Tungstophosphoric acid catalyzed synthesis of N-sulfonyl-1,2,3,4-tetrahydroisoquinoline analogs

作     者：Ratchanok Pingaew Supaluk Prachayasittikul Somsak Ruchirawat Virapong Prachayasittikul 

作者机构：Department of ChemistryFaculty of ScienceSrinakharinwirot University Center of Data Mining and Biomedical InformaticsFaculty of Medical TechnologyMahidol University Chulabhorn Research Institute Chulabhorn Graduate Institute and Center of Excellence on Environmental Health and Toxicology (EHT) Department of Clinical Microbiology and Applied TechnologyFaculty of Medical TechnologyMahidol University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2013年第24卷第10期

页      面：941-944页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the research grant from Srinakharinwirot University(B.E.2555) supported by Offce of the Higher Education Commission Mahidol University under the National Research Universities Initiative 

主　　题：Pictet Spengler reaction Isoquinoline Heteropoly acid Sulfonamide 

摘      要：An operationally simple and eco-friendly protocol has been developed for the synthesis of N-sulfonyl- 1,2,3,4-tetrahydroisoquinolines 3 using the modified Pictet-Spengler reaction of N-sulfonylphenylethy- lamines 1 and various aldehydes 2 in the presence of tungstophosphoric acid hydrate.