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Fluorescent probes and functional materials for biomedical applications

Frontiers of Chemical science and Engineering 2022年第10期16卷 1425-1437页

作者： Xi-Le Hu Hui-Qi Gan Fan-De Meng Hai-Hao Han De-Tai Shi Shu Zhang Lei Zou Xiao-Peng He Tony D.James key laboratory for Advanced Materials and Joint International Research laboratory of Precision chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Department of chemistry University of BathBath BA27AYUK Liver Cancer institute Zhongshan Hospitaland Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Fudan UniversityShanghai 200032China School of chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China School of Materials science and Engineering Jingdezhen Ceramic InstituteJingdezhen 333403China

Due to their simplicity in preparation,sensitivity and selectivity,fluorescent probes have become the analytical tool of choice in a wide range of research and industrial fields,facilitating the rapid detection of chemical substances of interest as well as the study of important physiological and pathological processes at the cellular *** addition,many long-wavelength fluorescent probes developed have also proven applicable for in vivo biomedical applications including fluorescenceguided disease diagnosis and theranostics(e.g.,fluorogenic prodrugs).Impressive progresses have been made in the development of sensing agents and materials for the detection of ions,organic small molecules,and biomacromolecules including enzymes,DNAs/RNAs,lipids,and carbohydrates that play crucial roles in biological and disease-relevant ***,we highlight examples of fluorescent probes and functional materials for biological applications selected from the special issues“Fluorescent Probes”and“Molecular Sensors and Logic Gates”recently published in this journal,offering insights into the future development of powerful fluorescence-based chemical tools for basic biological studies and clinical translation.

关键词： fluorescent probes imaging cell biomedicine biomolecules

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Sensitive and selective electrochemical sensor for the detection of dopamine by using AuPd@Fe_(2)O_(3) nanoparticles as catalyst

Advanced Sensor and Energy Materials

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Advanced Sensor and Energy Materials 2023年第1期2卷 24-31页

作者： Mengjiao Dai Qunyan Zhu Dongxue Han Li Niu Zhenxin Wang State key laboratory of electroanalytical chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of science and Technology of China Hefei 230026China National analytical Research Center of Electrochemistry and Spectroscopy Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Guangzhou key laboratory of Sensing Materials and Devices Center for Advanced Analytical ScienceSchool of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou 510006China Guangdong provincial key laboratory of Psychoactive Substances Monitoring and Safety Anti-Drug Technology Center of Guangdong ProvinceGuangzhou 510230China

The levels of dopamine(DA)in living organisms have strong effects on many biological processes and diseases,such as Parkinson's disease and Alzheimer's ***,it has great significance for sensitive and selective detection of ***,the AuPd@Fe_(2)O_(3) nanoparticles-based electrochemical(EC)sensor(AuPd@Fe_(2)O_(3) NPs/GCE)is developed for chronoamperometric detection of DA with high sensitivity and good anti-interference ability through simple immobilization of AuPd@Fe_(2)O_(3) nanoparticles on glassy carbon electrode(GCE)by *** the application of oxidation potential,the AuPd@Fe_(2)O_(3) NPs/GCE exhibits good electrocatalytic activity toward DA,which enables to linearly detect DA in the range of 10 nM–831.61μM(R^(2)=0.9983).The AuPd@Fe_(2)O_(3) NPs/GCE also shows good selectivity and reproducibility for the detection of ***,the practicability of AuPd@Fe_(2)O_(3) NPs/GCE has been demonstrated by detection of DA in dopamine hydrochloride injection and human serum.

关键词： Electrochemical sensor AuPd@Fe_(2)O_(3)nanoparticles Dopamine High sensitivity Good anti-interference ability

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Boric Acid-Based Dual Modulation Photoluminescent Glucose Sensor Using Thioglycolic Acid-Capped CdTe Quantum Dots

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Journal of Analysis and Testing 2017年第4期1卷 291-297页

作者： Saadat Majeed WenyueGao Jianping Lai Chao Wang JianpingLi Zhongyuan Liu Guobao Xu State key laboratory of electroanalytical chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun 130022JilinPeople’s Republic of China University of Chinese Academy of sciences Chinese Academy of SciencesNo.19A YuquanluBeijing 100049China Division of analytical chemistry Institute of Chemical SciencesBahauddin Zakariya UniversityMultan 60800Pakistan College of chemistry and Bioengineering Guilin University of TechnologyGuilin 541004People’s Republic of China

Most luminescent glucose sensors based on the interaction of glucose with organic boric acids or ***,a new luminescent glucose sensor is designed using thioglycolic acid-capped CdTe quantum dots in the presence of cheap inorganic boric *** peak position and intensities change upon the addition of glucose because of the interaction of boric acid with glucose and thioglycolic acid-capped CdTe quantum dots,which enables glucose detection by either color change or intensity *** luminescent intensities change linearly with glucose concentrations in the ranges from 0.03 to 1 mM and 1–25 mM with a detection limit of 10μM(S/N=3).Moreover,glucose concentrations can be conveniently detected by color change in the range from 1 mM–25 *** displays a highly selective response to glucose over other interfering but biologically important saccharides,amino acids,and common *** Abstract A thioglycolic acid-capped CdTe QD-based sensor can detect glucose with wide linear range by change in intensity or color in the presence of cheap inorganic boric acid.

关键词： CdTe quantum dots Glucose sensor Thioglycolic acid

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Aptamers based Biosensors for Sensitive and Selective Analysis

Aptamers based Biosensors for Sensitive and Selective Analys...

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第六届海峡两岸分析化学会议

作者：董绍俊 State key laboratory of electroanalytical chemistry Changchun institute of Applied chemistry Chinese Academy of sciences

＜正＞Aptamers can bind target molecules with high affinity and *** interests from various fields,especially analytical chemistry,grow rapidly in recent *** the aim to increase the detection sensitivty and simplify th...

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A novel polymer-based nitrocellulose platform for implementing a multiplexed microfluidic paperbased enzyme-linked immunosorbent assay

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Microsystems & Nanoengineering 2022年第3期8卷 199-208页

作者： Dong Lin Bowei Li Longwen Fu Ji Qi Chunlei Xia Yi Zhang Jiadong Chen Jaebum Choo Lingxin Chen CAS key laboratory of Coastal Environmental Processes and Ecological Remediation Shandong Key Laboratory of Coastal Environmental ProcessesYantai Institute of Coastal Zone ResearchChinese Academy of Sciences264003 YantaiChina School of Pharmacy Binzhou Medical University264003 YantaiChina University of Chinese Academy of sciences 100049 BeijingChina Center for Ocean Mega-science Chinese Academy of Sciences266071 QingdaoChina institute of analytical Food Safety School of Food Science and TechnologyJiangnan University214122 WuxiChina Department of chemistry Chung-Ang UniversitySeoul 06974South Korea

Nitrocellose(NC)membranes,as porous paper-like substrates with high protein-binding capabilties,are very popular in the field of point-of-care ***,generating robust hydrophobic structures in NC membranes to fabricate microfluidic paper-based analytical devices(μPADs)remains a great *** present,the main method relies on an expensive wax printer In addition,NC membranes very easy to adhere during the printing process due to electrostatic ***,we developed a facile,fast and low-cost strategy to fabricateμPADs in NC membranes by screen-printing polyurethane acrylate(PUA)as a barrier material for defning flow channels and reaction ***,hydrophobic barriers based on UV-curable PUA can resist various surfactant solutions and organic solvents that are generally used in immunoassays and biochemical *** validate the feasibility of this PUA-based NC membrane for immunoassays in point-of-care testing(POCT),we further designed and assembled a rotational paperbased analytical device for implementing a multiplexed enzyme-linked immunosorbent assay(ELISA)in a simple *** the proposed device under the optimal conditions,alpha fetoprotein(AFP)and carcinoembryonic antigen(CEA)could be identified,with limits of detection of 136 pg/mL and 174 pg/mL,respectively,which are below the threshold values of these two cancer biomarkers for clinical *** believe that this reliable device provides a promising plaform for the diagnosis of disease based on ELISA or other related bioassays in limited setings or remote regions.

关键词： diagnosis printing cellulose

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Electrochemiluminescence Imaging Techniques for Analysis and Visualizing

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Journal of Analysis and Testing 2020年第2期4卷 76-91页

作者： Tadesse Haile Fereja Fangxin Du Chao Wang Dmytro Snizhko Yiran Guan Guobao Xu State key laboratory of electroanalytical chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun 130022JilinPeople’s Republic of China University of Chinese Academy of sciences Beijing 100049People’s Republic of China Department of Pharmacy College of Medicine and Health SciencesAmbo UniversityP.O.Box 19AmboEthiopia University of science and Technology of China No.96Jin Zhai Road Baohe DistrictHefei 230026AnhuiPeople’s Republic of China laboratory of analytical Optochemotronics Kharkiv National University of Radio Electronics14 Nauka AveKharkiv 61166Ukraine

Electrochemiluminescence(ECL)-based imaging analysis is a dominant method to inspect the electrode composition,to study electrochemical reaction kinetics at a microscopic level,and also a rapid emerging technology in bioanalysis with high spatiotemporal resolutions,high-throughput and visualization *** comparison with other imaging microscopes,an optical excitation is not involved in imaging,thus the approach is free from background noise resulting in a low detec-tion *** this review work,the principle of ECL,its unique natures compared to other luminescence techniques were briefed at *** after,the progress and basic principles of ECL imaging were ***,recent and representative advances of ECL imaging for visualizing and sensing applications were ***,the perspectives in ECL imaging for further perspective were discussed.

关键词： Electrogenerated chemiluminescence Coreactants Electrochemiluminescence imaging Bioanalysis

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Water Molecule-Triggered Anisotropic Deformation of Carbon Nitride Nanoribbons Enabling Contactless Respiratory Inspection

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CCS chemistry 2021年第6期3卷 1615-1625页

作者： Yuye Zhang Yongxiu Song Yanfei Shen Kaiyang Chen Qing Zhou Yanqin Lv Hong Yang Ensheng Xu Songqin Liu Lei Liu Yuanjian Zhang Jiangsu Engineering laboratory of Smart Carbon-Rich Materials and Device Jiangsu Provincial Hi-Tech Key Laboratory for Biomedical ResearchSchool of Chemistry and Chemical EngineeringMedical SchoolSoutheast UniversityNanjing 211189 institute for Advanced Materials School of Material Science and TechnologyJiangsu UniversityZhenjiang 212013

The exploitation of the interaction between nanostructured matter and small molecules,such as H_(2)O at interfaces via dynamic hydrogen bonding,is essentially the key for smart,responsive nanodevices but remains ***,the authors report that the carbon nitride nanoribbons(CNNRs)with an anisotropic intraplanar and interplanar molecular arrangement underwent a deformation by H_(2)O *** experiments of bulk samples and single nanoribbons disclosed that the reversible formation of a hydrogen-bonded H_(2)O adsorption layer was the source of the CNNRs deformation,reminiscent of the hydration-triggered twist of natural bean pods in ***,CNNRs had a more balanced H_(2)O affinity,enabling a superior response and recovery *** coupling with carbon nanotubes,the authors also converted the deformation of CNNRs into more straightforward electrical readouts with record-fast response *** applied to capture fluctuations in humidity in real-time respiration,a higher detection sensitivity was obtained in a contactless mode,which compared favorably with the clinical breath-testing *** the carbon nitride family with various C/N ratios,surface properties,and topography,this finding that CNNRs are an outstanding H_(2)O transducer would significantly pave the way for the H_(2)O-triggered smart devices in broad prospective applications.

关键词： polymeric carbon nitride anisotropic deformation surface properties water molecules transducer contactless respiratory monitoring

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Engineering oxygen vacancies and localized amorphous regions in CuO-ZnO separately boost catalytic reactivity and selectivity

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Nano Research 2023年第2期16卷 2126-2132页

作者： Yongjun Ji Xiaoli Chen Shaomian Liu Liwen Xing Xingyu Jiang Bin Zhang Huifang Li Wenxing Chen Ziyi Zhong Ligen Wang Guangwen Xu Fabing Su School of Light Industry Beijing Technology and Business UniversityBeijing 100048China institute of Process Engineering Chinese Academy of SciencesBeijing 100190China College of chemistry and Materials Engineering Beijing Technology and Business UniversityBeijing 100048China institute of Industrial chemistry and Energy Technology Shenyang University of Chemical TechnologyShenyang 110142China analytical and Testing Center Chongqing UniversityChongqing 401331China Energy&Catalysis Center School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Department of Chemical Engineering Guangdong Technion-Israel Institute of Technology(GTIIT)Shantou 515063China Guangdong provincial key laboratory of Materials and Technologies for Energy Conversion(MATEC) GTIITGuangdong 515063China Gripm Advanced Materials Co. Ltd.Beijing 101407China

Generating different types of defects in heterogeneous catalysts for synergetic promotion of the reactivity and selectivity in catalytic reactions is highly challenging due to the lack of effective theoretical ***,we demonstrate a facile strategy to introduce two types of defects into the CuO-ZnO model catalyst,namely oxygen vacancies(OVs)induced by H2 partial reduction and localized amorphous regions(LARs)generated via the ball milling *** industrially important Rochow–Müller reaction as a representative,we found OVs predominantly improved the target product selectivity of dimethyldichlorosilane,while LARs significantly increased the conversion of reactant *** CuO-ZnO catalyst with optimized OVs and LARs contents achieved the best catalytic *** calculation further revealed that LARs promote the generation of the Cu3Si active phase,and OVs impact the electronic structure of the Cu3Si active *** work provides a new understanding of the roles of different catalyst defects and a feasible way of engineering the catalyst structure for better catalytic performances.

关键词： oxygen vacancy localized amorphous region CuO-ZnO catalyst reactivity selectivity

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L-cysteine-modified chiral gold nanoparticles promote periodontal tissue regeneration

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Bioactive Materials 2021年第10期6卷 3288-3299页

作者： Shuang Zhang Hong Zhou Na Kong Zezheng Wang Huangmei Fu Yangheng Zhang Yin Xiao Wenrong Yang Fuhua Yan Nanjing Stomatological Hospital Medical School of Nanjing UniversityNanjingJiangsuPeople’s Republic of China key laboratory of Optic-electric Sensing and analytical chemistry for Life science MOECollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao266042People’s Republic of China School of Life and Environmental science Centre for Chemistry and BiotechnologyDeakin UniversityGeelongVICAustralia institute of Health and Biomedical Innovation Queensland University of TechnologyBrisbaneQueensland4059Australia Australia-China Centre for Tissue Engineering and Regenerative Medicine Queensland University of TechnologyAustralia

Gold nanoparticles(AuNPs)with surface-anchored molecules present tremendous potential in tissue ***,little is known about chiral-modified *** this study,we successfully prepared L/D-cysteine-anchored AuNPs(L/D-Cys-AuNPs)and studied the effects of chiral-modified AuNPs on osteogenic differentiation and autophagy of human periodontal ligament cells(hPDLCs)and periodontal tissue *** vitro,more L-Cys-AuNPs than D-Cys-AuNPs tend to internalize in hPDLCs.L-Cys-AuNPs also significantly increased the expression of alkaline phosphatase,collagen type 1,osteocalcin,runt-related transcription factor 2,and microtubule-associated protein light chain 3 II and decreased the expression of sequestosome 1 in hPDLCs compared to the expression levels in the hPDLCs treated by *** vivo tests in a rat periodontal-defect model showed that L-Cys-AuNPs had the greatest effect on periodontal-tissue *** activation of autophagy in L-Cys-AuNP-treated hPDLCs may be responsible for the cell differentiation and tissue ***,compared to D-Cys-AuNPs,L-Cys-AuNPs show a better performance in cellular internalization,regulation of autophagy,cell osteogenic differentiation,and periodontal tissue *** demonstrates the immense potential of L-Cys-AuNPs for periodontal regeneration and provides a new insight into chirally modified bioactive nanomaterials.

关键词： Chirality Gold nanoparticles Periodontal Tissue regeneration Autophagy

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Analysis of the electron transfer pathway in small laccase by EPR and UV-vis spectroscopy coupled with redox titration

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Magnetic Resonance Letters 2024年第3期4卷 52-59页

作者： Lu Yu Aokun Liu Jian Kuang Ruotong Wei Zhiwen Wang Changlin Tian High Magnetic Field laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China Department of Endocrinology Institute of Endocrine and Metabolic DiseaseThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineHefei National Research Center for Physical Sciences at the MicroscaleJoint Center for Biological Analytical ChemistryAnhui Engineering Laboratory of Peptide DrugAnhui Laboratory of Advanced Photonic Science and TechnologyUniversity of Science and Technology of ChinaHefei230026China

Bacterial small laccases(SLAC) are promising industrial biocatalysts due to their ability to oxidize a broad range of substrates with exceptional thermostability and tolerance for alkaline p H. Electron transfer between substrate, copper centers, and O2is one of the key steps in the catalytic turnover of SLAC. However, limited research has been conducted on the electron transfer pathway of SLAC and SLAC-catalyzed reactions, hindering further engineering of SLAC to produce tunable biocatalysts for novel applications. Herein, the combinational use of electron paramagnetic resonance(EPR) and ultraviolet-visible(UV-vis) spectroscopic methods coupled with redox titration were employed to monitor the electron transfer processes and obtain further insights into the electron transfer pathway in SLAC. The reduction potentials for type 1 copper(T1Cu), type 2 copper(T2Cu) and type 3copper(T3Cu) were determined to be 367 ± 2 mV, 378 ± 5 m V and 403 ± 2 mV,respectively. Moreover, the reduction potential of a selected substrate of SLAC, hydroquinone(HQ), was determined to be 288 mV using cyclic voltammetry(CV). In this way, an electron transfer pathway was identified based on the reduction potentials. Specifically,electrons are transferred from HQ to T1Cu, then to T2Cu and T3Cu, and finally to ***, superhyperfine splitting observed via EPR during redox titration indicated a modification in the covalency of T2Cu upon electron uptake, suggesting a conformational alteration in the protein environment surrounding the copper sites, which could potentially influence the reduction potential of the copper sites during catalytic processes. The results presented here not only provide a comprehensive method for analyzing the electron transfer pathway in metalloenzymes through reduction potential measurements, but also offer valuable insights for further engineering and directed evolution studies of SLAC in the aim for biotechnological and industrial applications.

关键词： Electron paramagnetic resonance Redox titration Electron transfer Reduction Potential Small laccase

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