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High drug loading polymer micelle@ZIF-8 hybrid core–shell nanoparticles through donor–receptor coordination interaction for pH/H_(2)O_(2)-responsive drug release

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Frontiers of Materials Science 2022年第2期16卷 99-108页

作者： Yikun JIANG Zhentao LEI Zaizai TONG College of Materials Science and Engineering and Institute of Smart BiomaterialsZhejiang Sci-Tech UniversityHangzhou 310018China

Smart drug delivery nanocarriers with high drug loading capacity are of great importance in the treatment of diseases,and can improve therapeutic effectiveness as well as alleviate side effects in *** this work,a pH and H_(2)O_(2)-responsive drug delivery platform with high doxorubicin(DOX)loading capacity has been established through coordination interaction between DOX and phenylboronic acid containing block polymer.A composited drug nanocarrier is further fabricated by growing a zeolitic imidazolate framework 8(ZIF-8)on the surface of drug-loaded polymer *** study verifies that ZIF-8 shell can act as intelligent“switch”to prevent DOX leaking from core–shell nanoparticles upon H_(2)O_(2) ***,a burst drug release is detected upon pH and H_(2)O_(2) stimuli due to the further disassociation of ZIF-8 in acid ***,the in vitro anti-cancer experiments demonstrate that the DOX-loaded core–shell nanoparticles provide effective treatment towards cancer cells but have negligible effect on normal cells,which results from the high concentration of H_(2)O_(2) and low pH in the microenvironment of tumor cells.

关键词： block copolymer donor–acceptor high drug loading capacity dual responsiveness controlled drug release

Silicon-Based Molecular Switch Junctions

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Nano Research 2009年第8期2卷 648-659页

作者： Daijiro Nozaki Gianaurelio Cuniberti institute for Material Science and Max Bergmann Center of biomaterials Dresden University of TechnologyD-01062 DresdenGermany

In contrast to the static operations of conventional semiconductor devices,the dynamic conformational freedom in molecular devices opens up the possibility of using individual molecules as new types of devices such as a molecular conformational switch or for molecular data *** molecules such as those having two stable cis and trans isomeric confi gurations could provide,once clamped between two electrodes,a switching phenomenon in the non-equilibrium current ***,we model molecular switch junctions formed at silicon contacts and demonstrate the potential of such tunable molecular switches in electrode/molecule/electrode confi *** the non-equilibrium Green function(NEGF)approach implemented with the density-functional-based tight-binding(DFTB)theory,a series of properties such as electron transmissions,current voltage characteristics in the different isomer conformations,and potential energy surfaces(PESs)as a function of the reaction coordinates along the trans to cis transition were calculated for two azobenzene-based model ***,in order to investigate the stability of molecular switches under ambient conditions,molecular dynamics(MD)simulations at room temperature were performed and time-dependent fl uctuations of the conductance along the MD pathways were *** numerical results show that the transmission spectra of the cis isomers are more conductive than trans counterparts inside the bias window for both model *** currentvoltage characteristics consequently show the same ***,calculations of the time-dependent transmission fluctuations along the MD pathways have shown that the transmission in the cis isomers is always signifi cantly larger than that in their trans counterparts,showing that molecular switches can be expected to work as robust molecular switching components.

关键词： Molecular electronics molecular switches charge transport silicon–molecule interface

Analysis of the shape of heavy droplets on flat and spherical surface

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Science China(Physics,Mechanics & Astronomy) 2012年第6期55卷 1118-1124页

作者： WANG XueWei YU Yang Biomechanics and biomaterials Laboratory Department of MechanicsSchool of Aerospace EngineeringBeijing Institute of TechnologyBeijing 100081China

In this study,a theoretical model was established for predicting the equilibrium shape of the droplet on flat and spherical *** theoretical equilibrium shape of heavy droplets could be obtained once contact angle and volume of droplets were *** showed that the predictions of the theoretical flat model were in good agreement with the shape obtained by Surface Evolver when the contact angle is below 120 and the droplet size is on the order of capillary *** available range will decrease and increase when the heavy droplet is on convex and concave spherical surface,respectively,in contrast to that on flat *** available range will decrease more for higher curvature of convex spherical surfaces.

关键词： equilibrium shape heavy droplet ellipsoidal model Surface Evolver simulation

Fabrication of glycidyl methacrylate-modified silk fibroin/poly(L-lactic acid-co-ε-caprolactone)-polyethylene glycol diacrylate hybrid 3D nanofibrous scaffolds for tissue engineering

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Frontiers of Materials Science 2023年第2期17卷 79-91页

作者： Yongyong Fan Anlin Yin Yunhuan Li Qi Gu Yan Zhou Junlong Zhou Ruibo Zhao Kuihua Zhang institute of Smart biomaterials School of Materials Science and Engineering and Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China College of Materials and Textile Engineering Nanotechnology Research InstituteJiaxing UniversityJiaxing 314001China

In order to provide a biomimetic natural extracellular matrix microenvironment with excellent mechanical capacity for tissue regeneration,a novel porous hybrid glycidyl methacrylate-modified silk fibroin/poly(L-lactic acid-co-ε-caprolactone)–polyethylene glycol diacrylate(SFMA/P(LLA-CL)–PEGDA)hybrid three-dimensional(3D)nanofibrous scaffolds was successfully fabricated through the combination of 3D nanofibrous platforms and divinyl PEGDA based photocrosslinking,and then further improved water resistance by ethanol vapor *** electron microscopy and micro-computed tomography results demonstrated significant PEGDA hydrogel-like matrices bonded nanofibers,which formed a 3D structure similar to that of“steel bar(nanofibers)‒cement(PEGDA)”,with proper pore size,high porosity,and high pore connectivity ***,the hybrid 3D nanofibrous scaffolds showed outstanding swelling properties as well as improved compressive and tensile ***,these hybrid 3D nanofibrous scaffolds could provide a biocompatible microenvironment,capable of inducing the material‒cell hybrid and regulating human umbilical vein endothelial cells *** thus present significant potential in tissue regeneration.

关键词： hybrid 3D nanofibrous scaffold silk fibroin tissue engineering human umbilical vein endothelial cell

Structure and corrosion resistance of Al–Cu–Fe alloys

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Progress in Natural Science:Materials International 2020年第3期30卷 393-401页

作者： Rafa? Babilas Anna Bajorek Monika Spilka Adrian Radoń Wojciech ?oński Department of Engineering Materials and biomaterials Silesian University of Technology institute of Physics University of Silesia in Katowice ?ukasiewicz Research Network-institute of Non-Ferrous Metals

The microstructure and electrochemical properties of Al–Cu–Fe alloys with the atomic compositions of Al65Cu20Fe15,Al78Cu7Fe15and Al80Cu5Fe14Si1have been *** alloys were produced by induction melting of pure elements with copper mold *** microstructure of the alloys was analyzed by X-ray diffraction and high-resolution transmission electron *** formation of quasicrystalline phases in the Al–Cu–Fe alloys was *** presence of intermetallic phases was observed in the alloys after crystallization in a form of ingots and *** electrochemical measurements were conducted in 3.5%NaCl *** electronic structure of the alloys was determined by X-ray photoelectron *** post corrosion surface of the samples was checked using a scanning electron microscope equipped with the energydispersive X-ray *** was observed that the Al65Cu20Fe15alloy had the highest corrosion *** improved corrosion resistance parameters were noted for the plate samples rather than those in the as-cast *** the hardness of the Al65Cu20Fe15alloy was significantly higher than the other alloy samples.

关键词： Al-Cu-Fe alloys Copper mold casting X-ray diffraction High-resolution transmission electron microscopy X-ray photon spectroscopy Electrochemical impedance spectroscopy

Mesoporous bioactive glass composition effects on degradation and bioactivity

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Bioactive Materials 2021年第7期6卷 1921-1931页

作者： M.Schumacher P.Habibovic S.van Rijt Department of Instructive biomaterials Engineering MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht Universitythe Netherlands

Mesoporous bioactive glasses(MBGs)are promising materials for regenerative medicine,due to their favorable properties including bioactivity and *** key properties,but also their surface area,pore structure and pore volume are strongly dependent on synthesis parameters and glass ***,to date no systematic study on MBG properties covering a broad range of possible compositions ***,24 MBG compositions in the SiO_(2)-CaO-P_(2)O_(5) system were synthesized by varying SiO_(2)(60-90 mol%),CaO and P_(2)O_(5) content(both 0 to 40 mol-%),while other synthesis parameters were kept *** characteristics,degradability and bioactivity were *** results showed that,within the tested range of compositions,mesopore formation required a molar SiO_(2) content above 60%but was independent of CaO and P_(2)O_(5) *** mesopore size did not depend on glass stoichiometry,mesopore arrangement was influenced by the SiO_(2) *** surface area and pore volume were slightly altered by the SiO_(2) *** materials were degradable;however,degradation as well as bioactivity,*** ability to form a CaP mineral on the surface,depended on *** differences were found in early surface reactions in simulated body fluid:where some MBGs induced direct hydroxyapatite crystallization,high release of calcium in others resulted in calcite *** summary,degradation and bioactivity,both key parameters of MBGs,can be controlled by glass stoichiometry over a broad range while leaving the unique structural parameters of MBGs relatively *** allows targeted selection of material compositions for specific regenerative medicine applications.

关键词： bioactivity bioactive arrangement

Injectable bone cements:What benefits the combination of calcium phosphates and bioactive glasses could bring?

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Bioactive Materials 2023年第1期19卷 217-236页

作者： Öznur Demir-Oguz Aldo R.Boccaccini Dagnija Loca Rudolfs Cimdins Riga biomaterials Innovations and Development Centre of RTU Institute of General Chemical EngineeringFaculty of Materials Science and Applied ChemistryRiga Technical UniversityPulka St 3RigaLV-1007Latvia Baltic biomaterials Centre of Excellence Headquarters at Riga Technical UniversityRigaLatvia institute of biomaterials Department of Materials Science and EngineeringUniversity of Erlangen-Nuremberg91058ErlangenGermany

Out of the wide range of calcium phosphate(CaP)biomaterials,calcium phosphate bone cements(CPCs)have attracted increased attention since their discovery in the 1980s due to their valuable properties such as bioactivity,osteoconductivity,injectability,hardening ability through a low-temperature setting reaction and *** numerous researches have been performed to enhance the properties of ***,low mechanical performance of CPCs limits their clinical application in load bearing regions of ***,the in vivo resorption and replacement of CPC with new bone tissue is still controversial,thus further improvements of high clinical importance are *** glasses(BGs)are biocompatible and able to bond to bone,stimulating new bone growth while dissolving over *** the last decades extensive research has been performed analyzing the role of BGs in combination with different ***,the focal point of this review paper is to summarize the available research data on how injectable CPC properties could be improved or affected by the addition of BG as a secondary powder *** was found that despite the variances of setting time and compressive strength results,desirable injectable properties of bone cements can be achieved by the inclusion of BGs into *** published data also revealed that the degradation rate of CPCs is significantly improved by BG ***,the presence of BG in CPCs improves the in vitro osteogenic differentiation and cell response as well as the tissue-material interaction in vivo.

关键词： Calcium phosphate Bioactive glass Injectable bone cements Bone regeneration Calcium phosphate bone cements

Antibacterial Activity of Silicate Bioceramics

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Journal of Wuhan University of Technology(Materials Science) 2011年第2期26卷 227-231页

作者：扈盛常江 Department of Physical Education Huazhong Normal University biomaterials and Tissue Engineering Research Center Shanghai Institute of Ceramics

Four kinds of pure silicate ceramic particles,CaSiO3,Ca3SiO5,bredigite and akermanite were prepared and their bactericidal effects were systematically *** phase compositions of these silicate ceramics were characterized by *** ionic concentration measurement revealed that the Calcium （Ca） ion concentration were relatively higher in Ca3SiO5 and bredigite,and much lower in CaSiO3 and ***,the pH values of the four silicate ceramics extracts showed a positive correlation with the particle ***,by decreasing the particle size,higher Ca ion concentrations can be achieved,leading to the increase of aqueous pH value as *** summary,all of the four silicate ceramics tested in our study showed antibacterial effect in a dose-dependent ***,the order of their antibacterial activity against *** from strong to weak is Ca3SiO5,bredigite,CaSiO3 and akermanite.

关键词： silicate ceramics antibacterial activity specific surface area aqueous pH ionic concentration

Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone:A pilot study

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Bioactive Materials 2023年第8期26卷 14-23页

作者： Jonathan Espiritu Sandra Sefa Hanna Cwieka Imke Greving Silja Flenner Regine Willumeit-Römer Jan-Marten Seitz Berit Zeller-Plumhoff Syntellix AG HannoverGermany institute of Metallic biomaterials Helmholtz-Zentrum HereonGeesthachtGermany institute of Materials Physics Helmholtz-Zentrum HereonGeesthachtGermany

An increasing prevalence of bone-related injuries and aging geriatric populations continue to drive the orthopaedic implant market.A hierarchical analysis of bone remodelling after material implantation is necessary to better understand the relationship between implant and ***,which are housed and communicate through the lacuno-canalicular network(LCN),are integral to bone health and remodelling ***,it is essential to examine the framework of the LCN in response to implant materials or surface *** materials offer an alternative solution to permanent implants,which may require revision or removal *** alloys have resurfaced as promising materials due to their bone-like properties and safe degradation in *** further tailor their degradation capabilities,surface treatments such as plasma electrolytic oxidation(PEO)have demonstrated to slow *** the first time,the influence of a biodegradable material on the LCN is investigated by means of non-destructive 3D *** this pilot study,we hypothesize noticeable variations in the LCN caused by altered chemical stimuli introduced by the *** synchrotron-based transmission X-ray microscopy,we have characterised morphological LCN differences around uncoated and PEO-coated WE43 screws implanted into sheep *** specimens were explanted after 4,8,and 12 weeks and regions near the implant surface were prepared for *** from this investigation indicate that the slower degradation of PEO-coated WE43 induces healthier lacunar shapes within the ***,the stimuli perceived by the uncoated material with higher degradation rates induces a greater connected LCN better prepared for bone disturbance.

关键词： Nanotomography Lacuno-canalicular network Bone Magnesium Biodegradable implants