Zhejiang UniversityZhejiang University Shaoxing Institute of Zhejiang University Zhejiang University

Transformation optics(TO) provides an unprecedented technique to control electromagnetic(EM) waves by engineering the constitutive parameters of the surrounding medium through a proper spatial transformation. In general, ideal transformation optical devices require simultaneous electric and magnetic responses along all three dimensions. To ease the practical implementation, previous studies usually made use of reduced parameters or other simplified approaches, which inevitably introduce extra reflection or unwanted phase shift. Up to today, experimental realizations of full-parameter transformation optical devices in free space are still quite limited. Here, a general design strategy is proposed to solve this *** a specific example, a full-parameter spatial-compression TO medium with constitutive parameters taking the diagonal form diag(a, a, 1/a) for the TM wave incidence was designed and realized experimentally. Such spatial-compression TO media were then applied to the implementation of an ideal omnidirectional invisibility cloak capable of concealing a large-scale object over a wide range of illumination angles. Both the simulation and experiment confirm that the cloak allows for nearly unity transmission of EM waves in the forward direction without introducing extra scattering or phase shift. This work constitutes an important stepping stone for future practical implementation of arbitrary full-parameter omnidirectional transformation optical devices.

关键词： transformation optical devices omnidirectional impedance matching full-parameter invisibility cloak

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Prospects and challenges in augmented reality displays

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Virtual Reality & intelligent Hardware 2019年第1期1卷 10-20页

作者： Yun-Han LEE Tao ZHAN Shin-Ison WU College of optics&photonics University of Central FloridaOrlandoFL 32816USA

Augmented reality(AR)displays are attracting significant attention and *** this paper,we review the adopted device configurations of see-through displays,summarize the current development status and highlight future challenges in micro-displays.A brief introduction to optical gratings is presented to help understand the challenging design of grating-based waveguide for AR ***,we discuss the most recent progress in diffraction grating and its implications.

关键词： Near-eye displays See-through display Augmented reality Micro-displays Bragg gratings

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Tunnel silicon nitride manipulated reconfigurable bi-mode nociceptor analog

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photonics research 2024年第8期12卷 1820-1827页

作者： CHENGDONG YANG YILONG LIU LINLIN SU XINWEI LI LIHUA XU QIMEI CHENG Jiangsu Province Engineering research center of Integrated Circuit Reliability Technology and Testing System Wuxi UniversityWuxi 214105China

Neuromorphic applications have shown great promise not only for efficient parallel computing mode to hold certain computational tasks,such as perception and recognition,but also as key biomimetic elements for th intelligent sensory system of next-generation ***,achieving such a biomimetic nociceptor tha can adaptively switch operation mode with a stimulation threshold remains a *** rational design of material properties and device structures,we realized an easily-fabricated,low-energy,and reconfigurable no *** is capable of threshold-triggered adaptive bi-mode jump that resembles the biological alarm system With a tunnel silicon nitride(Si_(3)N_(4))we mimicked the intensity-and rehearsal-triggered jump by means of th tunneling mode transition of Si_(3)N_(4)*** threshold signals the device can also express some common synaptic functions with an extremely low energy density of 33.5 f J∕μm^(2).In addition,through the modulation o Si_(3)N_(4)thickness it is relatively easy to fabricate the device with differing pain *** nociceptor analog based on a tunneling layer provides an opportunity for the analog pain alarm system and opens up a new path toward threshold-related novel applications.

关键词： Tunnel tunneling rational

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Design and testing research of LiDAR for detecting atmospheric turbulence

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Optoelectronics Letters 2024年

作者： QIU Duoyang LI Xianyang YANG Hao ZHU Xiaomeng FANG Zhiyuan XU Xiang School of Advanced Manufacturing Engineering， Hefei University Anhui Provincial Engineering Technology research center of intelligent Vehicle Control and Integrated Design Technology， Hefei University Science Island Branch of Graduate School， University of Science and Technology of China School of Mechanical and Energy Engineering， Ningbo Tech University Key Laboratory of Atmospheric optics， Anhui Institute of optics and Fine Mechanics， Chinese Academy of Sciences

Atmospheric turbulence is an important parameter affecting laser atmospheric transmission. This paper reports on a self-developed atmospheric turbulence detection LiDAR system (scanning DIM-LiDAR system). By designing and simulating the optical system of atmospheric turbulence detection LiDAR， the basic optical imaging accuracy has been determined; By designing through electronics， the delay and gating time jitter of the system are kept within a small range， ensuring the accuracy of the sampling thickness of the optical column. The comparison observation results between the scanning DIM-LiDAR system and the ultrasonic anemometer show that both have the same trend of change， and the error is small. Long term observation results indicate that the scanning DIM-LiDAR developed based on optical and electronic design can effectively detect atmospheric turbulence profiles. This article can provide theoretical and experimental basis for subsequent related research.

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Energy-efficient integrated silicon optical phased array

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Frontiers of Optoelectronics 2023年第3期16卷 81-104页

作者： Huaqing Qiu Yong Liu Xiansong Meng Xiaowei Guan Yunhong Ding Hao Hu DTU Electro Department of Electrical and Photonics Engineering Technical University of Denmark Interuniversity Microelectronics center (IMEC) Jiaxing Key Laboratory of Photonic Sensing and intelligent Imaging intelligent optics and photonics research center Jiaxing Research Institute Zhejiang University

An optical phased array(OPA) is a promising non-mechanical technique for beam steering in solid-state light detection and ranging systems. The performance of the OPA largely depends on the phase shifter, which affects power consumption,insertion loss, modulation speed, and footprint. However, for a thermo-optic phase shifter, achieving good performance in all aspects is challenging due to trade-offs among these aspects. In this work, we propose and demonstrate two types of energy-efficient optical phase shifters that overcome these trade-offs and achieve a well-balanced performance in all ***, the proposed round-spiral phase shifter is robust in fabrication and fully compatible with deep ultraviolet(DUV)processes, making it an ideal building block for large-scale photonic integrated circuits(PICs). Using the high-performance phase shifter, we propose a periodic OPA with low power consumption, whose maximum electric power consumption within the field of view is only 0.33 W. Moreover, we designed Gaussian power distribution in both the azimuthal( φ) and polar( θ)directions and experimentally achieved a large sidelobe suppression ratio of 15.1 and 25 dB, respectively.

关键词： Optical phased array Optical phase shifter Silicon photonics Integrated optics

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Coherence phase spectrum analyzer for a randomly fluctuated fractional vortex beam

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photonics research 2024年第1期12卷 33-39页

作者： ZHUOYI WANG XINGYUAN LU JIANBO GAO XUECHUN ZHAO QIWEN ZHAN YANGJIAN CAI CHENGLIANG ZHAO School of Physical Science and Technology Soochow UniversitySuzhou 215006China School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shandong Provincial Engineering and Technical center of Light Manipulations&Shandong Provincial Key Laboratory of optics and Photonic Device School of Physics and ElectronicsShandong Normal UniversityJinan 250358China Shandong Joint research center of Light Manipulation Science and photonics Integrated Chip of East China Normal University and Shandong Normal University East China Normal UniversityShanghai 200241China

Fractional vortex beams exhibit a higher degree of modulation dimensions than conventional vortices,thus inheriting superior anti-turbulent transmission properties through the incorporation of additional coherence ***,aliasing the mixed modes induced by coherence degradation makes the quantitative measurement of the topological charge in fractional vortex beams *** this study,a coherence phase spectrum was introduced,and experimental demonstrations to quantitatively determine the fractional topological charge of partially coherent fractional vortex beams were *** leveraging the four-dimensional measurement of a partially coherent light field,the source coherence function was inversely reconstructed,and fractional topological charges were determined with high precision by extracting the phase spectrum of the coherence ***–Gaussian,elliptical Gaussian,and plane-wave-fraction vortex beams with various degrees of coherence were used to demonstrate measurement *** proposed method is applicable to X-rays and electron *** has potential applications in optical encryption,high-capacity optical communication,and quantum entanglement.

关键词： function fractional vortex

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Geometric regulation of collective cell tangential ordering migration

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 94-103页

作者： Hao Dong Yuming Zhou Xuehe Ma Junfang Liu Fulin Xing Jianyu Yang Qiushuo Sun Qingsong Hu Fen Hu Leiting Pan Jingjun Xu The Key Laboratory of Weak-Light Nonlinear photonics of Education Ministry School of Physics and TEDA Institute of Applied Physics Nankai University Tianjin 300071 P.R.China State Key Laboratory of Medicinal Chemical Biology Frontiers Science center for Cell Responses College of Life Sciences Nankai University Tianjin 300071 P.R.China Shenzhen research Institute of Nankai Uniwersity Shenzhen Guangdong 518083P.R.China Collaborative Innovation center of Extreme optics Shanxi University.Taiyuan Shanxi 030006P.R.China

Collective cell migration is a coordinated movement of multi-cell systems essential for various processes throughout *** collective motions often occur under spatial restrictions,hallmarked by the collective rotation of epithelial cells confined in circular ***,we aim to explore how geometric shapes of confinement regulate this collective cell *** develop quantitative methods for cell velocity orientation analysis,and find that boundary cells exhibit stronger tangential ordering migration than inner cells in circular ***,decreased tangential ordering movement capability of collective cells in triangular and square patterns are observed,due to the disturbance of cell motion at unsmooth corners of these *** the other hand,the collective cell rotation is slightly affected by a convex defect of the circular pattern,while almost hindered with a concave defect,also resulting from different smoothness features of their *** simulations employing cell Potts model well reproduce and extend experimental ***,our results highlight the importance of boundary smoothness in the regulation of collective cell tangential ordering migration.

关键词： Collective cell migration spatial restrictions tangential ordering geometric regula-tion cell Potts model

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photonics-assisted THz wireless communication enabled by wide-bandwidth packaged backilluminated modified uni-traveling-carrier photodiode

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Opto-Electronic Science 2024年第7期3卷 20-29页

作者： Yuxin Tian Boyu Dong Yaxuan Li Bing Xiong Junwen Zhang Changzheng Sun Zhibiao Hao Jian Wang Lai Wang Yanjun Han Hongtao Li Lin Gan Nan Chi Yi Luo Beijing National research center for Information Science and Technology(BNRist) Department of Electronic EngineeringTsinghua UniversityBeijing 100084China Key Laboratory of Information Science of Electromagnetic Waves(MoE) Department of Communication Science and EngineeringFudan UniversityShanghai 200433China Flexible intelligent Optoelectronic Device and Technology center Institute of Flexible Electronics Technology of THUJiaxing 314000China

This paper presents a wide-bandwidth back-illuminated modified uni-traveling-carrier photodiode(MUTC-PD)packaged with standard WR-5 rectangular waveguide for high-speed wireless *** optimized epitaxy structure and coplanar waveguide electrodes,the fabricated 4-μm-diameter PD exhibits ultra-flat frequency response and high saturation *** passive circuits including low-loss bias-tee and E-plane probe are designed to package the PD into a compact module with waveguide *** packaged PD module has demonstrated a flat frequency response with fluctuations within±2.75 d B over a broadband of 140–220 GHz and a high saturated output power of-7.8 d Bm(166μW)at 140 *** wireless communication applications,the packaged PD is used to implement 1-m free space transmission at carrier frequencies of 150.5 and 210.5 GHz,with transmission rates of 75 and 90 Gbps,respectively.

关键词： modified uni-traveling-carrier photodiode integrated bias-tee E-plane probe flat frequency response high saturation power WR-5 output THz wireless communications

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Spectral imaging with deep learning

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Light(Science & Applications) 2022年第6期11卷 1040-1058页

作者： Longqian Huang Ruichen Luo Xu Liu Xiang Hao State Key Laboratory of Modern Optical Instrumentation College of Optical Science and TechnologyZhejiang UniversityHangzhou 310027China College of Computer Science and Technology Zhejiang UniversityHangzhou 310027China Jiaxing Key Laboratory of Photonic Sensing&intelligent Imaging Jiaxing 314000China intelligent optics&photonics research center Jiaxing Research Institute Zhejiang UniversityJiaxing 314000China

The goal of spectral imaging is to capture the spectral signature of a *** scanning method for spectral imaging suffers from large system volume and low image acquisition speed for large *** contrast,computational spectral imaging methods have resorted to computation power for reduced system volume,but still endure long computation time for iterative spectral ***,deep learning techniques are introduced into computational spectral imaging,witnessing fast reconstruction speed,great reconstruction quality,and the potential to drastically reduce the system *** this article,we review state-of-the-art deep-learning-empowered computational spectral imaging *** are further divided into amplitude-coded,phase-coded,and wavelength-coded methods,based on different light properties used for *** boost future researches,we've also organized publicly available spectral datasets.

关键词： resort signature boost

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