Hyperuricemia and its related diseases:mechanisms and advances in therapy
作者机构：Sports Medicine CenterThe First Affiliated Hospital of Shantou University Medical CollegeShantou 515041China Institute of Sports MedicineShantou University Medical CollegeShantou 515041China Centre for Orthopaedic ResearchMedical SchoolThe University of Western AustraliaNedlandsWA 6009Australia Department of OrthopaedicsShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2024年第9卷第9期
页 面：3985-4013页
核心收录：
学科分类：02[经济学] 0202[经济学-应用经济学] 020206[经济学-国际贸易学]
基 金：performed with the support of the National Natural Science Foundation of China(82002339,81820108020) Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System(BJ1-9000-22-4002)
主 题：mechanisms elevated connecting
摘 要：Hyperuricemia,characterized by elevated levels of serum uric acid(SUA),is linked to a spectrum of commodities such as gout,cardiovascular diseases,renal disorders,metabolic syndrome,and diabetes,*** impairing the quality of life for those affected,the prevalence of hyperuricemia is an upward trend globally,especially in most developed *** possesses a multifaceted role,such as antioxidant,pro-oxidative,pro-inflammatory,nitric oxide modulating,anti-aging,and immune effects,which are significant in both physiological and pathological *** equilibrium of circulating urate levels hinges on the interplay between production and excretion,a delicate balance orchestrated by urate transporter functions across various epithelial tissues and cell *** existing research has identified hyperuricemia involvement in numerous biological processes and signaling pathways,the precise mechanisms connecting elevated UA levels to disease etiology remain to be fully *** addition,the influence of genetic susceptibilities and environmental determinants on hyperuricemia calls for a detailed and nuanced *** review compiles data from global epidemiological studies and clinical practices,exploring the physiological processes and the genetic foundations of urate transporters in ***,we uncover the complex mechanisms by which the UA induced inflammation influences metabolic processes in individuals with hyperuricemia and the association with its relative disease,offering a foundation for innovative therapeutic approaches and advanced pharmacological strategies.
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