High glucose promotes macrophage M1 polarization through miR-32/Mef2d/cAMP signaling pathway
作者机构：The First Affiliated HospitalInstitute of Endocrinology and MetabolismCenter for Clinical Research in DiabetesHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China The First Affiliated HospitalDepartment of Laboratory MedicineHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China The First Affiliated HospitalInstitute of OncologyHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2024年第11卷第2期
页 面：539-541页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by the National Natural Science Foundation of China(No.81873651) Natural Science Foundation of Hunan Province,China(No.2021JJ40490,2021JJ70113) Scientific Research Fund Project of Hunan Provincial Health Commission,China(No.20201981,20201901)
主 题：macrophage miR prevention
摘 要：Chronic inflammation is a crucial inducerof diabetesvascular *** is that high glucose easily induces macrophage activation.1 Macrophages are the principal participants in innate immunity and exist in all human *** pathological vascular,infiltrated macrophages secrete inflammatory factors leading to an increase in plaque stability.?In macrophage polarization,autophagy plays an important *** of macrophage autophagy could induce macrophage polarization from the M1 phenotype to M2 phenotype and inhibit inflammatory reactions.3 Our previous research found that high glucose condition promotes miR-32 expression and macrophage M1 polarization,4 but the mechanism of miR-32 promoting macrophage M1 polarization is *** this study,we found that,under a high-glucose condition,miR-32/Mef2d/cAMP signaling promoted M1 macrophage polarization via inhibited *** results provide a theoretical and experimental basis for the prevention and treatment of T2D vascular inflammation.
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