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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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A tiny dural arteriovenous fistula

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Chinese Medical Journal 2003年第7期116卷 1113-1114页

作者：张鹏朱风水凌锋 Christophe COGNARD Cerebral vascular disease institute Interventional Center of Xuanwu HospitalBeijing 100053 China Neurointerventional

Pulsatile tinnitus is commonly encountered in approximately 10% of a given population.1 Since causes of the disease vary, selecting appropriate protocols of imaging strategies is quite challenging.2 vascular anormalies or diseases including anormalies of the carotid arteries and jugular veins, intracranial arteriovenous malformation and dural arteriovenous fistula (DAVF) are major causative factors of the disease. Before imaging studies, history inquiry and physical examination are important for detect the possible causes of pulsatile tinnitus. Different imaging examinations are depended on histories and clinical signs of different patients.

关键词： ICA A tiny dural arteriovenous fistula

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning Chang Liu Yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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DNA Methylation and Transcription of HLA-F and Serum Cytokines Relate to Chinese Medicine Syndrome Classification in Patients with Chronic Hepatitis B

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Chinese Journal of Integrative Medicine 2022年第6期28卷 501-508页

作者： HU Xue-qing ZHOU Yuan CHEN Jian LU Yi-yu CHEN Qi-long HU Yi-yang SU Shi-bing Research Center for Traditional Chinese Medicine Complexity System Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai201203China Department of Medical Oncology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghai201203China Department of vascular disease Shanghai Traditional Chinese Medicine-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Department of vascular disease Shanghai Traditional Chinese Medicine-Integrated Institute of Vascular DiseaseShanghai201203China institute of Liver disease Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China

Objective:To explore the molecular bases of Chinese medicine(CM) syndrome classification in chronic hepatitis B(CHB) patients in terms of DNA methylation,transcription and ***:Genome-wide DNA methylation and 48 serum cytokines were detected in CHB patients(DNA methylation:15 cases;serum cytokines:62 cases) with different CM syndromes,including dampness and heat of Gan(Liver) and gallbladder(CHB1,DNA methylation:5 cases,serum cytokines:15 cases),Gan stagnation and Pi(Spleen) deficiency(CHB2,DNA methylation:5 cases,serum cytokines:15 cases),Gan and Shen(Kidney) yin deficiency(CHB3,DNA methylation:5 cases,serum cytokines:16 cases),CHB with hidden symptoms(HS,serum cytokines:16 cases) and healthy controls(DNA methylation:6 cases).DNA methylation of a critical gene was further validated and its mRNA expression was detected on enlarged ***-wide DNA methylation was detected using Human Methylation 450 K Assay and further verified using *** and mRNA expression of gene were evaluated using multiplex biometric enzyme-linked immunosorbent assay(ELISA)-based immunoassay and reverse transcription-quantitative polymerase chain reaction(RT-qPCR),***:Totally 28,667 loci,covering 18,403 genes were differently methylated among CHB1,CHB2 and CHB3(P 0.17).Further validation showed that compared with HS,the hg19 CHR6:29691140 and its closely surrounded 2 CpG loci were demethylated and its mRNA expressions were significantly up-regulated in CHB1(P0.05).Levels of Interleukin(IL)-12 were higher in CHB3 and HS than that in CHB1 and CHB2 groups(P<0.05).Levels of macrophage inflammatory protein(MIP)-1αand MIP-1β were higher in CHB3 than other groups and leukemia inhibrtory factor level was higher in CHB1 and HS than CHB2 and CHB3 groups(P<0.05).IL-12,MIP-1α and MIP-1β concentrations were positively correlated with human leukocyte antigen F(HLA-F)mRNA expression(R

关键词： cytokine chronic hepatitis B DNA methylation human leukocyte antigen F Chinese medicine syndrome

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Successful cardiopulmonary resuscitation combined with thrombolysis for massive pulmonary embolism during peri-cardiac arrest

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World Journal of Emergency Medicine 2022年第6期13卷 495-499页

作者： Mei-ning Li Yan-hui Lu Ya-min Li Hai-yun Wang Yu-hong Mi Emergency and Critical Care Center Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vascular DiseaseBeijing 100029China

Dear editor,Pulmonary thromboembolism(PTE)has become the third most lethal type of thrombotic disease in the world.[1]Thrombolysis has been advised for high-risk PTE patients,however due to its unique pathophysiology,which differs from other atherosclerotic diseases,this can still be a challenge for PTE patients.[2]We reported two cases with a high-risk of PTE that had the onset of or progressed to cardiac arrest(CA)during hospitalization and were successfully managed with cardiopulmonary resuscitation(CPR)combined with thrombolytic therapy.

关键词： resuscitation cardiac embolism

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Endarterectomy versus stenting for stroke prevention

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Stroke & vascular Neurology 2018年第2期3卷 101-106页

作者： A Ross Naylor The Leicester vascular institute Glenfield HospitalLeicesterUK

The European Society for vascular Surgery(ESVS)has recently prepared updated guidelines for the management of patients with symptomatic and asymptomatic atherosclerotic carotid artery disease,with specific reference to the roles of best medical therapy,carotid endarterectomy(CEA)and carotid artery stenting(CAS).In symptomatic patients,there is a drive towards performing carotid interventions as soon as possible after onset of *** is because it is now recognised that the highest risk period for recurrent stroke is the first 7-14 days after onset of *** guidelines advise that there is a role for both CEA and CAS,but the levels of evidence are slightly lower for CAS than for *** is because 30-day risks of death/stroke in the randomised controlled trials(RCTs)were significantly higher than after CEA(especially in the first 7-14 days after onset of symptoms)and there are concerns that the results obtained in the RCTs may not be generalisable into routine clinical *** asymptomatic patients,the 2018 ESVS guidelines were the first to recommend that CEA/CAS should be targeted into a smaller cohort of patients who may be‘higher risk for stroke’on medical *** with symptomatic patients,the ESVS guidelines advise that there is a potential role for both CEA and CAS,but the levels of evidence are again slightly lower for CAS than for *** is because 30-day risks of death/stroke in the two largest RCTs,which used credentialed(experienced CAS practitioners),were only just within the accepted 3%risk threshold and there remain concerns that the results obtained in RCTs may not be generalisable into routine clinical practice.

关键词： routine prevention Surgery

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Multilayer stents, a new progress in the endovascular treatment of aneurysms

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Chinese Medical Journal 2013年第3期126卷 536-541页

作者： ZHANG Yong-xue LU Qing-sheng JING Zai-ping Department of vascular Surgery Changhai Hospital Shanghai 200433 China Military institute of vascular disease Changhai Hospital Shanghai 200433 China

Objective To review the recent progress of multilayer stents in treating arterial aneurysms and to draw an initial conclusion about its paradigm. Data sources PubMed database and ELSEVIER database were searched with the keywords ＂cardiatis＂ or ＂multilayer stent＂ for relevant articles from January 2008 to September 2012. Relevant websites （provided by Cardiatis） were also involved in the review process. Study selection Well-controlled, relatively large-scale, retrospective studies as well as meaningful individual cases were all selected as materials. Results A total of 23 articles were involved in this review. The newly introduced Cardiatis muttilayer stent aims at creating an active flow-modulating barrier between normal blood flow and aneurismal sac, which can induce thrombosis within aneurismal sac and preserve collateral circulation at the same time. Currently, it has been applied for complicated aneurysms located in different segments of the arterial system. Conclusion This new concept of multilayer uncovered stent offers a promising alterative in the treatment of arterial aneurysms. However, a further larqe-scale clinical and hemodynamic study is reauired to evaluate the Iona-term effects.

关键词： multilayer stents grafted stents aneurysm hemodynamics

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Endovascular aneurysm repair as a mean of treatment for ruptured abdominal aortic aneurysms

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Chinese Medical Journal 2013年第3期126卷 558-564页

作者： Manish Mehta John Byme John Taggert vascular Group Institute for Vascular Health and Disease Albany Medical College Albany Medical Center Albany New York 12208 USA

The metamorphosis of abdominal aortic aneurysm （AAA） repair from open surgical to endovascular means has evolved substantially over the past 2 decades. Today, endovascular abdominal aneurysm repair （EVAR） is consi... 详细信息

关键词： abdominal aorta aneurysm endovascular treatment

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Role of macrophages in aortic dissection pathogenesis:insights from preclinical studies to translational prospective

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Science China(Life Sciences) 2024年第11期67卷 2354-2367页

作者： Shiyi Li Weiguo Fu Lixin Wang Department of vascular Surgery Zhongshan HospitalFudan UniversityShanghai 200032China vascular Surgery institute of Fudan University Shanghai 200032China National Clinical Research Center for Interventional Medicine Shanghai 200032China Key Laboratory of Panvascular disease Precision Medicine Zhongshan Hospital XiamenFudan UniversityXiamen 361015China Fudan Zhangjiang institute Shanghai 201203China

Aortic dissection is a critical vascular disease that is characterized by a high mortality rate and inflammation significantly influences its onset and *** studies highlight the integral role of macrophages,key players in the immune system,in the pathological landscape of aortic *** cells are involved in crucial processes,such as the remodeling of the extracellular matrix,immunocyte infiltration,and phenotypic switching of smooth muscle cells,which are essential for the structural integrity and functional dynamics of the aortic *** these insights,the specific contributions of macrophages to the development and progression of aortic dissection remains *** review explores the pathogenesis of aortic dissection with a focus on macrophages and describes their origins,phenotypic variations,and potential roles based on the most recent research ***,we discuss key molecules related to macrophages during aortic dissection,their interactions with other cellular components within the aorta,and the implications of these interactions for future therapeutic *** comprehensive analysis aimed to improve our understanding of macrophages in aortic dissection and promote the development of targeted interventions.

关键词： aortic dissection macrophages extracellular matrix cytokines

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DNA Methylation and SNPs in VCX are Correlated with Sex Differences in the Response to Chronic Hepatitis B

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Virologica Sinica 2019年第5期34卷 489-500页

作者： Xue-Qing Hu Yuan Zhou Jian Chen Yu Zhao Yi-Yu Lu Qi-Long Chen Yuanjia Hu Yi-Yang Hu Shi-Bing Su Research Center for Traditional Chinese Medicine Complexity System Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Medical Oncology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai TCM-Integrated Hospital Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of vascular disease Shanghai TCM-Integrated Institute of Vascular DiseaseShanghai 201203China institute of liver disease Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoChina

The study was conducted to explore the mechanisms of sex differences in the response to chronic hepatitis B(CHB)in terms of DNA methylation,SNP genotype,and gene *** DNA was isolated from peripheral blood mononuclear cells(PBMCs)of CHB patients and healthy controls and evaluated using the Human Methylation 450 K *** DNA methylation level at hg37 chromosome(CHR)X:7810800 was further validated using *** genotypes,VCX mRNA expression of PBMCs,and plasma VCX protein concentration were further examined using SNaPshot,RT-qPCR,and Western blot,*** showed that a total of 5529 CpG loci were differentially methylated between male and female CHB *** methylation level and CC+CT frequency at CHR X:7810800,VCX mRNA expression of PBMCs,and plasma VCX protein concentration were higher in female than in male CHB *** CHR X:7810800 locus was hypermethylated in CHB patients with CC+CT genotypes in comparison with those with the TT *** cases of CC-f CT genotypes,VCX mRNA expression was negatively correlated with the DNA methylation *** patients with higher levels of HBV DNA,AST,and GGT or higher GPRI scores exhibited lower VCX *** conclusion,SNPs and DNA methylation at the CHR X:7810800 locus cooperatively regulate VCX expression in *** upregulated VCX expression in female CHB patients might represent a mechanism of protection from more severe liver dysfunction and extensive fibrosis,as observed in male CHB patients.

关键词： Hepatitis B DNA methylation Sex•Single nucleotide polymorphisms(SNP) VCX

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