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Broad-spectrum ginsentides are principal bioactives in unraveling the cure-all effects of ginseng

Acta Pharmaceutica Sinica B 2024年第2期14卷 653-666页

作者： Shining Loo Antony Kam Bamaprasad Dutta Xiaohong Zhang Nan Feng Siu Kwan Sze Chuan-Fa Liu Xiaoliang Wang James P.Tam School of biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Academy of Pharmacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Department of biological Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China institute of Materia Medica Chinese Academy of Medical SciencesBeijing 100050China Department of Health Sciences Brock UniversityNiagara RegionON L2S 3A1Canada

Stress and illness connection is complex and involves multiple physiological *** ginsengs,reputed for their broad-spectrum“cure-all”effect,are widely prescribed to treat stress and related ***,the identity of ginseng’s“cure-all”medicinal compounds that relieve stress remains ***,we identify ginsentides as the principal bioactives that coordinate multiple systems to restore homeostasis in response to *** are disulfide-rich,cell-penetrating and proteolytic-stable *** affinity-enrichment mass spectrometry target identification together with in vitro,ex vivo and in vivo validations,we show that highly purified or synthetic ginsentides promote vasorelaxation by producing nitric oxide through endothelial cells via intracellular PI3K/Akt signaling pathway,alleviate a1-adrenergic receptor overactivity by reversing phenylephrine-induced constriction of aorta,decrease monocyte adhesion to endothelial cells via CD166/ESAM/CD40 and inhibit P2Y12 receptors to reduce platelet *** administered ginsentides were effective in animal models to reduce ADP-induced platelet aggregation,to prevent collagen and adrenalineinduced pulmonary thrombosis as well as anti-stress behavior of tail suspension and forced swimming tests in ***,these results strongly suggest that ginsentides are the principal panacea compounds of ginsengs because of their ability to target multiple extra-and intra-cellular proteins to reverse stress-induced damages.

关键词： Ginseng Cysteine-rich peptides Microproteins Cure-all Stress Homeostasis

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Engineering of oxygen vacancy and bismuth cluster assisted ultrathin Bi_(12)O_(17)Cl_(2)nanosheets with efficient and selective photoreduction of CO_(2)to CO

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Carbon Energy 2024年第4期6卷 1-11页

作者： Meili Guan Ni Lu Xuan Zhang Qiuwan Wang Jian Bao Guiye Chen Hao Yu Huaming Li Jiexiang Xia Xuezhong Gong College of Chemical and biological Engineering Shandong University of Science and TechnologyQingdaoShandongChina institute for Energy Research Jiangsu UniversityZhenjiangJiangsuChina National Center of International Joint Research for Hybrid Materials Technology Institute of Hybrid MaterialsCollege of Materials Science andEngineeringNational Base of International Science and Technology Cooperation on Hybrid MaterialsQingdao UniversityQingdaoShandongChina

The photocatalytic conversion of CO_(2)into solar‐powered fuels is viewed as a forward‐looking strategy to address energy scarcity and global *** work demonstrated the selective photoreduction of CO_(2)to CO using ultrathin Bi_(12)O_(17)Cl_(2)nanosheets decorated with hydrothermally synthesized bismuth clusters and oxygen vacancies(OVs).The characterizations revealed that the coexistences of OVs and Bi clusters generated in situ contributed to the high efficiency of CO_(2)–CO conversion(64.3μmol g^(−1)h^(−1))and perfect *** OVs on the facet(001)of the ultrathin Bi_(12)O_(17)Cl_(2)nanosheets serve as sites for CO_(2)adsorption and activation sites,capturing photoexcited electrons and prolonging light absorption due to defect *** addition,the Bi‐cluster generated in situ offers the ability to trap holes and the surface plasmonic resonance *** study offers great potential for the construction of semiconductor hybrids as multiphotocatalysts,capable of being used for the elimination and conversion of CO_(2)in terms of energy and environment.

关键词： Bi cluster Bi_(12)O_(17)Cl_(2)nanosheet oxygen vacancy photocatalytic CO_(2)reduction

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Nano-sized stationary phase packings retained by single-particle frit for microchip liquid chromatography

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Chinese Chemical Letters 2024年第4期35卷 486-489页

作者： Wangyan Hu Ke Li Xiangnan Dou Ning Li Xiayan Wang Center Excellence for Environmental Safety and biological Effects Beijing Key Laboratory for Green Catalysis and SeparationDepartment of ChemistryBeijing University of TechnologyBeijing 100124China Center for Environmental Metrology National Institute of MetrologyBeijing 100029China

Modern chromatography is increasingly focused on miniaturization and integration. Compared to conventional liquid chromatography, microfluidic chip liquid chromatography(microchip-LC) has the potential due to its zero-dead volume connection and ease of integration. Nano-sized packings have the potential to significantly enhance separation performance in microchip-LC. However, their application has been hindered by packing difficulties. This study presents a method for packing nano-sized silica particles into a microchannel as the stationary phase. The microchip-LC packed column was prepared by combining the weir and the porous silica single-particle as frit to retain the packing particles. A surface tensionbased single-particle picking technique was established to insert porous single-particle frit into glass microchannels. Additionally, we developed a slurry packing method that utilizes air pressure to inject nano-sized packing into the microchannel. Pressure-driven chromatographic separation was performed using this nano-packed column integrated into a glass microchip. The mixture of four PAHs was successfully separated within just 8 min using a 5 mm separation channel length, achieving high theoretical plates(10~6plates/m). Overall, these findings demonstrate the potential of utilizing nano-sized packings for enhancing chromatographic performance in microchip systems.

关键词： Nano-size packing Single-particle frit Packed column Microchip LC Chromatographic separation

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Phylogenetic study on Scenedesmacae with the description of a new genus Coccoidesmus ***.(Chlorophyceae,Chlorophyta)and chloroplast genome analyses

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Journal of Oceanology and Limnology 2024年第4期42卷 1272-1285页

作者： Qinghua WANG Ying HOU Yanhui LI Ying SHI Guoxiang LIU College of biological Sciences and Technology Taiyuan Normal UniversityJinzhong 030619China Shanxi Vocational University of Engineering Science and Technology Jinzhong 030619China Key Laboratory of Algal Biology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China

Members of the family Scenedesmaceae are some of the most common algal taxa in inland ecosystems,and they are widely distributed in freshwaters,aerial,and sub-aerial *** the continuous updating of methods,the classic morphological taxonomy of this family needs to be *** recent years,many genera of Scenedesmaceae have been established via the use of molecular *** phylogenetic relationships within Scenedesmaceae were analyzed using different molecular markers and morphological data,and the new freshwater genus Coccoidesmus Wang,Hou et Liu *** *** new species in this genus were also *** analysis based on tufA genes revealed that the new genus formed an independent clade closely related to ***,these two genera are characterized by significant morphological differences in colony arrangement and cell *** chloroplast genome of the type species was assembled and annotated,and analyses of genome structure and sequences were *** genome data could help clarify the phylogenetic relationships within this family.

关键词： phylogenetic Scenedesmaceae Coccoidesmus morphology chloroplast genome

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Achieving superior performance in powder-metallurgy near-βtitanium alloy by combining hot rolling and rapid heat treatment followed by aging

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Journal of Materials Science & Technology 2024年第4期171卷 24-36页

作者： Fucheng Qiu Tuo Cheng Yuchao Song Orest M.Ivasishin Dmytro G.Savvakin Guangyu Ma Huiyan Xu College of Materials Science and Engineering Jilin UniversityChangchun 130025China International Center of Future Science Jilin UniversityChangchun 130025China G.V.Kurdyumov institute for Metal Physics KyivUkraine College of biological and Agricultural Jilin UniversityChangchun 130025China

Heat treatment plays an important role in tailoring the mechanical properties of powder-metallurgy(PM)titanium ***,only limited work about the rapid heat treatment(RHT)of PM titanium alloys has been *** this work,RHT was applied to PM Ti-5Al-5Mo-5V-1Cr-1Fe alloy after hot rolling to study the evolution of its mechanical properties and the influence of residual pores on its *** hot rolling and annealing,a fine and uniformα+βstructure with few residual pores is *** RHT,the primaryαdissolves gradually and completes in theβregion,and theβgrains then grow,resulting in the continuous decrease in elongation after ***,the tensile strength first increases and then decreases with increasing RHT temperature,owing to the increase in volume fraction of secondaryαinα+βregion and theβgrain growth inβ*** contrast to the RHT of cast-and-wrought titanium,the negative influence of residual pores lowers the RHT temperature for obtaining the highest tensile strength to a temperature below theβ-transus *** the negative influence of the residual pores,retained primaryαand fineβgrains with fine secondaryαinside contribute to achieving a good strength/ductility balance(1570 MPa and 6.1%,respectively).Addi-tionally,although at higher cycles to failure,the negative influence of residual pores increases as it affects the crack initiation zone at the subsurface,the good resistance of secondaryαto fatigue crack propaga-tion still enhances the fatigue strength considerably(about 300 MPa).This work suggests a cost-effective strategy to produce titanium alloys with high performance.

关键词： Rapid heat treatment Powder metallurgy Mechanical properties Near-βtitanium Residual pores

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Bulging Distortion of Austenitic Stainless Steel Sheet on the Partially Penetrated Side of Non-Penetration Lap Laser Welding Joint

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 286-295页

作者： Chengwu Yao Enze Liu Jiaming Ni Binying Nie Shanghai Key Laboratory of Materials Laser Processing and Modification School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Aerospace Precision Machinery institute Shanghai 201600China Chemical and biological Engineering College Yichun UniversityYichun 336000China

Non-penetration laser welding of lap joints in austenitic stainless steel sheets is commonly preferred in fields where the surface quality is of utmost ***,the application of non-penetration welded austenitic stainless steel parts is limited owing to the micro bulging distortion that occurs on the back surface of the partial penetration *** this paper,non-penetration lap laser welding experiments,were conducted on galvanized and SUS304 austenitic stainless steel plates using a fiber laser,to investigate the mechanism of bulging distortion.A comparative experiment of DC01 galvanized steel-Q235 carbon steel lap laser welding was carried out,and the deflection and distortion profile of partially penetrated side of the sheets were measured using a noncontact laser *** addition,the cold-rolled SUS304 was subjected to heat holding at different temperatures and water quenching after bending to characterize its microstructure under tensile and compressive *** results show that,during the heating stage of the thermal cycle of laser lap welding,the partial penetration side of the SUS304 steel sheet generates compressive stress,which extrudes the material in the heat-affected zone to the outside of the back of the SUS304 steel sheet,thereby forming a *** findings of these experiments can be of great value for controlling the distortion of the partial penetrated side of austenitic stainless steel sheet during laser non-penetration lap welding.

关键词： Non-penetration lap laser welding Bulging distortion Austenitic stainless steel Compressive stress Tension stress

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Regulation of aging by NELF-A and RNA polymerase Ⅱ elongation

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Neural Regeneration Research 2024年第7期19卷 1415-1416页

作者： Chin-Tong Ong Zhen-Kai Ngian Temasek Life Sciences Laboratory and Department of biological Sciences National University of SingaporeSingaporeSingapore Department of Genetics Harvard Medical SchoolBostonMAUSA institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingaporeSingapore

Epigenetic regulation of aging:Aging is defined as the gradual decline of physiological function and cellular integrity,causing o rganismal vulnerability to age-onset diseases and *** in different animal models have l... 详细信息

关键词： aging twelve integrity

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Identification of overlay differentially expressed genes in both rats and goats with blast lung injury through comparative transcriptomics

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Chinese Journal of Traumatology 2024年第1期27卷 34-41页

作者： Hong Wang Jun-Hong Gao Xiao-Lin Fan Qing Lu Liang Li Ning Ma Qi Wang Yu-Hao Zhang Xi'an Key Laboratory of Toxicology and biological Effects Research Center for Toxicological and Biological EffectsInstitute for Hygiene of Ordnance IndustryXi'an710065China

Purpose:To identify the potential target genes of blast lung injury(BLI)for the diagnosis and ***:This is an experimental *** BLI models in rats and goats were established by conducting a fuel-air explosive power test in an unobstructed environment,which was subsequently validated through hematoxylin-eosin *** sequencing was performed on lung tissues from both goats and *** expressed genes were identified using the criteria ofq≤0.05 and|log2 fold change|≥*** that,enrichment analyses were conducted for gene ontology and the Kyoto Encyclopedia of Genes and Genomes *** potential target genes were further confirmed through quantitative real-time polymerase chain reaction and enzyme linked immunosorbent ***:Observations through microscopy unveiled the presence of reddish edema fluid,erythrocytes,and instances of focal or patchy bleeding within the alveolar *** sequencing analysis identified a total of 83 differentially expressed genes in both rats and ***,49 genes exhibited a consistent expression pattern,with 38 genes displaying up-regulation and 11 genes demonstrating *** analysis highlighted the potential involvement of the interleukin-17 signaling pathway and vascular smooth muscle contraction pathway in the underlying mechanism of ***,the experimental findings in both goats and rats demonstrated a strong association between BLI and several key genes,including anterior gradient 2,ankyrin repeat domain 65,bactericidal/permeability-increasing fold containing family A member 1,bactericidal/permeability-increasing fold containing family B member 1,and keratin 4,which exhibited ***:Anterior gradient 2,ankyrin repeat domain 65,bactericidal/permeability-increasing fold containing family A member 1,bactericidal/permeability-increasing fold containing family B member 1,and keratin 4 hold potential as target genes

关键词： Blast lung injury Transcriptomic Target genes Differentially expressed genes

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Design and experiment of high-speed straw cleaning unit with double air springs

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International Journal of Agricultural and biological Engineering 2024年第4期17卷 89-97页

作者： Xiaomeng Xia Honggang Li Shuyan Liu Ruiqiang Ran Yongjian Cong Yuhan Jin Dongyan Huang School of biological and Agricultural Engineering Jilin UniversityChangchun 130022China Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun 130022China Jilin Agricultural Machinery Research institute Changchun 130022China

No-tillage planters need to be equipped with row cleaners to remove post-harvest plant residue from the *** two-disc row cleaners cannot effectively remove the plant residue at high speed because the working depth is unstable,which leads to poor seeding quality of the seeder.A straw cleaning unit with double air springs was designed to achieve better straw cleaning performance at high *** analysis of the mechanical characteristics of the double air spring system showed that it enabled separate adjustment of force and stiffness.A dynamic model of the straw cleaning unit was established,and the effectiveness of the double air spring system with adjustable stiffness in stabilizing the working depth of the row cleaners was *** experiments were conducted to evaluate the straw cleaning performance and consistency of downforce against the ground of the straw cleaning unit with double air springs at different high *** results showed that the stiffness of the double air spring system for better straw cleaning performance of the straw cleaning unit was different at different working speed,and the required stiffness increased as the working speed increased;When the working speed was 8-12 km/h,the coefficient of variation of cleaned strip width was 6.9%-12.1%,the straw cleaning rate was 81.6%-92.2%and the root mean square error of downforce was 19.93-28.63 N;the coefficient of variation of cleaned strip width was moderately positively correlated with the root mean square error of downforce,and the cleaned strip width consistency was better when the root mean square error of downforce was lower than 25.00 N.

关键词： conservation tillage row cleaners straw cleaning unit double air spring system

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Cofitness network connectivity determines a fuzzy essential zone in open bacterial pangenome

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mLife 2024年第2期3卷 277-290页

作者： Pan Zhang Biliang Zhang Yuan-Yuan Ji Jian Jiao Ziding Zhang Chang-Fu Tian State Key Laboratory of Plant Environmental Resilience and College of Biological SciencesChina Agricultural UniversityBeijingChina MOA Key Laboratory of Soil Microbiology and Rhizobium Research CenterChina Agricultural UniversityBeijingChina Shenzhen institute of Synthetic Biology Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina State Key Laboratory of Livestock and Poultry Biotechnology Breeding and College of Biological SciencesChina Agricultural UniversityBeijingChina

Most in silico evolutionary studies commonly assumed that core genes are essential for cellular function,while accessory genes are dispensable,particularly in nutrient-rich ***,this assumption is seldom tested genetically within the pangenome *** this study,we conducted a robust pangenomic Tn-seq analysis of fitness genes in a nutrient-rich medium for Sinorhizobium strains with a canonical open *** evaluate the robustness of fitness category assignment,Tn-seq data for three independent mutant libraries per strain were analyzed by three methods,which indicates that the Hidden Markov Model(HMM)-based method is most robust to variations between mutant libraries and not sensitive to data size,outperforming the Bayesian and Monte Carlo simulation-based ***,the HMM method was used to classify the fitness *** genes,categorized as essential(ES),advantage(GA),and disadvantage(GD)genes for growth,are enriched in core genes,while nonessential genes(NE)are over-represented in accessory *** ES/GA genes showed a lower fitness effect than core ES/GA *** degrees in the cofitness network decrease in the order of ES,GD,and GA/*** addition to accessory genes,1599 out of 3284 core genes display differential essentiality across test *** the pangenome core,both shared quasi-essential(ES and GA)and strain-dependent fitness genes are enriched in similar functional *** analysis demonstrates a considerable fuzzy essential zone determined by cofitness connectivity degrees in Sinorhizobium pangenome and highlights the power of the cofitness network in understanding the genetic basis of ever-increasing prokaryotic pangenome data.

关键词： cofitnessnetwork pangenome Tn-seq

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