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Journal of Bio-X Research 2021年第4期4卷 145-150页

作者： Honglan Zheng Wanning Cui Zhiqiang Yan institute of Molecular Physiology Shenzhen Bay LaboratoryShenzhenGuangdong Province State Key Laboratory of Medical Neurobiology and moe frontiers center for brain science Institutes of Brain ScienceSchool of Life SciencesFudan UniversityShanghaiChina

Sensorineural hearing loss is the most common sensory deficit in humans,with an estimated prevalence of 1 in 500 *** half of childhood hearing loss is attributed to genetic factors and can be classified as syndromic or non-syndromic based on the inheritance *** ion channel genesKCNQ1,KCNE1,KCNQ4,P2RX2,TMC1,KCNJ10,andCACNA1D have frequently been associated with genetic hearing *** of the important roles these genes play in cochlear hair cell function and the auditory pathways,mutations in these genes that result in impaired ion channel function can lead to hereditary hearing *** main purpose of this review was to examine the latest research progress on the functional roles,inheritance pattern,gene expression,protein structure,clinical phenotypes,mouse models,and possible treatments of the most commonly studied ion channels associated with inherited deafness.A comprehensive summary could help highlight ion channels that should be investigated as potential drug targets for the treatment of inherited deafness.

关键词： channelopathies gene mutation genetic hearing loss ion channel therapy

The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities

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Neuroscience Bulletin 2023年第3期39卷 393-408页

作者： Qiyuan Zhuang Hui Yang Ying Mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghai 200040China National center for Neurological Disorders Huashan HospitalFudan UniversityShanghai 200040China Shanghai Key Laboratory of brain Function Restoration and Neural Regeneration Huashan HospitalFudan UniversityShanghai 200040China institute for Translational brain Research Fudan UniversityShanghai 200032China State Key Laboratory of Medical Neurobiology and moe frontiers center for brain science Institute for Translational Brain ResearchInstitutes of Brain ScienceFudan UniversityShanghai 200032China Neurosurgical institute of Fudan University Shanghai 200032China

Glioma is the most common and lethal intrinsic primary tumor of the *** controversial origins may contribute to its heterogeneity,creating challenges and difficulties in the development of *** the components constituting tumors,glioma stem cells are highly plastic subpopulations that are thought to be the site of tumor *** stem cells/progenitor cells and oligodendrocyte progenitor cells are possible lineage groups populating the bulk of the tumor,in which gene mutations related to cell-cycle or metabolic enzymes dramatically affect this *** approaches have revealed the tumor-promoting properties of distinct tumor cell states,glial,neural,and immune cell populations in the tumor *** between tumor cells and other normal cells manipulate tumor progression and influence sensitivity to ***,we discuss the heterogeneity and relevant functions of tumor cell state,microglia,monocyte-derived macrophages,and neurons in glioma,highlighting their bilateral effects on ***,we describe potential therapeutic approaches and targets beyond standard treatments.

关键词： Glioma origin Stem/progenitor cell Oncometabolite Immune heterogeneity Neuron-tumor interaction

Monolayer molecular crystals for low-energy consumption optical synaptic transistors

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Nano Research 2022年第8期15卷 7639-7645页

作者： Zhekun Hua Ben Yang Junyao Zhang Dandan Hao Pu Guo Jie Liu Lang Jiang Jia Huang Interdisciplinary Materials Research center School of Materials Science and EngineeringFrontiers Science Center for Intelligent Autonomous SystemsTongji UniversityShanghai 201804China Beijing National Laboratory for Molecular sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Translational Research institute of brain and brain-Like intelligence Shanghai Fourth People's Hospital Affiliated to Tongji UniversitySchool of Materials Science and EngineeringTongji UniversityShanghai 200434China

Artificial synaptic devices hold great potential in building neuromorphic *** to the unique morphological features,twodimensional organic semiconductors at the monolayer limit show interesting properties when acting as the active layers for organic field-effect ***,organic synaptic transistors are prepared with 1,4-bis((5’-hexyl-2,2’-bithiophen-5-yl)ethyl)benzene(HTEB)monolayer molecular *** similar to biological synapses,including excitatory postsynaptic current(EPSC),pair-pulse facilitation,and short/long-term memory,have been *** synaptic device achieves the minimum power consumption of 4.29 fJ at low drain voltage of−0.01 ***,the HTEB synaptic device exhibits excellent long-term memory with 109 s EPSC estimated retention ***-like functions such as dynamic learning-forgetting process and visual noise reduction are demonstrated by nine *** unique morphological features of the monolayer molecular semiconductors help to reveal the device working mechanism,and the synaptic behaviors of the devices can be attributed to oxygen induced energy *** work shows the potential of artificial neuroelectronic devices based on organic monolayer molecular crystals.

关键词： monolayer molecular crystals synaptic devices organic field-effect transistors optical synaptic transistors

Deep Learning‑Assisted Quantitative Susceptibility Mapping as a Tool for Grading and Molecular Subtyping of Gliomas

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Phenomics 2023年第3期3卷 243-254页

作者： Wenting Rui Shengjie Zhang Huidong Shi Yaru Sheng Fengping Zhu YiDi Yao Xiang Chen Haixia Cheng Yong Zhang Ababikere Aili Zhenwei Yao Xiao‑Yong Zhang Yan Ren Department of Radiology Huashan HospitalFudan UniversityMid 12 Wulumuqi RoadShanghai 200040China institute of science and technology for brain‑inspired intelligence Fudan UniversityShanghai 200433China moe Key Laboratory of Computational Neuroscience and brain‑inspired intelligence MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200433China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai 200040China Department of Neuropathology Huashan HospitalFudan UniversityShanghai 200040China GE Healthcare MR ResearchHuatuo RoadShanghai 201203China Department of Radiology Kuqa County People’s HospitalXinjiang 842000China

This study aimed to explore the value of deep learning(DL)-assisted quantitative susceptibility mapping(QSM)in glioma grading and molecular ***-two patients with gliomas,who underwent preoperative T2 fluid-attenuated inversion recovery(T2 FLAIR),contrast-enhanced T1-weighted imaging(T1WI+C),and QSM scanning at 3.0T magnetic resonance imaging(MRI)were included in this *** and immunohistochemistry staining were used to determine glioma grades,and isocitrate dehydrogenase(IDH)1 and alpha thalassemia/mental retardation syndrome X-linked gene(ATRX)*** segmentation was performed manually using Insight Toolkit-SNAP program(***).An inception convolutional neural network(CNN)with a subsequent linear layer was employed as the training encoder to capture multi-scale features from MRI *** cross-validation was utilized as the training strategy(seven samples for each fold),and the ratio of sample size of the training,validation,and test dataset was 4:1:*** performance was evalu-ated by the accuracy and area under the curve(AUC).With the inception CNN,single modal of QSM showed better perfor-mance in differentiating glioblastomas(GBM)and other grade gliomas(OGG,grade II–III),and predicting IDH1 mutation and ATRX loss(accuracy:0.80,0.77,0.60)than either T2 FLAIR(0.69,0.57,0.54)or T1WI+C(0.74,0.57,0.46).When combining three modalities,compared with any single modality,the best AUC/accuracy/F1-scores were reached in grading gliomas(OGG and GBM:0.91/0.89/0.87,low-grade and high-grade gliomas:0.83/0.86/0.81),predicting IDH1 mutation(0.88/0.89/0.85),and predicting ATRX loss(0.78/0.71/0.67).As a supplement to conventional MRI,DL-assisted QSM is a promising molecular imaging method to evaluate glioma grades,IDH1 mutation,and ATRX loss.

关键词： Quantitative susceptibility mapping Glioma classification Isocitrate dehydrogenase Alpha thalassemia/mental retardation syndrome X-linked gene Deep learning

Reconstruction of behavior-relevant individual brain activity:an individualized fMRI study

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science China(Life sciences) 2020年第3期63卷 410-418页

作者： Dongya Wu Xin Li Tianzi Jiang brainnetome center Institute of AutomationChinese Academy of SciencesBeijing 100190China National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China CAS center for Excellence in brain science and intelligence technology Institute of AutomationChinese Academy of SciencesBeijing 100190China The Clinical Hospital of Chengdu brain science institute MOE Key Lab for NeuroinformationUniversity of Electronic Science and Technology of ChinaChengdu 625014China The Queensland brain institute University of QueenslandBrisbane QLD 4072Australia University of Chinese Academy of sciences Beijing 100049China School of Mathematical sciences Zhejiang UniversityHangzhou 310027China

Different patterns of brain activity are observed in various subjects across a wide functional ***,these individual differences,which are often neglected through the group average,are not yet completely *** on the fundamental assumption that human behavior is rooted in the underlying brain function,we speculated that the individual differences in brain activity are reflected in the individual differences in *** 98 behavioral measures and assessing the brain activity induced at seven task functional magnetic resonance imaging states,we demonstrated that the individual differences in brain activity can be used to predict behavioral measures of individual subjects with high accuracy using the partial least square regression *** addition,we revealed that behavior-relevant individual differences in brain activity transferred between different task states and can be used to reconstruct individual brain *** individual brain activity retained certain individual differences which were lost in the group average and could serve as an individual functional ***,our results suggest that the individual differences in brain activity contain behavior-relevant information and should be included in group ***,reconstructed individual brain activity shows a potential use in precise and personalized medicine.

关键词： individual difference brain function behavior prediction fMRI

A paternal protein facilitates sperm RNA delivery to regulate zygotic development

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science China(Life sciences) 2023年第10期66卷 2342-2353页

作者： Dongdong Li Shijing Huang Yongping Chai Ruiqian Zhao Jing Gong Qiangfeng Cliff Zhang Guangshuo Ou Wenyu Wen Tsinghua-Peking center for Life sciences Beijing Frontier Research Center for Biological StructureMcGovern Institute for Brain ResearchSchool of Life Sciences and MOE Key Laboratory for Protein ScienceTsinghua UniversityBeijing 100084China Department of Neurosurgery Huashan Hospitalthe Shanghai Key Laboratory of Medical EpigeneticsInstitutes of Biomedical SciencesState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceNational Center for Neurological DisordersSchool of Basic Medical SciencesFudan UniversityShanghai 200032China

Sperm contributes essential paternal factors,including the paternal genome,centrosome,and oocyte-activation signals,to sexual ***,it remains unresolved how sperm contributes its RNA molecules to regulate early embryonic ***,we show that the Caenorhabditis elegans paternal protein SPE-11 assembles into granules during meiotic divisions of spermatogenesis and later matures into a perinuclear structure where sperm RNAs *** reconstitute an SPE-11 liquid-phase scaffold in vitro and find that SPE-11 condensates incorporate the nematode RNA,which,in turn,promotes SPE-11 phase *** of SPE-11 does not affect sperm motility or fertilization but causes pleiotropic development defects in early embryos,and spe-11 mutant males reduce m RNA levels of genes crucial for an oocyte-to-embryo transition or embryonic *** results reveal that SPE-11 undergoes phase separation and associates with sperm RNAs that are delivered to oocytes during fertilization,providing insights into how a paternal protein regulates early embryonic development.

关键词： SPE-11 phase separation paternal factor early embryonic development

Unveiling Dynamic System Strategies for Multisensory Processing: From Neuronal Fixed-Criterion Integration to Population Bayesian Inference

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Research 2023年第2期2022卷 81-100页

作者： Jiawei Zhang Yong Gu Aihua Chen Yuguo Yu State Key Laboratory of Medical Neurobiology and moe frontiers center for brain science Shanghai Artificial Intelligence LaboratoryResearch Institute of Intelligent and Complex Systems and Institute of Science and Technology for Brain-Inspired IntelligenceHuman Phenome InstituteShanghai 200433China Key Laboratory of Primate Neurobiology Institute of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghaiChina Key Laboratory of brain Functional Genomics(Ministry of Education) East China Normal University3663 Zhongshan Road N.Shanghai 200062China

Multisensory processing is of vital importance for survival in the external *** circuits can both integrate and separate visual and vestibular senses to infer self-motion and the motion of other ***,it is largely debated how multisensory brain regions process such multisensory information and whether they follow the Bayesian strategy in this process.

关键词： Integration Fixed Criterion

Bioinspired organic optoelectronic synaptic transistors based on cellulose nanopaper and natural chlorophyll-a for neuromorphic systems

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npj Flexible Electronics 2022年第1期6卷 286-295页

作者： Junyao Zhang Dapeng Liu Qianqian Shi Ben Yang Pu Guo Lu Fang Shilei Dai Lize Xiong Jia Huang Interdisciplinary Materials Research center School of Materials Science and EngineeringFrontiers Science Center for Intelligent Autonomous SystemsTongji UniversityShanghai 201804People’s Republic of China Translational Research institute of brain and brain-Like intelligence Shanghai Fourth People’s Hospital Affiliated to Tongji UniversitySchool of Materials Science and EngineeringTongji UniversityShanghai 200434People’s Republic of China

inspired by human brains,optoelectronic synapses are expected as one of significant steps for constructing neuromorphic *** addition,intensive attention has been paid to biodegradable and biocompatible materials for developing green *** this regard,environmentally friendly organic optoelectronic synaptic transistors based on wood-derived cellulose nanopaper(WCN)as dielectric/substrate and nature chlorophyll-a as photoactive material are *** WCN and chlorophyll-a are biocompatible and biodegradable materials from natural *** synaptic behaviors have been well mimicked by the modulation of both electrical and optical *** significantly,optical wireless communication is experimentally emulated and the information processing capability is also verified in pattern recognition ***,the flexible synaptic transistors exhibit no apparent synaptic performance degradation even when the bending radius is reduced to 1 *** work may develop a promising approach for the development of green and flexible electronics in neuromorphic visual systems.

关键词： optoelectronic radius synaptic

Divergent Projection Patterns Revealed by Reconstruction of Individual Neurons in Orbitofrontal Cortex

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Neuroscience Bulletin 2021年第4期37卷 461-477页

作者： Junjun Wang Pei Sun Xiaohua Lv Sen Jin Anan Li Jianxia Kuang Ning Li Yadong Gang Rui Guo Shaoqun Zeng Fuqiang Xu Yu-Hui Zhang Britton Chance center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and TechnologyWuhan430074China moe Key Laboratory for Biomedical Photonics School of Engineering SciencesHuazhong University of Science and TechnologyWuhan430074China Centre for brain science State Key Laboratory of Magnetic Resonance and Atomic Molecular PhysicsKey Laboratory of Magnetic Resonance in Biological SystemsWuhan Institute of Physics and MathematicsCAS Centre for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesWuhan430071China

The orbitofrontal cortex(OFC)is involved in diverse brain functions via its extensive projections to multiple target *** is a growing understanding of the overall outputs of the OFC at the population level,but reports of the projection patterns of individual OFC neurons across different cortical layers remain ***,by combining neuronal sparse and bright labeling with a whole-brain florescence imaging system(fMOST),we obtained an uninterrupted three-dimensional whole-brain dataset and achieved the full morphological reconstruction of 25 OFC pyramidal *** compared the wholebrain projection targets of these individual OFC neurons in different cortical layers as well as in the same cortical *** found cortical layer-dependent projections characterized by divergent patterns for information *** study not only provides a structural basis for understanding the principles of laminar organizations in the OFC,but also provides clues for future functional and behavioral studies on OFC pyramidal neurons.

关键词： Orbitofrontal cortex Whole-brain imaging Morphological reconstruction Output Projection pattern