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Effect of add-on therapy with Traditional Chinese Medicine on the survival of patients with anemic lower-risk myelodysplastic syndromes in the real-world setting:a retrospective study

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Journal of Traditional Chinese Medicine 2025年第1期45卷 152-159页

作者： QU Weiying TAN Xyucheng ZHAO Yihan YU Yanan ZHAO Lin Department of Hematology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine institute of Basic Research in clinical Medicine China Academy of Chinese Medical Sciences Department of Hematology and CHEN Jianjie National Famous Old Chinese Medicine Expert Inheritance Studio Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

OBJECTIVE: To illustrate the effect of add-on therapy of Traditional Chinese Medicine(TCM) on the long-term survival of anemic lower-risk myelodysplastic syndromes(LR-MDS) patients. METHODS: In this study, we conducted a retrospective analysis of the data of patients with LR-MDS who were identified from Shuguang Hospital between January 2006 and June 2020. The Kaplan-Meier method was used to calculate overall survival(OS), while the Cox model was employed to analyze prognostic factors of long-term survival. A total of 162 patients who met the inclusion criteria were divided into two groups: the TCM group(n = 78) or the non-TCM group(n = 84). RESULTS: There were no significant differences in baseline characteristics. The cumulative survival rate of the TCM group was significantly higher than that of the non-TCM group [log-rank P = 0.029, hazard ratio(HR) = 0.484, 95% confidence interval(CI)(0.249, 0.942), P 0.05). CONCLUSIONS: The integration of TCM and Western Medicine has the potential to extend the OS of LR-MDS patients when compared to the use of Western Medicine alone.

关键词： lower-risk myelodysplastic syndromes medicine, Chinese traditional overall survival retrospective studies

Antibody-drug conjugates in breast cancer: advances and prospects

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Cancer Biology & Medicine 2025年第02期 83-92页

作者： Zhiqiang Shi Yongjin Lu Qiuchen Zhao Yongsheng Wang Pengfei Qiu Breast Cancer Center Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Tianjin Medical University Cancer institute & Hospital National Clinical Research Center for Cancer Shandong First Medical University (Shandong Academy of Medical sciences) Cancer Research UK Cambridge Centre Ph D Programme University of Cambridge

The “Global Cancer Statistics Report 2022” estimates that there were approximately 20 million new cancer cases worldwide, including 9.7 million in females, of which 2.31 million were breast cancer cases1. Breast cancer is the most common malignant tumor in women and one of the leading causes of cancer-related deaths.

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Composite score of PD-1+CD8+ tumor-infiltrating lymphocytes and CD57+CD8+ tumor ascites lymphocytes is associated with prognosis and tumor immune microenvironment of patients with advanced high-grade serous ovarian cancer

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Chinese Journal of Cancer Research 2025年第01期 73-99页

作者： Tianhui He Jie Zhang Lin Zeng Zhongnan Yin Bo Yu Xi Zhang Xiaoxue Yang Chunliang Shang Lixiang Xue Hongyan Guo Department of Obstetrics and Gynecology Peking University Third Hospital Center of Basic Medical Research Institute of Medical Innovation and Research Peking University Third Hospital Biobank Peking University Third Hospital Research Center of clinical Epidemiology Peking University Third Hospital

Objective: The expression of programmed death 1（PD-1） on CD8+T cells is associated with their activation and exhaustion, while CD57 serves as a senescence marker. The impact of PD-1+and CD57+CD8+T cells on the prognosis of patients with advanced high-grade serous ovarian cancer（HGSOC） remain ***: We assessed the percentages of PD-1+and CD57+CD8+T cells in tumor-infiltrating lymphocytes（TILs, n=85） and tumor ascites lymphocytes（TALs, n=87） using flow cytometry. The optimal cutoffs for these markers in TILs and TALs were determined through the log-rank maximization method. Gene expression analysis elucidated the tumor immune microenvironment（TIME, n=36）.Results: Patients with higher PD-1+CD8+TILs（>87.8%） exhibited longer platinum-free interval（PFI） and overall survival（OS）. In contrast, those with elevated CD57+CD8+TALs（>28.69%） were more likely to experience chemotherapy and had lower complete remission rates, shorter PFI and OS. PD-1+CD8+TILs are primarily displayed an effector memory state with strong proliferative and secretory capabilities. Approximately 50% of CD57+CD8+TALs were terminally differentiated, exhibiting significantly impaired proliferation. Based on the proportions of PD-1+CD8+TILs and CD57+CD8+TALs, patients were categorized into good, median and poor prognosis groups, with median PFI of 47.78, 27.29 and 11.96 months, respectively（P<0.0001）. Median OS for these groups was not reach, 49.23 and 30.92 months, respectively（P<0.0001）. Patients with poor prognosis exhibit significantly reduced CD8+T cell proportion and increased M2 macrophage in the TIME, alongside downregulation of multiple T cell activation-related ***: Lower levels of PD-1+CD8+TILs and higher CD57+CD8+TALs, assessed prior to treatment,correlated with poor prognosis and suppressive TIME in advanced HGSOC.

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The Impairment Attention Capture by Topological Change in Children With Autism Spectrum Disorder

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生物化学与生物物理进展 2025年第1期52卷 223-232页

作者： XU Hui-Lin XI Huan-Jun DUAN Tao LI Jing LI Dan-Dan WANG Kai ZHU Chun-Yan School of Mental health and Psychological sciences Anhui Medical UniversityHefei 230032China institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China Anhui Provincial institute of Translational Medicine Hefei 230032China Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefei 230032China Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders Anhui Medical UniversityHefei 230032China Collaborative Innovation Center of Neuropsychiatric Disorders and Mental health Anhui Medical UniversityHefei 230032China

Objective Autism spectrum disorder(ASD)is a neurodevelopmental condition characterized by difficulties with communication and social interaction,restricted and repetitive *** studies have indicated that individuals with ASD exhibit early and lifelong attention deficits,which are closely related to the core symptoms of *** visual attention processes may provide a critical foundation for their social communication and interaction ***,this study explores the behavior of children with ASD in capturing attention to changes in topological *** Our study recruited twenty-seven ASD children diagnosed by professional clinicians according to DSM-5 and twenty-eight typically developing(TD)age-matched *** an attention capture task,we recorded the saccadic behaviors of children with ASD and TD in response to topological change(TC)and non-topological change(nTC)*** reaction time(SRT),visual search time(VS),and first fixation dwell time(FFDT)were used as indicators of attentional *** correlation tests between the clinical assessment scales and attentional bias were *** This study found that TD children had significantly faster SRT(P0.05).Additionally,ASD children demonstrated significantly less attention towards the TC targets(measured by FFDT),in comparison to TD children(P<0.05).Furthermore,ASD children exhibited a significant negative linear correlation between their attentional bias(measured by VS)and their scores on the compulsive subscale(P<0.05).Conclusion The results suggest that children with ASD have difficulty shifting their attention to objects with topological changes during change *** atypical attention may affect the child’s cognitive and behavioral development,thereby impacting their social communication and

关键词： attention autism spectrum disorder perceptual object topological perception

Attitude towards genetic testing for breast cancer susceptibility genes and choice of prevention strategies in Chinese women with or without breast cancer

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Cancer Biology & Medicine 2025年第1期22卷 28-32页

作者： Xue Yu Furong Kou Yuntao Xie Department of Breast Surgery Peking University International Hospital Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Comprehensive Clinical Trial WardPeking University Cancer Hospital & Institute Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Familial and Hereditary Cancer Center Peking University Cancer Hospital & Institute

Breast cancer (BC) is now the most common cancer and the fifth leading cause of cancer-associated mortality among women in China1. Germline pathogenic variants (PVs) of BC susceptibility genes, such as the well-known BRCA1/2 genes, increase the risk of BC and other cancers (ovarian and pancreatic cancer)2,3. Recent studies have demonstrated substantial benefits of poly (adenosine diphosphate ribose) polymerase inhibitors in the treatment of BC patients who carry BRCA1/2 PVs4.

关键词： strategies chinese attitude cancer genetic genes breast choice prevention susceptibility

Immortalization of epidural fat-derived mesenchymal stem cells: In vitro characterization and adipocyte differentiation potential

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World Journal of Stem Cells 2025年第1期17卷 40-52页

作者： Seoung-Woo Lee Young-Ju Lim Hee-Yeon Kim Wansoo Kim Wook-Tae Park Min-Jung Ma Junho Lee Min-Soo Seo Young In Kim Sangbum Park Seong-Kyoon Choi Gun Woo Lee Core Protein Resources Center Daegu-Gyeongbuk Institute of Science and TechnologyDaegu 42988South Korea Department of Orthopedic Surgery Yeungnam University Medical CenterYeungnam University College of MedicineDaegu 42415South Korea Department of Veterinary Pathology College of Veterinary MedicineKyungpook National UniversityDaegu 41566South Korea School of Life science BK21 FOUR KNU Creative BioResearch GroupKyungpook National UniversityDaegu 41566South Korea Laboratory of Veterinary Tissue Engineering College of Veterinary MedicineKyungpook National UniversityDaegu 41566South Korea College of Veterinary Medicine Kyungpook National UniversityDaegu 41566South Korea Department of Veterinary Tissue Engineering Kyungpook National UniversityDaegu 41566South Korea Cellexobio. Ltd.Daegu 42415South Korea Michigan State University Institute for Quantitative Health Science&EngineeringEast LansingMI 48824United States Department of Orthopedic Surgery Yeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Mesenchymal stem cells(MSCs)are promising candidates for regenerative therapy due to their self-renewal capability,multilineage differentiation potential,and immunomodulatory *** molecular characteristics of MSCs are influenced by their ***,epidural fat(EF)and EF-derived MSCs(EF-MSCs)have garnered attention due to their potential benefits to the spinal microenvironment and their high expression of neural SC ***,their clinical applications are limited due to cell senescence and limited accessibility of *** many studies have attempted to establish an immortalized,stable SC line,the characteristics of immortalized EF-MSCs remain to be *** To establish and analyze stable immortalized *** The phenotypes of EF-MSCs were analyzed using optical *** immortalization was performed using lentiviral *** biomolecular characteristics of the cells were analyzed by immunoblotting,quantitative PCR,and *** The immortalized EF-MSCs demonstrated a significantly extended lifespan compared to the control group,with well-preserved adipogenic potential and SC surface marker *** of human telomerase reverse transcriptase genes markedly increased the lifespan of *** analysis revealed substantial increase in the expression of DNA replication pathway components in immortalized *** Immortalized EF-MSCs exhibited significantly enhanced proliferative capacity,retained adipogenic potential,and upregulated the expression of DNA replication pathway components.

关键词： Immortalization Transfection Stem cell Epidural fat Proteomics

Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

Research Progress of Chinese Medicine Monomers in Treatment of Cholangiocarcinoma

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Chinese Journal of Integrative Medicine 2025年第2期31卷 170-182页

作者： WANG Xiang WANG Xiao-qing LUO Kai BAI He QU Jia-lin ZHANG Gui-xin Department of General Surgery the Second Hospital of Dalian Medical UniversityDalianLiaoning Province(116027)China clinical Laboratory of Integrative Medicine First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning Province(116021)China Hepatobiliary Surgery Department Shandong Provincial Third HospittalShandong UniversityJinan(250031)China institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning Province(116044)China

Cholangiocarcinoma(CCA)is a malignant tumor originating from ***,it remains unclear about the pathogenesis of this carcinoma,which may be related to multiple ***,CCA is mainly treated by surgery,chemotherapy,and *** them,surgery is the only potentially curative option for ***,the high malignancy and asymptomatic nature of CCA may lead to poor treatment *** has been demonstrated that Chinese medicine(CM)plays a significant role in various antitumor ***,CM exhibits fewer side effects and high ***,the in vitro application of CM monomers has been explored in many domestic and foreign *** article mainly reviews the signaling pathways and molecular mechanisms of CM monomers in the treatment of CCA in recent *** findings are expected to provide new insights into the treatment of CCA.

关键词： cholangiocarcinoma Chinese medicine monomers antitumor signaling pathways molecular mechanisms review

Physical activity, aging, and health in China: Addressing public health needs in the presence of continued economic growth and urbanization

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Journal of Sport and health science 2016年第3期5卷 253-254,382页

作者： Fuzhong Li Yu Liu Peter A.Harmer Oregon Research institute Key Laboratory of exercise and health sciences of Ministry of Education Shanghai University of Sport Department of exercise science Willamette University

The significant increase in the number of older adults in China,coupled with continuing industrialization and urbanization,has profound social and economic ramifications,including the evolution of major challenges to public health,elder care services,policy-making,and the nation’s healthcare *** the unprecedented changes in political and economic structures have obviously increased China’s productivity and revenues,what is less well understood is how they

关键词： urbanization political unprecedented continuing continued understood older elder profound challenges