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Printing perovskite and graphene parallel structure-based optical-mechanical sensors for human-machine interaction

Science China Technological Sciences 2025年

作者： Sisi CHEN Jiemin ZHANG Nan CHENG Wenbo LI Jing LIU Hongfei XIE Jie ZHANG Yueying CHENG Xiaotong ZHAO Meng SU Yanlin SONG Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular Sciences Institute of ChemistryChinese Academy of Sciences (ICCAS) University of Chinese Academy of Sciences Weiyang College Tsinghua University Department of cardiovascular Surgery First Medical Center PLA General Hospital AECC Beijing institute of Aeronautical Materials Beijing institute of Graphene Technology Beijing Engineering Research Centre of Graphene Application School of Integrated Circuit & Beijing National Research Center for Information Science and Technology (BNRist) Tsinghua University

Surgical robots are designed to provide enhanced precision and dexterity compared to manual surgical procedures,which mainly rely on multimodal sensing technologies for the surgeon to seamlessly operate the robotic arms and *** with single-mode sensors, optical and mechanical bi-modal sensors provide improved precision, enhanced safety,and robustness of human-machine interaction systems. Here, the template-guided and pneumatic printing technologies are combined to construct perovskite and graphene parallel structures with both optical and mechanical sensing capabilities. The printed uniformly crystallized perovskite microstructure exhibits fast and sensitive photoelectric response characteristics,enabling shadow recognition functionality. The combination of graphene and elastic rubber endows the great printability to prepare parallel structures near the perovskite arrays for force sensing capabilities. Thus, the printed perovskite and graphene structures possess non-contact optical sensing capabilities to detect hand position by recognizing shadows between the hand and the sensor, as well as contact mechanical sensing capabilities to detect touch force applied by the hand. It provides a synergistic platform for real-time and multidimensional feedback to improve human-machine interaction.

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Beneficial effects of a polysaccharide from Salvia miltiorrhiza on myocardial ischemia-reperfusion injury in rats

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中国循环杂志 2016年第Z1期31卷 -页

作者： Mingbao Song Lan Huang Gang Zhao Yaoming Song institute of cardiovascular diseases of pla Xinqiao Hospital Third Military Medical University Chongqing China

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The role of transcriptional factor D-site-binding protein in circadian CCL2 gene expression in anti-Thy1 nephritis

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Cellular & Molecular Immunology 2019年第9期16卷 735-745页

作者： Yang Lu Yan Mei Lei Chen Lingling Wu Xu Wang Yingjie Zhang Bo Fu Xizhao Chen Yuansheng Xie Guangyan Cai Xueyuan Bai Qinggang Li Xiangmei Chen Department of Nephrology Chinese PLA General HospitalChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijingChina

Mesangial proliferative glomerulonephritis(MsPGN)is an inflammatory disease,but both the nature of disease progression and its regulation remain *** the present study,we monitored the course of anti-Thy1 nephritis from days 1 to 5 and established gene expression profiles at each time point using microarrays to explore the development of *** to the gene expression profiles,macrophage infiltration(triggered by CCL2 activation)was evident on day 1 and enhanced inflammation over the next few *** screened for genes with expression levels similar to CCL2 and found that the upregulation of the circadian gene albumin D-site-binding protein(DBP)was involved in CCL2 activation in mesangial *** importantly,CCL2 expression showed oscillatory changes similar to DBP,and DBP induced peak CCL2 expression at 16:00 a clock on day 1 in the anti-Thy1 nephritis *** knocked down DBP through transfection with a small interfering RNA(siRNA)and used RNA sequencing to identify the DBP-regulated TNF-α-CCL2 *** performed chromatin immunoprecipitation sequencing(ChIP-Seq)and the dual luciferase assay to show that DBP bound to the TRIM55 promoter,regulating gene expression and in turn controlling the TNF-α-CCL2 *** conclusion,DBP-regulated circadian CCL2 expression by the TRIM55-TNF pathway in injured mesangial cells at an early stage,which promoted macrophage recruitment and in turn triggered infiltration and inflammation in a model of anti-Thy1 nephritis.

关键词： Mesangial proliferative glomerulonephritis DBP CCL2 Trim 55 Macrophage

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Purification and functional assessment of smooth muscle cells derived from mouse embryonic stem cells

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Journal of Geriatric Cardiology 2013年第3期10卷 272-280页

作者： Xiao-Xiang Tian Jian Kang Cheng-Hui Yan Kai Xu Jie Tao Gui-Tang Yang Ya-Ling Han General Hospital of Shenyang Military Region Department of Cardiology Chinese pla cardiovascular Research institute

Objective To obtain a pure population of smooth muscle cells(SMC) derived from mouse embryonic stem cells(ESC) and further assess their *** A vector,expressing both puromycin resistance gene(puror) and enhanced green fluorescent protein(EGFP) gene driven by smooth muscle 22a(SM22a) promoter,named pSM22a-puror-IRES2-EGFP was constructed and used to transfect *** ESC(Tg-ESC) clones were selected by G418 and identified by PCR amplification of *** characteristics of Tg-ESC were detected by alkaline phosphatase(ALP) staining,SSEA-1 immunofluorescence and teratoma formation test in *** induction of SMC differentiation by all-trans retinoic acid,differentiated Tg-ESC were treated with 10 μg/mL puromycin for three days to obtain purified SMC(P-SMC).Percentage of EGFP+cells in P-SMC was assessed by flow *** of smooth muscle specific markers were detected by immunostaining and Western ***,migration and contractility of P-SMC were analyzed by growth curve,trans-well migration assay,and carbachol treatment,***,both P-SMC and unpurified SMC(unP-SMC) were injected into syngeneic mouse to see teratoma *** Tg-ESC clone was successfully established and confirmed by PCR detection of purorgene in its genomic *** Tg-ESC was positive for ALP staining,SSEA-1 staining and formed teratoma containing tissues derived from three germ *** retinoic acid induction,large amount of EGFP positive cells outgrew from differentiated *** days of puromycin treatment produced a population of P-SMC with an EGFP+percentage as high as 98.2%in contrast to29.47%of *** with primary mouse vascular smooth muscle cells(VSMC),P-SMC displayed positive,but lowered expression of SMC-specific markers including SM α-actin and myosin heavy chain(SM-MHC) detected either,by immunostaining,or immunoblotting,accelerated proliferation,improved migration(99.33 ± 2.04 vs.44.00±2.08

关键词： Differentiation Embryonic stem cell Phenotype SM22α Smooth muscle cell

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Efficacy and Safety of Flos Abelmoschus Manihot(Malvaceae) on Type 2 Diabetic Nephropathy:A Systematic Review

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Chinese Journal of Integrative Medicine 2015年第6期21卷 464-472页

作者：陈意志龚智翔蔡广研高清陈香美汤力魏日胞周建辉 Department of Nephrology Chinese PLA General HospitalChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney Diseases Division of Infectious diseases Chinese PLA 532 HospitalHuangshan Department of Nephrology Zhongshan HospitalXiamen University

Objective： To evaluate the efficacy and safety of Flos Abelmoschus manihot （Malvaceae） on type 2 diabetic nephropathy （DN）. Methods： The Cochrane Library, PubMed/MEDLINE, Excerpta Medical Database, Chinese electronic literature databases, and the references of relevant articles were searched in March 2012 for randomized controlled trials （RCTs） that reported the effects of Flos A. manihot on type 2 DN patients with overt but subnephrotic-range proteinuria （500-3,500 mg/24 h）. The quality of trials was evaluated using the Cochrane-recommended method. The results were summarized as risk ratios （RRs） for dichotomous outcomes or mean differences （MDs） for continuous outcomes. Results： Seven trials （531 patients） were included. F/os A. manihot significantly decreased proteinuria [MD -317.32 mg/24 h, 95% confidence interval （CI） [-470.48, -164.17], P〈0.01]. After excluding a trial that only included patients with well-preserved renal function, F/os A. manihot was associated with a significant decrease in serum creatinine （MD -11.99 i~ mol/L, 95% CI [-16.95, -7.04], P〈0.01）. Serious adverse events were not observed. The most common adverse event was mild to moderate gastrointestinal discomfort; however, patients receiving this herb did not have an increased risk for tolerated gastrointestinal discomfort （RR 1.48, 95% CI [0.39, 5.68], P=0.57）. Conclusions： F/os A. manihot may be considered as an important adjunctive therapy with the first-line and indispensable therapeutic strategies for type 2 DN. High-quality RCTs are urgently needed to confirm the effect of Flos A. manihot on definite endpoints such as end-stage renal disease.

关键词： Flos Abelmoschus manihot Huangkui Capsule Chinese medicine type 2 diabetic nephropathy systematic review meta-analysis randomized controlled trial

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Risk factors of prognosis after acute kidney injury in hospitalized patients

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Frontiers of Medicine 2017年第3期11卷 393-402页

作者： Sasa Nie Zhe Feng Lihua Xia Jiuxu Bai Fenglin Xiao Jian Liu Li Tang Xiangmei Chen Department of Nephrology Chinese PLA General Hospital Chinese PLA Institute of Nephrology State Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing 100853 China

The risk factors, especially laboratory indicators, of prognosis after acute kidney injury （AK1） remain unclear. We conducted a retrospective survey of Chinese People＇s Liberation Army General Hospital from January 1, 2012 to December 31, 2012 according to the AKI diagnosis standard issued by Kidney Disease Improving Global Outcomes. The epidemiological features and factors influencing hospital mortality and renal function recovery were evaluated through logistic regression analysis. Among 77 662 cases of hospitalized patients, 1387 suffered from AKI. The incidence rate and mortality of AKI were 1.79~ and 14.56%, respectively. Multivariate logistic regression analysis revealed that high AKI stage, age greater than 80 years, neoplastic disease, low cardiac output, increased white blood cell count, and decreased platelet count and serum albumin levels were the risk factors affecting the mortality of AKI patients. Conversely, body mass index between 28 and 34.9 was a protective factor. Increased AKI stage, tumor disease, post-cardiopulmonary resuscitation, and RRT were the risk factors of renal function recovery upon discharge. In addition to traditional risk factors, white blood cell count, platelet count, albumin, and BMI were the predictors of the mortality of AKI patients. No laboratory indicators were found to be the risk factors of renal function recovery in AKI patients.

关键词： acute kidney injury risk factors prognosis

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Protective effects of astragaloside in rats with adriamycin nephropathy and underlying mechanism

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Chinese Journal of Natural Medicines 2016年第4期14卷 270-277页

作者： WANG Na WEI Ri-Bao LI Qing-Ping YANG Xi CHEN Xiang-Mei Department of Nephrology Chinese PLA General Hospital Chinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijingChina 100853

The present study was designed to determine the mechanism underlying the treatment of nephrotic syndrome using astragaloside by observing the effects of astragaloside on the expression of nephrin and podocin proteins and genes in kidneys of rats with adriamycin nephropathy. The rats were injected with adriamycin and, after successful model establishment, randomly divided into a model group, a Methylprednisolone(MP) group, and an astragaloside group. The 24-h complete urine samples were collected. Biochemical indicators were monitored, and kidney tissues were collected for pathological analysis using light microscopy and electron microscopy. The m RNA expression of nephrin and podocin was measured in the kidney tissues using the real-time q PCR, and the protein expression levels of nephrin and podocin were detected using Western blot analysis. At the end of 12 weeks of drug intervention, the urinary protein level was lower in the MP and astragaloside groups than that in the model group(P = 0.008 and P = 0.01, respectively). Serum albumin was higher in the MP and astragaloside groups than in the model group(P < 0.001 and P = 0.012, respectively). Podocytes in the MP group were nearly normal, and fusion of podocytes in the astragaloside group was significantly less than that in the control group. The nephrin and podocin m RNA and protein expression levels in the intervention groups were higher(P < 0.05) than that in the model group. Due to the increased expression of podocyte-related nephrin and podocin proteins, astragaloside maintained slit diaphragm integrity and decreased the level of proteinuria in rats with adriamycin nephropathy.

关键词： Astragaloside Adriamycin nephropathy Podocyte Nephrin Podocin

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Association between physiological responses after exercise at low altitude and acute mountain sickness upon ascent is sex-dependent

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Military Medical Research 2021年第2期8卷 174-182页

作者： Yang Shen Yuan-Qi Yang Chuan Liu Jie Yang Ji-Hang Zhang Jun Jin Hu Tan Fang-Zheng-Yuan Yuan Jing-Bin Ke Chun-Yan He Lai-Ping Zhang Chen Zhang Jie Yu Lan Huang institute of cardiovascular diseases of pla the Second Affiliated HospitalArmy Medical UniversityChongqing 400037China Department of Cardiology the Second Affiliated HospitalArmy Medical UniversityChongqing 400037China

Background:Acute mountain sickness(AMS)is the mildest form of acute altitude illnesses,and consists of nonspecific symptoms when unacclimatized persons ascend to elevation of≥2500 *** factors of AMS include:the altitude,individual susceptibility,ascending rate and degree of *** the current study,we examined whether physiological response at low altitude could predict the development of ***:A total of 111 healthy adult healthy volunteers participated in this trial;and 99(67 men and 32 women)completed the entire study *** were asked to complete a 9-min exercise program using a mechanically braked bicycle ergometer at low altitude(500 m).Heart rate,blood pressure(BP)and pulse oxygen saturation(SpO2)were recorded prior to and during the last minute of *** ascent from 500 m to 4100 m was completed in 2 *** was defined as≥3 points in a 4-item Lake Louise Score,with at least one point from headache wat 6–8 h after the ***:Among the 99 assessable subjects,47(23 men and 24 women)developed AMS at 4100 *** comparison to the subjects without AMS,those who developed AMS had lower proportion of men(48.9%vs.84.6%,P<0.001),height(168.4±5.9 cm vs.171.3±6.1 cm,P=0.019),weight(62.0±10.0 kg vs.66.7±8.6 kg,P=0.014)and proportion of smokers(23.4%vs.51.9%,P=0.004).Multivariate regression analysis revealed the following independent risks for AMS:female sex(odds ratio(OR)=6.32,P<0.001),SpO2 change upon exercise at low altitude(OR=0.63,P=0.002)and systolic BP change after the ascent(OR=0.96,P=0.029).Women had larger reduction in SpO2 after the ascent,higher AMS percentage and absolute AMS *** reduction of SpO2 after exercise was associated with both AMS incidence(P=0.001)and AMS score(P<0.001)in men but not in ***:Larger SpO2 reduction after exercise at low altitude was an independent risk for AMS upon *** an association was more robust in men than in *** registration:Chinese Clinical

关键词： High altitude Exercise testing Sex differences Acute mountain sickness Individual susceptibility

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Expression of AT_(1a) mRNA in rat hepatic stellate cells and its effects on cell growth collagen production

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Chinese Medical Journal 2004年第5期117卷 772-774页

作者：张艺军杨希山吴平生廖贵清杨国平张晓峰陈晓清 Department of Gernotology pla institute of Digestive diseases Department of Cardiology Department of Oral and Maxillofacial Surgery

Activated hepatic stellate cells (HSCs) play important roles in hepatic fibrosis. Studies on HSCs activation in vitro have shown that this process is regulated by a wide variety of growth factors and cytokines.1 Recent data indicate that AngⅡ is responsible for the mechanisms of myocardial fibrosis and kidney fibrosis; but there are only few reports on hepatic fibrosis.2-8

关键词： AT 1a mRNA·angiotensinⅡ· losartan ·hepatic stellate cell

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Changes in the spectrum of gastric polyps in the Chinese population

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World Journal of Gastroenterology 2015年第33期21卷 9758-9764页

作者： Nan-Nan Fan Jing Yang Gang Sun Zhong-Sheng Lu En-Qiang Ling Hu Xiang-Dong Wang Yun-Sheng Yang institute of Digestive diseases Chinese PLA General Hospital Nankai University School of Medicine

AIM: To evaluate the change in spectrum of gastric polyps in the Chinese population in the past ten ***: A total of 157902 consecutive patients undergoing esophagogastroduodenoscopy(EGD) from 2004 to 2013 in a tertiary hospital were retrospectively reviewed using an EGD *** records of 4043 patients diagnosed with gastric polyps were recalled for *** including demographics,information on polyps such as location,pathological diagnosis,reflux esophagitis and Helicobacter pylori infection were *** focused on epithelial polyps,especially hyperplastic polyps,fundic gland polyps and adenomas,and histological classification of specimens from biopsy and endoscopic polypectomy was performed by professional pathologists,based on the updated *** explore the age distribution of gastric polyps over time,we divided patients with polyps into four groups: A(aged 60 years).Differences in localization,age,and sex distribution of gastric polyps were analyzed by statistical ***: A total of 157902 EGD procedures were performed in ten years at our digestive endoscopy center,of which 4043 cases were diagnosed with gastric polyps confirmed by *** were 2574(63%) female and 1469(37%) male patients with an average age of 54.7 *** overall prevalence of gastric polyps was 2.6%(4043/157902).Our database demonstrated a rising prevalence of gastric polyps over the decade,increasing from 1.0%(80/8025) to 4.70%(828/17787) between 2004 and *** has been a change in the spectrum of gastric polyps with the frequencies of FGPs increasing from 19%(15/80) to 77%(638/828) and hyperplastic polyps decreasing from 65%(52/80) to 15%(123/828).Moreover,data on 1921 polyps in 828 patients diagnosed with gastric polyps in 2013 showed that FGP was the most common type in the current polyp spectrum,making up 81.3%(1562/1921).Location and age distribution of gastri

关键词： Gastric polyps Hyperplastic polyps Fundic gland po

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