Divergent Projection Patterns Revealed by Reconstruction of Individual Neurons in Orbitofrontal Cortex

作     者：Junjun Wang Pei Sun Xiaohua Lv Sen Jin Anan Li Jianxia Kuang Ning Li Yadong Gang Rui Guo Shaoqun Zeng Fuqiang Xu Yu-Hui Zhang Junjun Wang;Pei Sun;Xiaohua Lv;Sen Jin;Anan Li;Jianxia Kuang;Ning Li;Yadong Gang;Rui Guo;Shaoqun Zeng;Fuqiang Xu;Yu-Hui Zhang

作者机构：Britton Chance Center for Biomedical PhotonicsWuhan National Laboratory for Optoelectronics-Huazhong University of Science and TechnologyWuhan430074China MoE Key Laboratory for Biomedical PhotonicsSchool of Engineering SciencesHuazhong University of Science and TechnologyWuhan430074China Centre for Brain ScienceState Key Laboratory of Magnetic Resonance and Atomic Molecular PhysicsKey Laboratory of Magnetic Resonance in Biological SystemsWuhan Institute of Physics and MathematicsCAS Centre for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesWuhan430071China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2021年第37卷第4期

页      面：461-477页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：the National Natural Science Foundation of China(61827825,31770924,31470056,and 31600692) the Science Fund for Creative Research Group of China(61721092) the Director Fund of Wuhan National Laboratory for Optoelectronics 

主　　题：Orbitofrontal cortex Whole-brain imaging Morphological reconstruction Output Projection pattern 

摘      要：The orbitofrontal cortex(OFC)is involved in diverse brain functions via its extensive projections to multiple target *** is a growing understanding of the overall outputs of the OFC at the population level,but reports of the projection patterns of individual OFC neurons across different cortical layers remain ***,by combining neuronal sparse and bright labeling with a whole-brain florescence imaging system(fMOST),we obtained an uninterrupted three-dimensional whole-brain dataset and achieved the full morphological reconstruction of 25 OFC pyramidal *** compared the wholebrain projection targets of these individual OFC neurons in different cortical layers as well as in the same cortical *** found cortical layer-dependent projections characterized by divergent patterns for information *** study not only provides a structural basis for understanding the principles of laminar organizations in the OFC,but also provides clues for future functional and behavioral studies on OFC pyramidal neurons.