Lymph node metastatic patterns of gastric carcinoma with a combination of adenocarcinoma and neuroendocrine carcinoma components
作者机构：Department of Gastrointestinal SurgeryPeking University Cancer Hospital and InstituteBeijing 100142China Department of PathologyKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijing 100142China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文))
年 卷 期：2025年第31卷第8期
页 面：24-37页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by the National Key Research and Development Program of China,No.2023YFF1204702 the National Natural Science Foundation of China,No.82173151 Capital’s Funds for Health Improvement and Research,No.CFH 2022-4-1025 Beijing Hospitals Authority Clinical Medicine Development of Special Funding,No.XMLX202119 Science Foundation of Peking University Cancer Hospital,No.PY202329
主 题：Gastric mixed-adenoneuroendocrine carcinoma Lymph node metastatic patteren Clinicopathological features Adjuvant chemotherapy regimens Prognosis
摘 要：BACKGROUND Gastric mixed-adenoneuroendocrine carcinoma(G-MANEC)is a subtype of gastric *** upon prior research findings,we propose that tumours containing both neuroendocrine carcinoma(NEC)and adenocarcinoma(AC)components,with each component ranging from 1%to 99%of the tumour,be classified as a distinct *** hereby term this adenoneuroendocrine mixed gastric cancer(G-ANEC).Research on lymph node(LN)involvement in GMANEC has focused mainly on metastasis status,with limited studies on metastatic *** To investigate the LN metastasis patterns of G-ANEC,the clinicopathological features associated with these metastasis patterns,and to explore adjuvant chemotherapy regimens for *** We analyzed 68 G-ANEC cases treated with radical surgery and confirmed LN metastasis at Peking University Cancer Hospital between August 2012 and June ***χ2 tests in IBM statistical product and service solutions statistics and R *** We identified three distinct LN metastasis patterns in G-ANEC that were significantly associated with the NEC proportion,tumour invasion depth,Lauren classification,and tumour location(P values:0.008,0.015,0.01,and 0.004,respectively).When the SOX/XELOX regimen was applied for adjuvant chemotherapy,patients with LN metastasis comprising only AC exhibited better overall survival(OS)(94.25±11.07 months vs 54.36±11.36 months)than did those with *** LN metastasis components contained NEC,there was a trend towards improved OS(64±10.77 months vs 54.35±11.36 months)and disease-free survival(71.28±9.92 months vs 66.28±11.93 months)in patients treated with the etoposide and cisplatin compared to those receiving the SOX/XELOX *** We found a significant correlation between the NEC percentage,tumour invasion depth,Lauren classification,and tumour location and LN metastasis patterns in *** G-ANEC,a lower proportion of NEC or AC in the primary lesion does not preclude the possibility of thes
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