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International Journal of Ophthalmology(English edition) 2021年第11期14卷 1765-1770页

作者： carlos Cifuentes-González Stefania Amaris-Martínez Juliana Reyes-Guanes Pilar Uribe-Reina Alejandra de-la-Torre Neuroscience Research Group Escuela de Medicina y Ciencias de la SaludUniversidad del RosarioBogota 111221Colombia Escuela Barraquer Research Group Escuela Superior de Oftalmología del Instituto Barraquer de AméricaBogota 110111Colombia

AIM:To provide an epidemiological characterization of ocular cicatricial pemphigoid(OCP)in ***:We conducted a cross-sectional study using *** applied the specific code of the International Classification of Diseases for Ocular Pemphigoid,from 2009-2019 to estimate prevalence,incidence,and the demographic status of the disease in ***:The estimated average prevalence was 0.22 per 1000000 inhabitants,and the estimated average incidence was 0.24 per 1000000 *** a female predominance of 62.5%,and a male/female ratio of 1:*** group of patients diagnosed with the disease after the age of 80 presented the highest *** departments with the highest prevalence were Antioquia,Bogotá,and ***:There are important differences between worldwide and Colombian prevalence and incidence data,which may be related to genetic and epigenetic factors,and the possible underdiagnosis of the *** to the results,OCP is an extremely rare disease in ***,it is important to encourage awareness of the disease due to its devastating consequences.

关键词： ocular cicatricial pemphigoid epidemiology incidenee ophthalmology Colombia autoimmune diseases

Role of artificial intelligence in cardiology

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World Journal of Cardiology 2023年第4期15卷 116-118页

作者： Rafael Vidal-Perez Jose Manuel Vazquez-Rodriguez Servicio de Cardiología Unidad de Imagen y Función CardíacaComplexo Hospitalario Universitario A Coruña Centro de Investigación Biomédica en Red-Instituto de Salud Carlos ⅢA Coruña 15006A CoruñaSpain Servicio de Cardiología Complexo Hospitalario Universitario A CoruñaA Coruña 15006A CoruñaSpain

Artificial intelligence(AI)is the process of having a computational program that can perform tasks of human intelligence by mimicking human thought *** is a rapidly evolving transdisciplinary field which integrates many elements to develop algorithms that aim to simulate human intuition,decision-making,and object *** overarching aims of AI in cardiovascular medicine are threefold:To optimize patient care,improve efficiency,and improve clinical *** cardiology,there has been a growth in the potential sources of new patient data,as well as advances in investigations and therapies,which position the field well to uniquely benefit from *** this editorial,we highlight some of the main research priorities currently and where the next steps are heading us.

关键词： Artificial intelligence Machine learning deep learning Electrocardiography Cardiac imaging

Perspectives of nano-carrier drug delivery systems to overcome cancer drug resistance in the clinics

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Cancer Drug Resistance 2021年第1期4卷 44-68页

作者： Anna Ulldemolins Joaquin Seras-Franzoso Fernanda Andrade Diana Rafael Ibane Abasolo Petra Gener Simo Schwartz Jr Drug delivery and Targeting Group Molecular Biology and Biochemistry Research Centre for Nanomedicine(CIBBIM-Nanomedicine)Vall d’Hebron Institut de RecercaUniversitat Autonoma de BarcelonaBarcelona 08035Spain Networking Research Centre for Bioengineering Biomaterialsand Nanomedicine(CIBER-BBN)Instituto de Salud Carlos IIIZaragoza 50009Spain

Advanced cancer is still considered an incurable disease because of its metastatic spread to distal organs and progressive gain of *** though considerable treatment progress and more effective therapies have been achieved over the past years,recurrence in the long-term and undesired side effects are still the main drawbacks of current clinical ***,a majority of chemotherapeutic drugs are highly hydrophobic and need to be diluted in organic solvents,which cause high toxicity,in order to reach effective therapeutic *** limitations of conventional cancer therapies prompted the use of nanomedicine,the medical application of nanotechnology,to provide more effective and safer cancer *** of nanomedicines to overcome resistance,ameliorate solubility,improve pharmacological profile,and reduce adverse effects of chemotherapeutical drugs is thus highly *** use in the clinical setting has increased over the last *** the various existing nanosystems,nanoparticles have the ability to transform conventional medicine by reducing the adverse effects and providing a controlled release of therapeutic ***,their small size facilitates the intracellular ***,we provide a closer review of clinical prospects and mechanisms of action of nanomedicines to overcome drug *** significance of specific targeting towards cancer cells is debated as well.

关键词： Drug delivery systems resistance nanomedicine cancer treatment

FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes

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Cellular & Molecular Immunology 2021年第10期18卷 2457-2459页

作者： Gema Frühbeck Victoria Catalán Víctor Valentí Rafael Moncada Javier Gómez-Ambrosi Sara Becerril Camilo Silva Piero Portincasa Javier Escalada Amaia Rodríguez Metabolic Research Laboratory Clínica Universidad de NavarraPamplonaSpain CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN) Instituto de Salud Carlos IIIMadridSpain Obesity and Adipobiology Group Instituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain department of Endocrinology and Nutrition Clínica Universidad de NavarraPamplonaSpain department of Surgery Clínica Universidad de NavarraPamplonaSpain department of Anesthesia Clínica Universidad de NavarraPamplonaSpain department of Biomedical Sciences and Human Oncology Clinica Medica“A.Murri”University of Bari Medical SchoolPoliclinico HospitalBariItaly.

A sedentary lifestyle and obesity are important risk factors for severe COVID-19 complications and death[1,2].Excessive adipose tissue(AT)might contribute to more extensive viral spread with increased shedding,immune activation,and cytokine amplification[3].Several factors secreted by contracting muscle,termed myokines,mediate the beneficial effects of exercise in a wide range of diseases,including obesity[4].Thus,we conducted a study to explore the potential role of myokines of the fibronectin type III domain-containing family,FNDC4 and FNDC5,in mechanisms underlying the increased susceptibility to COVID-19 complications in obesity.

关键词： FNDC5 obesity FND

Taurine: a promising nutraceutic in the prevention of retinal degeneration

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Neural Regeneration Research 2024年第3期19卷 606-610页

作者： Diego García-Ayuso Johnny Di Pierdomenico Ana Martínez-Vacas Manuel Vidal-Sanz Serge Picaud María PVillegas-Pérez Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaEspaña Sorbonne Université INSERMCNRSInstitut de la VisionParisFrance

Taurine is considered a non-essential amino acid because it is synthesized by most ***,dietary intake of taurine may be necessary to achieve the physiological levels required for the development,maintenance,and function of certain *** may be especially important for the *** concentration of taurine in the retina is higher than that in any other tissue in the body and taurine deficiency causes retinal oxidative stress,apoptosis,and degeneration of photoreceptors and retinal ganglion *** plasma taurine levels may also underlie retinal degeneration in humans and therefore,taurine administration could exert retinal neuroprotective *** has antioxidant,anti-apoptotic,immunomodulatory,and calcium homeostasis-regulatory *** review summarizes the role of taurine in retinal health and disease,where it appears that taurine may be a promising nutraceutical.

关键词： amino acid anti-inflammatory antioxidant gamma-aminobutyric acid nutraceutical photoreceptor degeneration retina retinitis pigmentosa taurine

Prevalence of and risk factors for erectile dysfunction in young nondiabetic obese men:results from a regional study

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Asian Journal of Andrology 2020年第4期22卷 372-378页

作者： María Molina-Vega Maite Asenjo-Plaza María JoséBanderas-Donaire María Dolores Hernández-Ollero Silvia Rodríguez-Moreno Juan Jálvarez-Millán Pablo Cabezas-Sanchez Fernando Cardona-Díaz Juan Alcaide-Torres Lourdes Garrido-Sánchez Daniel Castellano-Castillo Francisco J Tinahones JoséC Fernández-García department of Endocrinology and Nutrition Virgen de la Victoria University Hospital(IBIMA)Málaga UniversityMálaga 29010Spain Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición(CIBEROBN) Instituto de Salud Carlos IIIMadrid 28029Spain Cruz de Humilladero Primary Care Center Málaga 29010Spain Teatinos Primary Care Center Málaga 29010Spain Chemical Sanitary Consulting(CQS Lab) Madrid 28003Spain

Erectile dysfunction(ED),a condition closely related to cardiovascular morbidity and mortality,is frequently associated with *** this study,we aimed to determine the prevalence of ED and evaluate the associated risk factors in a cohort of 254 young(18–49 years)nondiabetic obese(body mass index[BMI]≥30 kg m−2)men from primary *** function(International Index of Erectile Function[IIEF-5]questionnaire),quality of life(Aging Males'Symptoms[AMS scale]),and body composition analysis(Tanita MC-180MA)were *** testosterone was determined using high-performance liquid chromatography–mass *** logistic regression analysis was used to study the factors associated with *** prevalence was 42.1%.Subjects with ED presented higher BMI,waist circumference,number of components of the metabolic syndrome,AMS score,insulin resistance,and a more unfavorable body composition than those without *** logistic regression analysis showed that a pathological AMS score(odds ratio[OR]:4.238,Pdegree of obesity(BMI≥40 kg m−2,OR:2.602,P=0.005,compared with BMI 30–34.9 kg m−2),high-density lipoprotein(HDL)-cholesterol levels(OR:0.956,P=0.004),and age(OR:1.047,P=0.016)were factors independently associated with *** conclusion,we demonstrate that,in a primary care-based cohort of nondiabetic young obese men,ED affected>40%of subjects.A pathological AMS score,the degree of obesity,and age were positively associated with ED,while elevated HDL-cholesterol levels were inversely associated with the odds of presenting *** prospective studies are needed to evaluate the long-term consequences of ED in this population.

关键词： Aging Males'Symptoms score erectile dysfunction International Index of Erectile Function-5 questionnaire obesity testosterone

Screening for cervical neoplasia in a health center in Western Andalusia

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Open Journal of Nursing 2012年第2期2卷 36-40页

作者： Concepción Duclós-García Carmen Pareja-Arcos Manuel Ortega-Calvo Bellavista Health Center Seville Spain Esperanza Macarena Health Center Instituto de Salud Carlos III Seville Spain

We have analyzed the annual burden of 736 smears collected in the screening of cervical neoplasia at primary care facility where we work. We could not detect any neoplasia. Of the 50 positive smears (6.79% of total), 4 cases showed HSIL (high grade intraepithelial lesion) (median age 32 years) and 10 cases had LSIL (low grade intraepithelial lesion) (median age 25.5 years). The median age of the 733 satisfactory smears was 40 years. Age was a significant predictor for having an altered cytology (OR = 0.96, 95% CI = 0.93 to 0.98, p = 0.001190). Candida albicans was the microorganism more frequently associated with non- neoplastic inflammatory changes.

关键词： Primary Care Cervical Neoplasia Pap Test Logistic Regression Secondary Prevention

Arrhythmic syncope: From diagnosis to management

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World Journal of Cardiology 2023年第4期15卷 119-141页

作者： Jaume Francisco Pascual Pablo Jordan Marchite Jesús Rodríguez Silva Nuria Rivas Gándara Unitat d’Arritmies Servei de Cardiologia VHIR Hospital Universitari Vall d’HebronBarcelona 08035Spain Grup de Recerca Cardiovascular Vall d’Hebron Institut de RecercaBarcelona 08035Spain CIBER de Enfermedades Cardiovasculares Instituto de Salud Carlos ⅢMadrid 28029Spain departament de Medicina Universitat Autònoma de BarcelonaBellaterra 08193Spain

Syncope is a concerning symptom that affects a large proportion of *** can be related to a heterogeneous group of pathologies ranging from trivial causes to diseases with a high risk of sudden ***,benign causes are the most frequent,and identifying high-risk patients with potentially severe etiologies is crucial to establish an accurate diagnosis,initiate effective therapy,and alter the *** term cardiac syncope refers to those episodes where the cause of the cerebral hypoperfusion is directly related to a cardiac disorder,while arrhythmic syncope is cardiac syncope specifically due to rhythm ***,arrhythmias are the most common cause of cardiac *** bradyarrhythmia and tachyarrhythmia can cause a sudden decrease in cardiac output and produce *** this review,we summarized the main guidelines in the management of patients with syncope of presumed arrhythmic ***,we presented a thorough approach to syncope work-up through different tests depending on the clinical characteristics of the patients,risk stratification,and the management of syncope in different scenarios such as structural heart disease and channelopathies.

关键词： Syncope Arrhythmia Electrophysiological study Loop recorder Myocardiopathy Atrioventricular conduction block

The lymphocyte scavenger receptor CD5 plays a nonredundant role in fungal infection

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Cellular & Molecular Immunology 2021年第2期18卷 498-500页

作者： María Velasco-de-Andrés Cristina Català Sergi Casadó-Llombart Inês Simões Oscar Zaragoza Esther Carreras Francisco Lozano Immunoreceptors of the Innate and Adaptive System Institut d’Investigacions Biomèdiques August Pi i Sunyer08036BarcelonaSpain Mycology Reference Laboratory National Centre for MicrobiologyInstituto de Salud Carlos III28220MajadahondaSpain Servei d’Immunologia Centre de Diagnòstic BiomèdicHospital Clínic de Barcelona08036BarcelonaSpain departament de Biomedicina Universitat de Barcelona08036BarcelonaSpain

Invasive fungal diseases(IFD)impact morbidity,mortality,hospital stay and healthcare costs in critically ill patients,constituting an unmet medical need.1 Pathogenic fungi rarely cause IFD in immunocompetent individuals but become life-threatening in cases of immunodeficiency,young infants,disrupted mucosal barriers or polyantibiotic therapy,highlighting the role of immune surveillance in IFD control.^(2)

关键词： fungal mortality diseases

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Neural Regeneration Research 2021年第1期16卷 123-124页

作者： carlos Bueno Salvador Martínez instituto de Neurociencias de Alicante(UMH-CSIC) San JuanAlicanteSpain

Human neurological disorders and spinal cord injuries are caused by a loss of neurons and glial cells in the brain or spinal *** proof-ofprinciple of cell therapy is that replacing damaged cells with new healthy ones will restore the lost *** and manipulating autologous neural stem cells(NSCs)could provide an ideal source of cells for use in cell replacement and the transfer of genes to a diseased central nervous *** are immature cells present,not only during embryonic development,but also in the adult brain of all mammalian species,including *** presence of NSCs in the adult mammalian brain has been described in two neurogenic niches,the ventricular-subventricular zone(V-SVZ)of the anterolateral ventricle wall and the subgranular zone of the hippocampal dentate ***,NSCs are defined as self-renewing multipotent cells that can generate neurons,astrocytes and *** major barrier to isolating adult NSCs in humans is the inaccessibility of living *** this reason,an enormous effort has been made to derive neurons from human adult stem cells isolated from various tissue sources.

关键词： injuries ventricular adult