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Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment

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Chinese Chemical Letters 2024年第4期35卷 414-419页

作者： Peide Zhu Yangjia Liu Yaoyao Tang Siqi Zhu Xinyang Liu Lei Yin Quan Liu Zhiqiang Yu Quan Xu Dixian Luo Juncheng Wang State Key Laboratory of Heavy Oil Processing China University of Petroleum-BeijingBeijing 102249China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer ResearchAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523058China Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518052China institute of Stomatology First Medical CenterChinese PLA General HospitalBeijing 100853China

Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation. However, it is difficult to accurately reveal liposome delivery modes and drug release rates at different p H values to assess the biodistribution and drug delivery pathways in vivo. Here, we established a strategy to integrate Bi-doped carbon quantum dots(CQDs)with liposomes to produce fluorescence visualization and therapeutic effects, namely lipo/Bi-doped ***/Bi-doped CQDs show good water solubility and physicochemical properties, which can be used for in vitro labeling of colon cancer(CT26) cells and in vivo imaging localization tracking tumors for monitoring. Simultaneously, thanks to the excellent p H sensitivity and ion doping characteristic of Bi-doped CQDs, lipo/Bi-doped CQDs can be used to reveal the drug release rate of liposomes at different p H values and exhibit potential effects in vivo antitumor therapy.

关键词： Bi-doped CQDs Lipo/Bi-doped CQDs pH sensitivity In vitro/in vivo imaging Diagnosis and treatment integration

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In situ observation of surface structures of cardiovascular endothelial cells with atomic force microscope

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Journal of Geriatric Cardiology 2009年第3期6卷 178-181页

作者： Tong Yin Jin Luo Ya-Min Ma Xiao-Long Ji Yu-Sheng Zhao Shi-Wen Wang institute of Geriatric Cardiology Department of Cardiovascular Surgery General Hospital of PLA Beijing 100853 China institute of nanomedicine General Hospital o fArmed Police Forces Beo＇ing 100039 China

Objective To observe the surface structures of cardiovascular endothelial cells in situ with atomic force microscope （AFM）. Methods Fresh aorta and aortic valve were dissected from 10 healthy male New Zealand white rabbits. Before fixed in 1% formaldehyde, the fresh tissues were washed in the buffer phosphate solution. Under general microscope, the fixed aorta or valve was spread on the double side stick tape which had already been stuck on the glass slide. The intima of aorta or the aorta side of valve was towards upside, Then the specimen was dried under 37 degrees centigrade in an attemperator and was washed with pure water. After dried again, the specimen was loaded on the platform ofNanoScope Ⅲa AFM and was scanned in tapping mode with the scanning speed of 0.5 HZ. Results The surface structures of endothelial cell on the fixed and dried tissue could be observed clearly in situ with AFM. aortic endothelial cells were large, branched and arranged sparsely and parallel to the direction of blood flow, whereas endothelial cells on aorta valve surface were small, less branched and arranged intensively and vertical to the direction of blood flow. When the scanning range was dwindled, granular ultra-structures could be observed on the surface of endothelial cells, and, as the scanning range was dwindled further, fissure and convolution could be seen on the surface of granules from aortic endothelial cells. Centre cavity and surrounding swelling volcano-like structure could be seen on the surface of granules from endothelial cells of aortic valve. Conclusions It＇s feasible to observe the surface ultra-structures of cardiovascular endothelial cells in situ with AFM and morphological information provided by AFM might be of clinical value in future histopathological diagnosis（JGeriatr Cardiol2009; 6：178-181）.

关键词： atomic force microscope endothelial cell

Cell-penetrating riboflavin conjugate for antitumor photodynamic therapy

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Chinese Chemical Letters 2022年第9期33卷 4339-4344页

作者： Chunlei Wu Yanyan Li Zhehong Cheng Pengxin Wang Zhilong Ma Ke Liu Yulian Cheng Yimin Zhou Xian Lin Ximing Shao Yong Yang Hongchang Li Lijing Fang Guangdong Key Laboratory of nanomedicine Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Biomedical Engineering Southern University of Science and Technology(SUSTech)Shenzhen 518055China

Riboflavin(RF,vitamin B2)is an essential vitamin and has been considered as a promising natural photosensitizer for photodynamic therapy(PDT).However,further exploration of RF in antitumor application was limited by its poor cellular *** this study,using cell-penetrating peptides Arg8,(Cha-Arg)3 and small molecule triphenylphosphine(TPP)as delivery compounds,three RF conjugates were prepared to increase the accumulation of RF in cells,termed as Arg8-RF,(Cha-Arg)3-RF and TPP-RF,*** with TPP-RF and Arg8-RF,(Cha-Arg)3-RF exhibited better cell internalization and stronger cytotoxicity against HeLa cells upon exposure to blue *** researches proved that(Cha-Arg)3-RF generated reactive oxygen species(ROS)under irradiation,which could indiscriminately destroy endogenous proteins and mitochondria,ultimately inducing cell *** work provides a new approach to explore RF as a natural photosensitizer for antitumor photodynamic therapy.

关键词： Riboflavin Antitumor Photodynamic therapy Cell-penetrating peptides

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A boronate-based modular assembly nanosystem to block the undesirable crosstalk between hepatic stellate cells and Kupffer cells

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Bioactive Materials 2023年第7期25卷 569-579页

作者： Huizhen Jia Ling Ding Ao Yu Weimin Tang Siyuan Tang Chuhan Zhang David Oupický Center for Drug Delivery and nanomedicine Department of Pharmaceutical SciencesCollege of PharmacyUniversity of Nebraska Medical CenterOmahaNE68198USA

Crosstalk between Kupffer cells(KCs)and hepatic stellate cells(HSCs)plays an important role in multiple liver disease conditions,including the formation of liver fibrosis in alcohol-associated liver disease(AALD).Therapeutic targeting of the KC-HSC crosstalk is a prime target for therapeutic ***,a novel modular nanosystem was designed and prepared through the self-assembly utilizing boric acid and catechol interactions to prepare polymers modified with a CXCR4-inhibiting *** polymers were used to encapsulate anti-miR-155 and to block the undesirable crosstalk between HSCs and KCs by downregulating miR-155 expression in KCs with the parallel inhibition of CXCR4 signaling in activated *** combined inhibition of miR-155 and CXCR4 at two different liver cell types achieved improved antifibrosis effects in a mouse model of AALD *** finding highlights the key role that blocking the undesirable crosstalk between HSCs and KCs plays in reversing AALD fibrosis as well as demonstrates a proof-of-concept approach for designing and constructing multifunctional delivery nanosystems using orthogonal functional modules based on the understanding of disease mechanisms.

关键词： Nanoparticles miRNA CXCR4 Liver fibrosis Undesirable crosstalk Modular assembly

Electrochemical Analysis for Multiscale Single Entities on the Confined Interface

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Chinese Journal of Chemistry 2021年第6期39卷 1745-1752页

作者： Haipei Zhao Jinliang Ma Xiaolei Zuo Fan Li School of Chemistry and Chemical Engineering and Institute of Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and NanomedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Single entities detection reveals heterogeneity and random processes hidden in ensemble *** accurate single-entity information is *** electrochemical analysis is at high spatial resolution and high temporal resolution to analyze single entities and measure the fast kinetics *** this minireview,we will focus on the electrochemical strategies for single multiscale entities.

关键词： Electrochemistry Sensors Single-molecule studies Single-particle studies Single-cells studies

Emerging two-dimensional material nanozymes for theranostic nanomedicine

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Biophysics Reports 2021年第3期7卷 159-172页

作者： Yanling You Zhongmin Tang Han Lin Jianlin Shi State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of Sciences Center for nanomedicine Brigham and Women's HospitalHarvard Medical School

Nanomaterials-based artificial enzymes(nanozymes) with valuable enzyme-like catalytic properties have been booming during the past few years. Promoted by the advances in biological medicine and nanotechnology, nanozymes possess the potential to serve as an emerging agent for biosensing, immunoassays, detection and diagnosis, catalytic therapeutics, and other applications in the biomedicine field. Two-dimensional(2 D) nanomaterials are of considerable interest in biomedical applications due to their ultrathin layered structure and unique physiochemical properties. Inspired by the diversified catalytic performance of 2 D nanomaterials, scientists extensively have developed 2 D materials as bioactive nanozymes for theranostic nanomedicine. Here, recent advances in enzyme-like 2 D nanomaterials design and construction are comprehensively presented. Additionally, we exhibit that, with the synergistic effect of catalytic activities and desirable physicochemical performances, 2 D nanozymes can serve as versatile platforms with extensive applications from target detection to in vivo theranostic. It is believed that such promising alternatives towards natural enzymes will be of vital significance in the field of nanotechnology and biomedicine.

关键词： Two-dimensional nanomaterials Nanozymes nanomedicine

Oxidations of two-dimensional semiconductors:Fundamentals and applications

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Chinese Chemical Letters 2022年第1期33卷 177-185页

作者： Junqiang Yang Xiaochi Liu Qianli Dong Yaqi Shen Yuchuan Pan Zhongwang Wang Kui Tang Xianfu Dai Rongqi Wu Yuanyuan Jin Wei Zhou Song Liu Jian Sun School of Physics and Electronics Central South UniversityChangsha 410083China State Key Laboratory of Chemical Biosensing and Chemometrics College of Chemistry and Chemical EngineeringInstitute of Chemical Biology and Nanomedicine(ICBN)Hunan UniversityChangsha 410082China

Since the discovery of graphene,two-dimensional(2D)semiconductors have been attracted intensive interest due to their unique *** have exhibited potential applications in next generation electronic and optoelectronic ***,most of the 2D semiconductor are known to suffer from the ambient oxidation which degrade the materials and therefore hinder us from the intrinsic materials’properties and the optimized performance of *** this review,we summarize the recent progress on both fundamentals and applications of the oxidations of 2D *** begin with the oxidation mechanisms in black phosphorus,transition metal dichalcogenides and transition metal monochalcogenides considering the factors such as oxygen,water,and *** we show the commonly employed passivation *** the end,the emerging applications utilizing controlled oxidations will be introduced.

关键词： Two-dimensional materials Oxidation Passivation Surface modification Doping

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Targeted nanoparticles for the non-invasive detection of traumatic brain injury by optical imaging and fluorine magnetic resonance imaging

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Nano Research 2016年第5期9卷 1276-1289页

作者： Luis Javier Cruz Ivo Que Markus Aswendt Alan Chan Mathias Hoehn Clemens Lowik nanomedicine and Molecular Imaging Department of Radiology Leiden University Medical Center 2333ZA Leiden the Netherlands In-Vivo-NMR Laboratory Max Planck Institute for Neurological Research Cologne D-50931 Cologne Germany Percuros 7522NB Enschede the Netherlands

Necrosis is a form of cell death that occurs only under pathological conditions such as ischemic diseases and traumatic brain injury （TBI）. Non-invasive imaging of the affected tissue is a key component of novel therapeutic interventions and measurement of treatment responses in patients. Here, we report a bimodal approach for the detection and monitoring of TBI. PEGylated poly（lactic-coglycolic acid）（PLGA） nanoparticles （NPs）, encapsulating both near infrared （NIR） fluorophores and perfluorocarbons （PFCs）, were targeted to necrotic ceils. We used cyanine dyes such as IRDye 800CW, for which we have previously demonstrated specific targeting to intracellular proteins of cells that have lost membrane integrity. Here, we show specific in vivo detection of necrosis by optical imaging and fluorine magnetic resonance imaging （^19F MRI） using newly designed PLGA NP（NIR700 ＋ PFC）-PEG-800CW. Quantitative ex vivo optical imaging and ^19F MR spectroscopy of NIR-PFC content in injured brain regions and in major organs were well correlated. Both modalities allowed the in vivo identification of necrotic brain lesions in a mouse model of TBI, with optical imaging being more sensitive than ^19F MRI. Our results confirm increased blood pool residence time of PLGA NPs coated with a PEG layer and the successful targeting of TBI-damaged tissue. A single PLGA NP containing NIR-PFC enables both rapid qualitative optical monitoring of the TBI state and quantitative 3D information from deeper tissues on the extent of the lesion by MRI. These necrosis-targeting PLGA NPs can potentially be used for clinical diagnosis of brain injuries.

关键词： imaging nanoparticles contrast agents magnetic resonance imaging brain injury stroke

Identification of a mitochondria-targeting fluorescent small molecule for dual phototherapy

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Journal of Innovative Optical Health Sciences 2018年第4期11卷 27-34页

作者： Jie Chen Xu Tan Shenglin Luo Lei Long Lang Liu Zujuan Liu Yu Wang Chunmeng Shi State Key Laboratory of Trauma Burns and Combined Injury Institute of Combined Injury Chongqing Engineering Research Center for Nanomedicine College of Preventive Medicine Army Medical University30Gaotanyan Street Chongqing 400038P.R.China

Phototherapy,mainly induding photodynamic therapy(PDT)and photothermal therapy(PTT),is a noninvasive and effective approach for cancer *** integration of PDT and PTT for simultaneous synergistic PDT/PTT treatment enables us to improve phototherapeutic eficacy significantly,it has been attracting a lot of investigations in current ***,we introduce IR-52,a new mitochondria-targeting near infrared(NIR)fAuorescent small molecule,which possesses structure inherent PTT and PDT synergistic photother apeutic effects wit hout conjugation to specific *** NIR light irradiation(808 nm,2 W/cm^(2),5min),both the hyperthermia and excessive singlet oaxygen levels were determined when dis-solving IR-52 in aqueous *** vitro photoinduced cytotoxicity studies showed signifcant lower cell viabilities and higher necrotic/apoptotic rates when cancer cells were treated with IR-52 and irradiation,and its'mitochondrial localization in cancer cells would partially explain its high *** in vivo synergetic PDT and PTT effects were demonstrated by high tumor surface temperature and sigmificant inhibition of tumor *** results strongly suggest that IR-52,which possesses excellent photosensitivity,may provide a promising strategy for tumor treatment with decreased side effects.

关键词： Photosensitizer photodynamic therapy photother mal therapy mitochondria