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Chinese Science Bulletin 1989年第13期34卷 1134-1139页

作者：夏萤张安中曹小定唐琴梅徐修容 Department of neurobiology Shanghai Medical University Shanghai institute of Materia Medica Academia Sinica

It has been demonstrated that excitation of hypothalamic defence area (HDA) causes an increase in sympathetic activity of the cardiovascular system and changes of other functions, which may be related to the activities of central monoamines; electroacupuncture applied to "Zusanli" or deep peroneal nerve stimulation (DPNS) can inhibit HDA stimulation-induced pressor, ventricular extrasystoles and other de-

关键词： deep peroneal nerve defence reaction hypothalamus

Learning to become addicted,one synapse at a time

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Neural Regeneration Research 2024年第2期19卷 401-402页

作者： Alessio Attardo Sidney B.Cambridge Leibniz institute for neurobiology MagdeburgGermany institute for Anatomy II Dr.Senckenberg AnatomyGoethe-University Frankfurt am MainFrankfurtGermany

Addiction has been extensively studied on many levels:from the molecular level,with various“omics”approaches(Natividad et al.,2018;Grecco et al.,2021),to the clinical level,with psychotherapy and MRI imaging(Ceceli ... 详细信息

关键词： clinical therapy

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

INTRASPINAL CONNECTIONS OF DORSAL COLUMN POSTSYNAPTIC NEURONS IN THE CAT——A PHYSIOLOGICAL ANALYSIS

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Science China Chemistry 1985年第9期28卷 972-978页

作者：吕国蔚,GARY J.BENNETT,NOZOMU NISHIKAWA,MARVIN J.HOFFERT,RONALD DUBNER Department of Neurophysiology Beijing Second Medical College China neurobiology and Anesthesiology Branch National institute of Dental Research National institutes of Health USA neurobiology and Anesthesiology Branch National institute of Dental Research National institutes of Health USA Department of Anesthesiology Shiga University of Medical Seience Shiga Japan neurobiology and Anesthesiology Branch National institute of Dental Research National institutes of Health USA Department of Neurology Univeraity of Wisenonsin Medieal School Madison Wisconsin 53792 U.S.A neurobiology and Anesthesiology Branch National institute of Dental Research National institutes of Health USA

Dorsal column postsynaptic (DCPS) neurons in the dorsal horn of the spinal cord have been identified by antidromic stimulation and intracellularly recorded in anesthetized cats. In about one-half of the cells, the antidromic stimulus evokes only an antidromic potential. This potential sometimes has an atypical shape due to penetration-induced depolarization. Atypieal potentials arc converted into typical antidromic spike potentials after intracellular injection of hyperpolarizing current. In the other one-half, the antidromic potentials are followed by postsynaptic activity. Intracellular analysis indicates that this postsynaptic activity is generated largely by activation of the intraspinal collaterals of A-beta primary afferents that are ascending the dorsal columns. Part of this postsynaptic activity has been produced monosynaptically. Polysynaptic responses are also evident; these are thought to be initiated by A-beta axons, desending axons from neurons in the dorsal column nuclei, or the local coll

关键词： A PHYSIOLOGICAL ANALYSIS

End-to-end and end-to-side neurorrhaphy between thick donor nerves and thin recipient nerves:an axon regeneration study in a rat model

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Neural Regeneration Research 2018年第4期13卷 699-703页

作者： Tohru Tateshita Kazuki Ueda Akiyoshi Kajikawa Department of Plastic and reconstructive Surgery St.Marianna Medical University Department of Plastic and reconstructive Surgery Fukushima Medical University

During nerve reconstruction,nerves of different thicknesses are often sutured together using end-to-side neurorrhaphy and end-to-end neurorrhaphy *** this study,the effect of the type of neurorrhaphy on the number and diameter of regenerated axon fibers was studied in a rat facial nerve repair *** inflow-type end-to-side and end-to-end neurorrhaphy model with nerve stumps of different thicknesses（2：1 diameter ratio） was created in the facial nerve of 14 adult male Sprague-Dawley *** 6 and 12 weeks,nerve regeneration was evaluated in the rats using the following outcomes：total number of myelinated axons,average minor axis diameter of the myelinated axons in the central and peripheral sections,and axon regeneration ***-to-end neurorrhaphy resulted in a significantly greater number of regenerated myelinated axons and rate of regeneration after 6 weeks than end-to-side neurorrhaphy;however,no such differences were observed at 12 *** the regenerated axons were thicker at 12 weeks than at 6 weeks,no significant differences in axon fiber thickness were detected between end-to-end and end-toside ***,end-to-end neurorrhaphy resulted in greater numbers of regenerated axons and increased axon regeneration rate during the early postoperative *** rapid reinnervation is one of the most important factors influencing the restoration of target muscle function,we conclude that end-to-end neurorrhaphy is desirable when suturing thick nerves to thin nerves.

关键词： epineural window transplantation nerve reconstruction suturing facial nerve repair axonal repair neurosurgery peripheral nerve neural regeneration

Deciphering the transcriptomic signature of synaptic activity

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Neural Regeneration Research 2022年第1期17卷 82-84页

作者： Guido Hermey institute for Molecular and Cellular Cognition Center for Molecular Neurobiology HamburgUniversity Medical Center Hamburg-EppendorfHamburgGermany

Neurons undergo activity-dependent changes in their molecular composition and structure in order to regulate cellular processes such as dendritic growth,synapse elimination,spine maturation and synaptic *** synaptic plasticity plays an important role during a critical period in brain development and contributes to sensory adaptation and to learning and memory in the mature nervous *** dysregulation underlies a number of pathological processes in psychiatric and neurodegenerative disorders,such as addiction.

关键词： strength. signature elimination

DEVELOPMENTAL STUDIES OF ELECTRICAL PROPERTIES IN CULTURED RAT BRAIN NEURONS

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Science China Chemistry 1990年第1期33卷 35-43页

作者：王海薇吕国蔚张炳烈李文彬 Department of neurobiology Capital Institute of Medicine Beiling 100054 PRC institute of Basical Medicine Academy of Military Medical Sciences Beijing 100850 PRC

The rat brain neurons isolated from 15—17-day embryos were grown in dissociated cell culture and maintained in vitro for 3 weeks, The developmental process of the neurons was observed from the early stage of development in terms of passive and active electrical parameters and their changes induced by perfusion of ionic channel *** neurons' development could be morphologically divided into stages Ⅰ (from seedling to 5 days), Ⅱ (7—11 days), Ⅲ (12—20 days)andlV (21—22 days). The relative values of resting membrane potentials (RMP) for stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 1, 3.46, 4.07 and 6.54, respectively; the corresponding values of input resistance (Rin) were 10 1.48, 2.53 and 4.56, respectively. The current-voltage relationship in stages Ⅱ and Ⅲ was exponential in the direction of depolarization and the Rin's change with time was nearly linear. Spontaneous activities increased with prolongation of culture and the amplitude of evoked action potentials reached the maximum during stages Ⅲ and Ⅳ. The RMP and Rin were markedly decreased by perfusion of TEA while no change was seen in TTX perfusion *** results indicate that potassium ionic channels develop slower in stages Ⅱ and Ⅳ, faster in stages Ⅰ and Ⅲ and mature by the end of stage Ⅳ.

关键词： cultured neurons development membrane electrical proper ties ionic channel blockers.

RELATIONSHIP BETWEEN THE BRAIN MONO-AMINE NEUROTRANSMITTERS AND ENDOGE-NOUS OPIOID PEPTIDES DURING INHIBITION OF DEFENCE PRESSOR RESPONSE BY INPUTS OF DEEP PERONEAL NERVE IN RABBITS

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Chinese Science Bulletin 1989年第14期34卷 1221-1225页

作者：夏萤张安中曹小定唐琴梅徐修容 Department of neurobiology Shanghai Medical University Shanghai institute of Materia Medica Academia Sinica

It has been reported that stimulation of hypothalamic defence area (HDA) led to the increased release of central NA and other monoamine neurotransmitters,

关键词： deep peroneal nerve defence reaction pressor endogenous opioid peptide monoamine neurotransmitter

Management of complex and redo cases of pelvic fracture urethral injuries

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Asian Journal of Urology 2018年第2期5卷 107-117页

作者： Sanjay BKulkarni Sandesh Surana Devang JDesai Hazem Orabi Subramanian Iyer Jyotsna Kulkarni Ajit Dumawat Pankaj M.Joshi Department of reconstructive Urology Kulkarni Reconstructive Urology CentrePuneIndia

Objectives:Pelvic fracture urethral injuries(PFUI)result from traumatic disruption of the urethra.A significant proportion of cases are complex rendering their management *** described management strategies for eight different complex PFUI ***:Our centre is a tertiary referral centre for complex PFUI *** maintain a prospective database(1995e2016),which we retrospectively *** patients with PFUI managed at our institute were ***:Over two decades 1062 cases of PFUI were managed at our institute(521 primary and 541 redo cases).Most redo cases were referred to us from other *** cases had up to five prior attempts at *** managed complex cases,which included bulbar ischemia,young boys and girls with PFUI,PFUI with double block,concomitant PFUI and iatrogenic anterior urethral *** ischemia merits substitution urethroplasty,most commonly,using pedicled preputial *** in young girls is usually associated with urethrovaginal *** boys with PFUI commonly have a long gap necessitating trans-abdominal *** success rate with individualised management is 85.60%in primary cases,79.13%in redo cases and 82.40%in cases of bulbar ***:The definition of complex PFUI is ever *** best chance of success is at the first *** urethroplasty for PFUI should be performed in experienced hands at high volume centres.

关键词： Urethral reconstruction Pelvic fracture urethral distraction defects Pelvic fracture urethral injuries Bulbar necrosis Long gap Bladder neck injury Rectourethral fistula

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation