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Signal Transduction and Targeted Therapy 2024年第5期9卷 1793-1795页

作者： Tobias Langenhan Rudolf Schönheimer institute of Biochemistry Division of General BiochemistryMedical FacultyLeipzig UniversityLeipzigGermany Comprehensive Cancer Center Central Germany(CCCG) Leipzig UniversityLeipzigGermany institute of Biology Faculty of Life SciencesLeipzig UniversityLeipzigGermany

A recent report has uncovered a fascinating aspect of how neurons utilize alternative splicing of transcripts of an adhesion G protein-coupled receptor(aGPCR)gene to serve specific functions in the life of a synapse.1 The work provides significant insight into the ability of cells to support distinct biochemical and physiological operations through post-transcriptional processing of genetic information that is encoded in a single aGPCR locus.

关键词： GPCR utilize operations

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani Joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany institute of Human Genetics Leipzig University Medical CenterLeipzigGermany institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

Removal of endocrine disrupting chemicals from water through urethane functionalization of microfiltration membranes via electron beam irradiation

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 61-74页

作者： Zahra Niavarani Daniel Breite Muhammad Yasir Vladimir Sedlarik Andrea Prager Nadja Schönherr Bernd Abel Roger Gläser Agnes Schulze Leibniz institute of Surface Engineering eV.(IOM) Permoserstrasse 1504318 LeipzigGermany Centre of Polymer Systems University InstituteTomas Bata University in ZlinTrida Tomase Bati 567876001 ZlinCzech Republic institute of Chemical Technology Leipzig UniversityLinnestrasse 304103 LeipzigGermany

Polyethersulphone(PES)membranes modified with urethane functional groups were prepared through an interfacial reaction using electron beam *** removal of eight endocrine disrupting chemicals(EDCs)was studied using both pristine and functionalized PES *** prepared membranes underwent characterization using several techniques,including attenuated total reflectance-Fourier transform infrared(ATR-FTIR)spectroscopy,scanning electron microscopy,contact angle analysis,and measurements of pure water ***,dynamic adsorption experiments were conducted to evaluate the adsorption mechanism of the prepared membrane toward the eight *** urethane functionalized membranes were hydrophilic(52°contact angle)and maintained a high permeate flux(26000 L/h m^(2) bar)throughout the filtration *** adsorption results demonstrated that the introduction of urethane functional groups on the membranes significantly enhanced the removal efficiency of 17β-estradiol,estriol,bisphenol A,estrone,ethinylestradiol,and *** adsorption loading of 17β-estradiol on the functionalized PES membrane was 6.7±0.7 mg/m^(2),exhibiting a 5-fold increase compared to the unmodified PES *** membranes were successfully regenerated and reused for three adsorption cycles without experiencing any loss of adsorption capacity.

关键词： Surface functionalization Electron beam irradiation Microfiltration Endocrine disrupting chemicals

Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2349-2357页

作者： Rabea Voget Julian Breidenbach Tobias Claff Alexandra Hingst Katharina Sylvester Christian Steinebach Lan Phuong Vu Renato H.Weiße Ulrike Bartz Norbert Sträter Christa E.Müller Michael Gütschow Pharmaceutical institute Pharmaceutical&Medicinal ChemistryUniversity of BonnBonn 53121Germany institute of Bioanalytical Chemistry Center for Biotechnology and BiomedicineLeipzig UniversityLeipzig 04103Germany Department of Natural Sciences University of Applied Sciences Bonn-Rhein-SiegRheinbach 53359Germany

A titrant for the SARS-CoV-2 main protease(M^(pro))was developed that enables,for the first time,the exact determination of the concentration of the enzymatically active M^(pro) by active-site *** covalent binding mode of the tetrapeptidic titrant was elucidated by the determination of the crystal structure of the enzyme–titrant *** fluorogenic substrates of M^(pro),including a prototypical,internally quenched Dabcyl-EDANS peptide,were compared in terms of solubility under typical assay *** exploiting the new titrant,key kinetic parameters for the M^(pro)-catalyzed cleavage of these substrates were determined.

关键词： COVID-19 SARS-CoV-2 Main protease Peptide nitriles Fluorogenic substrates Active-site titration X-ray crystallography Inner filter effect

Prefrontocortical Astrocytes Regulate Dominance Hierarchy in Male Mice

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Neuroscience Bulletin 2024年第3期40卷 415-417页

作者： Yong Tang Hai-Yan Yin Peter Illes School of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu 610075China International Joint Research Center on Purinergic Signaling Chengdu University of Traditional Chinese MedicineChengdu 610075China Rudolf Boehm institute for Pharmacology and Toxicology University of Leipzig04107 LeipzigGermany

Social hierarchy is a general self-organizational scheme in animal societies in which each member achieves a certain status of domination or subordination when getting access to resources,with profound consequences for survival,health,reproductive success,and multiple behaviors[1,2].The prefrontal cortex(PFC)was recognized as a central regulator of neuronal circuits determining the formation of social hierarchy;brain areas upstream of the PFC convey information about social status,and downstream brain regions execute dominance behavior[3].Social deficits have been suggested to be due to an elevation of excitatory/inhibitory(E/l)balance within the mouse dorsomedial(dm)PFC[4].A compensatory increase of inhibitory cell excitability partially rescued social deficits caused by such a disturbance of E/l balance.

关键词： consequences hierarchy determining

PVR update:pathophysiology and clinical management

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1577-1580页

作者： Peter Wiedemann Yan-Nian Hui Medical Faculty Leipzig UniversityLeipzig 04103Germany Department of Ophthalmology Eye Institute of Chinese PLAXijing HospitalFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

Wound-healing diseases present complex challenges,and proliferative vitreoretinopathy(PVR)has been a problem in the surgical retina for *** is a prolonged and abnormal healing response to retinal injury,such as primary retinal detachment(RD)or post-RD surgery,characterized by the formation of pre/subretinal membranes,retinal gliosis and shortening,retinal pigment epithelium cell(RPE)proliferation,and increased activity of glial cells(mainly Müller cells).

关键词： healing epithelium diseases

Tighter sum uncertainty relations via(α,β,γ)weighted Wigner–Yanase–Dyson skew information

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Communications in Theoretical Physics 2024年第3期76卷 91-99页

作者： Cong Xu Zhaoqi Wu Shao-Ming Fei School of Mathematical Sciences Capital Normal UniversityBeijing 100048China Department of Mathematics Nanchang UniversityNanchang 330031China Max-Planck-institute for Mathematics in the Sciences 04103 LeipzigGermany

We establish tighter uncertainty relations for arbitrary finite observables via(α,β,γ)weighted Wigner–Yanase–Dyson((α,β,γ)WWYD)skew *** results are also applicable to the(α,γ)weighted Wigner–Yanase–Dyson((α,γ)WWYD)skew information and the weighted Wigner–Yanase–Dyson(WWYD)skew *** also present tighter lower bounds for quantum channels and unitary channels via(α,β,γ)modified weighted Wigner–Yanase–Dyson((α,β,γ)MWWYD)skew *** examples are provided to illustrate the tightness of our uncertainty relations.

关键词： quantum channels (α,β,γ)WWYD skew information (α,β,γ)MWWYD skew information uncertainty relations

Global assessment of terrestrial productivity in response to water stress

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Science Bulletin 2024年第15期69卷 2352-2356页

作者： Qi Liu Huadong Guo Jiahua Zhang Shijie Li Ji Li Fengmei Yao Miguel D.Mahecha Jian Peng School of Computer Engineering Jiangsu University of TechnologyChangzhou 213001China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 101408China Department of Remote Sensing Helmholtz Centre for Environmental ResearchUFZLeipzig 04318Germany Remote Sensing Centre for Earth System Research Leipzig UniversityLeipzig 04103Germany Aerospace Information Research institute Chinese Academy of SciencesBeijing 100094China Remote Sensing and Digital Earth Center School of Computer Science and TechnologyQingdao UniversityQingdao 266071China Key Laboratory of Earth Observation of Hainan Province Hainan Aerospace Information Research InstituteChinese Academy of SciencesSanya 572000China School of Geographical Sciences Nanjing University of Information Science and TechnologyNanjing 210044China Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China German Centre for Integrative Biodiversity Research(iDiv) Halle-Jena-Leipzig 04103Germany

In recent decades, climate warming has led to an increase in atmospheric water demand, a potential reduction in soil moisture and a rise in the frequency and intensity of droughts. This has intensified the effects of water stress on plants, leading to more vegetated areas experiencing water stress [1,2]. Soil moisture (SM)and vapor pressure deficit (VPD) are considered the two main factors that exert water stress on vegetation activity and terrestrial productivity, thereby affecting the global carbon cycle [3].

关键词： soil moisture terrestrial

Bone marrow microRNA-34a is a good indicator for response to treatment in acute myeloid leukemia

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Oncology Research 2024年第3期32卷 577-584页

作者： MONA SA BDELLATEIF NAGLAA MHASSAN MAHMOUD MKAMEL YOMNA MEL-MELIGUI Department of Cancer Biology Medical Biochemistry and Molecular BiologyNational Cancer InstituteCairo UniversityCairo11976Egypt Department of Cinical pathology National Cancer InstituteCairo UniversityCairo11976Egypt

Background:microRNA 34a(miR 34a)had been reported to have a diagnostic role in acute myeloid leukemia(AML).However,its value in the bone marrow(BM)of AML patients,in addition to its role in response to therapy is still *** current study was designed to assess the diagnostic,prognostic,and predictive significance of miR 34a in the BM of AML ***:The miR.34a was assed in BM aspirate of 82 AML patients in relation to 12 normal control subjects using *** data were assessed for correlation with the relevant dinical critenia,response to therapy,disease-free survival(DFS),and overall survival(OS)***:miR.34a was significantly downregulated in AML patients[0.005(3.3×10^(-6)-1.32)],compared to the control subjects[0.108(3.2× 10^(-4)-1.64),p=0.021].*** relative quantification(RQ)of miR-34a was 0.106(range;0-32.12).The specifaity,sensitivity,and area under the curve(AUC)for the diagnosis of AML were(58.3%,69.5%,0.707,respectively,p=0.021).patients with upregulated miR-34a showed decreased platelets count<34.5 × 10^(9)/L,and achieved early complete remission(CR,p=0.031,p=0.044,respectively).Similarly,patients who were refractory to therapy showed decreased miR 34a levels in comparison to those who achieved CR[0.002(0-0.01)and 0.12(0-32.12),respectively,p=0.002].Therefore,miR 34a could significantly identify patients with CR with a specificity of 75%and sensitivity of 100%at a cut-off of 0.014(AUC=0.927,p=0.005).There was no considerable association between miR-34a expression and survival rates of the induded AML ***:miR-34a could be a beneficial diagnostic biomarker for AML *** addition,it serves as a good indicator for response to therapy,which could possibly identify patients who are refractory to treatment with 100%sensitivity and 75%specificity.

关键词： AML miR 34a microRNA Leukemia

A strategy for mechanically integrating robust hydrogeltissue hybrid to promote the anti-calcification and endothelialization of bioprosthetic heart valve

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Regenerative Biomaterials 2024年第2期3卷 123-136页

作者： Haoshuang Wu Nuoya Chen Tiantian Zheng Li Li Mengyue Hu Yumei Qin Gaoyang Guo Li Yang Yunbing Wang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China institute of Clinical pathology West China Hospital of Sichuan UniversityChengdu 610041China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065China

Bioprosthetic heart valve(BHV)replacement has been the predo-minant treatment for severe heart valve diseases over *** clinically available BHVs are crosslinked by glutaraldehyde(GLUT),while the high toxicity of residual GLUT could initiate calcification,severe thrombosis,and delayed ***,we construed a mechanically integrating robust hydrogel-tissue hybrid to improve the performance of *** particular,recombinant humanized coilagen type Ⅲ(rhCOLⅢ),which was precisely customized with anti-coagulant and pro-endothelialization bioactivity,was first incorporated into the polyvinyl alcohol(PVA)-based hydrogel via hydrogen bond ***,tannic acid was introduced to enhance the mechanicalperfo of PVA-based hvdrogel and interfacial bonding between the hydrogel layer and bio-derived tissue due to the strong affinity for a wide range of *** vitro and in vivo experimental results confirmed that the GLUT-crosslinked BHVs modified by the robust PVA-based hydrogel embedded rhCOLII and TA possessed long-term anti-coagulant,accelerated endothelialization,mild inflammatory response and anti-calcification ***,our mechanically integrating robust hydrogel-tissue hybrid strategy showed the potential to enhance the service function and prolong the service life of the BHVs after implantation.

关键词： bioprosthetic heart valves recombinant humanized collagen typeⅢ endothelialization anti-calcification anti-coagulation