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Identification of a mitochondria-targeting fluorescent small molecule for dual phototherapy

作     者:Jie Chen Xu Tan Shenglin Luo Lei Long Lang Liu Zujuan Liu Yu Wang Chunmeng Shi 

作者机构:State Key Laboratory of TraumaBurns and Combined Injury Institute of Combined Injury Chongqing Engineering Research Center for Nanomedicine College of Preventive Medicine Army Medical University30Gaotanyan Street Chongqing 400038P.R.China 

出 版 物:《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志(英文))

年 卷 期:2018年第11卷第4期

页      面:27-34页

核心收录:

学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基  金:the National Natural Science Foundation of China(Grant No.81402784) University Innovation Team Building Program of Chongqing(CXTDG201602020) 

主  题:Photosensitizer photodynamic therapy photother mal therapy mitochondria 

摘      要:Phototherapy,mainly induding photodynamic therapy(PDT)and photothermal therapy(PTT),is a noninvasive and effective approach for cancer *** integration of PDT and PTT for simultaneous synergistic PDT/PTT treatment enables us to improve phototherapeutic eficacy significantly,it has been attracting a lot of investigations in current ***,we introduce IR-52,a new mitochondria-targeting near infrared(NIR)fAuorescent small molecule,which possesses structure inherent PTT and PDT synergistic photother apeutic effects wit hout conjugation to specific *** NIR light irradiation(808 nm,2 W/cm^(2),5min),both the hyperthermia and excessive singlet oaxygen levels were determined when dis-solving IR-52 in aqueous *** vitro photoinduced cytotoxicity studies showed signifcant lower cell viabilities and higher necrotic/apoptotic rates when cancer cells were treated with IR-52 and irradiation,and its mitochondrial localization in cancer cells would partially explain its high *** in vivo synergetic PDT and PTT effects were demonstrated by high tumor surface temperature and sigmificant inhibition of tumor *** results strongly suggest that IR-52,which possesses excellent photosensitivity,may provide a promising strategy for tumor treatment with decreased side effects.

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