检索结果-南通市图书馆

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Immune regulation of the gut-brain axis and lung-brain axis involved in ischemic stroke

引用

Neural Regeneration Research 2024年第3期19卷 519-528页

作者： Xiaodi Xie Lei Wang Shanshan Dong ShanChun Ge Ting Zhu institute of neuroregeneration&neurorehabilitation Department of PathophysiologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjingJiangsu ProvinceChina Department of Rehabilitation Medicine The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Local ischemia often causes a series of inflammatory reactions when both brain immune cells and the peripheral immune response are *** the human body,the gut and lung are regarded as the key reactional targets that are initiated by brain ischemic *** microorganisms play an important role in immune regulation and metabolism and affect blood-brain barrier *** addition to the relationship between peripheral organs and central areas and the intestine and lung also interact among each ***,we review the molecular and cellular immune mechanisms involved in the pathways of inflammation across the gut-brain axis and lung-brain *** found that abnormal intestinal flora,the intestinal microenvironment,lung infection,chronic diseases,and mechanical ventilation can worsen the outcome of ischemic *** review also introduces the influence of the brain on the gut and lungs after stroke,highlighting the bidirectional feedback effect among the gut,lungs,and brain.

关键词： enteric glia cells gut microbiota gut-brain axis immune response inflammation ischemic stroke lung-brain axis microglia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury

引用

Chinese Journal of Traumatology 2023年第1期26卷 20-26页

作者： Ting Zhu Qi Wan institute of neuroregeneration&neurorehabilitation Department of PathophysiologySchool of Basic MedicineQingdao UniversityQingdao266071Shandong ProvinceChina

Panax notoginseng is an ancient Chinese medicinal plant that has great clinical value in regulating cardiovascular disease in *** a single component of panax notoginosides,notoginsenoside R1(NGR1)belongs to the panaxatriol *** reports have demonstrated that NGR1 exerts multiple pharmacological effects in ischemic stroke,myocardial infarction,acute renal injury,and intestinal ***,we outline the available reports on the pharmacological effects of NGR1 in ischemia-reperfusion(I/R)*** also discuss the chemistry,composition and molecular mechanism underlying the anti-I/R injury effects of ***1 had significant effects on reducing cerebral infarct size and neurological deficits in cerebral I/R injury,ameliorating the impaired mitochondrial morphology in myocardial I/R injury,decreasing kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in renal I/R injury and attenuating jejunal mucosal epithelium injury in intestinal I/R *** various organ anti-I/R injury effects of NGR1 are mainly through the suppression of oxidative stress,apoptosis,inflammation,endoplasmic reticulum stress and promotion of angiogenesis and *** findings provide a reference basis for future research of NGR1 on I/R injury.

关键词： Notoginsenoside R1 Ischemia/reperfusion injury Chemistry Pharmacological properties Molecular mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Celastrol inhibits inflammatory factors expression in glioblastoma

引用

Traditional Medicine Research 2024年第6期9卷 1-11页

作者： Na Qin Shu-Xian Yang Shi-Man Gao Ting Zhu institute of neuroregeneration&neurorehabilitation Department of PathophysiologySchool of Basic MedicineQingdao UniversityQingdao 266071China Department of Pharmacy Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Women and Children’s Hospital Qingdao UniversityQingdao 266034China

Background:Glioblastoma is one of the most common primary intracranial tumors of the central nervous system in *** chemotherapy is an important component of glioblastoma treatment,its effectiveness remains *** to multiple immunosuppressive mechanisms,glioblastoma immunotherapy has not been effective in treating many patients as a result of the clinical breakthroughs in the ***,the development of cancer immunotherapy relies on the understanding of how tumors interact with the immune system and the analysis of their molecular *** study identified the key interactions between immune cells in the glioma microenvironment using RNA microarrays and single-cell ***:First,we screened differentially expressed genes in tumor and control samples from GSE29796 and GSE50161 datasets using *** differentially expressed genes were used to perform enrichment analysis and construct protein-protein interaction topological analysis to analyze the interaction between *** single-cell RNA sequencing data from the GSE162631 database,we identified immune cell types within the glioblastoma microenvironment,and validated the hub gene expression in these *** addition,based on the GEPIA and TIMER databases,hub genes were investigated and compared with immune infiltration to determine differential ***,CellChat was used to visualize the gene expression distribution and cell-to-cell communication analysis of the proteins between different types of ***:We found that monocytes/macrophages may communicate with each other in the tumor microenvironment through MIF-(CD74+CXCR4)and MIF-(CD74+CD44).In addition,our study indicated that celastrol has the ability to inhibit inflammatory factors expression by MIF/CD74 signaling pathway in U87 ***:This study improved the effectiveness of cancer immunotherapy strategies and developed new ideas for immunotherapy that can be applied to gl

关键词： glioblastoma monocytes/macrophages single-cell RNA sequencing MIF/CD74 signaling pathway celastrol

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

引用

Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and neurorehabilitation institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chemokine Receptor CXCR3 in the Spinal Cord Contributes to Chronic Itch in Mice

引用

Neuroscience Bulletin 2018年第1期34卷 54-63页

作者： Peng-Bo Jing De-Li Cao Si-Si Li Meixuan Zhu Xue-Qiang Bai Xiao-Bo Wu Yong-Jing Gao Pain Research Laboratory Institute of Nautical MedicineJiangsu Key Laboratory of Neuroregeneration Nantong University Co-innovation Center of neuroregeneration Nantong University

Recent studies have shown that the chemokine receptor CXCR3 and its ligand CXCL10 in the dorsal root ganglion mediate itch in experimental allergic contact dermatitis （ACD）. CXCR3 in the spinal cord also con- tributes to the maintenance of neuropathic pain. However, whether spinal CXCR3 is involved in acute or chronic itch remains unclear. Here, we report that Cxcr3-/- mice showed normal scratching in acute itch models but reduced scratching in chronic itch models of dry skin and ACD. In contrast, both formalin-induced acute pain and complete Freund＇s adjuvant-induced chronic inflammatory pain were reduced in Cxcr3-/- mice. In addition, the expression of CXCR3 and CXCL10 was increased in the spinal cord in the dry skin model induced by acetone and diethyl ether followed by water （AEW）. Intrathecal injection of a CXCR3 antagonist alleviated AEW-induced itch. Further- more, touch-elicited itch （alloknesis） after compound 48/80 or AEW treatment was suppressed in Cxcr3-/- mice. Finally, AEW-induced astrocyte activation was inhibited in Cxcr3-/- mice. Taken together, these data suggest that spinal CXCR3 mediates chronic itch and alloknesis, and targeting CXCR3 may provide effective treatment for chronic pruritus.

关键词： Chronic itch Alloknesis Dry skin CXCR3 CXCL10 - Spinal cord

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Current AAV-mediated gene therapy in sensorineural hearing loss

引用

Fundamental Research 2025年第1期5卷 192-202页

作者： Jieyu Qi Xiaolong Fu Liyan Zhang Fangzhi Tan Nianci Li Qiuhan Sun Xiaojie Hu Zuhong He Ming Xia Renjie Chai State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologySchool of MedicineAdvanced Institute for Life and HealthJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China Department of Neurology Aerospace Center HospitalSchool of Life ScienceBeijing Institute of TechnologyBeijing 100081China State Key Laboratory of Hearing and Balance Science Beijing Institute of TechnologyBeijing 100081China Advanced Technology Research institute Beijing Institute of TechnologyJinan 250300China Department of Otorhinolaryngology-Head and Neck Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Otolaryngology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250021China Co-Innovation Center of neuroregeneration Nantong UniversityNantong 226001China Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Southeast University Shenzhen Research institute Shenzhen 518063China

The number of patients with hearing loss is on the rise due to congenital abnormalities,degenerative changes in old age,and acquired injuries such as virus or ototoxic drug-induced *** loss is a refractory and disabling disease that has serious negative effects on quality of *** pathology of hearing loss in the inner ear is characterized by varying degrees of damage to the cochlear sensory epithelium cells(such as hair cells and supporting cells),stria vascularis(including marginal,intermediate and basal cells)and spiral ganglion *** or direct repair of damaged cells in the inner ear is an effective way to treat sensorineural *** is currently possible to regenerate hair cells to treat sensorineural hearing loss by FX-322,a small molecule drug in clinical *** the development of genetic engineering technology,gene therapy has brought a promising treatment strategy for many previously intractable *** therapy has been regarded as a promising method in the treatment and rehabilitation of sensorineural hearing loss,and recombinant adeno-associated virus gene therapy has been widely used in fundamental research into hearing loss *** present,gene therapy for hearing loss is transitioning from feasibility studies to explorations of its safety and its therapeutic *** present article reviews the concepts,strategies,and applications of gene therapy mediated by recombinant adeno-associated viruses in the field of hearing loss treatment.

关键词： Hearing loss Cochlea Gene therapy Adeno-associated virus Auditory repair

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Commentary on:“Human neural stem cell-derived artificial organelles to improve oxidative phosphorylation”

引用

Neural Regeneration Research 2025年第10期20卷 3040-3040页

作者： Kwok-Fai So Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Neuroscience and neurorehabilitation institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Mitochondrial function is fundamental to neuroregeneration,particularly in neurons,where high energy demands are essential for repair and recovery(Patrón and Zinsmaier,2016;Beckervordersandforth et al.,2017;Iwata et al.,2023).Mitochondrial dysfunction,characterized by an imbalance in ATP levels and excessive production of mitochondrial reactive oxygen species,is a key factor that impedes neural regeneration in neurodegenerative diseases and after neuronal injury(Han et al.,2016,2020;Zheng et al.,2016;Zong et al.,2024).

关键词： neural Becker Human

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Why microglia kill neurons after neural disorders? The friendly fire hypothesis

引用

Neural Regeneration Research 2019年第9期14卷 1499-1502页

作者： Walace Gomes-Leal Laboratory of Experimental Neuroprotection and neuroregeneration Institute of Biological Sciences Federal University of Para-Brazil

Neuroinflammation plays a fundamental role on the pathophysiology of acute and chronic neural *** activation is a major event following central nervous system inflammation displaying different phenotypes with beneficial and detrimental actions(a Janus face).The reason for this apparent duality is *** have previously shown that following experimental middle cerebral artery occlusion in the rat brain,microglia seem to support and impair adult neurogenesis in the same ischemic *** on these results,we raised the hypothesis that in the same pathologic environment,gradients of different ligands distributed over different anatomical niches might contribute to both detrimental and beneficial microglial *** ligands(“danger signals”)are released by dying cells and bind to microglial receptors in their *** of different microglial receptors induces downstream biochemical pathways culminating in a spectrum of microglial phenotypes like M1 and M2 and *** this paper,we first review the immune functions of microglia and the role of toll-like receptors on the fight against *** then briefly revise the dual role of microglia after neural *** then propose a novel hypothesis to explain the Janus face of microglia during the pathophysiology of central nervous system diseases:the“friendly fire hypothesis”.According to this idea“danger signals”or danger associated molecular patterns released by stressed,damaged and/or dying cells during stroke,trauma and other diseases might activate microglial pattern-recognition receptors(i.e.,toll like receptors)or other unidentified receptors normally activated by *** could activate the same genetic and biochemical machinery used by microglia to fight against pathogens even in the absence of *** to this notion,microglia may cause bystander neuronal damage with a kind of blind“friendly fire”,fighting against a non-existing infection during

关键词： stroke trauma Alzheimer’s disease neuroinflammation glial cells phenotypes degeneration neuroprotection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NRF1-mediated microglial activation triggers high-altitude cerebral edema

引用

Journal of Molecular Cell Biology 2022年第5期14卷 43-56页

作者： Xueting Wang Guijuan Chen Baolan Wan Zhangji Dong Yan Xue Qianqian Luo Dan Wang Yapeng Lu Li Zhu institute of Special Environmental Medicine Nantong UniversityNantong 226019China Co-nnovation Center of neuroregeneration iangsu Key Laboratory of NeuroregenerationNantong UniversityNantong 226019China Key Laboratory of neuroregeneration of Jiangsu and Ministry of Education Nantong UniversityNantong 226019China

High-altitude cerebral edema(HACE)is a potentially fatal encephalopathy associated with a time-dependent exposure to the hypobaric hypoxia of *** formation of HACE is affected by both vasogenic and cytotoxic *** over-activated microglia potentiate the damage of blood-brain barrier(BBB)and exacerbate cytotoxic *** light with the activation of microglia in HACE,we aimed to investigate whether the over-activated microglia were the key turning point of acute mountain sickness to *** in vivo experiments,by exposing mice to hypobaric hypoxia(7000 m above sea level)to induce HACE model,we found that microglia were activated and migrated to blood *** depletion by PLX5622 obviously relieved brain *** in vitro experiments,we found that hypoxia induced cultured microglial activation,leading to the destruction of endothelial tight junction and astrocyte ***-regulated nuclear respiratory factor 1(NRF1)accelerated pro-inflammatory factors through transcriptional regulation on nuclearfactorkappa B p65(NF-kB p65)and mitochondrial transcription factorA(TFAM)in activated microglia under ***1 also up-regulated phagocytosis by transcriptional regulation on caveolin-1(CAV-1)and adaptorrelated protein complex 2 subunit beta(AP2B1).The present study reveals a new mechanism in HACE:hypoxia over-activates microglia through up-regulation of NRF1,which both induces inflammatory response through transcriptionally activating NF-kB p65 and TFAM,and enhances phagocytic function through up-regulation of CAV-1 and AP2B1;hypoxia-activatedmicroglia destroy the integrity of BBB and release pro-inflammatory factors that eventually induce HACE.

关键词： high-altitude cerebral edema hypoxia microglia inflammation nuclear respiratory factor 1 endocytosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：