检索结果-南通市图书馆

Hyperuricemia and its related diseases:mechanisms and advances in therapy

Signal Transduction and Targeted Therapy 2024年第9期9卷 3985-4013页

作者： Lin Du Yao Zong Haorui Li Qiyue Wang Lei Xie Bo Yang Yidan Pang Changqing Zhang Zhigang Zhong Junjie Gao sports medicine Center The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041China institute of sports medicine Shantou University Medical CollegeShantou 515041China Centre for Orthopaedic Research Medical SchoolThe University of Western AustraliaNedlandsWA 6009Australia Department of orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

Hyperuricemia,characterized by elevated levels of serum uric acid(SUA),is linked to a spectrum of commodities such as gout,cardiovascular diseases,renal disorders,metabolic syndrome,and diabetes,*** impairing the quality of life for those affected,the prevalence of hyperuricemia is an upward trend globally,especially in most developed *** possesses a multifaceted role,such as antioxidant,pro-oxidative,pro-inflammatory,nitric oxide modulating,anti-aging,and immune effects,which are significant in both physiological and pathological *** equilibrium of circulating urate levels hinges on the interplay between production and excretion,a delicate balance orchestrated by urate transporter functions across various epithelial tissues and cell *** existing research has identified hyperuricemia involvement in numerous biological processes and signaling pathways,the precise mechanisms connecting elevated UA levels to disease etiology remain to be fully *** addition,the influence of genetic susceptibilities and environmental determinants on hyperuricemia calls for a detailed and nuanced *** review compiles data from global epidemiological studies and clinical practices,exploring the physiological processes and the genetic foundations of urate transporters in ***,we uncover the complex mechanisms by which the UA induced inflammation influences metabolic processes in individuals with hyperuricemia and the association with its relative disease,offering a foundation for innovative therapeutic approaches and advanced pharmacological strategies.

关键词： mechanisms elevated connecting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PM_(2.5):A barrier to fitness and health promotion in China

引用

Journal of Sport and Health Science 2017年第3期6卷 292-294页

作者： Jincheng Xu Can Gao Jason Kai Wei Lee Jiexiu Zhao Sport Biological Center China Institute of Sport Science sports Hospital National Institute of Sports Medicine Yong Loo Lin School of medicine National University of Singapore

*** Physical inactivity has been identified as the fourth leading risk factor for global mortality.~1Globally,it accounts for about6%of deaths,21%–25%of breast and colon cancers,27%of diabetes,and 30%of ischemic heart disease.~1In China,the economic costs of health diseases due to physical inactivity had reached 6.7 billion US dollars in 2007,which accounted

关键词： PM A barrier to fitness and health promotion in China SDG

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integrative transcriptome analysis identifies MYBL2 as a poor prognosis marker for osteosarcoma and a pan-cancer marker of immune infiltration

引用

Genes & Diseases 2024年第3期11卷 351-367页

作者： Xinzhu Quiu Hongbo He Hao Zeng Xiaopeng Tongg Can Zhang Yupeng Liu Zhan Liao Qing Liu Department of orthopaedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalChangshaHunan 410008China Department of sports medicine Research Center of Sports MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China

MYBL2(MYB proto-oncogene like 2)is an emerging prognostic marker for malignant tumors,and its potential role in osteosarcoma and its relationship with immune infiltration in pan-cancer is yet to be *** constructed a transcription factor activity profile of os-teosarcoma using the single-cell regulatory network inference algorithm based on single-cell RNA sequencing data obtained from the Gene Expression ***,we calcu-lated the extent of MYBL2 activation in malignant proliferative *** also explored the association between MYBL2 and chemotherapy resistance in ***,we systematically correlated MYBL2 with immunological signatures in the tumor microenviron-ment in pan-cancer,including immune cell infiltration,immune checkpoints,and tumor immu-notherapy ***,we developed and validated a risk score(MRGS),derived an osteosarcoma risk score nomogram based on MRGS,and tested its ability to predict ***2 and gene enrichment analyses in osteosarcoma and pan-cancer revealed that MYBL2 was positively correlated with cell proliferation and tumor immune ***2 expres-sion positively correlated with SLC19A1 in pan-cancer and osteosarcoma cell ***-cancer immune infiltration analysis revealed that MYBL2 was correlated with myeloid-derived sup-pressor cells,Th2 cell infiltration,CD276,RELT gene expression,and tumor mutation burden.

关键词： Biomarker Immunecheckpoint MYBL2 Osteosarcoma Pan-cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Chronic Noise Exposure on Expression of N-Methyl-D-Aspartic Acid Receptor 2B and Tau Phosphorylation in Hippocampus of Rats

引用

Biomedical and Environmental Sciences 2013年第3期26卷 163-168页

作者： CUI Bo WU Ming Quan ZHU Li Xing SHE Xiao Jun MA Qiang LIU Hong Tao Department of Occupational Hygiene Institute of Health and Environmental MedicineAcademy of Military Medical Sciences Tianjin College of sports

Objective To study the effect of chronic noise exposure on expression of N-methyI-D-aspartic acid receptor 2B （NR2B） and tau phosphorylation in hippocampus of rats. Methods Twenty-four male SD rats were divided in control group and chronic noise exposure group. NR2B expression and tau phosphorylation in hippocampus of rats were detected after chronic noise exposure （100 dB SPL white noise, 4 h/dx30d） and their mechanisms underlying neuronal apoptosis in hippocampus of rats with TUNEL staining. Results The NR2B expression decreased significantly after chronic noise exposure which resulted in tau hyperphosphorylation and neural apoptosis in hippocampus of rats. Immunohistochemistry showed that the tau hyperphosphorylation was most prominent in dentate gyrus （DG） and CA1 region of rat hippocampus. Conclusion The abnormality of neurotransmitter system, especially Glu and NR2B containing NMDA receptor, and tau hyperphosphorylation in hippocampus of rats, may play a role in chronic noise-induced neural apoptosis and cognition impairment.

关键词： Noise N-methyI-D-aspartic acid receptor 2B subunit Tau hyperphosphorylation Apoptosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Functional Outcomes of Limb Salvage Surgery in Patients with Giant Cell Tumor of Bone of the Lower Extremities: A Retrospective Study

引用

Journal of Oncology Research 2021年第2期3卷 60-69页

作者： Daniela Kristina D.Carolino Edwin Joseph R.Guerzon Richard S.Rotor institute of orthopaedics and sports medicine St.Luke’s Medical CenterPhilippines

Giant cell tumor of the bone(GCTB)is a benign,locally aggressive neoplasm that is relatively rare,with a propensity to result in progressive bone destruction,and is associated with a high risk of *** is no widely held consensus regarding its ideal ***,there are varying techniques ranging from intralesional curettage to resection of the lesion,supplemented with combinations of numerous adjuncts and fillers,depending on the resected amount and integrity of bone,as well as the preference of the *** was a cross-sectional study that included 20 patients who underwent limb salvage surgery for giant cell tumor of the bone of the lower extremities from January 2009 to February 2020 at two tertiary *** mean follow-up period was 37.3 months(SD=2.84).The extended curettage(EC)group had a mean Musculoskeletal Tumor Rating Scale(MSTS)score of 28.18(SD=7.51)which is considered as an excellent outcome,while the resection(RS)group had an mean MSTS score of 19.67(SD=11.02),which is considered as a good *** resulted to a total of eight complications(47%),while RS had one complication(33%).Prevalence of recurrence was noted to be 11.75%among those who underwent EC,while no recurrence was noted among those in the RS *** of bone cement as a filler was noted to have less recurrence as compared with the use of bone grafts,however were both were noted to result in excellent functional *** the prevalence of complications and recurrence of GCTB of the salvaged extremity in those who underwent EC,there is still report of excellent *** is hence important to disclose all these possible outcomes and to stress the importance of compliance to follow-up for monitoring of these events.

关键词： Giant cell tumor Functional outcomes Complications Recurrence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of exercise on markers of B cell-related immunity:A systematic review

引用

Journal of Sport and Health Science 2024年第3期13卷 339-352,I0002页

作者： David Walzik Sergen Belen Karen Wilisch Marie Kupjetz Silvana Kirschke Tobias Esser Niklas Joisten Alexander Schenk Sebastian Proschinger Philipp Zimmer Division of Performance and Health(sports medicine) Institute for Sport and Sport ScienceTU Dortmund UniversityDortmund 44227Germany

Background:B cells represent a crucial component of adaptive immunity that ensures long-term protection from infection by generating pathogen-specific *** alters B cell counts and immunoglobulin levels,but evidence-based conclusions on potential benefits for adaptive immunity are *** systematic review assessed current literatures on the impact of acute exercise and exercise training on B cells,immunoglobulins,and markers of secretory immunity in human ***:According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,MEDLINE,Web of Science,and Embase were searched on March 8,***-randomized controlled trials and crossover trials investigating the impact of acute exercise or exercise training on B cell counts and proportions,immunoglobulin levels,salivary flow rate,or secretory immunoglobulin A secretion rate were *** and reporting of exercise training studies were assessed using the Tool for the Assessment of Study Quality and reporting in *** characteristics,outcome measures,and statistically significant changes were summarized ***:Of the 67 eligible studies,22 applied acute exercise and 45 applied exercise *** included outcomes revealed significant alterations over time in acute exercise and exercise training context,but only a few investigations showed significant differences compared to control *** and plasma immunoglobulin A levels were most consistently increased in response to exercise ***:B cell-related outcomes are altered by acute exercise and exercise training,but evidence-based conclusions cannot be drawn with high confidence due to the large heterogeneity in populations and exercise ***-designed trials with large sample sizes are needed to clarify how exercise shapes B cell-related immunity.

关键词： Antibody B-lymphocyte Exercise Humoral immunity Immune system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy

引用

Science China(Life Sciences) 2018年第11期61卷 1320-1332页

作者： Dongdong Ti Yunfei Niu Zhiqiang Wu Xiaobing Fu Weidong Han Department of Immunology Institute of Basic Medicine Chinese PLA General Hospital Department of orthopaedics Changhai Hospital Second Military Medical University

The host immune system plays an instrumental role in the surveillance and elimination of tumors by recognizing and destroying cancer cells. In recent decades, studies have mainly focused on adoptive immunotherapy using engineered T cells for the treatment of malignant diseases. Through gene engraftment of the patient's own T cells with chimeric antigen receptor(CAR),they can recognize tumor specific antigens effectively and eradicate selectively targeted cells in an MHC-independent *** date, CAR-T cell therapy has shown great clinical utility in patients with B-cell leukemias. Owing to different CAR designs and tumor complex microenvironments, genetically redirected T cells may generate diverse biological properties and thereby impact their long-term clinical performance and outcome. Meanwhile some unexpected toxicities that result from CAR-T cell application have been examined and limited the curative effects. Diverse important parameters are closely related with adoptively transferred cell behaviors, including CAR-T cells homing, CAR constitutive signaling, T cell differentiation and exhaustion. Thus, understanding CARs molecular design to improve infused cell efficacy and safety is crucial to clinicians and patients who are considering this novel cancer therapeutics. In this review, the developments in CAR-T cell therapy and the limitations and perspectives in optimizing this technology towards clinical application are discussed.

关键词： genetic engineering chimeric antigen receptors cancer immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Green Biocompatible Fabrication of Highly Porous Functional Ceramics with High Strength and Controllable Pore Structures

引用

Journal of Materials Science & Technology 2016年第8期32卷 729-732页

作者： Changlu Xu Haoran Liu Huilin Yang Lei Yang Orthopaedic institute and Department of orthopaedics The First Affiliated Hospital Soochow University International Research Center for Translational orthopaedics (IRCTO) Soochow University

A green biocompatible foaming method utilizing natural coconut oil and cornstarch was developed to fabricate highly porous functional ceramics with controllable strengths and pore structures. The poros- ity of A1203 ceramics prepared via this method reached 79.6%-86.9% while these ceramics maintained high compressive strengths of 2.2-5.5 MPa. More importantly, porous A1203 ceramic with a pore size gra- dient was also readily fabricated by casting serial layers of foams that were set for different time periods. The potential applications of porous Al2O3 and HA ceramics fabricated by this green foaming method in- cluding scaffolds for oil cleaning and cell culture, respectively, were also demonstrated.

关键词： Porous ceramic Pore structure Bioceramics Hydroxyapatite Alumina

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Functional biomaterials for tendon/ligament repair and regeneration

引用

Regenerative Biomaterials 2022年第1期9卷 1061-1079页

作者： Yunkai Tang Zhen Wang Lei Xiang Zhenyu Zhao Wenguo Cui Department of orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025P.R.China

With an increase in life expectancy and the popularity of highintensity exercise,the frequency of tendon and ligament injuries has also *** to the specificity of its tissue,the rapid restoration of injured tendons and ligaments is challenging for *** review summarizes the latest progress in cells,biomaterials,active molecules and construction technology in treating tendon/ligament *** characteristics of supports made of different materials and the development and application of different manufacturing methods are *** development of natural polymers,synthetic polymers and composite materials has boosted the use of *** addition,the development of electrospinning and hydrogel technology has diversified the production and treatment of ***,this article briefly introduces the structure,function and biological characteristics of tendons/***,it summarizes the advantages and disadvantages of different materials,such as natural polymer scaffolds,synthetic polymer scaffolds,composite scaffolds and extracellular matrix(ECM)-derived biological scaffolds,in the application of tendon/ligament *** then discuss the latest applications of electrospun fiber scaffolds and hydrogels in regeneration ***,we discuss the current problems and future directions in the development of biomaterials for restoring damaged tendons and ligaments.

关键词： tendon/ligament repair biomaterials electrospinning hydrogel tissue regeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A cost-effective method to enhance adenoviral transduction of primary murine osteoblasts and bone marrow stromal cells

引用

Bone Research 2016年第2期4卷 91-100页

作者： Atum M Buo Mark S Williams Jaclyn P Kerr Joseph P Stains Department of orthopaedics University of Maryland School of Medicine Department of Microbiology and Immunology University of Maryland School of Medicine

We report here a method for the use of poly-L-lysine （PLL） to markedly improve the adenoviral transduction efficiency of primary murine osteoblasts and bone marrow stromal cells （BMSCs） in culture and in situ, which are typically difficult to transduce. We show by fluorescence microscopy and flow cytometry that the addition of PLL to the viral-containing medium significantly increases the number of green fluorescence protein （GFP）-positive osteoblasts and BMSCs transduced with an enhanced GFP-expressing adenovirus. We also demonstrate that PLL can greatly enhance the adenoviral transduction of osteoblasts and osteocytes in situ in ex vivo tibia and calvaria, as well as in long bone fragments. In addition, we validate that PLL can improve routine adenoviral transduction studies by permitting the use of low multiplicities of infection to obtain the desired biologic effect. Ultimately, the use of PLL to facilitate adenoviral gene transfer in osteogenic cells can provide a cost-effective means of performing efficient gene transfer studies in the context of bone research.

关键词： A cost-effective method to enhance adenoviral transduction of primary murine osteoblasts and bone marrow stromal cells PLL bone

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：