检索结果-南通市图书馆

Effects of Kampo medicine hangebyakujutsutemmato on persistent postural-perceptual dizziness:A retrospective pilot study

引用

World Journal of Clinical Cases 2022年第20期10卷 6811-6824页

作者： Toru Miwa Shin-ichi Kanemaru Department of otolaryngology-Head and Neck Surgery Osaka Metropolitan UniversityOsaka 5458585Japan Department of otolaryngology-Head and Neck Surgery Tazuke Kofukai Medical Research InstituteKitano HospitalOsaka 5308480Japan Department of otolaryngology-Head and Neck Surgery Kyoto UniversityKyoto 7507501Japan

BACKGROUND Persistent postural-perceptual dizziness(PPPD)is a functional disorder,typically preceded by acute vestibular *** is characterized by a shift in processing spatial orientation information,to favor visual over vestibular and somatosensory inputs,and a failure of higher cortical *** date,no therapies for PPPD have been *** medicine hangebyakujutsutemmato(HBT)has been reported to alleviate disturbances of *** hypothesized that HBT would be a beneficial treatment for *** To examine the efficacy of HBT for the treatment of *** Patients with PPPD were enrolled and divided into two groups:The HBT group(n=24)and the non-HBT group(n=14).The participants completed questionnaire surveys[Niigata PPPD questionnaire(NPQ),dizziness handicap inventory,hospital anxiety and depression scale(HADS),orthostatic dysregulation questionnaire,pittsburg sleep quality index(PSQI),and motion sickness scores]before and after HBT ***,to identify HBT responders,multivariate regression analysis was performed using the results of the ques-tionnaire surveys and equilibrium tests;including stabilometry,and caloric,vestibular evoked myogenic response,and head-up tilt *** Thirty-eight outpatients were included in this study,of which 14 patients(3 men,11 women;mean age,63.5±15.9 years)received treatment without HBT,and 24(1 man,23 women;mean age,58.2±18.7 years)received combination treatment with *** HBT treatment,NPQ scores decreased significantly(baseline 40.1±10.0 vs 2 mo 24.6±17.7,P<0.001).No statistically significant changes were observed in the NPQ scores in the non-HBT group(baseline 38.6±12.2 vs 2 mo 39.4±14.4,P=0.92).Multivariable regression analysis revealed that the results of stabilometry(P=0.02)and the caloric(P=0.03),and head-up tilt tests(P<0.001),HADS(P=0.003),and PSQI(P=0.01)were associated with HBT responsiveness in PPPD *** HBT may be an effective adjunct therapy fo

关键词： Hangebyakujutsutemmato Kampo medicine Persistent postural-perceptual dizziness Niigata persistent postural-perceptual dizziness questionnaire score Sensory reweighting Treatment responder

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

LOWER DOSE OF AMINOGLYCOSIDE OTOTOXIC EXPOSURE CAUSES PRESYNAPTIC ALTERATIONS ASSOICATED WITH HEARING LOSS

引用

Journal of Otology 2014年第1期9卷 36-42页

作者： LIU Ke WANG Xiaoyu LI Sijun TANG Siquan XU Yice WANG Xuefeng SUN Jianhe YANG Weiyan YANG Shiming Department of otolaryngology-Head and Neck Surgery PLA General Hospital PLA Institute of Otolaryngology Department of otolaryngology-Head and Neck Surgery the Affiliated Hospital North SiChuan Medical College Department of otolaryngology-Head and Neck Surgery the First Affiliated Hospital Liaoning Medical University

Objective To study presynaptic alternations of cochlear ribbons arising from aminoglycoside ototoxic stimuli in C57BL/6J mice. Methods Animals were injected with low dose gentamicin (100 mg/kg/day) for 14 days, From the 14th to 28th days, the mice were maintained free of gentamicin treatment. Immunohisto-chemistry labeling was employed to trace RIBEYE, a major presynaptic componment of ribbon synapses. RIBEYE/CtBP2 expression levels were assessed and compared with hearing threshold shifts. Auditory func-tion was assessed by auditory brainstem responses. The stereocilia of outer hair cells (OHCs) and IHCs was examined by scanning electron microscopy (SEM). Results Hearing thresholds were elevated with peak hearing loss observed on the 7th day after gentamicin exposure, followed by improvement after the 7th day. RIBEYE/CtBP2 expression directly correlated with observed hearing threshold shifts. Strikingly, we did not see any obvious changes in stereocilia in both OHCs and IHCs until the 28th day. Mild changes in stereocil-ia were only observed in OHCs on the 28th day. Conclusions These findings indicate that presynapse co-chlear ribbons, rather than stereocilia, may be sensitive to aminoglycoside ototoxic exposure in mice cochle-ae. A pattern of RIBEYE/CtBP2 expression changes seems to parallel hearing threshold shifts and suggests presynaptic response properties to lower dosage of aminoglycoside ototoxic stimuli.

关键词： Inner Hair Cells Ribbon Synapse Aminoglycoside Ototoxicity RIBEYE/CtBP2 Stereocilia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

EFFECTS OF MODERATE NOISE EXPOSURE ON HEARING FUNCTION IN C57BL/6J MICE

引用

Journal of Otology 2014年第2期9卷 81-85页

作者： SHI Chuang SHI Lei JIANG Xuejun YANG Shiming LIU Ke Department of otolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical University Department of otolaryngology Head and Neck surgery Shiyan Taihe Hospital Department of otolaryngology Head and Neck surgery Institute of OtolaryngologyChinese PLA General Hospital

Objective To study characteristics of hearing loss after exposure to moderate noise exposure in C57BL/6J mice. Methods Male C57BL/6J mice with normal hearing at age of 5-6 weeks were chosen for this study. The mice were randomly sclccted to be studied immediately after exposure （Group P0）, or 1 day （Group P1）, 3 days （Group P3）, 7 day （Group P7） or 14 days （P14） after exposure. Their before exposure condition served as the normal control. All mice were exposed to a broad-band white noise at 100 dB SPL for 2 hours, ABR thresholds were used to estimate hearing status at each time point. Results ABR threshold elevation was seen at every tested frequency at P0 （P〈0.01）. Elevation at high-frequencies （16 kHz and 32 kHz） was greater than at lower frequencies （4 kHz and 8 kHz, P〈0.05）. From P1 to P14, ABR thresholds continuously improved, and there was no significant difference between P14 and before exposure （P〉0.05）. Conclusion There is a frequency specific re- sponse to 100 dB SPL broad-band white noise in C57BL/6J mice, with the high-frequency being more susceptible. Hearing loss induced by moderate noise exposure appears reversible in C57BL/6J mice.

关键词： C57BL/6J mice Noise exposure Hearing loss Temporary noise-induced hearing loss ABR threshold shift

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An investigation into hearing loss among patients of 50 years or older

引用

Journal of Otology 2011年第1期6卷 44-49页

作者： JI Fei LEI Lei ZHAO Su-ping LIU Ke-fang ZHOU Qi-you YANG Shi-ming Department of otolaryngology/ Head and Neck Surgery Chinese PLA Institute of Otolaryngology Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China

Objects To investigate the extent of hearing loss in an elderly sample population to estimate hearing disorders among the age-equivalent population in China and to study primary clinical characteristics of presbycusis. Methods Clinical data from 110 hearing loss patients of both senium and pre-senium ages （95 males and 15 females, mean age = 74.4±12.1 years） were reviewed. Patients aged from 50 to 59 years were accepted as the pre-seni- um control group （n=15）. The 95 senium patients （〉 60 years of age） were divided into 4 groups according to age： 60＋ group（60 to 69 years, n=25）, 70＋ group （70 to79 years, n=26）, 80＋ group （80 to 89 years, n=32） and 90＋ group （90 years or older, n=12）. Pure tone audiometry thresholds were measured in all 110 patients. Hearing loss severity of each tested ear was rated according to the Goodman classification criteria. Besides, audiometric configuration was examined in each ear. Results Audiometric testing showed normal hearing in 65 ears （29.5%）, slight to moderately severe hearing loss in 131 ears （59.5%）, and severe and profound loss in 24 ears （11%）. Air-bone gaps were found in 12 ears （5.45%） indicating conductive hearing loss. Except the 12 ears with conductive hearing loss, audiograms showed gradually sloping loss in 99 ears （45%）, sharply sloping loss in 34 ears （15.45%）, fiat loss in 45 ears （20.45%）, notch pattern loss in 5 ears（2.27%）, trough and rising pattern loss in 2 ears（0.91%）, total deafness in 2 ears （0.91%）, and normal hearing in 21 ears（9.55%）. On average, hearing thresholds increased at a rate of approximately 10 dB per 10 year for subjects aged 60 and older. Conclusions Hearing thresholds tend to be stable in presbycusis patients aged from 50 to 70 years, increase significantly between 70 and 80 years of age, and reach another stable stage at high levels after 80 years of age, especially in high frequencies. Hearing loss in middle frequencies accounts for most of recession in loudness perception.

关键词： elderly presbycusis hearing loss

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular genetic studies of familial Meniere’s disease

引用

Science China(Life Sciences) 2019年第11期62卷 1557-1560页

作者： Jing Zhang Jing Guan Hongyang Wang Dayong Wang Lidong Zhao Huifang Zhou Qiuju Wang Chinese PLA institute of otolaryngology Chinese PLA General HospitalMedical School of Chinese PL ABeijing 100853China Department of otolaryngology of Tianjin Medical University General Hospital Tianjin 300052China

Dear ***'s disease(MD,MIM 156000),a chronic clinical illness affecting the inner ear,presents as episodes of spontaneous vertigo,fluctuating sensorineural hearing loss,tinnitus,and aural *** hydrops in the cochlear duct and vestibular organs is considered the underlying histopathologic characteristic of *** MD cases are sporadic(sporadic Meniere's disease,SMD),and approximately 4%-20%of patients with MD have a familial history.

关键词： Meniere familial organs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hearing analysis in heterozygous and homozygous klotho gene deficient mice

引用

Journal of Otology 2018年第4期13卷 131-134页

作者： Na Yuan Shiwei Qiu Qian Wang Wei Zhuang Guoping Li Tiantian Sun Shiming Yang Yuehua Qiao Xi Shi The institute of Audiology and Balance Science Xuzhou Medical University Department of otolaryngology-Head & Neck Surgery Institute of Otolaryngology of PLA Chinese PIA General Hospital Clinical Hearing Center Affiliated Hospital of Xuzhou Medical University

Objective: To understand the crucial role of the klotho gene in hearing development in mouse ***: PCR was used to identify CBA mice with different genotypes, i.e. WT, heterozygous(klotho +/-)or homozygous(klotho-/-). Mice phenotype and weight were recorded postnatal 25 days(P-25) and auditory brainstem responses(ABR) were used to determine auditory function at ***: klotho-/-mice tended to have smaller size, lighter weight and higher ABR thresholds at P-60,showing early onset age-related hearing loss(ARHL).Conclusion: Heterozygous and homozygous klotho deficient mice exhibit different degrees of hearing loss at young age, with homozygous mice(klotho-/-) showing more severe hearing loss. Our results indicate that persisted expression of klotho protein in the inner ear may potentially delay the onset of ARHL and play an important role in the protection of auditory function.

关键词： Homozygous Klotho gene Inner ear Hearing loss

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Measurement of Ca^(2+) Flow in Cochlear Cells Using Non-Invasive Micro-Test Technique

引用

Journal of Otology 2010年第2期5卷 90-96页

作者： CHEN Shi-qin YU Ning YE Sheng-nan YANG Shi-ming ZHAI Suo-qiang Department of otolaryngology Head and Neck Surgery Oto-Neurobiology CentreInstitute of OtolaryngologyChinese PLA General HospitalBeijing 100853China Department of otolaryngology Affiliated First HospitalFujian Medical UniversityFuzhou 350005China

Objective To test Calcium ion(Ca2+) flow at the head and end of outer hair cells(OHCs) in resting state and in response to Nimodipine *** Non-invasive micro-test techniques were used to study Ca2+ in isolated OHCs in adult guinea *** Four types of Ca2+ transport were identified in OHCs on basilar membrane tissue fragments:influx at the head of with efflux at the bottom(type 1):efflux at the head of OHCs with influx at the bottom(type 2);influx at the both head and bottom(type 3);and efflux at the both head and bottom(type 4).However,only type 1 and type 3 of Ca2+ ion transport were detected in the *** propose that Ca2+ ion transport exists in adult guinea pig cochlear OHCs in resting state and is ***2 + flow in OHC can be inhibited by Nimodipine in resting state.

关键词： Guinea pig outer hair cells Ca2+ ion non-invasive micro-test technique nimodipine.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation

引用

Chinese Journal of Natural Medicines 2022年第6期20卷 443-457页

作者： DUAN Fei-Peng LI Yi-Sheng HU Tian-Yong PAN Xin-Quan MA Fang FENG Yue QIU Shu-Qi ZHENG Yi-Qing institute of otolaryngology Institute of Hearing and Speech of Sun Yat-sen UniversitySun Yat-sen Me-morial HospitalSun Yat-sen UniversityGuangzhou 510520China Department of otolaryngology Longgang E.N.T hospital&Shenzhen Key Laboratory of E.N.TInstitute of E.N.TShenzhen 518172China

Antibiotic exposure-induced dysbiosis of the intestinal flora increases the risk of developing allergic ***,regulating the balance of intestinal flora may be useful for preventing and treating allergic ***,the underlying mechanism is *** nobile(Shihu)exhibits anti-inflammatory and immune ***,in this study,we investigated the mechanism via which Shihu may improve allergic *** models of allergic rhinitis with intestinal flora dysbiosis(Model-D,antibiotics induce intestinal flora dysbiosis with ovalbumin-induced allergy)and normal intestinal flora with allergic rhinitis(Model-N,ovalbumin-induced allergy)were *** effect of Shihu on intestinal flora and inflammation caused during allergic rhinitis were *** symptoms,infiltration of hematoxylin and eosin in the lungs and nose,and the release of various factors[interleukin(IL)-2,IL-4,IFN-y,IL-6,IL-10,and IL-17]in the lungs were *** results indicate that intestinal flora dysbiosis exacerbated lung and nose inflammation in allergic ***,treatment with the Shihu extract effectively reversed these ***,the Shihu extract inhibited the PI3K/AXT/mTOR pathway and increased the level of Forkhead box protein in the ***,the Shihu extract reversed intestinal flora dysbiosis at the phylum and genus levels and improved regulator T cell ***,in the Model-D group,the Shihu extract inhibited the decrease in the diversity and abundance of the intestinal *** was performed to determine which intestinal flora was positively correlated with Treg differentiation using Spearman5 s correlation *** conclusion,we showed that Shihu extract restored the balance in intestinal flora and ameliorated inflammation in the lungs of allergic rhinitis mice and predicted a therapeutic new approach using Traditional Chinese Medicine to improve allergic rhinitis.

关键词： Dendrobium nobile(Shihu) Allergic rhinitis Intestinal flora Regulator T cell Inflammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Classification of facial nerve aberration in congenital malformation of middle ear:Implications for surgery of hearing restoration

引用

Journal of Otology 2018年第4期13卷 122-127页

作者： Jin Hao Liping Xu Shuling Li Xinxing Fu Shouqin Zhao Department of otolaryngology Head and Neck Surgery Beijing Tongren Hospital of Capital Medical University Department of Radiology Beijing Tongren Hospital of Capital Medical University Key Laboratory of otolaryngology Head and Neck Surgery (Capital Medical University)Ministry of EducationBeijing Institute of Otolaryngology

Objectives: Facial nerve aberration is the most troublesome situation in congenital malformations of middle *** aim of our study is to investigate its imaging and clinical features as well as relevant choice of surgical techniques for hearing ***: A retrospective study involving review of clinical data of 227 patients(256 ears) with congenital middle ear anomaly was undertaken, including preoperative computed tomography(CT) data, surgical records and ***: Aberration involving intratemporal facial nerve was found in 82/256 ears(32.03%) with congenital middle ear anomaly. The most common forms of aberration included overhanging over the oval window(50/82 ears, 60.98%), bifurcation(3/82 ears, 3.66%) and transverse over the promontory(3/82 ears, 3.66%), counting for 68.29%(56/82) of the cases with facial nerve aberration. Concomitant stapes malformation was found in 76/82 ears(92.68%) and atresia or stenosis of the oval window in 27/82 ears(32.93%). In 9/82 ears(10.98%) both stapes and oval window was absent. Elective surgeries for the purpose of hearing improvement included stapodotomy + piston implantation, labyrinthotomy, labyrinthotomy + total ossicular replacement prosthesis(TORP) implantation and Vibrant Soundbridge(VSB) ***: The majority of facial nerve aberration in congenital malformation of middle ear involves displacement of facial nerve, in addition to concomitant malformations of the stapes and/or oval window, which may influence the choice of surgery for hearing improvement. VSB implantation may be considered as a useful option.

关键词： Congenital middle ear anomaly Facial nerve Stapes Oval window Vibrant Soundbridge(VSB)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recording potentials from scala media, saccule and utricle in mice

引用

Journal of Otology 2015年第2期10卷 87-91页

作者： Huizhan Liu Lidong Zhao Hair Cell Biophysics Laboratory Department of Biomedical Sciences Creighton University School of Medicine Department of otolaryngology Head and Neck Surgery Institute of Otolaryngology Chinese PLA General Hospital

Objective： To describe a protocol for recording electrical potentials from the scala media, saccule, and utricle in mice. Method： CBA/J mice were used and potentials were recorded with glass electrodes inserted through the basilar membrane using a patch clamp system. Results： Resting potentials were successfully recorded from the scala media, saccule and utricle using described protocols. Conclusions： With the method described, one can measure resting potentials from the scala media, saccule and utricle, as well as cochlear microphonics （CM） and even auditory nerve compound action potentials （CAP）, in a single mouse.

关键词： Electric potentials Inner ear Mice

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：