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Neural Regeneration Research 2024年第3期19卷 497-498页

作者： Luís Gales i3S−instituto de Investigação e Inovação em Saúde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAS−instituto de Ciências Biomédicas Abel Salazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly specific interactions between biomolecules,such as antigen-antibody,protein-ligand,or nucleic acid base pair complementary are on the basis of the organization of complex organisms.The same principles may be tentatively used in molecular medicine for diagnosis and therapeutics.A molecule can be designed to selectively bind a protease and thereby inhibit the production of a peptide that forms toxic aggregates in the brain or an antibody may be produced to bind specifically to that peptide for detection or clearance purposes.Unfortunately,interference in biological systems is not that simple.For a start there is the inhibition of the physiological role of the protease;moreover,several cleavage fragments may be produced,which may continue to diverge due to putative post-translational modification and self-assembly processes,hiding the toxic target in a“soup”of peptide species varying in size,structure and chemical composition.A perspective of the current status and challenges in targeting peptide species for diagnosis and treatment in the context of Alzheimer’s disease is given.

关键词： Alzheimer diagnosis thereby

Spatiotemporal oxygen dynamics in young leaves reveal cyclic hypoxia in plants

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molecular Plant 2024年第3期17卷 377-394页

作者： Paolo M.Triozzi Luca Brunello Giacomo Novi Gianmarco Ferri Francesco Cardarelli Elena Loreti Mariano Perales Pierdomenico Perata PlantLab Center of Plant SciencesSant'Anna School of Advanced Studies56010 PisaItaly Centro de Biotecnologia y Genomica de plantas Universidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA-CSIC)Campus de Montegancedo UPMPozuelo de Alarcon28223 MadridSpain Fondazione Pisana per la Scienza 56017 PisaItaly Laboratorio NEST Scuola Normale SuperioreIstituto Nanoscienze-CNRPiazza S.Silvestro1256127 PisaItaly institute of Agricultural Biology and Biotechnology National Research Council56124 PisaItaly departamento de Biotecnologia-biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasUniversidad Politecnica de Madrid(UPM)28040 Madrid.Spain

Oxygen is essential for plant growth and development.Hypoxia occurs in plants due to limited oxygen avail-abilityfollowing adverse environmental conditions as well inhypoxic niches in otherwisenormoxic environ-ments.However,the existence and functional integration of spatiotemporal oxygen dynamics with plant development remains unknown.In animal systems dynamic fluctuations in oxygen availability are known as cyclic hypoxia.In this study,we demonstrate that cyclic fluctuations in internal oxygen levels occur in young emerging leaves of Arabidopsis plants.Cyclic hypoxia in plants is based on a mechanism requiring the ETHyLENE RESPONSE FACTORS type VII(ERFVII)that are central components of the oxygen-sensing machinery in plants.The ERFVll-dependent mechanism allows precise adjustment of leaf growth in response to carbon status and oxygen availability within plant cells.This study thus establishes a functional connection between internal spatiotemporal oxygen dynamics and developmental processes of plants.

关键词： Arabidopsis hypoxia cyclic hypoxia leaf development oxygen-sensing mechanism ERFVII

CRISPR-Cas-based plant genome engineering goes viral

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molecular Plant 2023年第4期16卷 660-661页

作者： Jose-Antonio Daros Fabio Pasin Fernando Merwaiss instituto de biologia molecular y celular de plantas(CSiC-Universitat Politecnica deValencia) 46022ValenciaSpain

Biotechnological advances in the field of plant biology based on the bacterial and archaeal CRiSPR-Cas systems promise a new generation of crop plants that are more productive and nutritive,resistant to pest and pathogens,and better adapted to environmental stresses.However,application of this technology in plants still encounters some burdens,especially related to the expression of the CRISPR-Cas reaction components in plant cells.

关键词： plant CRISPR adapted

Dual regulation of SnRK2 signaling by Raf-like MAPKKKs

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molecular Plant 2022年第8期15卷 1260-1262页

作者： Gaston A.Pizzio Pedro L.Rodriguez institutode biologia molecular y celularde plantas Consejo Superior de Investigaciones Cientificas-Universidad Politecnica de Valencia46022 ValenciaSpain

Plants must adapt to unfavorable growth conditions such as drought,salinity,or extreme temperature and,in addition,need the flexibility to resume growth when conditions become favorable.Sensing of extracellular environmental stress and signal transduction rely on pathways that in many cases use phosphorylation of target proteins to amplify and transmit the extracellular signal.

关键词： SnRK2 extracellular resume

Linking plant metabolism and immunity through methionine biosynthesis

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molecular Plant 2022年第1期15卷 6-8页

作者： Francisco Escaray Amelia Felipo-Benavent Pablo Vera instituto de Biología molecular y celular de plantas Universidad Politécnica de Valencia-C.S.I.CCiudad Politécnica de la InnovaciónEdificio 8EIngeniero Fausto Elios/n46022 ValenciaSpain

Plants respond to pathogenic cues with a transcriptional reprog-ramming that leads to de novo production of defense-related pro-teins and a huge variety of secondary metabolites(e.g.,phyto-alexins,phenolics,etc.).Activation of these host defenses,which contribute to halt the intruder as part of the resistance,im-plies an increased demand for metabolic energy and carbon skel-etons derived from primary metabolism(Bolton,2009).

关键词： metabolism immunity Bolton

Characterization and QTL identification in eggplant introgression lines under two N fertilization levels

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Horticultural Plant Journal(园艺学报:英文版) 2023年第5期9卷 971-985页

作者： Elena Rosa-Martínez Gloria Villanueva Ahmet Sahin Pietro Gramazio María Dolores García-Martínez María Dolores Raig on Santiago Vilanova Jaime Prohens Mariola Plazas instituto de Conservacion y Mejora de la Agrodiversidad Valenciana Universitat Politecnica de ValenciaCamino de Vera 1446022 ValenciaSpain instituto de Biología molecular y celular de plantas Consejo Superior de Investigaciones Científicas-Universitat Politecnica de ValenciaCamino de Vera 1446022 ValenciaSpain

Lowering nitrogen inputs is a major goal for sustainable agriculture.In the present study,a set of 10 Solanum melongena introgression lines(ILs)developed using Solanum incanum as the exotic donor parent were grown under two nitrogen fertilization doses supplied with the irrigation system:1)8.25 mmol·L-1NH4NO3,corresponding to the high nitrogen treatment(HN),and 2)no external nitrogen supply,corresponding to the low nitrogen treatment(LN).Twenty traits,including plant growth and yield parameters,fruit size and morphology,nitrogen and carbon content in leaf and fruit,and phenolics content in fruit,were evaluated.The aim was to select of potential materials for eggplant breeding under low N inputs,as well as to identify and locate putative QTLs associated with the traits evaluated.No significant differences were observed between the soil characteristics of the HN and LN treatments,except for nitrogen and iron content,which was slightly lower in the HN,probably as a consequence of higher nutrient removal from soil by plants in the latter group.Analysis of variance showed that lowering nitrogen inputs did not significantly affect the final yield,fruit morphology,size and phenolics content.Most agronomic traits were highly and positively correlated with each other under both treatments,as well as total phenolics with chlorogenic acid content.The assessment of the differences between each IL and the recipient parent resulted in the identification of 36 QTLs associated with most of the traits—12 were specific to the HN,17 specific to the LN,and 7 were stable across treatments.The introgressed fragment of S.incanum generally had a negative effect on the trait,except for QTLs for fruit dry matter,for fruit length on chromosome 10 under the HN,and for fruit pedicel length on chromosome 9 under the LN.The increase over AN-S-26 of the allele of S.incanum for the QTLs detected ranged between-73.98% and 26.03% in HN and-73.67%and 34.43% in LN.These findings provide useful tools for the utilization of S.incanum in eggplant breed

关键词： Solanum melongena Solanum incanum Wild relatives N fertilization Abiotic stress QTL

The left-right side-specific endocrine signaling:implications for neurological deficits in stroke and neurodevelopmental disorders

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Neural Regeneration Research 2022年第11期17卷 2431-2433页

作者： Georgy Bakalkin Nikolay Lukoyanov Igor Lavrov Mengliang Zhang department of Pharmaceutical Biosciences Uppsala University departamento de Biomedicina da Faculdade de Medicina da Universidade do Porto Instituto de Investiga??o e Inova??o em SaúdeInstituto de Biologia Molecular e Celular department of Neurology Mayo Clinic department of molecular Medicine University of Southern Denmark

Brain injury-induced neurological deficits typically develop on the contralateral side of the body and include abnormal posture,motor weakness,and spasticity.It is believed that the interruption of descending neural p... 详细信息

关键词： neurological typically deficit

Gibberellin signaling turns blue

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molecular Plant 2021年第8期14卷 1226-1228页

作者： Noel Blanco-Tourinan David Alabadi Plant Vascular development Group ETH Zurich8092 ZurichSwitzerland instituto de biologia molecular y celular de plantas(CSIC-UPV) 46022 ValenciaSpain

The effect of envir on mental light on plant growth is mediated,at least in part,by the hormones gibberellins(GAs).The current model is that light signaling affects the GA pathway by transcrip-tional regulation of GA metabolism genes and by degradation of the negative regulators deLLA proteins by COP1.Two new studies provide evidenee showing that the blue light photoreceptor CRy1 directly regulates GA signaling.

关键词： CRy1 Gibberellin photoreceptor

The transcriptional regulator JAZ8 interacts with the C2 protein from geminiviruses and limits the geminiviral infection in Arabidopsis

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Journal of Integrative Plant Biology 2023年第7期65卷 1826-1840页

作者： Tabata Rosas-Diaz Pepe Cana-Quijada Mengshi Wu Du Hui Gemma Fernandez-Barbero Alberto PMacho Roberto Solano Araceli GCastillo Xiao-Wei Wang Rosa Lozano-Duran Eduardo R.Bejarano departamento de Biología celular Genética y FisiologíaFacultad de CienciasInstituto de Hortofruticultura Subtropical y Mediterránea“La Mayora”(IHSM‐UMA‐CSIC)Universidad de MálagaMálagaSpain Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China Institute of Insect Sciences Zhejiang UniversityHangzhou 310058China departamento de Genética molecular de plantas Centro Nacional de Biotecnología‐Consejo Superior de Investigaciones CientíficasMadrid 28049Spain department of Plant Biochemistry Centre for Plant Molecular BiologyEberhard Karls UniversityTübingen D‐72076Germany

Jasmonates(JAs) are phytohormones that finely regulate critical biological processes, including plant development and defense. JASMONATE ZIM-DOMAIN(JAZ) proteins are crucial transcriptional regulators that keep JA-responsive genes in a repressed state. In the presence of JA-Ile, JAZ repressors are ubiquitinated and targeted for degradation by the ubiquitin/proteasome system,allowing the activation of downstream transcription factors and, consequently, the induction of JA-responsive genes. A growing body of evidence has shown that JA signaling is crucial in defending against plant viruses and their insect vectors. Here, we describe the interaction of C2proteins from two tomato-infecting geminiviruses from the genus Begomovirus, tomato yellow leaf curl virus(TyLCV) and tomato yellow curl Sardinia virus(TyLCSaV), with the transcriptional repressor JAZ8 from Arabidopsis thaliana and its closest orthologue in tomato, SlJAZ9. Both JAZ and C2proteins colocalize in the nucleus, forming discrete nuclear speckles. Overexpression of JAZ8did not lead to altered responses to TyLCV infection in Arabidopsis;however, knock-down of JAZ8 favors geminiviral infection. Low levels of JAZ8 likely affect the viral infection specifically,since JAZ8-silenced plants neither display obvious developmental phenotypes nor present differences in their interaction with the viral insect vector. In summary, our results show that the geminivirus-encoded C2 interacts with JAZ8 in the nucleus, and suggest that this plant protein exerts an anti-geminiviral effect.

关键词： C2 protein geminivirus jasmonates JAZ8 transcriptional repressor TyLCV

Repression of Cell Proliferation by miR319-Regulated TCP4

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molecular Plant 2014年第10期7卷 1533-1544页

作者： Carla Schommer Juan M. debernardi Edgardo G. Bresso Ramiro E. Rodriguez Javier F. Palatnik IBR (instituto de biologia molecular y celular de Rosario) CONICET and Facultad de Ciencias Bioquimicas y Farmaceuticas UniversidadNacional de Rosario 2000 Rosario Argentina

Leaf development has been extensively studied on a genetic level. However, little is known about the inter- play between the developmental regulators and the cell cycle machinery--a link that ultimately affects leaf form and size. miR319 is a conserved microRNA that regulates TCP transcription factors involved in multiple developmental pathways, including leaf development and senescence, organ curvature, and hormone biosynthesis and signaling. Here, we analyze the participation of TCP4 in the control of cell proliferation. A small increase in TCP4 activity has an immediate impact on leaf cell number, by significantly reducing cell proliferation. Plants with high TCP4 levels have a strong reduction in the expression of genes known to be active in G2-M phase of the cell cycle. Part of these effects is mediated by induction of miR396, which represses Growth-Regulating Factor （GRF） transcription factors. detailed analysis revealed TCP4 to be a direct regulator of MIR396b. However, we found that TCP4 can control cell proliferation through additional pathways, and we identified a direct connection between TCP4 and ICK1/KRP1, a gene involved in the progression of the cell cycle. Our results show that TCP4 can activate different pathways that repress cell proliferation.

关键词： microRNA miR396 miR319 TCP GRF ICK1 KRP1 proliferation.