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Safety and efficacy of Danqipiantan capsule for treatment of stroke: a systematic review

Safety and efficacy of Danqipiantan capsule for treatment of stroke: a systematic review

作     者:Jiashen Li Haizhen Zheng Xiaofeng Zhao Shu Wang Xuemin Shi 

作者机构:Institute of Acupuncture and Moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of Acupuncture and Moxibustion Science 

出 版 物:《Journal of Traditional Chinese Medicine》 (中医杂志(英文版))

年 卷 期:2013年第33卷第6期

页      面:707-714页

核心收录:

学科分类:1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基  金:Supported by The National Science and Technology Infrastructure Program of China(2006BAI04A02-2) the National Basic Research Program of China(2012CB518505) the Natural Science Foundation of China(81173416) 

主  题:KeStroke Treatment outcome Safety Re-view Danqipiantan capsule 

摘      要:OBJECTIVE: To evaluate the efficacy and safety of Danqipiantan capsule (DPC) for the treatment of stroke. METHODS: PubMed, China Science And Technolo- gy Journal Database, Wanfang Database, Chinese periodicals in the China National Knowledge Infra- structure, and the General Hospital of Tianjin Medi- cal University's Library were searched until July 2012. Randomized controlled trials (RCTs) and ob- servational studies that reported the use of DPC for treatment of stroke were selected. RESULTS: Eleven articles that included 12 RCTs, and 2 articles that included 3 observational studies were identified. A total of 2590 patients participat- ed in the studies. We found that there was a signifi-cant statistical difference between DPC treatment groups and the control groups in terms of the effec- tive rate [risk ratio (RR), 1.14; 95% confidence inter- vals (CI), 1.04, 1.25; P=0.01], FugI-Meyer Assessment Scale [weighted mean difference (WMD), 9.77; 95% CI (4.84, 14.70); P=0.00], Barthel Index [WMD=6.40; 95% CI (3.15, 9.65)], and mean flow velocity [WMD= 5.79; 95% CI (1.64, 9.94)]. There were no significant differences for The National Institutes of Health Stroke Scale [WMD=0.60; 95% CI ( - 1.09, 2.29)], vi- sual field defects [left visual field: WMD= - 203.10; 95% CI ( - 424.41, 18.21); right visual field: WMD= - 172.60; 95% CI ( - 409.29, 64.09)] or the functional independence measure [WMD= - 7.90; 95% CI ( - 16.64, 0.84)]. Seven articles that included eight RCTs reported the safety of DPC treatment. Two ar- ticles that included three observational studies also reported beneficial effects for DPC. Because the Chinese studies were of poor methodological quali- ty, and most of the sample sizes were small, our analysis was likely affected by bias. CONCLUSION: DPC has a beneficial effect and is relatively safe when used for the treatment of stroke.

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