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Mechanism of relation among heart meridian,referred cardiac pain and heart

Science China(Life Sciences) 2002年第5期45卷 538-545页

作者：朱兵荣培晶 institute of acupuncture-moxibustion CATCM Beijing China

It has been demonstrated that an important clinical phenomenon often associated with visceral diseases is the referred pain to somatic structures, especially to the body areaof homo-segmental innervation. It is interesting that the somatic foci of cardiac referred pain wereoften and mainly distributed along the heart meridian (HM), whereas the acupoints of HM havebeen applied to treat cardiac disease since ancient times. The purpose of this study was to inves-tigate the neural relationship between the cardiac referred pain and the heart *** triple-labeling was injected into the pericardium, some acupoints of HM and lung me-ridian (LM, for control). The responses of the left cardiac sympathetic nerve and of the EMG in left HM and LM were electrophysiologically studied, when the electrical stimuli were applied to the acupoints of left HM and to the left cardiac sympathetic nerve. More double-labeled neurons in HM-heart, not in LM-heart, were observed in the ipsilateral dorsal root ganglia of the spinal segments C8-T3. Electric stimulation of the acupoints of left HM was able to elicit more responses of left cardiac sympathetic nerve than that of the LM-acupoints. Electric stimulation of the left cardiac sympathetic nerve resulted in stronger activities of EMG-response in the acupoints of left HM than in LM-acupoints. We conclude that double-labeling study has provided direct evidence for the existence of dichotomizing afferent fibers that supply both the pericardium and HM. Electrophysiological results show that HM is more closely related functionally to heart. These findings provide a possible morphological and physiological explanation for the referred cardiac pain and HM-heart interrelation.

关键词： dichotomization of DRG, heart, heart meridian, somato-visceral connection.

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Effect of moxa-burning heat stimulating Liangmen(ST 21) and Zusanli(ST 36) on proliferation and apoptosis signaling proteins in rats with stress-induced gastric ulcer

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Journal of Traditional Chinese Medicine 2016年第3期36卷 340-346页

作者： Peng Li Wang Yadong Chang Xiaorong Wu Huangan Liu Mi Ma Fuqiang Wang Hong Chen Jiaolong Wang Chao Quan Renfu Yang Zongbao Medical College Xiamen University acupuncture and moxibustion college Hunan University of TCM Research institute of acupuncture and moxibustion Shanghai University of TCM Research institute of acupuncture and moxibustion Xiaoshan Traditional Chinese Medical Hospital

OBJECTIVE: To observe the effect of moxa-burning heat stimulating acupoints of Liangmen(ST 21)and Zusanli(ST 36) on the proliferation and apoptosis signaling proteins in rats with stress-induced gastric ***: Forty rats were randomly divided into four groups: negative control(NC), ulcer control(UC), acupoints of stomach meridian(ASM), and acupoints control(AC). The acute gastric ulcer model was established by bound and water *** in NC and UC groups didn't receive any moxa-burning heat stimulating treatment, while rats in ASM and AC groups were treated with buringmoxa heat stimulating the acupoints of Liangmen(ST 21) and Zusanli(ST 36) and their controlled points, respectively. Rats in all groups were sacrificed after 12 consecutive days treatment. The ulcer index was evaluated by using Guth's *** expression of tumor necrosis factor-alpha(TNF-α), apoptotic protease activating facter-1(Apaf-1), Caspase-3, p21 activated kinase 1(PAK1),extracellular regulated protein kinases 2(ERK2),phosphorylated ERK2(p ERK2), phosphoinositide3-kinase(PI3K) and RAC-alpha serine/threonine-protein kinase(Akt) in gastric mucosa was detected by enzyme linked immunosorbent assay(ELISA).RESULTS: Compared with UC group, the ulcer index of ASM and AC groups decreased, and the injured gastric mucosa was improved, the expression of TNF-α, Apaf-1 and Caspase-3 in gastric mucosa was significantly reduced(P < 0.05), while the ex-pression of PAK1, ERK2, p ERK2, PI3 K and Akt in gastric mucosa was significantly increased(P < 0.05).And ASM showed better effect than AC group(P <0.05).CONCLUSION: Moxa-burning Heat stimulating of Liangmen(ST 21) and Zusanli(ST 36) could promote the recovery of gastric mucosal lesion probably by inhibiting cell apoptosis and promoting cell proliferation in stress-induced gastric ulcer.

关键词： moxibustion Point ST 21(Liangmen) Point ST 36(Zusanli) Stomach ulcer Apoptosis Cell proliferation

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Safety and efficacy of Danqipiantan capsule for treatment of stroke: a systematic review

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Journal of Traditional Chinese Medicine 2013年第6期33卷 707-714页

作者： Jiashen Li Haizhen Zheng Xiaofeng Zhao Shu Wang Xuemin Shi institute of acupuncture and moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of acupuncture and moxibustion Science

OBJECTIVE： To evaluate the efficacy and safety of Danqipiantan capsule （DPC） for the treatment of stroke. METHODS： PubMed, China Science And Technolo- gy Journal Database, Wanfang Database, Chinese periodicals in the China National Knowledge Infra- structure, and the General Hospital of Tianjin Medi- cal University＇s Library were searched until July 2012. Randomized controlled trials （RCTs） and ob- servational studies that reported the use of DPC for treatment of stroke were selected. RESULTS： Eleven articles that included 12 RCTs, and 2 articles that included 3 observational studies were identified. A total of 2590 patients participat- ed in the studies. We found that there was a signifi-cant statistical difference between DPC treatment groups and the control groups in terms of the effec- tive rate [risk ratio （RR）, 1.14; 95% confidence inter- vals （CI）, 1.04, 1.25; P=0.01], FugI-Meyer Assessment Scale [weighted mean difference （WMD）, 9.77; 95% CI （4.84, 14.70）; P=0.00], Barthel Index [WMD=6.40; 95% CI （3.15, 9.65）], and mean flow velocity [WMD= 5.79; 95% CI （1.64, 9.94）]. There were no significant differences for The National institutes of Health Stroke Scale [WMD=0.60; 95% CI （ - 1.09, 2.29）], vi- sual field defects [left visual field： WMD= - 203.10; 95% CI （ - 424.41, 18.21）; right visual field： WMD= - 172.60; 95% CI （ - 409.29, 64.09）] or the functional independence measure [WMD= - 7.90; 95% CI （ - 16.64, 0.84）]. Seven articles that included eight RCTs reported the safety of DPC treatment. Two ar- ticles that included three observational studies also reported beneficial effects for DPC. Because the Chinese studies were of poor methodological quali- ty, and most of the sample sizes were small, our analysis was likely affected by bias. CONCLUSION： DPC has a beneficial effect and is relatively safe when used for the treatment of stroke.

关键词： KeStroke Treatment outcome Safety Re-view Danqipiantan capsule

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Experimental Study on acupuncture Activating the Gonadotropin-releasing Hormone Neurons in Hypothalamus

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Journal of Traditional Chinese Medicine 2010年第1期30卷 30-39页

作者：王少军朱兵任晓暄谭连红王友京 institute of acupuncture and moxibustion China Academy of Chinese Medical Sciences

Objective:To probe into the most effective site,extra-ordinary point,acupoint and channel for regulating reproductive endocrine function by means of the study on acupuncture activating the gonadotropin-releasing hormone neurons(GnRH) in ***:Female SD rats of reproductive age were used,and the in vivo study on GnRH neurons in hypothalamus was made with mimic sexual stimulation and feedback *** neuron-activating effects of the acupoints on the channels pertaining to the zang-and fu-organs related with reproductive endocrine and the extra-ordinary points in different regions were studied using the discharge of the neuron as index,and then the neurons were labeled with horseradish peroxidase(HRP) .Results:acupuncture was given at two acupoints each on the three yin channels of foot,the three yang channels of foot,the Conception Vessel and the Governor *** order of the mean increasing percentage in the hypothalamic GnRH neuron electric activity was:the Gallbladder Channel>the Spleen Channel>the Stomach Channel/the Bladder Channel/the Conception Vessel>the Liver Channel>the Kidney Channel>the Governor Vessel;for different acupoints,it was:Guanyuan(CV 4) >Sanyinjiao(SP 6) >Zusanli(ST 36) >Daimai(GB 26) /Yanglingquan(GB 34) >Shenshu(BL 23) >Weizhong(BL 40) >Yaoyangguan(GV 3) /Liangmen(ST 21) /Fujie(SP 14) >Qimen(LR 14) /Yingu(KI 10) >Tangzhong(CV 17) /Zhiyang(GV 9) ;for different positions,it was:the lower abdominal part/the lower limb part>the thoracodorsal part;for the extra-ordinary points,it was:Zigong(EX-CA1) >Dannang(EX-LE6) /Yaoyan(EX-B7) >Baichongwo(EX-LE3) /Qianzheng>Jingbi/Bizhong/Taiyang(EX-HN5) >Erbai(EX-UE2) /Dingchun;and for the distribution sites of the extra-ordinary points:lower abdominal region>the lower limb region>the craniofacial region>the upper limb region/the thoracodorsal ***:For regulating the reproductive endocrine function,the acupoints located at the same neural segment with the reproductive organ

关键词： mimic sexual stimulation feedback regulation,gonadotropin-releasing hormone (GnRH) neurons in hypothalamus

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Effect of electro-acupuncture on substance P, its receptor and corticotropin-releasing hormone in rats with irritable bowel syndrome

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World Journal of Gastroenterology 2009年第41期15卷 5211-5217页

作者： Xiao-Peng Ma Lin-Ying Tan Yun Yang Huan-Gan Wu Bin Jiang Hui-Rong Liu Ling Yang Shanghai institute of acupuncture-moxibustion and Meridian Shanghai 200030 China

AIM： To investigate the effect and mechanism of electro-acupuncture lEA） at ST25 and ST37 on irritable bowel syndrome （IBS） of rats. METHODS： A total of 21 male Sprague-Dawley rats were randomly divided into normal group, model group and EA group. A rat model of IBS was established by constraining the limbs and distending the colorectum of rats. Rats in EA group received bilateral EA at ST25 and ST37 with a sparse and intense waveform at a frequency of 2/50 Hz for 15 min, once a day for 7 d as a course. Rats in normal and model groups were stimulated by distending colorectum （CR）. An abdominal withdrawal reflex （AWR） scoring system was used to evaluate improvements in visceral hypersensitivity. Toluidine blue-improved method, immunohistochemistry and radioimmunoassay were used to observe mucosal mast cells （MC）, changes of substance P （SP） and substance P receptor （SPR） in colon and change of corticotropin-releasing hormone （CRH） in hypothalamus. RESULTS： The threshold of visceral sense was significantly lower in model group than in normal group,and significantly higher in EA group than in model group. The number of mucosal MC was greater in model group than in normal group and significantly smaller in EA group than in model group. The CRH level in hypothalamus of rats was significantly higher in model group than in normal group, which was remarkably decreased after electro-acupuncture treatment. The SP and SPR expression in colon of rats in model group was decreased after electro-acupuncture treatment. CONCLUSION： EA at ST25 and ST37 can decrease the number of mucosal MC and down-regulate the expression of CRH in hypothalamus, and the expression of SP and SPR in colon of rats with IBS.

关键词： Electro-acupuncture Corticotropin-releasing hormone Irritable bowel syndrome Substance P Substance P receptor

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Somato Stimulation and acupuncture Therapy

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Chinese Journal of Integrative Medicine 2016年第5期22卷 394-400页

作者：赵敬军荣培晶石力贲卉朱兵 institute of acupuncture-moxibustion China Academy of Chinese Medical Sciences

acupuncture is an oldest somato stimulus medical technique. As the most representative peripheral nerve stimulation therapy, it has a complete system of theory and application and is applicable to a large population. This paper expounds the bionic origins of acupuncture and analyzes the physiological mechanism by which acupuncture works. For living creatures, functionally sound viscera and effective endurance of pain are essential for survival. This paper discusses the way in which acupuncture increases the pain threshold of living creatures and the underlying mechanism from the perspective of bionics. acupuncture can also help to adjust visceral functions and works most effectively in facilitating the process of digestion and restraining visceral pain. This paper makes an in-depth overview of peripheral nerve stimulation therapy represented by acupuncture. We look forward to the revival of acupuncture, a long-standing somato stimulus medicine, in the modern medical systems.

关键词： somato stimulus acupuncture mechanism of action

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Effects of Guasha on histomorphology of scraped skins and on expression of calcitonin gene-related peptide and substance P in rats

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Journal of Traditional Chinese Medicine 2018年第4期38卷 562-569页

作者： Wang Yingying Xu Dongsheng Bai Wanzhu Yang Jinsheng institute of acupuncture and moxibustion China Academy of Chinese Medical Sciences

OBJECTIVE:To reveal the effects of Guasha(scraping therapy) on the histomorphology of scraped skins and on the expressions of calcitonin gene-related peptide(CGRP) and substance P(SP).METHODS:50 rats,as experimental subjects,were randomly divided into 5 groups according to different observation time *** setae were shaved for the exposure of skin on both sides of the *** reinforcing and reducing method was applied to the rats in Guasha groups on the site equivalent to bladder meridian of human body on one side of the spine,and the skin was scraped from top to bottom until rash of measles *** skin tissues with rash of measles were taken down after *** corresponding sites of rats in group A were also taken down as *** tissues were made to sections and used for immunofluorescence histochemical staining and HE staining of antibodies such as SP and ***:After Guasha,there were significant differences in appearance,hair follicle and blood vessel on local skin scraped on the back of rats when compared with control;In different time points,the differences *** was no significant difference in expression of CGRP and SP when compared local skin scraped on the back of rats in different time ***:Guasha didn't significantly change the morphology of nerve fibers inside local skin,and the histomorphology of hair follicle,blood vessel and ***,after Guasha they basically returned to normal level within five days.

关键词： Guasha(Scraping therapy) Morphology Immunohistochemistry Substance P(SP) Calcitonin gene-related peptide(CGRP)

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Effect of manual acupuncture on bowel motility in normal kunming mouse

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Journal of Traditional Chinese Medicine 2015年第2期35卷 227-233页

作者： Zhao Yuxue Cui Changxiang Qin Qingguang Ben Hui Gao Junhong Yu Xiaochun Zhu Bing institute of acupuncture and moxibustion China Academy of Chinese Medical Sciences

OBJECTIVE:To observe the effects of acupuncture on motility of jejunum and distal colon at different acupoints on normal Kunming ***:The jejunal and colorectal motor activity of forty Kunming mice were recorded by the intra-intestinal *** capsules contained with distilled water were placed into the cavities of jejunum and distal *** changes of bowel were compared with the background activity recorded before any *** chosen acupoints were as follows:Zusanli(ST 36) on the lower legs,Tianshu(ST 25) on the mid-lower ***:Manual acupuncture(MA) at Zusanli(ST36) significantly promoted the motility of jejunum and distal colon(manifested as increased change rate of average amplitude and increased change rate of mean area under the contractile curve) of normal Kunming mice(P < 0.01).MA atTianshu(ST25) significantly inhibited the motility of jejunum(manifested as decreased change rate of average amplitude,decreased change rate of mean area under the contractile curve,and the reduced frequency) of normal Kunming mice(P < 0.01),while significantly increased the distal colonic motility(manifested as increased amplitude and increased mean area under the contractile curve) of normal Kunming mice(P < 0.01).CONCLUSION:MA at specific acupoints[Zusanli(ST 36),Tianshu(ST 25)]has different effects on the motility of jejunum and distal colon,which might involve the segmental innervations of the related nerve.

关键词： Hand acupuncture Point ST 36(Zusanli) Point ST 25(Tianshu) Gastrointestinal motility

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The Expression of Calcitonin Gene-related Peptide on the Neurons Associated Zusanli(ST 36)in Rats

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Chinese Journal of Integrative Medicine 2015年第8期21卷 630-634页

作者：崔晶晶朱新龙石宏宿杨帅景向红白万柱 institute of acupuncture and moxibustion China Academy of Chinese Medical Sciences

Objective： To investigate the biochemical characteristic of the neurons associated Zusanli （ST 36） in the rat by using Alexa Fluor 594 conjugated cholera toxin subunit B （AF594-CTB） neural tracing and calcitonin gene-related peptide （CGRP） fluorescent immunohistochemical techniques. Methods： Four male Sprague Dawley rats were injected with AF594-CTB into the corresponding area of the Zusanli in the human body. After 3 surviving days, the rat＇s spinal cord and dorsal root ganglia （DRGs） at lumbar segments were dissected following perfusion with 4% paraformaldehyde, cut into sections, and then stained with CGRP- fluorescent immunohistochemical method. Results： AF594-CTB labeled sensory neurons were detected in the L3-L6 DRGs with high concentration in L4 DRG, and the labeled motor neurons located in the dorsolateral and intermediate regions of lamina IX from L3-L5 segments with high concentration at L4. Meanwhile, CGRP- positive neural labeling distributed symmetrically on both sides of DRGs, anterior and dorsal horns of spinal cord. In the AF594-CTB labeled neurons, 37% sensory neurons and 100% motor neurons expressed CGRP- positive. Conclusion： These findings present the morphological evidence to demonstrate that the sensory and motor neurons associated Zusanli in the rat distributed with segmental and regional patterns, and contained CGRP-expression.

关键词： Zusanli (ST 36) neural tracing calcitonin gene-related peptide Alexa Fluor 594 conjugated cholera toxin subunit B sensory neuron motor neuron

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The influence of different methods of acupuncture on skin surface perfusion

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Journal of Traditional Chinese Medicine 2012年第1期32卷 40-44页

作者：黄涛王瑞红张维波韩彬王广军田宇瑛张宇沁 institute of acupuncture and moxibustion China Academy of Chinese Medical Sciences

OBJECTIVE:To compare the effects on the body surface of different kinds of placebo/sham acupuncture with that of traditional needling sensation ***:Point Neiguan(PC 6) of 29 healthy subjects,19 males and 10 females,was stimulated with needling sensation,shallow,placebo and deep acupuncture at the *** stimulation with different methods of acupuncture,the change in perfusion of the micrangium in the skin surface around the elbow joint,with Point Quze(PC 3) as its center,was observed with laser Doppler blood-flow ***:Judging from the absolute value of perfusion of the skin surface micrangium,several methods of acupuncture can cause change in blood *** ratio of blood-flow perfusion in the meridian area in and around Quze declined before and after needling insertion in needling sensation acupuncture and shallow *** observation did not occur in placebo and non-acupoint *** sensation acupuncture at an acupoint can relatively reduce the perfusion ofthe micrangium in the projective area of the meridian where the acupoint is located on the body surface(Pacupuncture can cause change in blood flow in the skin near the needling ***,the biological mechanism underlying this phenomenon needs to be further explored.

关键词： Skin surface perfusion acupuncture

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