检索结果-南通市图书馆

Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第2期45卷 242-252页

作者： Xiu-Sheng Chen Rui Han Yan-Ting Liu Wei Huang Qi Wang Xin Xiong Ying Zhang Jian-Guo Zhao Shi-Hua Li Xiao-Jiang Li Wei-Li Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)GHM Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

PTEN-induced putative kinase 1(PINK1),a mitochondrial kinase that phosphorylates Parkin and other proteins,plays a crucial role in mitophagy and protection against neurodegeneration.Mutations in PINK1 and Parkin can lead to loss of function and early onset Parkinson's disease.However,there is a lack of strong in vivo evidence in rodent models to support the theory that loss of PINK1 affects mitophagy and induces neurodegeneration.Additionally,PINK1 knockout pigs(Sus scrofa)do not appear to exhibit neurodegeneration.In our recent work involving non-human primates,we found that PINK1 is selectively expressed in primate brains,while absent in rodent brains.To extend this to other species,we used multiple antibodies to examine the expression of PINK1 in pig tissues.In contrast to tissues from cynomolgus monkeys(Macaca fascicularis),our data did not convincingly demonstrate detectable PINK1expression in pig tissues.Knockdown of PINK1 in cultured pig cells did not result in altered Parkin and BAD phosphorylation,as observed in cultured monkey cells.A comparison of monkey and pig striatum revealed more PINK1-phosphorylated substrates in the monkey brain.Consistently,PINK1 knockout in pigs did not lead to obvious changes in the phosphorylation of Parkin and BAD.These findings provide new evidence that PINK1expression is specific to primates,underscoring the importance of non-human primates in investigating PINK1function and pathology related to PINK1 deficiency.

关键词： PINK1 Parkin Mitochondria Phosphorylation Non-human primates Pigs

维普期刊数据库博看期刊

Foam rolling and stretching do not provide superior acute flexibility and stiffness improvements compared to any other warm-up intervention: A systematic review with meta-analysis

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第4期13卷 509-520页

作者： Konstantin Warneke Gerit Plöschberger Lars H.Lohmann Eric Lichtenstein Daniel Jochum Stanislav D.Siegel Astrid Zech David G.Behm institute of Sport Science University of KlagenfurtKlagenfurt am Wörthersee 9020Austria Department of human Motion Science and Exercise Physiology Friedrich Schiller UniversityJena 07749Germany Department Sport Exercise and HealthUniversity of BaselBasel 4052Switzerland Department of Health Sciences and Technology ETH ZurichZurich 8092Switzerland School of human Kinetics and Recreation Memorial University of NewfoundlandSt.JohnsNL A1C 5S7Canada

Background:Acute improvement in range of motion(ROM)is a widely reported effect of stretching and foam rolling,which is commonly explained by changes in pain threshold and/or musculotendinous stiffness.Interestingly,these effects were also reported in response to various other active and passive interventions that induce responses such as enhanced muscle temperature.Therefore,we hypothesized that acute ROM enhancements could be induced by a wide variety of interventions other than stretching or foam rolling that promote an increase in muscle temperature.Methods:After a systematic search in PubMed,Web of Science,and SPORTDiscus databases,38 studies comparing the effects of stretching and foam rolling with several other interventions on ROM and passive properties were included.These studies had 1134 participants in total,and the data analysis resulted in 140 effect sizes(ESs).ES calculations were performed using robust variance estimation model with R-package.Results:Study quality of the included studies was classified as fair(PEDro score=4.58)with low to moderate certainty of evidence.Results showed no significant differences in ROM(ES=0.01,p=0.88),stiffness(ES=0.09,p=0.67),or passive peak torque(ES=-0.30,p=0.14)between stretching or foam rolling and the other identified activities.Funnel plots revealed no publication bias.Conclusion:Based on current literature,our results challenge the established view on stretching and foam rolling as a recommended component of warm-up programs.The lack of significant difference between interventions suggests there is no need to emphasize stretching or foam rolling to induce acute ROM,passive peak torque increases,or stiffness reductions.

关键词： Range of motion Passive properties Muscletendon unit Muscle tissue

Identification of novel mammalian viruses in tree shrews(Tupaia belangeri chinensis)

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第2期45卷 429-438页

作者： Hong Zhou Ren-Rong Tian Xiu-Rong Wang Jin-Xuan Yang Yun-Xiao Wang Ming-Liang Zhao Xu-Dong Zhang Yu-Hua Ma Long-Bao Lv Edward CHolmes Yong-Tang Zheng Wei-Feng Shi School of Clinical and Basic Medical Sciences Shandong First Medical University&Shandong Academy of Medical SciencesJi’nanShandong 250117China Key Laboratory of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University and Shandong Academy of Medical SciencesTaianShandong 271000China Key Laboratory of Animal Models and human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJi’nanShandong 250117China National Resource Center for Non-human Primates Kunming Primate Research CenterKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Sydney institute for Infectious Diseases School of Medical SciencesThe University of SydneySydneyNew South Wales 2006Australia Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai institute of virology Shanghai Jiao Tong University School of MedicineShanghai 200025China

The Chinese tree shrew(Tupaia belangeri chinensis),a member of the mammalian order Scandentia,exhibits considerable similarities with primates,including humans,in aspects of its nervous,immune,and metabolic systems.These similarities have established the tree shrew as a promising experimental model for biomedical research on cancer,infectious diseases,metabolic disorders,and mental health conditions.Herein,we used metatranscriptomic sequencing to analyze plasma,as well as oral and anal swab samples,from 105 healthy asymptomatic tree shrews to identify the presence of potential zoonotic viruses.In total,eight mammalian viruses with complete genomes were identified,belonging to six viral families,including Flaviviridae,Hepeviridae,Parvovirinae,Picornaviridae,Sedoreoviridae,and Spinareoviridae.Notably,the presence of rotavirus was recorded in tree shrews for the first time.Three viruses-hepacivirus 1,parvovirus,and picornavirus-exhibited low genetic similarity(94%)to known viral strains.Phylogenetic analyses also revealed that the rotavirus and mammalian orthoreovirus identified in this study may be novel reassortants.These findings provide insights into the diverse viral spectrum present in captive Chinese tree shrews,highlighting the necessity for further research into their potential for crossspecies transmission.

关键词： Tree shrew(Tupaia belangeri chinensis) Meta-transcriptomic sequencing Mammalian viruses Genomic analysis

维普期刊数据库博看期刊

Rights for People With Disabilities Guaranteed

在线全文

学校读者我要写书评

暂无评论

China News Release 2024年第4期 31-35页

作者： Zhou Lulu the China Society for human Rights Studies Guangzhou University Research institute for human Rights

According to data released by the China Disabled Persons’Federation,the total number of people with disabilities in China has reached over 85 million,equivalent to one disabled person for every 16 Chinese people.These 85 million people with disabilities make up 6.34%of the country’s total population.This significant groups living conditions are closely linked to the quality of life and happiness of millions of families.

关键词： abilities population dis

Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第7期19卷 1584-1592页

作者： Jong Mi Park Masoud Rahmati Sang Chul Lee Jae Il Shin Yong Wook Kim Department and Research institute of Rehabilitation Medicine Yonsei University College of MedicineSeoulSouth Korea Department of Physical Education and Sport Sciences Faculty of Literature and Human SciencesLorestan UniversityKhoramabadIran Department of Pediatrics Yonsei University College of MedicineSeoulSouth Korea

Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgro

关键词： animal animal experimentation mesenchymal stem cells models Parkinson’s disease stem cell transplantation

Genetic Basis for Mucormycosis Progression in COVID-19 Patients:From Susceptibility to Severity

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases & Immunity 2024年第2期4卷 86-92页

作者： Jethendra Kumar Muruganantham Ramakrishnan Veerabathiran human Cytogenetics and Genomics Laboratory Faculty of Allied Health SciencesChettinad Hospital and Research InstituteChettinad Academy of Research and EducationKelambakkamTamilnadu 603103India.

The dynamics of COVID-19 and mucormycosis reveal a complex interplay of genetic factors that influence the susceptibility,severity,and immune responses.COVID-19,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),exhibits an increased incidence of mucormycosis,particularly in individuals with comorbidities or corticosteroid therapy.Mucormycosis is a fungal infection that affects the sinuses,orbits,and lungs and demands timely intervention with antifungal medications and surgery because of its life-threatening nature.Research on the genetic underpinnings of this intersection has unveiled key insights into the pathogenicity of Mucorales.Breakthroughs in genetic tools have exposed virulence factors,such as the CotH protein family and high-affinity iron-uptake mechanisms.Genetic susceptibility is a pivotal element in identifying individuals at risk of developing COVID-19,facilitating early detection,and allowing for personalized treatment strategies.DPP9,MIF,and TYK2 are among the genes implicated in COVID-19 severity,emphasizing the intricate relationship between genetic makeup and viral response.The genetic landscape extends to viral entry mechanisms,thereby affecting infection efficiency.Specific polymorphisms in genes such as IFNAR2,OAS3,and TYK2 are associated with COVID-19 severity,indicating shared genetic bases between severe and hospitalized cases.Mucormycosis is genetically predisposed,particularly in immunocompromised individuals.The challenge lies in understanding the genetic factors influencing susceptibility and offering insights into pathogenesis and potential therapeutic avenues.Organ transplantation adds another layer,increasing susceptibility to infections such as COVID-19 and mucormycosis.The impact of immunosuppression on COVID-19 severity remains elusive,necessitating ongoing research on the immunological mechanisms.Despite the challenges posed by emerging SARSCoV-2 variants,the intricate connection between genetic factors and the interplay of COVID-19 and mucormycosis presents

关键词： COVID-19 Mucormycosis Pathogenesis Genetics basis

An Extensive Review of Vitiligo-Associated Conditions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Dermatology And Venereology 2024年第1期07卷 44-51页

作者： Premkumar Madhavi Kalarani Iyshwarya Bhaskar Mohammed Vajagathali Veerabathiran Ramakrishnan human Cytogenetics and Genomics Laboratory Faculty of Allied Health Sciences Chettinad Hospital and Research institute Chettinad Academy of Research and Education Kelambakkam Tamil Nadu 603103 India

Vitiligo is an autoimmune disorder caused by the destruction of melanocytes in various body regions. Numerous diseases may accompany vitiligo. The prevalence of vitiligo varies among geographical regions and shows no relation to sex or age. However, vitiligo most commonly affects people aged 10 to 30 years. The clinical symptoms of vitiligo include irregular patches on the skin and various diseases associated with this disorder. The present review focuses on the clinical effects and risk factors of vitiligo-associated conditions and the current therapeutics for treating vitiligo. This systematic review was performed based on the PRISMA guidelines and articles published from 2000 to 2023 in Web of Science, PubMed, PsycINFO, and Embase. The most clinically significant diseases associated with vitiligo are alopecia areata, autoimmune thyroid disease, Addison disease, and type 1 diabetes mellitus. No targeted population is specifically prone to vitiligo; it does not affect any particular race or sex. Hence, awareness of the diseases associated with vitiligo is necessary to control them through various medical and surgical treatments with the proper facilities.

关键词： vitiligo autoimmune disorder melanocyte Addison disease atopic dermatitis

An extended social force model on unidirectional flow considering psychological and behavioral impacts of hazard source

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第2期33卷 567-576页

作者：邓凯丰李梦胡祥敏陈涛 institute of Public Safety Research Department of Engineering PhysicsTsinghua UniversityBeijing 100084China Anhui Province Key Laboratory of human Safety Hefei 230601China Beijing Key Laboratory of Comprehensive Emergency Response Science Beijing 100084China

An accurate assessment of the evacuation efficiency in case of disasters is of vital importance to the safety design of buildings and street blocks.Hazard sources not only physically but psychologically affect the pedestrians,which may further alter their behavioral patterns.This effect is especially significant in narrow spaces,such as corridors and alleys.This study aims to integrate a non-spreading hazard source into the social force model following the results from a previous experiment and simulation,and to simulate unidirectional pedestrian flows over various crowd densities and clarity–intensity properties of the hazard source.The integration include a virtual repulsion force from the hazard source and a decay on the social force term.The simulations reveal(i)that the hazard source creates virtual bottlenecks that suppress the flow,(ii)that the inter-pedestrian push forms a stabilisation phase on the flow-density curve within medium-to-high densities,and(iii)that the pedestrians are prone to a less orderly and stable pattern of movement in low clarity–intensity scenarios,possibly with lateral collisions passing the hazard source.

关键词： evacuation social force model hazard source unidirectional pedestrian flow

The anti-inflammatory effects of exercise on autoimmune diseases:A 20-year systematic review

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第3期13卷 353-367,I0001页

作者： Beibei Luo Dao Xiang Xiaorong Ji Xuan Chen Rui Li Shuxin Zhang Yujun Meng David C.Nieman Peijie Chen School of Exercise and Health Shanghai University of SportShanghai 200438China Shanghai Key Laboratory of human Performance Shanghai University of SportShanghai 200438China Department of Diving and Hyperbaric Medicine Naval Medical CenterShanghai 200433China National Key Laboratory of Immunity and Inflammation Naval Medical UniversityShanghai 200433China human Performance Laboratory Appalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA Research institute for Doping Control Shanghai University of SportShanghai 200438China

Background:The anti-inflammatory effect of exercise may be an underlying factor in improving several autoimmune diseases.The aim of this systematic review was to examine the evidence on the role of exercise training in mitigating inflammation in adolescents and adults with autoimmune disease.Methods:PubMed,Web of Science,and Embase databases were systematically reviewed for related studies published between January 1,2003,and August 31,2023.All randomized and non-randomized controlled trials of exercise interventions with autoimmune disease study participants that evaluated inflammation-related biomarkers were included.The quality of evidence was assessed using the Tool for the assEssment of Study qualiTy and reporting in EXercise scale and Cochrane bias risk tool.Results:A total of 14,565 records were identified.After screening the titles,abstracts,and full texts,87 were eligible for the systematic review.These studies were conducted in 25 different countries and included a total of 2779 participants(patients with autoimmune disease,in exercise or control groups).Overall,the evidence suggests that inflammation-related markers such as C-reactive protein,interleukin 6,and tumor necrosis factor a were reduced by regular exercise interventions.Regular exercise interventions combined with multiple exercise modes were associated with greater benefits.Conclusion:Regular exercise training by patients with autoimmune disease exerts an anti-inflammatory influence.This systematic review provides support for the promotion and development of clinical exercise intervention programs for patients with autoimmune disease.Most patients with autoimmune disease can safely adopt moderate exercise training protocols,but changes in inflammation biomarkers will be modest at best.Acute exercise interventions are ineffective or even modestly but transiently pro-inflammatory.

关键词： Autoimmune diseases Cytokines Inflammation Physical activity Training