Mesoporous bioactive glass composition effects on degradation and bioactivity

作     者：M.Schumacher P.Habibovic S.van Rijt 

作者机构：Department of Instructive Biomaterials EngineeringMERLN Institute for Technology-Inspired Regenerative MedicineMaastricht Universitythe Netherlands 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第7期

页      面：1921-1931页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This work was supported by the Alexander von Humboldt Foundation(Germany) This research has been in part made possible with the support of the Dutch Province of Limburg(LINK project).PH gratefully acknowledges the Gravitation Program‘Materials-Driven Regeneration’(024.003.013),funded by the Netherlands Organisation for Scientific Research 

主　　题：bioactivity bioactive arrangement 

摘      要：Mesoporous bioactive glasses(MBGs)are promising materials for regenerative medicine,due to their favorable properties including bioactivity and *** key properties,but also their surface area,pore structure and pore volume are strongly dependent on synthesis parameters and glass ***,to date no systematic study on MBG properties covering a broad range of possible compositions ***,24 MBG compositions in the SiO_(2)-CaO-P_(2)O_(5) system were synthesized by varying SiO_(2)(60-90 mol%),CaO and P_(2)O_(5) content(both 0 to 40 mol-%),while other synthesis parameters were kept *** characteristics,degradability and bioactivity were *** results showed that,within the tested range of compositions,mesopore formation required a molar SiO_(2) content above 60%but was independent of CaO and P_(2)O_(5) *** mesopore size did not depend on glass stoichiometry,mesopore arrangement was influenced by the SiO_(2) *** surface area and pore volume were slightly altered by the SiO_(2) *** materials were degradable;however,degradation as well as bioactivity,*** ability to form a CaP mineral on the surface,depended on *** differences were found in early surface reactions in simulated body fluid:where some MBGs induced direct hydroxyapatite crystallization,high release of calcium in others resulted in calcite *** summary,degradation and bioactivity,both key parameters of MBGs,can be controlled by glass stoichiometry over a broad range while leaving the unique structural parameters of MBGs relatively *** allows targeted selection of material compositions for specific regenerative medicine applications.