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Potential medicinal plants involved in inhibiting 3CL^(pro) activity:A practical alternate approach to combating COVID-19

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Journal of Integrative Medicine 2022年第6期20卷 488-496页

作者： Fan Yang Xiao-lan Jiang Akash Tariq Sehrish Sadia Zeeshan Ahmed Jordi Sardans Muhammad Aleem Riaz Ullah Rainer W.Bussmann The Medical Center of General Practice Sichuan Academy of Medical Science and Sichuan Provincial People’s HospitalChengdu 610041Sichuan ProvinceChina Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqi 830041Xinjiang Uygur Autonomous RegionChina department of Biological Sciences University of Veterinary and Animal SciencesRavi CampusPattoki 55300Pakistan Consejo Superior de investigaciones científicas Global Ecology UnitCentre for Ecological Research and Forestry Applications-Consejo Superior de Investigaciones Científicas-Universitat Autònoma de BarcelonaBellaterra08193 BarcelonaCataloniaSpain Centre for Ecological Research and Forestry Applications Cerdanyola del Vallès 08193CataloniaSpain department of Pharmacognosy College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia department of Ethnobotany Institute of Botanyllia State UniversityTbilisi 0105Georgia

At present,a variety of vaccines have been approved,and existing antiviral drugs are being tested to find an effective treatment for coronavirus disease 2019(COVID-19).However,no standardized treatment has yet been approved by the World Health *** virally encoded chymotrypsin-like protease(3CL^(pro))from severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which facilitates the replication of SARS-CoV in the host cells,is one potential pharmacological target for the development of antiSARS *** search engines,such as Web of Science,Google Scholar,Scopus and PubMed,were used to retrieve data on the traditional uses of medicinal plants and their inhibitory effects against the SARS-CoV 3CL^(pro).Various pure compounds,including polyphenols,terpenoids,chalcones,alkaloids,biflavonoids,flavanones,anthraquinones and glycosides,have shown potent inhibition of SARS-CoV-2 3CL^(pro) activity with 50% inhibitory concentration(IC_(50))values ranging from 2-44μg/***,most of these active compounds,including xanthoangelol E(isolated from Angelica keiskei),dieckol 1(isolated from Ecklonia cava),amentoflavone(isolated from Torreya nucifera),celastrol,pristimerin,tingenone and iguesterin(isolated from Tripterygium regelii),tannic acid(isolated from Camellia sinensis),and theaflavin-3,3’-digallate,3-isotheaflav1in-3 gallate and dihydrotanshinone I(isolated from Salvia miltiorrhiza),had IC_(50)values of less than 15μg/*** mechanistic studies of several active compounds revealed that their mode of inhibition was dose-dependent and competitive,with K_(i)values ranging from 2.4-43.8μmol/*** the significance of plant-based compounds and the many promising results obtained,there is still need to explore the phytochemical and mechanistic potentials of plants and their *** medicinal plants could serve as an effective inexpensive nutraceutical for the general public to help manage COVID-19.

关键词： COVID-19 SARS-CoV-2 Coronavirus 3C proteases Medicinal plants Plant-derived compounds Drug development

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Suitable conditions for natural regeneration in variable retention harvesting of southern Patagonian Nothofagus pumilio forests

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Ecological Processes 2019年第1期8卷 240-251页

作者： Mónica D.R.Toro Manríquez Juan M.Cellini María V.Lencinas Pablo L.Peri Karen A.Peña Rojas Guillermo J.Martínez Pastur Centro Austral de investigaciones científicas(CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Houssay 200(9410)UshuaiaTierra del FuegoArgentina Laboratorio de investigaciones en Maderas(LIMAD) Universidad Nacional de la Plata(UNLP)Diagonal 113 n°469(1904)La PlataBuenos AiresArgentina instituto Nacional de Tecnología Agropecuaria(INTA) Universidad Nacional de la Patagonia Austral(UNPA)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)cc 332(9400)Río GallegosSanta CruzArgentina departamento de Silvicultura y Conservación de la Naturaleza Facultad de Ciencias Forestales y de Conservación de la NaturalezaUniversidad de Chilecc 9206SantiagoChile.

Background:Variable retention(aggregated and dispersed retention)harvesting proposed for Nothofagus pumilio was designed for timber purposes and biodiversity *** by opening canopy generates different microenvironments and creates contrasting conditions for seedling establishment,growth,and eco-physiology performance due to synergies(positives or negatives)with biotic and abiotic *** study evaluated the regeneration in different microenvironment conditions within managed stands during 5 years after *** forest structure after harvesting and different microenvironments were characterized in managed stands,where 105 regeneration plots were measured(3 stands×7 microenvironments×5 replicas).We characterized the seedling bank,as well as growth and ecophysiology performance of the *** and multivariate analyses were conducted for the ***:Microenvironments offered different environmental conditions for natural regeneration(soil moisture and light availability).Seedling under debris and dicot plants showed better eco-physiological performance,establishment,and growth than plants growing under monocots or located in the dispersed retention without the protection of other understory *** most unfavorable microenvironment conditions were high canopy cover of remnant trees(inside the aggregates or close to trees in the dispersed retention)and heavily impacted areas(skidder extraction roads).Conclusions:Favorable microenvironments in the harvested areas will improve the natural recruitment,growth,and eco-physiology performance of the natural regeneration after *** is necessary to develop new silvicultural practices that decrease the unfavorable microenvironments(e.g.,road density or excessive woody accumulation),to assure the success of the proposed silvicultural method.

关键词： Aggregated retention Dispersed retention Microenvironments Environmental variables Biometric values Biomass allocation Eco-physiology

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Response of Soil Microbial Community to a High Dose of Fresh Olive Mill Wastewater

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Pedosphere 2013年第3期23卷 281-289页

作者： J.L.MORENO F.BASTIDA M.A.S NCHEZ-MONEdeRO T.HERNNdeZ C.GARCíA department of Soil and Water Conservation Centro de Edafología y Biología Aplicada del Segura-Consejo Superior de Investigaciones Científicas (CEBAS-CSIC) Campus Universitario de Espinardo

An incubation experiment was designed in order to determine the further microbiological response to an addition (500m^3 ha^(-1) ) of fresh olive mill wastewater (FOMWW) in a soil that has been frequently amended with uncontrolled doses of OMWW since the 1990s in an active disposal site (ADS soil). To achieve this aim, the phospholipid fatty acid (PLFA) profiles, microbial biomass C (C_(mic)), and dehydrogenase (DHA) and urease activities (URA) were monitored at the beginning (T_0), 3 h (T_1) and 97 d (T_f, i.e., the end) of incubation after FOMWW addition. After the FOMWW addition, an increase in the ratio of fungal to bacterial PLFAs was observed in ADS soil. Moreover, a relative increase of monounsaturated fatty acids (MUFAs) with respect to saturated fatty acids (SATFA) was found in the ADS soil. An increase of the Gram-positive to Gram-negative ratio was observed in this soil at the end of the incubation. While DHA and C_(mic) increased in the ADS soil after FOMWW addition, URA showed a decrease. Fungi and Gram-positive bacterial biomass experienced an increase after addition of a high dose of FOMWW in laboratory conditions.

关键词：土壤微生物群落中段废水高剂量橄榄油新鲜微生物生物量碳磷脂脂肪酸细菌生物量

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Effect of Water Stress Induced by Polyethylene Glycol on Growth, Proline Accumulation in Agave americana L.

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Phyton-International Journal of Experimental Botany 2023年第2期92卷 629-643页

作者： Alfaro-Corres Arnoldo Enrique Lecona-Guzman Carlos Alberto Gutiérrez-Miceli Federico Antonio Martínez-Esteves Manuel Silverio-Gómez María del Carmen Medina-Lara María de Fátima Ruiz-Lau Nancy Laboratorio de Biotecnología vegetal Instituto Tecnológico de Tuxtla GutiérrezTuxtla Gutiérrez29050México Centro de Investigación científica de Yucatán Unidad de Bioquímica y Biología Molecular de PlantasMérida97205México Insituto Nacional de investigaciones Forestales Agrícolas y PecuariasHuimanguilloTabasco86400México CONACYT-Tecnológico Nacional de México/instituto Tecnológico de Tuxtla Gutiérrez Tuxtla Gutiérrez29050México

The effect of water deficit was determined on both in vitro and soil seedling as well as in cells in suspension of Agave americana *** order to do the establishment of cells,the formation of callus was induced;for it two auxins were evaluated:2,4-dichlorophenoxyacetic acid(2,4-D)and 4-mino-3,5,6-trichloropicolinic acid(picloram)at three concentrations(0.25,0.5 and 0.75 mg L−1)in three explants(leaf,root and meristems)cultured in MS semisolid *** callogenesis response was related to the type and section of the explant,as well as the regulator used,and a cell suspension was established using 0.5 mg L−1 naphthaleneacetic acid(NAA)+0.5 mg L−1 Benzylaminopurine(BAP).Seedlings were exposed to polyethyleneglycol(15%and 30%w/v)with a water potential of−0.87 and−2.67 MPa,respectively,under soil *** stress was applied through restricted *** weight,root system growth,and chlorophyll concentration were some of the parameters that were affected by the effect of water deficit on *** *** concentration values were significantly decreased by 15 at 30%PEG(19.6 SPAD units)compared to the control *** in vitro plants,the highest concentration of proline was found in the roots,being the treatment with 30%polyethylene glycol where the highest concentration of this osmoregulator was obtained(62.5 mg g−1 DW).Under restricted irrigation conditions,an increase in proline concentration was observed both in the aerial part(2.2μg 100 g−1 DW)and in the root system(1.8μg 100 g−1 DW).However,the concentrations found were approximately ten times greater,less than those found under in vitro ***,the accumulation of proline can be considered an indicator of stress in Agave Americana *** in vitro.

关键词： Agave americana water deficit proline

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Home range variability,spatial aggregation,and excursions of Akodon azarae and Oligoryzomys flavescens in Pampean agroecosystems

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Integrative Zoology 2020年第5期15卷 401-415页

作者： Irene GOROSITO Ailén BENÍTEZ Maria BUSCH Laboratorio de Ecología de PoblacionesFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos Airesand Instituto de EcologíaGenética y Evolución de Buenos AiresConsejo Nacional de Investigaciones Científicas y TécnicasBuenos AiresArgentina Laboratorio de Ecología de Poblaciones Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresBuenos AiresArgentina Laboratorio de Ecología de Poblaciones Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos Airesand Instituto de EcologíaGenética y Evolución de Buenos AiresConsejo Nacional de Investigaciones Científicas y TécnicasBuenos AiresArgentina

Rodents are reservoirs of various types of hantavirus,some of which are agents of hantavirus pulmonary syndrome in *** hantavirus is associated with a single rodent host species but successive spill-over events may eventually lead to host-switching and new species’becoming host of a given *** study aims to gain an understanding of the spatial ecology of two hantavirus-host species,Akodon azarae,and Oligoryzomys flavescens,by identifying factors modulating their home range sizes and stability,and by evaluating intra-and interspecific spatial aggregation for these species and a third one—Oxymycterus rufus—living in *** this,eleven capture-mark-recapture surveys were carried out,spanning 22 *** found that *** males have larger and more mobile home ranges than females,independently of the ***,males could likely have a more relevant role in the transmission of hantavirus because of their greater exposure both to a higher number of contacts between individuals and viral contamination of the ***,*** individuals showed negligible displacements of their home range through time,which could limit the range of hantavirus spread in host *** *** is host to Lechiguanas hantavirus(pathogenic to humans)this result encompasses epidemiological relevance,for it may imply the existence of local foci of ***,individuals of both species performed excursions outside their home *** events could enable hantavirus spread over distances beyond the normal range of movements and lead to new hantavirus outbreaks in formerly non-infected rodent populations,favoring the persistence of the virus in nature.

关键词： hantavirus home range intra-and interspecific contact rodent spatial ecology

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Geomechanical model for a seismically active geothermal field:Insights from the Tinguiririca volcanic-hydrothermal system

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Geoscience Frontiers 2019年第6期10卷 2117-2133页

作者： L.Giambiagi P.Alvarez S.Spagnotto E.Godoy A.Lossada J.Mescua M.Barrionuevo J.Suriano IANIGLA CCT MendozaCONICETParque San Martín s/n5500MendozaArgentina TEHEMA S.A. Subercaseaux 4100PirqueChile Universidad Nacional de San Luis Consejo Nacional de Investigaciones Científicas y TécnicasArgentina Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasInstituto de Estudios Andinos(IDEAN)Facultad de Ciencias Exactas y NaturalesBuenos AiresArgentina Facultad de Ciencias Exactas y Naturales Universidad Nacional de CuyoArgentina

In this work,we develop a multidisciplinary approach to investigate a geothermal system located at the volcanic arc of a subduction-related orogen and highlight the interplay between active *** field and fluid *** using results of field investigations from the Tinguiririca geothermal field in the High Andes of Chile(35°S),empirical analysis,and numerical models of static stress variations,we proposed a geomechanical model for evaluating the distribution of hydrothermal manifestations in a seismically-active *** present geomechanical model follows four major steps:(1)development of the 3 D structural model of fault pattern;(2)estimation of the in-situ stress field;(3)calculation of the resolved-shear-to-normal-stress ratio(slip tendency)on each fault with varying geomechanical parameters(coefficient of friction,pore pressure and cohesion)as inputs;and(4)estimation of Coulomb static stress changes as a consequence of failure in a nearby *** combination of all these analyses,we characterize in detail both the active deformation in the geothermal field and its relationship with hot fluid migration.

关键词： Southern central Andes Paleostress analysis Fluid migration Coulomb staric stress change

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Petrography and tectonic provenance of the Permian Tunas Formation:Implications on the paleotectonic setting during the ClaromecóForeland Basin evolution,southwestern Gondwana margin,Argentina

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Journal of Palaeogeography 2022年第3期11卷 427-447页

作者： María Belén Febbo Renata N.Tomezzoli Nora N.Cesaretti Giselle Choque Natalia B.Fortunatti Guadalupe Arzadún Consejo Nacional de investigaciones científicas y Técnicas(CONICET) Argentina Dpto.de Geología Universidad Nacional del SurAvenida Alem 1253B8000ICPBahía BlancaArgentina Centro de Geología Aplicada y Medio Ambiente(CGAMA CIC–UNS)Dpto.de GeologíaUniversidad Nacional del SurBahía BlancaArgentina Laboratorio de Paleomagnetismo“Daniel A.Valencio” Instituto de Geociencias BásicasAplicadas y Ambientales de Buenos Aires(IGEBA)Departamento de Ciencias GeológicasFacultad de Ciencias Exactas y Naturales(FCEyN)Universidad de Buenos Aires(UBA)Pabellón II(1428)CABAArgentina Laboratorio de Termocronología(La.Te Andes–CONICET) Las Moreras 310A4401XBAVaquerosSaltaArgentina

The Claromec o Basin is located at the south-western sector of the Buenos Aires province,*** basin is considered a foreland basin closely related to the evolution of the southwestern Gondwana *** contribution focuses on the provenance analysis of the Tunas Formation(Permian,Pillahuinc o Group),which represents the last filling stage for the Claromec o Foreland *** and tectonic provenance analyses were performed in sandstones recovered from subsurface(PANG 0001 and PANG0003 exploration wells)and outcrops located close to the basin center(Gonzales Chaves locality).In the subsurface,the analyzed succession is composed of medium-to fine-grained sandstones interbedded with tuffs,mudrocks,carbonaceous mudrocks and coal *** outcrops,the succession is dominated by mediumto fine-grained sandstones interbedded with *** composition patterns are distributed into the recycled orogen and transitionally recycled to mixed *** analyses,in addition to provenance and sedimentological studies,confirm that sedimentary material was derived from a mixed source,which largely comes from the Sierras Australes fold and thrust belt,located towards the W-SW,where the sedimentary succession is interbedded with volcanic *** Tunas Formation shows clear differences in its modal composition,paleocurrent direction and paleoenvironmental conditions with respect to the underlying units of the Pillahuinc o Group(Sauce Grande,Piedra Azul and Bonete formations).Source areas changed from cratonic to mixed fold belt/arc-derived material,suggesting variations in the Claromec o Basin configuration during the Late *** in the paleotectonic scenario during the deposition of the Tunas Formation have been interpreted as a consequence of a compressive post-collisional deformation event,the product of adjustment,accommodation and translation of terrains towards the equator during the Permian-Triassic to form Pangea.

关键词： Provenance area Petrography Tunas Formation ClaromecóForeland Basin Southwestern Gondwana margin Permian Upper Paleozoic

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Microglia-precursor cell interactions in health and in pathology

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BIOCELL 2018年第2期42卷 41-45页

作者： Estela M.MUÑOZ instituto de Histología y Embriología de Mendoza Dr.Mario H.Burgos(IHEM) Universidad Nacional de Cuyo(UNCuyo)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)MendozaArgentina

Until recently,microglia were mainly known as the resident phagocytes of the brain,***‘immunological warriors’of the ***,extensive knowledge is being accumulated about the functions of microglia beyond ***,it is well accepted that microglial cells are highly dynamic and responsive,and that they intervene in a dual manner in many developmental processes that shape the central nervous system,including neurogenesis,gliogenesis,spatial patterning,synaptic formation and elimination,and neural circuit establishment and *** differentiation and the pool of precursor cells were also shown to be under microglia regulation via bidirectional *** this concise review,I discuss our recent work in microglia-Pax6+cell interactions in one of the circumventricular organs,the pineal *** analogy with the rest of the central nervous system is also *** addition,I briefly examine mechanisms of interaction between microglia and non-microglial cells in both health and *** avenues are also introduced,which may lead us to better comprehend the impact of microglia in physiological and pathological conditions.

关键词： Phagocyte Phagocytosis Phagoptosis Apoptosis Autophagy

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Integrated operational planning of hydrothermal power and natural gas systems with large scale storages

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Journal of Modern Power Systems and Clean Energy 2017年第3期5卷 299-313页

作者： Diego Mauricio OJEDA-ESTEYBAR Ricardo German RUBIO-BARROS Alberto VARGAS instituto de Energı´a Ele´ctrica(IEE) Universidad Nacional de San Juan(UNSJ)Consejo Nacional de Investigaciones Cientı´ficas y Tecnolo´gicas(CONICET)Av.Libertador Gral.San Martı´n West 11095400 San JuanArgentina

The growing installation of natural gas fired power plants has increased the integration of natural gas and electricity sectors. This has driven the need investigate the interactions among them and to optimize energy resources management from a centralized planning perspective. Thus, a combined modeling of the reservoirs involved in electric power and gas systems and their locations on both networks are essential features to be considered in the operational planning of energy *** paper presents a modeling and optimization approach to the operational planning of electric power and natural gas systems, taking into account different energy storage facilities, such as water reservoirs, natural gas storages and line packs of pipelines. The proposed model takes advantage of captures both energy systems synergy and their associated networks. This approach identifies the interactions between the energy storage facilities and their economic impact over their optimal scheduling. The results show the benefits of an integrated operational planning of electric power and natural gas systems, the close interdependency between the energy resources stored in both systems, and the effects of a combined scheduling.

关键词： Energy storage Hydrothermal scheduling Integrated operational planning Integrated energy systems Natural gas

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Mind the gap among patches in arid plant communities:rapid root proliferation in response to N addition

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Journal of Plant Ecology 2019年第1期12卷 89-95页

作者： Maria Fernanda Reyes Martín RAguiar instituto de investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura(IFEVA)and Consejo Nacional de investigaciones científicas y Técnicas(CONICET) Universidad de Buenos AiresAv.San Martín 4453Buenos Aires C1417DSEArgentina

Aims In arid communities,it has been proposed that individual plants can extend their roots beyond their canopy exploring neighbour-ing bare ground *** becomes relevant in systems where the vegetation is distributed in patches surrounded by bare ***,whether roots of different species may be overlapping under bare ground areas is still *** factors control-ling root responses when no plants appear to be directly influ-encing the gap among patches are still *** aim of our study was to detect perennial grasses responses to an N enrich-ment *** In a semi-arid steppe(Patagonia,Argentina),we buried root traps filled with sieved soil with and without N addition,under bare soil *** were harvested after 4 and 6 *** neighbour-hoods(30 cm in diameter)included at least three of the dominant tussock *** harvests,we identified species in the traps by root traits and quantified diversity,biomass and specific relative growth *** Findings Bare ground areas show simultaneous root growth of different *** of perennial grass roots was higher with N addition than without it in the first harvest(4 months),but this difference disappeared in the second harvest(6 months).Root biomass was maximal after 6 months in N addition *** preferred by herbivores(Bromus pictus and Poa ligularis)showed rapid growth and responses to N *** between harvests may be an indicative that N pulses interact with rising temperatures and soil water content as growing season progress.

关键词： belowground community ecology grass species roots Patagonian steppe patchiness root growth rates zone of influence

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