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Establishment and Validation of a Four-stress Granule-related Gene Signature in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 1-14页

作者： Mengzhu Li Xiude Fan Jiajun Zhao Dawei Wang Department of endocrinology Shandong Provincial HospitalShandong UniversityJinanShandongChina Key Laboratory of Endocrine Glucose&Lipids metabolism and Brain Aging Ministry of EducationDepartment of EndocrinologyShandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Shandong Key Laboratory of endocrinology and Lipid metabolism JinanShandongChina Shandong institute of Endocrine and Metabolic Diseases JinanShandongChina

Background and Aims:Stress granules(SGs)as membrane-less cytoplasmic foci formed in response to unfavorable external stimuli could promote cancer cells to adapt to hostile *** carcinoma(HCC)is prone to be highly aggressive once diagnosed,which markedly reduces patient survival ***,it is crucial to develop valid diagnostic markers to prognosticate HCC patient prognosis,which promotes individualized precision therapeutics in *** the pro-tumorigenic activity of SGs,it is of great potential value to construct a prognostic tool for HCC based on the expression profiles of SG-related genes(SGGs).Methods:Bioinformatic analysis was employed to establish an SGG-based prognostic *** blotting and realtime polymerase chain reaction assays were used to assess the expression patterns of the related ***-of-function experiments were performed to analyze the effect of the SGGs on SG formation and cell ***:A four-SGG signature(KPNA2,MEX3A,WDR62,and SFN)targeting HCC was established and validated to exhibit a robust performance in predicting HCC ***,all four genes were further found to be highly expressed in human HCC *** important,we demonstrated that individually knocking down the four SGGs significantly reduced HCC cell proliferation and metastasis by compromising the SG formation ***:We developed an SGG-based predictive signature that can be used as an independent prognostic tool for *** strong predictive power of this signature was further elucidated by the carcinogenic activity of KPNA2,MEX3A,WDR62,and SFN in HCC cells by regulating SG formation.

关键词： Hepatocellular carcinoma Stress granules Prognostic factor G3BP1

Remission of type 2 diabetes mellitus

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World Journal of Diabetes 2024年第7期15卷 1384-1389页

作者： Afif Nakhleh Elya Halfin Naim Shehadeh institute of endocrinology Diabetes and MetabolismRambam Health Care CampusHaifa 3109601Israel Diabetes and endocrinology Clinic Maccabi Healthcare ServicesHaifa 3299001Israel The Azrieli Faculty of Medicine Bar-Ilan UniversitySafed 1311502Israel

The surge in type 2 diabetes mellitus(T2DM)is tightly linked to obesity,leading to ectopic fat accumulation in internal *** management has become a cornerstone of T2DM treatment,with evidence suggesting that significant weight loss can induce ***,defined as sustained hemoglobin(HbA1c)below 6.5% for at least 3 months without medication,can be achieved through various approaches,including lifestyle,medical,and surgical *** bariatric surgery offers significant remission rates,particularly for patients with severe *** lifestyle modifications,including lowcalorie diets and exercise,have also demonstrated significant *** like incretin-based agents show robust results in improving beta-cell function,achieving glycemic control,and promoting weight *** complete remission without medication may not be attainable for everyone,especially those with severe insulin resistance or deficiency,early and aggressive glycemic control remains a crucial *** HbA1c below 6.5%from the time of diagnosis reduces the risk of long-term complications and ***,considering a broader definition of remission,encompassing individuals with sustained control on medication,could offer a more comprehensive and inclusive approach to managing this chronic disease.

关键词： Type 2 diabetes mellitus Remission Lifestyle intervention Metabolic bariatric surgery Glucose-lowering medications Weight management medications

Beyond reproduction:unraveling the impact of sex hormones on cardiometabolic health

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Medical Review 2024年第4期4卷 284-300页

作者： Viktoria Xega Jun-Li Liu MeDiC Program The Research Institute of McGill University Health CentreMontrealCanada Division of endocrinology and metabolism Department of MedicineMcGill UniversityMontrealCanada

This review thoroughly explores the multifaceted roles of sexual hormones,emphasizing their impact beyond reproductive functions and underscoring their signiﬁcant inﬂuence on cardiometabolic *** analyzes the broader physiological implications of estrogen,testosterone,and progesterone,highlighting their eﬀects on metabolic syndrome,lipid metabolism,glucose homeostasis,and car-diovascular *** from diverse molecular,clin-ical,and therapeutic studies,the paper delves into the intricate interplay between these hormones and car-diometabolic *** presenting a comprehensive analysis that goes beyond traditional perspectives,and recognizing sexual hormones as more than reproductive agents,the review sheds light on their broader signiﬁcance in health and disease management,advocating for holistic and personalized medical approaches.

关键词： estrogens progesterone androgens metabolic syndrome cardiovascular diseases

Influence of ear tags on the results of body composition analysis in mice

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Animal Models and Experimental Medicine 2024年第4期7卷 578-583页

作者： He Liu Yinghua Zhang Peng Zhang Weiping Teng Zhongyan Shan Yushu Li Dan Wang Department of endocrinology and metabolism and the institute of endocrinology NHC Key Laboratory of Diagnosis and Treatment of Thyroid DiseasesThe First Hospital of China Medical UniversityShenyangChina School of Public Health China Medical University China Medical UniversityShenyangChina Shenyang Food and Drug Inspection institute ShenyangChina

Background:The aim of this study was to investigate the influence of marking meth-ods on the outcomes of body composition analysis and provide guidance for the se-lection of marking methods in mouse body composition ***:Male C57BL/6J mice aged 6 weeks were randomly assigned for pre-and post-ear tagging *** body composition of the mice was measured using a small animal body composition analyzer,which provided measurements of the mass of fat,lean,and free ***,the mass of fat,lean and free fluid to body weight ratio was *** data analysis was conducted to obtain the range and coeffi-cient of variation in body composition measurements for each *** distribution of fat and lean tissue in the mice was also analyzed by comparing the fat-to-lean ***:(1)The mass of all body composition components in the ear tagging group was significantly lower than that in the control group.(2)There was a significant in-crease in the range and coefficient of variation of body composition measurements between the ear tagging group and the control group.(3)The fat-to-lean ratio in the ear tagging group was significantly lower than that in the control ***:Ear tagging significantly lowered the results of body composition analy-sis in mice and higher the results of measurement ***,ear tagging should be avoided as much as possible when conducting body composition analysis experi-ments in mice.

关键词： body composition analysis ear tagging labeling method stainless steel toe clipping

The gut–liver axis calibrates PEDF production for ISC homeostasis

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Biophysics Reports 2024年第3期10卷 175-177页

作者： Ying Huang Xinran Wang Lulu Sun State Key Laboratory of Female Fertility Promotion Department of Endocrinology and Metabolism Peking University Third Hospital institute of Advanced Clinical Medicine Peking University

The biliary tract, portal vein, and systemic circulation are the anatomical linkages that enable bidirectional inter-organ communications through the gut–liver axis.(Han et al. 2023). Under physiological conditions, the proliferation of intestinal stem cells(ISCs) materializes the self-renewal of the intestinal epithelium for gut barrier integrity(van der Flier and Clevers 2009), and such crosstalk contributes to the repair capacity of the intestinal tract by accommodating the ISCs(Chen et al.2022; Hegyi et al. 2018). Nonetheless, in pathological conditions such as inflammatory bowel disease(IBD),the compromised intestinal barrier caused by inflammation increases the translocation of microorganisms(Wigg et al. 2001).

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Honeymoon phase in type 1 diabetes mellitus: A window of opportunity for diabetes reversal?

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World Journal of Clinical Cases 2024年第1期12卷 9-14页

作者： Madhukar Mittal Pradakshna Porchezhian Nitin Kapoor Department of endocrinology and metabolism All India Institute of Medical Sciences JodhpurJodhpur 342005India Department of endocrinology Diabetes and MetabolismChristian Medical College and HospitalVellore 632004Tamil NaduIndia

The knowledge of the pathogenesis of type 1 diabetes mellitus(T1DM)continues to rapidly *** natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic *** all individuals of T1DM progress in that specific *** hereby present a case of T1DM with a classical third phase(honeymoon phase)and discuss the intri-cacies of this interesting phase along with a possible future promise of“cure”with the use of *** now know that the course of T1DM may not be in only one direction towards further progression;rather the disease may have a waxing and waning course with even reversal of type 1 diabetes concept being *** third phase popularly called the“honeymoon phase”,is of special interest as this phase is complex in its *** honeymoon phase of T1DM seems to provide the best window of opportunity for using targeted therapies using various immunomodulatory agents leading to the possibility of achieving the elusive“diabetes reversal”in *** this phase is therefore the key,with a lot of varying criteria having been proposed.

关键词： Diabetes reversal Diabetes remission Type 1 diabetes Honeymoon phase Immunomodulation

Metabolomic profiling reveals decreased serum cysteine levels during gestational diabetes mellitus progression

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Journal of Molecular Cell Biology 2024年第3期16卷 35-45页

作者： Mengyu Lai Jiaomeng Li Jiaying Yang Qingli Zhang Yujia Gong Yuhang Ma Fang Fang Na Li Yingxiang Zhai Tingting Shen Yongde Peng Jia Liu Yufan Wang Department of endocrinology and metabolism Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Shanghai institute of Materia Medica Chinese Academy of SciencesShanghai 201203China School of Pharmacy Henan UniversityKaifeng 475004China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310058China

Gestational diabetes mellitus(GDM)is a pregnancy-related metabolic disorder associated with short-term and long-term adverse health outcomes,but its pathogenesis has not been clearly *** of the dynamic changes in metabolomic markers in different trimesters may reveal the underlying pathophysiology of GDM ***,in the present study,we analysed the metabolic profiles of 75 women with GDM and 75 women with normal glucose tolerance throughout the three *** found that the variation trends of 38 metabolites were significantly changed during GDM ***,longitudinal analyses revealed that cysteine(Cys)levels significantly decreased over the course of GDM *** study showed that Cys alleviated GDM in female mice at gestational day 14.5,possibly by inhibiting phosphoenolpyruvate carboxykinase to suppress hepatic *** together,these findings suggest that the Cys metabolism pathway might play a crucial role in GDM and Cys supplementation represents a potential new treatment strategy for GDM patients.

关键词： gestational diabetes mellitus metabolomics cysteine

High glucose promotes macrophage M1 polarization through miR-32/Mef2d/cAMP signaling pathway

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Genes & Diseases 2024年第2期11卷 539-541页

作者： Cong Chen Jingsong Cao Yan Gao Xiaoping Xie Zhibo Zhao Qing Yuan Yuqi He Xuyu Zu Jianghua Liu The First Affiliated Hospital Institute of Endocrinology and MetabolismCenter for Clinical Research in DiabetesHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China The First Affiliated Hospital Department of Laboratory MedicineHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China The First Affiliated Hospital Institute of OncologyHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China

Chronic inflammation is a crucial inducerof diabetesvascular *** is that high glucose easily induces macrophage activation.1 Macrophages are the principal participants in innate immunity and exist in all human *** pathological vascular,infiltrated macrophages secrete inflammatory factors leading to an increase in plaque stability.?In macrophage polarization,autophagy plays an important *** of macrophage autophagy could induce macrophage polarization from the M1 phenotype to M2 phenotype and inhibit inflammatory reactions.3 Our previous research found that high glucose condition promotes miR-32 expression and macrophage M1 polarization,4 but the mechanism of miR-32 promoting macrophage M1 polarization is *** this study,we found that,under a high-glucose condition,miR-32/Mef2d/cAMP signaling promoted M1 macrophage polarization via inhibited *** results provide a theoretical and experimental basis for the prevention and treatment of T2D vascular inflammation.

关键词： macrophage miR prevention

Serum 25-hydroxyvitamin D,genetic susceptibility,and the risk of incident type 2 diabetes:A prospective cohort in East China

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Chinese Medical Journal 2024年第8期137卷 972-979页

作者： Ying Sun Haojie Zhang Bin Wang Yuying Wang Chi Chen Yi Chen Yingli Lu Ningjian Wang institute and Department of endocrinology and metabolism Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200011China Department of endocrinology and metabolism and Department of Guideline and Rapid Recommendation Cochrane China CenterMAGIC China CenterChinese Evidence-Based Medicine CenterWest China HospitalSichuan UniversityChengduSichuan 610041China Department of endocrinology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

Background:The serum vitamin D level varies widely by population,and studies have linked vitamin D levels with the risk of type 2 diabetes mellitus(T2DM).However,the relationship is inconsistent and the impact of vitamin D on T2DM among East Chinese adults is *** study aimed to investigate the association between serum 25-hydroxyvitamin D(25[OH]D)levels and the risk of T2DM and evaluated whether the association is modified by genetic ***:In the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors(SPECT-China)cohort,1862 participants free of T2DM at baseline were included.A weighted genetic risk score was calculated with 28 variants associated with *** logistic models were used to examine the association of serum 25(OH)D and genetic risk with ***:After a 5-year follow-up,132 cases of T2DM were *** observed no significant association between quartiles of serum 25(OH)D and T2DM risk after multivariable adjustment(χ^(2)=0.571,P_(for trend)=0.426).Compared to those in the lowest quartile of 25(OH)D,the odds ratios(ORs)(95%confidence interval[CI])for participants with increased quartiles were 1.29(0.74-2.25),1.35(0.77-2.36),and 1.27(0.72-2.24),*** observed a positive association of glycated hemoglobin(HbA1c)with 25(OH)D at baseline(β=1.752,P=0.001)and after follow-up(β=1.385,P=0.003),and a negative association of ln conversion homeostasis model assessment(HOMA)-βwith 25(OH)D at baseline(β=-0.982,P=0.021).There was no significant interaction between 25(OH)D and diabetes genetic predisposition on the risk of T2DM(χ^(2)=2.710,P_(for interaction)=0.100).The lowest OR(95%CI)of T2DM was among participants with low genetic risk and the highest quartile of 25(OH)D(0.17[0.05-0.62]).Conclusion:Serum 25(OH)D may be irrelevant to the risk of incident T2DM among East Chinese adults regardless of genetic predisposition.

关键词： Vitamin D Diabetes mellitus,Type 2 Genetic predisposition to disease Prospective cohort Glycated hemoglobin SPECT-China