Expression of AT_(1a) mRNA in rat hepatic stellate cells and its effects on cell growth collagen production

作     者：张艺军 杨希山 吴平生 廖贵清 杨国平 张晓峰 陈晓清 

作者机构：Department of Gernotology PLA Institute of Digestive Diseases Department of Cardiology Department of Oral and Maxillofacial Surgery 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2004年第117卷第5期

页      面：772-774页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：ThisstudywassupportedbyasgrantfromtheNationalNaturalScienceFoundationofChina (No 3 9870 3 3 1and 3 0 2 70 610 ) 

主　　题：AT 1a mRNA·angiotensinⅡ· losartan ·hepatic stellate cell 

摘      要：Activated hepatic stellate cells (HSCs) play important roles in hepatic fibrosis. Studies on HSCs activation in vitro have shown that this process is regulated by a wide variety of growth factors and cytokines.1 Recent data indicate that AngⅡ is responsible for the mechanisms of myocardial fibrosis and kidney fibrosis; but there are only few reports on hepatic fibrosis.2-8