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Studies on the Structure of Kansuinine A from Euphorbia kansui

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Chinese Chemical Letters 2002年第12期13卷 1178-1180页

作者： Qin PAN Zhi Da MIN Department of natural medicine chemistry China Pharmaceutical UniversityNanjing 210009

Kansuinine A is a macrocyclic jatrophane diterpene that was isolated from Euphorbia kansui. Further investigation of the structure was revealed that the benzoyl group located at C-8 and the position of C-3 was the pr... 详细信息

关键词： Euphorbia kansui kansuinine A.

Sesquiterpene Lactones from Elephantopus scaber

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Chinese Chemical Letters 2002年第4期13卷 343-344页

作者： Qiao Li LIANG Zhi Da MIN Department of natural medicine chemistry China Pharmaceutical UniversityNanjing 210009

A new germacranolide sesquiterpene lactone, isoscabertopin, was isolated from Elephantopus scaber together with the known scabertopin. Their structures were determined by spectroscopic methods.

关键词： Elephantopus scaber Compositae germacranolide sesquiterpene lactone isoscabertopin.

Novel and efficient supramolecular synthesis of pyrroles in the presence of β-cyclodextrin in water

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Chinese Chemical Letters 2012年第12期23卷 1331-1334页

作者： K.Ramesh K.Karnakar G.Satish Y.V.D.Nageswar CSIR-natural Product chemistry Indian Institute of Chemical Technology

A simple and efficient synthesis of highly substituted pyrroles was achieved in water medium via multi-component strategy, using amine, DMAD/DEAD as well as phenacyl bromide catalyzed by β-CD. Utilizing this protocol... 详细信息

关键词： Amine DMAD/DEAD Phenacyl bromide Water Recyclability β-Cyclodextrin

Development of a validated UPLC-qTOF-MS/MS method for determination of bioactive constituent from Glycyrrhiza glabra

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Journal of Pharmaceutical Analysis 2013年第3期3卷 205-210页

作者： D.K.Gupta M.K.Verma R.Anand R.K.Khajuria natural Product chemistry Division CSIR-Indian Institute of Integrative Medicine Analytical chemistry Division CSIR-Indian Institute of Integrative Medicine

An ultra-performance liquid chromatography quadrupole time of flight mass spectrometry （UPLC-qTOF-MS/MS） method was developed and validated for the simultaneous determination of glycyrrhizin and glycyrrhetic acid. These analytes were separated on a reverse phase C18 column using a mobile phase of acetonitrile：2% acetic acid in water （75：25, v/v） with a flow rate of 200 μL/min. The qTOF-MS was operated under multiple reaction monitoring （MRM） mode using the electrospray ionization （ESI） technique with positive ion polarity. A comparison of three different extraction techniques i.e. accelerated solvent extraction （ASE）, extraction under ultrasonic waves （USW） and the classical extraction by percolation （CE） method was done and quantification of these extracts was also carried out by the proposed method.

关键词： Glycyrrhiza glabra Glycyrrhizin Glycyrrhetic acid Accelerated solventextraction Ultrasonication Ultra-performanceliquid chromatographyquadrupole time offlight mass spectrometer(UPLC-qTOF-MS/MS)

Deep learning for development of organic optoelectronic devices:efficient prescreening of hosts and emitters in deep-blue fluorescent OLEDs

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npj Computational Materials 2022年第1期8卷 1406-1416页

作者： Minseok Jeong Joonyoung F.Joung Jinhyo Hwang Minhi Han Chang Woo Koh Dong Hoon Choi Sungnam Park Department of chemistry and Research institute for natural Science Korea UniversitySeoul02841Korea

The highest occupied molecular orbital(HOMO)and lowest unoccupied molecular orbital(LUMO)energies,which are key factors in optoelectronic devices,must be accurately estimated for newly designed ***,we developed a deep learning(DL)model that was trained with an experimental database containing the HOMO and LUMO energies of 3026 organic molecules in solvents or solids and was capable of predicting the HOMO and LUMO energies of molecules with the mean absolute errors of 0.058 ***,we demonstrated that our DL model was efficiently used to virtually screen optimal host and emitter molecules for organic light-emitting diodes(OLEDs).Deep-blue fluorescent OLEDs,which were fabricated with emitter and host molecules selected via DL prediction,exhibited narrow emission(bandwidth=36 nm)at 412 nm and an external quantum efficiency of 6.58%.Our DL-assisted virtual screening method can be further applied to the development of component materials in optoelectronics.

关键词： emitter optoelectronic OLEDs

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

Gamma oscillations and their role in orchestrating balance and communication following stroke

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Neural Regeneration Research 2025年第2期20卷 477-478页

作者： Montana Samantzis Cong Wang Matilde Balbi Queensland Brain institute The University of QueenslandBrisbaneQLDAustralia Engineering Research Centre of Traditional Chinese medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina

Induced brain oscillations in the gamma range have recently garnered attention due to their reported neuroprotective effects in the treatment of Alzheimer’s *** method differs from pharmacological approaches by tapping into the neuronal population dynamics that underlie the homeostatic processes in the brain that are crucial for the recovery of ***,induced gamma-range oscillations have been used to improve cerebral blood flow,motor function,and synaptic plasticity in a mouse model of focal stroke,highlighting the broad potential of recruiting intrinsic recovery processes for the treatment of neurological *** open questions,such as the frequency specificity of the benefits,will shed light on the intrinsic processes involved and allow clinicians to optimize recovery after stroke.

关键词： protective specificity Alzheimer

Coulometric determination of dissolved hydrogen with a multielectrolytic modified carbon felt electrode-based sensor

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Journal of Environmental Sciences 2013年第6期25卷 1077-1082页

作者： Hiroaki Matsuura Yosuke Yamawaki Kosuke Sasaki Shunichi Uchiyama Department of Life Science & green chemistry Faculty of EngineeringSaitama Institute of Technology Department of Applied chemistry Graduate School of EngineeringSaitama Institute of Technology

A multielectrolytic modified carbon electrode （MEMCE） was fabricated by the electrolytic-oxidation/reduction processes. First, the functional groups containing nitrogen atoms such as amino group were introduced by the electrode oxidation of carbon felt electrode in an ammonium carbamate aqueous solution, and next, this electrode was electroreduced in sulfuric acid. The redox waves between hydrogen ion and hydrogen molecule at highly positive potential range appeared in the cyclic voltammogram obtained by MEMCE. A coulometric cell using MEMCE with a catalytic activity of electrooxidation of hydrogen molecule was constructed and was used for the measurement of dissolved hydrogen. The typical current vs. time curve was obtained by the repetitive measurement of the dissolved hydrogen. These curves indicated that the measurement of dissolved hydrogen was finished completely in a very short time （ca. 10 sec）. A linear relationship was obtained between the electrical charge needed for the electrooxidation process of hydrogen molecule and dissolved hydrogen concentration. This indicates that the developed coulometric method can be used for the determination of the dissolved hydrogen concentration.

关键词： multielectrolytic modified carbon electrode (MEMCE) coulometric determination dissolved hydrogen

Metalloporphyrin receptors for histidine-containing peptides

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Chinese Chemical Letters 2014年第5期25卷 659-662页

作者： Hui Liu Zhan-Ting Li Key Laboratory for green Chemical Process of Ministry of Education School of Chemical Engineering & PharmacyWuhan Institute of Technology State Key Laboratory of Bio-Organic and natural Products chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences

Two new ditopic metalloporphyrin receptors constructed by combining metalloporphyrin with crown ethers have been prepared and characterized.1H NMR and MS spectra confirmed the complexation of receptor with peptide driven by coordination interaction and hydrogen ***/vis experiments revealed that the receptors exhibited high binding affinity to histidine-containing *** receptors could differentiate short peptides of C-terminal histidine and N-terminal histidine and formed the most stable complexes with tripeptide.

关键词： Metallop or phyrin Crown ether Synthetic receptor Peptide