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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile instituto de ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico instituto de ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria S.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdiSNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Airborne bacteria associated with particulate matter from a highly urbanised metropolis:A potential risk to the population’s health

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Frontiers of Environmental Science & Engineering 2022年第9期16卷 99-114页

作者： María del Carmen Calderón-Ezquerro Elizabeth Selene Gómez-Acata Carolina Brunner-Mendoza instituto de ciencias de la atmósfera y cambio climático Universidad Nacional Autónoma de MéxicoCiudad de México 04510Mexico Facultad de Medicina Universidad Nacional Autónoma de MéxicoCiudad de México 04510Mexico

Bacteria in the air present patterns in space and time produced by different sources and environmental *** studies have focused on the link between airborne pathogenic bacteria in densely populated cities,and the risk to the population’s *** associated with particulate matter(PM)were monitored from the air of Mexico City(Mexico).We employed a metagenomic approach to characterise bacteria using the 16S rRNA *** bacteria sampling was carried out in the north,centre,and south of Mexico City,with different urbanisation rates,during *** added to the particles were sampled using high-volume PM_(10) *** ascertain significant differences in bacterial diversity between zones and seasons,the Kruskal-Wallis,Wilcoxon tests were done on alpha diversity ***-three air samples were collected,and DNA was sequenced using next-generation *** results indicated that the bacterial phyla in the north and south of the city were Firmicutes,Cyanobacteria,Proteobacteria,and Actinobacteria,while in the central zone there were more *** were no differences in the alpha diversity indices between the sampled *** to the OTUs,the richness of bacteria was higher in the central *** diversity was higher in the rainy season than in the dry season;the Shannon index and the OTUs observed were higher in the central zone in the dry *** bacteria such as Kocuria,Paracoccus,and Micrococcus predominated in both seasonal times,while Staphylococcus,Corynebacterium,and Nocardioides were found during the rainy season,with a presence in the central zone.

关键词： Airborne bacteria Urbanisation PM10 Mexico City Microbiome

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Long-term stability in protected-areas?A vision from American/New World amphibians

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Geography and Sustainability 2024年第4期5卷 673-683页

作者： Leticia M.Ochoa-Ochoa Julian A.Velasco Facultad de ciencias Universidad Nacional Autónoma de MexicoCP 04510Mexico CityMexico instituto de ciencias de la atmósfera y cambio climático Universidad Nacional Autónoma de MexicoCP 04510Mexico CityMexico

Protected areas(PA)have proven to be one of the best ways to conserve biodiversity against environmental *** are considered the most threatened group,with habitat loss due to deforestation identified as their major ***,we assessed for each PA of the American continent:1)amphibian’s occurrence(Global Biodiversity Information Facility(GBIF)*** Union for Conservation of Nature(IUCN)data);2)temperature velocity and estimated the climate residence time,and using the latest models of the land future use;3)we estimated the changes of natural *** cover in three future *** occurrence showed differences between databases,while GBIF data shows that 52%of the amphibian species occurring in the continent are in PA,based on IUCN data,85%are *** from climate change show a low pace of climate velocity during the last century that is maintained in the green scenario(SSP126).However,change in temperature increases in rate in the rest of the scenarios,with scenario SSP58 showing the highest velocity of temperature *** estimates of residence times in PA show that lower levels as emission scenarios tend to be *** results are worrisome since climate lag,specifically temperature increase over the PA will probably affect amphibian communities as shown in previous *** in climate patterns have a direct—mostly negative—impact on amphibians’ability to disperse and *** results of land use change were unexpected,since the categories showed minimal ***,the data on urbanization changes do not seem to be reflecting the trends of other databases,which may be causing artifacts in the comparisons in the future models of land *** research will be necessary to evaluate the extent of similarities and differences in future projections of land use including urbanization and human population between different databases.

关键词： climate lag Conservation Future land use models Governance Temperature tendency

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Assessing the Environmental Impact of Extensive Beef Production in Grazing lands of Argentina

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 1943-1962页

作者： Ernesto Viglizzo Florencia Ricard instituto de ciencias de la Tierra y Ambientales de la Pampa Consejo Nacional de Investigaciones Científicas y TécnicasSanta Rosa6300La PampaArgentina Universidad Austral Rosario2000Santa FeArgentina Secretaría de Ambiente y cambio climático del Gobierno de la Pampa Santa Rosa6300La PampaArgentina Facultad de ciencias Exactas y Naturales Universidad Nacional de La PampaSanta Rosa6300La PampaArgentina

Because of environmental constraints,beef cattle was for more than a century the only viable farming option in the extensive semiarid and subhumid lands of Argentina and the main source of nutrients for humans as ***,a growing concern and criticism have risen today about its possible negative impact on the climate and the *** worries tend to affect current public opinions,national policies,and international *** on 40 beef cattle farms scattered across different semiarid and subhumid regions of Argentina,here we evaluated the impact of extensive cattle production on carbon,water,and nutrient ***-Cycle Assessment(LCA)and land-Based Assessment(LBA)were the two approaches we used here to compare the environmental impact of beef *** the environmental footprint(EF)resulting from LCA expresses the impact per unit of food,the environmental balance(EB),derived from LBA,aims at quantifying the impact per unit of *** such,the EB considers both negative and positive impacts on the farm as an integrated *** standardized procedures,we evaluated EF and EB up to the farm gate,leaving aside delocalized post-farm impacts such as those of processing,packaging,and transportation that occur beyond the farm *** agreement with previous evidence,our results show that the EF tends to decrease as per-head production *** coefficients and statistical significance were the following for carbon(R=−0.574;py,the EB seems to be highly sensitive,and as per-hectare beef production *** were the following for carbon emissions(CE:R=0.955;p<0.01),water consumption(WC:R=0.822;p<0.01),nitrogen excretion(NE:R=0.948;p<0.01)and phosphorus excretion(PE:R=0.945;p<0.01).What our results suggest is that the notion of EF is useful to evaluate the environmental impact in intensive beef

关键词： Beef production extensive cattle raising grazing conditions environmental impact assessment

Tropical tree community composition and diversity variation along a volcanic elevation gradient

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Journal of Mountain Science 2022年第12期19卷 3475-3486页

作者： Ruben MARTINEZ-CAMILO Manuel MARTINEZ-MELENdeZ Nayely MARTINEZ-MIELENdeZ derio Antonio JIMENEZ-LOPEZ Mauricio JOSE-RIOS Unidad Villa Corzo Facultad de IngenieríaUniversidad de Ciencias y Artes de Chiapas30520 Villa CorzoChiapasMexico instituto de ciencias Biológicas Universidad de Ciencias y Artes de Chiapas29039 Tuxtla GutiérrezChiapasMexico Eizia A.C. 29045 Tuxtla GutiérrezChiapasMexico departamento de Conservación de la Biodiversidad El Colegio de la Frontera Sur29290 San Cristóbal de las CasasChiapasMexico Orquidiario y Jardín Botánico de Comitán Secretaría de Medio Ambiente e Historia Natural30106 Comitán de DomínguezChiapasMexico instituto de Investigación en Gestión de Riesgos y cambio climático Universidad de Ciencias y Artes de Chiapas29039 Tuxtla GutiérrezChiapasMexico

Unraveling the factors that determine variation of diversity in tropical mountain systems is a topic for debate in plant *** is especially true in areas where topography is complex due to volcano elevational gradients and where forests are vulnerable to human *** this study we used a set of climatic(temperature,rainfall,and radiation solar),topographic(elevation,slope aspect,and slope orientation)and human disturbance variables to determine their effect on diversity and composition patterns of a tree community,considering three slope aspects of a tropical volcano in southeastern *** sampled trees in seventy 0.1-ha plots distributed on three slope aspects of the Tacanávolcano along an elevational gradient of 1500 to 2500 *** determined diversity patterns(general tree richness,exponential of Shannon index,and pioneer species richness)with linear regression models,and for beta diversity,we used a dissimilarity index(within and between elevational bands 100 m wide).The effect of a set of environmental and human disturbance variables on tree diversity and community composition was analyzed with general linear models and multivariate analyses,*** registered 2,949 individual trees belonging to 176 species and *** average species richness and alpha diversity per plot were 13(standard deviation±6)and 9(±5),*** tree richness and alpha diversity increased in the middle part(unimodal patterns)of the elevational gradient,but pioneer species richness decreased linearly with *** variance explained by general linear models was greater in richness(32%)than in alpha diversity(25.3%).The most important predictor variables were temperature(elevational gradient),which explained the unimodal pattern(richness and alpha diversity increase at intermediate levels of temperature),and slope orientation,which explained the increase in richness and alpha diversity toward the geographic *** temperature had a signific

关键词： Composition Environmental gradient Tree diversity patterns Tropical humid cloud forest Tropical volcanoes