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Sex-specific association between coffee consumption and incident chronic kidney disease: a population-based analysis of 359,906 participants from the UK Biobank

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Chinese Medical Journal 2022年第12期135卷 1414-1424页

作者： Lei Tang Lina Yang Wenwen Chen Chunyang Li Yu Zeng Huazhen Yang Yao Hu Yuanyuan Qu Huan Song Xiaoxi Zeng Ping Fu Division of Nephrology Kidney Research InstituteWest China HospitalSichuan UniversityChengduSichuan 610041China Biomedical big data Center of West China Hospital Med-X Center for InformaticsSichuan UniversityChengduSichuan 610041China Center of Pubic Health Sciences Faculty of MedicineUniversity of IcelandReykjavikIceland

Background:The risk for chronic kidney disease(CKD)is influenced by genetic predisposition,sex,and *** research indicates that coffee is a potentially protective factor in *** current study aims to investigate whether sex disparity exists in the coffee–CKD association,and whether genetic risk of CKD or genetic polymorphisms of caffeine metabolism affect this ***:A total of 359,906 participants from the UK Biobank who were enrolled between 2006 and 2010 were included in this prospective cohort study,which aimed to estimate the hazard ratios for coffee intake and incident CKD using a Cox proportional hazard *** scores of CKD and caffeine metabolism were additionally adjusted for in a subsample with qualified genetic data(n=255,343).Analyses stratified by genetic predisposition,comorbidities,and sex hormones were *** based on Bayesian model averaging were conducted to ascertain the robustness of the ***:Coffee was inversely associated with CKD in a dose-dependent *** effects of coffee did not differ across different strata of genetic risk for CKD,but were more evident among slower genetically predicted caffeine *** sex disparity was observed(P value for interaction=0.013),in that coffee drinking was only associated with the risk reduction of CKD in *** analysis revealed that testosterone and sex hormone-binding globulin(SHBG),but not estradiol,modified the coffee–CKD ***:In addition to the overall inverse coffee–CKD association that was observed in the general population,we could also establish that a sex disparity existed,in that females were more likely to experience the benefit of the *** and SHBG may partly account for the sex disparity.

关键词： Coffee Chronic kidney diseases Genotype Sex

A hyperspectral unmixing approach for ink mismatch detection in unbalanced clusters

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Journal of Information and Intelligence 2024年第2期2卷 177-190页

作者： Faryal Aurooj Nasir Salman Liaquat Khurram Khurshid Nor Muzlifah Mahyuddin Department of Electrical Engineering Institute of Space TechnologyIslamabad 44000Pakistan School of Electrical and Electronic Engineering Universiti Sains MalaysiaPenang 14300Malaysia

Detecting ink mismatch is a significant challenge in verifying the authenticity of documents,especially when dealing with uneven ink *** imaging methods frequently fail to distinguish visually similar *** study presents a novel hyperspectral unmixing approach to detect ink mismatches in unbalanced *** proposed method identifies unique spectral characteristics of different inks employing k-means clustering and Gaussian mixture models(GMMs)to perform color segmentation on different ink types and utilizes elbow estimation and silhouette coefficient to evaluate the number of inks estimation *** a more accurate estimation of quantity,which is generally not an attribute of clustering methods,we employed entropy calculations in the red,green,and blue depth channels for precise abundance estimation of *** unique combination of basic techniques in conjunction exhibits better efficacy in performing ink unmixing and provides a real-world document forensic solution compared to current methods that rely on assumptions like prior knowledge of the inks used in a document and deep learning-based methods that rely heavily on abundant training *** evaluate our approach on the ivision handwritten hyperspectral images dataset(iVision HHID),which is a comprehensive and rich dataset that surpasses the commonly-used UWA writing inks hyperspectral images(WIHSI)database in size and *** study has accomplished the unmixing task with three main challenges:unmixing of diverse ink spectral signatures(149 spectral bands instead of 33 bands in the previous dataset),without using prior knowledge and assumptions about the number of inks used in the questioned document,and not requiring large training data for performing ***,the security of the proposed document authentication methodology to address the likelihood of forgeries or manipulations in questioned documents is enhanced as compared to previous works relyin

关键词： k-means clustering Gaussian mixture model(GMM) Hyper spectral imaging(HSI) iVision handwritten hyperspectral images dataset(HHID) Document forensics

Overcoming the biofilm barrier by cell-like microbubbles for the treatment of biofilm-associated implant infections

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Biomedical Engineering Communications 2024年第2期3卷 1-3页

作者： Yan-Ling Hu Jin-Gai Jiang Hui-Juan Cheng Wei Shi Yan-Ni Song Min Zhang Dong-Liang Yang College of Life and Health Nanjing Polytechnic InstituteNanjing 210048China Hangzhou Huasu Industry Co. Ltd.Hangzhou 310012China Key Laboratory of Flexible Electronics(KLOFE)and institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(NanjingTech)Nanjing 211816China

Although the advent of antibiotics has significantly improved the quality of life of infected patients,bacterial infections continue to pose a serious threat to public health[1,2].According to a recent report,within the next 30 years,bacterial infections are projected to surpass cancer in terms of lethality rates,resulting in an alarming 10 million deaths annually by 2050 due to the development of bacterial resistance[3].Moreover,the formation of bacterial biofilms hampers the penetration of antibacterial agents and inhibits the host immune response,making biofilm infections extremely challenging to treat[4-7].Hence,the development of innovative antimicrobial biofilm therapeutics is imperative.

关键词： infections annually treatment

Potential Effects of Desalinated Seawater on Arteriosclerosis in Rats

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Biomedical and Environmental Sciences 2017年第10期30卷 762-766页

作者： DUAN Lian ZHANG Li Xia ZHANG Shao Ping KONG Jian ZHI Hong ZHANG Ming LU Kai ZHANG Hong Wei Department of Toxicology Institute for Environmental Health and Related Product SafetyChinese Center for Disease Control and PreventionBeijing 100021China Chinese Center for Disease Control and Prevention Beijing 102206China

To evaluate the potential risk of arteriosclerosis caused by desalinated seawater, Wistar rats were provided desalinated seawater over a 1-year period, and blood samples were collected at 0, 90, 180, and 360 days. Blood calcium, magnesium, and arteriosclerosis-related indicators were investigated. Female rats treated with desalinated seawater for 180 days showed lower magnesium levels than the control rats （P 〈 0.05）. The calcium and magnesium levels in female rats and the magnesium level in male rats were lower than the levels in the controls, following treatment with desalinated seawater for 360 days （P 〈 0.05）. Blood levels of arteriosclerosis-related lipid peroxidation indicators and C-reactive protein （CRP） in the treatment group did not differ from those in the controls. The levels of lipid peroxidation indicators and CRP in rats were not significantly affected by drinking desalinated seawater, and no increase in risk of arteriosclerosis was observed.

关键词： Desalinated seawater Lipid peroxidation CRP Arteriosclerosis

How Work Organization Affects the Prevalence of WMSDs: A Case-control Study

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Biomedical and Environmental Sciences 2015年第9期28卷 627-633页

作者： LIU Lu CHEN Song Gen TANG Shi Chuan WANG Sheng HE Li Hua GUO Ze Hua LI Jing Yun YU Shan Fa WANG Zhong Xu Department of Occupational and Environmental Health Science Peking University School of Public Health Foshan institute of Occupational Disease Prevention and Control Beijing Key Laboratory of Occupational Health and safety Beijing Municipal Institute of Labour Protection Beijing institute of Occupational Medicine for Chemical Industry Henan Provincial institute for Occupational Health Department of Occupational Health Protection Institute for Occupational Health and Poison ControlChinese Center of Disease Control and Prevention

Objective In this study, we aimed at exploring the association between work-related musculoskeletal disorders（WMSDs） and work organization based on a case-control study. Methods A total of 1938 workers who claimed to suffer from WMSDs were selected from Beijing, Henan, Hubei, and the Guangdong province. The control group consisted of 2009 workers employed in similar industries without severe disease or musculoskeletal discomforts. We used a modified version of the questionnaire developed by the NMQ and the DMQ to investigate individual and work-related factors. Results A total of 13 variables（P〈0.1） were selected by the chi-square test and finally, 7 variables entered into the equation, with 6 variables reaching statistical significance（P〈0.05）. The odds ratios（OR） of ＇work changing with season＇ and ＇sufficient rest time＇ did not reach 1（0.749 and 0.441, respectively）. In addition, ＇sufficient rest time＇ seemed to be the stronger protective factor according to its higher standardized coefficient. And ＇repetitive work every minute＇, ＇constantly repetitive work＇（every day）, ＇shortage of site personnel＇, and ＇often switching shifts with others＇ seemed to be the risk factors. Conclusion Work organization may have comprehensive effects on the occurrence of WMSDs. This pattern of associations suggests that further investigation into the mechanism of how work organization affects the prevalence of WMSDs is required.

关键词： WMSDs Work organization Case-control study Prevalence Risk factors

Multinational corporations and infectious disease: Embracing human rights management techniques

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Infectious Diseases of Poverty 2014年第1期3卷 354-366,353页

作者： Kendyl Salcito Burton H Singer Mitchell G Weiss Mirko S Winkler Gary R Krieger Mark Wielga Jürg Utzinger Department of Epidemiology and public Health Swiss Tropical and Public Health InstituteP.O.BoxCH-4002BaselSwitzerland University of Basel P.O.BoxCH-4003BaselSwitzerland NomoGaia 1900 Wazee StreetSuite 303DenverCO 80202USA NewFields LLCDenverCO 80202USA Emerging Pathogens institute University of FloridaGainesvilleFL 32610USA

Background:Global health institutions have called for governments,international organisations and health practitioners to employ a human rights-based approach to infectious *** motivation for a human rights approach is clear:poverty and inequality create conditions for infectious diseases to thrive,and the diseases,in turn,interact with social-ecological systems to promulgate poverty,inequity and *** and intergovernmental organisations should be concerned with the control and elimination of these diseases,as widespread infections delay economic growth and contribute to higher healthcare costs and slower processes for realising universal human *** social determinants and economic outcomes associated with infectious diseases should interest multinational companies,partly because they have bearing on corporate productivity and,increasingly,because new global norms impose on companies a responsibility to respect human rights,including the right to ***:We reviewed historical and recent developments at the interface of infectious diseases,human rights and multinational *** investigation was supplemented with field-level insights at corporate capital projects that were developed in areas of high endemicity of infectious diseases,which embraced rights-based disease control ***:Experience and literature provide a longstanding business case and an emerging social responsibility case for corporations to apply a human rights approach to health programmes at global ***,in an increasingly globalised and interconnected world,multinational corporations have an interest,and an important role to play,in advancing rights-based control strategies for infectious ***:There are new opportunities for governments and international health agencies to enlist corporate business actors in disease control and elimination *** offered by the United Nations in 2011 that is widel

关键词： Infectious diseases Human rights Systems-based interventions Multinational corporations Corporate social responsibility

Parallel Planning:A New Motion Planning Framework for Autonomous Driving

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IEEE/CAA Journal of Automatica Sinica 2019年第1期6卷 236-246页

作者： Long Chen Xuemin Hu Wei Tian Hong Wang Dongpu Cao Fei-Yue Wang IEEE School of data and Computer Science Sun Yat-sen University the School of Computer Science and Information Engineering Hubei University institute of Measurement and Control Systems Karlsruhe Institute of Technology Department of Mechanical and Mechatronics Engineering University of Waterloo the State Key Laboratory of Management and Control for Complex Systems.institute of Automation Chinese Academy of Sciences the Research Center for Military Computational Experiments and Parallel Systems Technology National University of Defense Technology

Motion planning is one of the most significant technologies for autonomous driving. To make motion planning models able to learn from the environment and to deal with emergency situations, a new motion planning framework called as"parallel planning" is proposed in this paper. In order to generate sufficient and various training samples, artificial traffic scenes are firstly constructed based on the knowledge from the reality.A deep planning model which combines a convolutional neural network(CNN) with the Long Short-Term Memory module(LSTM) is developed to make planning decisions in an end-toend mode. This model can learn from both real and artificial traffic scenes and imitate the driving style of human ***, a parallel deep reinforcement learning approach is also presented to improve the robustness of planning model and reduce the error rate. To handle emergency situations, a hybrid generative model including a variational auto-encoder(VAE) and a generative adversarial network(GAN) is utilized to learn from virtual emergencies generated in artificial traffic scenes. While an autonomous vehicle is moving, the hybrid generative model generates multiple video clips in parallel, which correspond to different potential emergency scenarios. Simultaneously, the deep planning model makes planning decisions for both virtual and current real scenes. The final planning decision is determined by analysis of real observations. Leveraging the parallel planning approach, the planner is able to make rational decisions without heavy calculation burden when an emergency occurs.

关键词： Autonomous driving artificial traffic scene deep learning emergencies motion planning parallel planning

Trends of autoimmune liver disease inpatient hospitalization and mortality from 2011 to 2017:A United States nationwide analysis

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World Journal of Hepatology 2024年第7期16卷 1029-1038页

作者： Ali Wakil Yasameen Muzahim Mina Awadallah Vikash Kumar Natale Mazzaferro Patricia Greenberg Nikolaos Pyrsopoulos Department of Gastroenterology and Hepatology The Brooklyn Hospital CenterBrooklynNY 11201United States Department of Gastroenterology and Hepatology University of Iowa Hospitals and ClinicsIowa CityIA 52242United States Department of Gastroenterology and Hepatology Rutgers the New Jersey Medical SchoolNewarkNJ 07103United States Department of Biostatistics and Epidemiology Rutgers School of Public HealthPiscatawayNJ 08854United States

BACKGROUND Autoimmune liver diseases(AiLD)encompass a variety of disorders that target either the liver cells(autoimmune hepatitis,AIH)or the bile ducts[primary biliary cholangitis(PBC),and primary sclerosing cholangitis(PSC)].These conditions can progress to chronic liver disease(CLD),which is characterized by fibrosis,cirrhosis,and hepatocellular *** studies have indicated a rise in hospitalizations and associated costs for CLD in the US,but information regarding inpatient admissions specifically for AiLD remains *** To examine the trends and mortality of inpatient hospitalization of AiLD from 2011 to *** This study is a retrospective analysis utilizing the National Inpatient Sample(NIS)*** subjects admitted between 2011 and 2017 with a diagnosis of AiLD(AIH,PBC,PSC)were identified using the International Classification of Diseases(ICD-9)and ICD-10 *** AiLD admission was defined if the first admission code was one of the AiLD *** AiLD admission was defined as having the AiLD diagnosis anywhere in the admission diagnosis(25 diagnoses).Subjects aged 21 years and older were *** national estimates of hospitalization were derived using sample weights provided by NIS.χ^(2)tests for categorical data were *** primary trend characteristics were in-hospital mortality,hospital charges,and length of *** From 2011 to 2017,hospitalization rates witnessed a significant decline,dropping from 83263 admissions to 74850 admissions(P65),mostly female(median 59%)(Pbig teaching institutions(median 63%)(P<0.05).Total charges for admissions rose from 66031 in 2011

关键词： Autoimmune hepatitis Autoimmune liver disease Epidemiology Cost-Effective care Admissions trend Mortality rate

A Modeling Study of Diurnal Rainfall Variations during the 21-Day Period of TOGA COARE

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Advances in Atmospheric Sciences 2009年第5期26卷 895-905页

作者：高守亭崔晓鹏 Xiaofan LI Laboratory of Cloud-Precipitation Physics and Severe Storms （ LACS） Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 Joint Center for Satellite data Assimilation and NOAA/NESDIS/Center for Satellite Applications and Research Camp Springs Maryland USA

The surface rainfall processes and diurnal variations associated with tropical oceanic convection are examined by analyzing a surface rainfall equation and thermal budget based on hourly zonal-mean data from a series of two-dimensional cloud-resolving simulations. The model is integrated for 21 days with imposed large-scale vertical velocity, zonal wind, and horizontal advection obtained from the Tropical Ocean Global Atmosphere Coupled Ocean-Atmosphere Response Experiment （TOGA COARE） in the control experiment. Diurnal analysis shows that the infrared radiative cooling after sunset, as well as the advective cooling associated with imposed large-scale ascending motion, destabilize the atmosphere and release convective available potential energy to energize nocturnal convective development. Substantial local atmospheric drying is associated with the nocturnal rainfall peak in early morning, which is a result of the large condensation and deposition rates in the vapor budget. Sensitivity experiments show that diurnal variations of radiation and large-scale forcing can produce a nocturnal rainfall peak through infrared and advective cooling, respectively.

关键词： diurnal rainfall variation cloud-resolving simulation tropical oceanic convection TOGACOARE