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Neural Regeneration Research 2024年第8期19卷 1649-1650页

作者： Vlad Ionut Viorel Ylenia Pastorello Nosherwan Bajwa Mark Slevin George Emil Palade University of Medicine PharmacyScience and TechnologyTârgu MuresRomania Department of Anatomy and Embryology George Emil Palade University of MedicinePharmacyScience and TechnologyTargu MuresRomania DIAKO Hospital FlensburgGermany Center for Advanced Medical and Pharmaceutical Research(CCAMF) George Emil Palade University of MedicinePharmacyScience and TechnologyTârgu MuresRomania Manchester Metropolitan University ManchesterUK

Alzheimer’s disease(AD),the most common type of dementia,affects millions of people worldwide,putting a significant strain on healthcare infrastructure and societal *** is characte rized by the build-up of amyloid-be... 详细信息

关键词： Alzheimer Aβ tau

Effect of Slag Basicity on Alumina Dissolution and Diffusivity:A High-temperature Confocal Laser Scanning Microscopy Study

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China's Refractories 2024年第2期33卷 27-34页

作者： Burhanuddin Harald HARMUtH Montanuniversität Leoben Leoben 8700Austria

Alumina is one of the crucial and extensively utilized refractory *** the refractory wear due to dissolution at elevated temperatures during operation is a major threat to refractory lifespan,quantifying dissolution is important for developing cost-effective and resource-efficient *** study investigated the dissolution of alumina particles in two silicate and one calcium aluminate slags at 1450,1500,and 1550°C using high-temperature confocal laser scanning microscopy(Ht-CLSM).Dissolution was quantified in terms of diffusivity,with all influencing factors,including Stefan flow and bath movement,incorporated into the determination *** trends observed in total dissolution time and diffusivity in three slags at three experimental temperatures could not be explained solely on the basis of slag *** parameters,considering the influencing factors,were introduced to explain these ***,the linear trend observed in Arrhenius plots of diffusivities supports the diffusivity ***,good agreement between the diffusivities of alumina in one silicate slag obtained via CLSM and rotating finger test investigations verified the reliability of the results.

关键词： alumina dissolution diffusivity corrosion refractory

the Paris 2024 Olympic and Paralympic Games

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Journal of Sport and Health Science 2024年第6期13卷 717-718页

作者： Walter Herzog Human Performance Laboratory Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada

the first modern Olympic Games took place in Athens in *** in those early days of the Olympics only amateur and gentleman athletes were allowed to participate,today Olympic athletes are highly trained professionals often dedicating decades of preparation for the chance to compete in the Olympic *** sharp contrast to these highly trained athletes,the world’s population becomes less physically active on average,resulting in an obesity epidemic with associated metabolic syndrome and increased mortality through non-communicable diseases(e.g.,Collins et al.^(1)).

关键词： Olympic allowed sharp

the turkish Economy in the Period between 1990 and 2000 in the Light of the Open Economy Policies of the 1980s Developments

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Economics World 2024年第3期11卷 122-135页

作者： Sitki Selim Dolanay Istanbul topkapi University IstanbulTürkiye

the structure of the economy seems to have been reshaped for the post-1980 period with the decisions of January 24,1980 and the structural changes that *** the 1980s,which can be called the transition process to a Free-Market Economy and an open economy,on the one hand,the privatization of state institutions and the determination of the prices of goods and services in free market conditions were tried to be ensured in order to withdraw the state from economic life,on the other hand,it was tried to grant freedom to foreign trade and capital *** these two main issues were being realized,the import substitution industrialization strategy was abandoned and the export-led growth model was started to be *** last step of this process of opening up and liberalization was realized with the decision numbered 32 in *** the change in the economic structure was achieved through domestic borrowing in the 1980s,with the liberalization of capital movements in the 1990s,it was seen that economic growth and development were tried to be achieved with hot money inflows rather than foreign direct *** orientation made the economy more open to crises,and for the first time there was a crisis in the form of the 1994 economic crisis,which was understood to be caused by hot *** 1994 economic crisis could only be overcome by giving government guarantees to bank deposits and issuing high-interest treasury *** the new banking regulations could not prevent the emergence of similar new economic crises in the following ***,we can say that the economic crisis experienced in the 2000s brought about a political transformation along with creating great economic problems.

关键词： turkish economy free market economy import export investments economic growth inflation

Alternative Method of Constructing Granular Neural Networks

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Computers, Materials & Continua 2024年第4期79卷 623-650页

作者： Yushan Yin Witold Pedrycz Zhiwu Li School of Electro-Mechanical Engineering Xidian UniversityXi’an710071China Department of Electrical and Computer Engineering University of AlbertaEdmontonABT6R 2V4Canada

Utilizing granular computing to enhance artificial neural network architecture, a newtype of network emerges—thegranular neural network (GNN). GNNs offer distinct advantages over their traditional counterparts: the ability toprocess both numerical and granular data, leading to improved interpretability. this paper proposes a novel designmethod for constructing GNNs, drawing inspiration from existing interval-valued neural networks built uponNNNs. However, unlike the proposed algorithm in this work, which employs interval values or triangular fuzzynumbers for connections, existing methods rely on a pre-defined numerical network. this new method utilizesa uniform distribution of information granularity to granulate connections with unknown parameters, resultingin independent GNN structures. to quantify the granularity output of the network, the product of two commonperformance indices is adopted: the coverage of numerical data and the specificity of information *** this combined performance index helps determine the optimal parameters for the network. Finally,the paper presents the complete model construction and validates its feasibility through experiments on datasetsfrom the UCIMachine Learning Repository. the results demonstrate the proposed algorithm’s effectiveness andpromising performance.

关键词： Granular neural network granular connection interval analysis triangular fuzzy numbers particle swarm optimization(PSO)

Upper and Lower Bounds of the α-Universal triple I Method for Unified Interval Implications

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Computers, Materials & Continua 2024年第4期79卷 1063-1088页

作者： Yiming tang Jianwei Gao Yifan Huang School of Computer and Information Hefei University of TechnologyHefei230601China Department of Electrical and Computer Engineering University of AlbertaEdmontonAB T6R 2V4Canada

theα-universal triple I(α-UtI)method is a recognized scheme in the field of fuzzy reasoning,whichwas proposed by our research group *** robustness of fuzzy reasoning determines the quality of reasoning algorithms to a large extent,which is quantified by calculating the disparity between the output of fuzzy reasoning with interference and the output without ***,in this study,the interval robustness(embodied as the interval stability)of theα-UtI method is explored in the interval-valued fuzzy *** begin with,the stability of theα-UtI method is explored for the case of an individual rule,and the upper and lower bounds of its results are estimated,using four kinds of unified interval implications(including the R-interval implication,the S-interval implication,the QL-interval implication and the interval t-norm implication).through analysis,it is found that theα-UtI method exhibits good interval stability for an individual ***,the stability of theα-UtI method is revealed in the case of multiple rules,and the upper and lower bounds of its outcomes are *** results show that theα-UtI method is stable for multiple rules when four kinds of unified interval implications are used,***,theα-UtI reasoning chain method is presented,which contains a chain structure with multiple *** corresponding solutions and their interval perturbations are *** is found that theα-UtI reasoning chain method is stable in the case of chain *** application examples in affective computing are given to verify the stability of theα-*** summary,through theoretical proof and example verification,it is found that theα-UtImethod has good interval robustness with four kinds of unified interval implications aiming at the situations of an individual rule,multi-rule and reasoning chain.

关键词： Fuzzy reasoning the CRI method the triple I method fuzzy implication interval robustness

Modelling of the elastoplastic behaviour of the bio-cemented soils using an extended Modified Cam Clay model

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2184-2197页

作者： Xuerui Wang Christian B.Silbermann thomas Nagel Udo Nackenhorst Institute of Mechanics and Computational Mechanics Leibniz UniversitätHannoverAppelstr.9aHannover30167Germany Gesellschaft für Anlagen-und Reaktorsicherheit(GRS)gGmbH Theodor-Heuss-Straße 4Braunschweig38122Germany Geotechnical Institute Technische Universität BergakademieFreibergGustav-Zeuner-Str.1Freiberg09599Germany

An elastoplastic constitutive model based on the Modified Cam Clay(MCC)model is developed to describe the mechanical behaviour of soils cemented via microbially induced calcite precipitation(MICP).It considers the increase of the elastic stiffness,the change of the yield surface due to MICP cementation and the degradation of calcium carbonate bonds during ***,to capture the typical contraction-dilation transition in MICP soils,the original volumetric hardening rule in the MCC model is modified to a combined deviatoric and volumetric hardening *** model could reproduce a series of drained triaxial tests on MICP-treated soils with different calcium carbonate ***,we carry out a parametric study and observe numerical instability in some *** combination with an analytical analysis,our numerical modelling has identified the benefits and limitations of using MCCbased models in the simulation of MICP-cemented soils,leading to suggestions for further model development.

关键词： Microbially induced calcite precipitation(MICP) Elastoplasticity Modified cam clay(MCC) OpenGeoSys MFront Contraction-dilation transition

Mast cell activation syndrome:An up-to-date review of literature

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World Journal of Clinical Pediatrics 2024年第2期13卷 104-113页

作者： ÖnerÖzdemir Gökçe Kasımoğlu Ayşegül Bak Hüseyin Sütlüoğlu Süreyya Savaşan Department of Pediatric Allergy and Immunology Sakarya UniversitySakaryaAdapazarı54100Türkiye Department of Pediatrics Sakarya UniversitySakaryaAdapazarı54100Türkiye Department of Pediatrics Kocaeli City HospitalKocaeli 50123Türkiye Department of Pediatrics Children’s Hospital of MichiganHematology/OncologyCentral Michigan University College of MedicineMount PleasantMI 48859United States Barbara Ann Karmanos Cancer Institute Wayne State UniversityDetroitMI 12345United States

Mast cells are a subtype of white blood cells and are involved in the immune *** cells contain many chemical substances called mediators,which are involved in the allergic *** fact that mast cells play a role in many events that require urgent intervention,especially anaphylaxis,has led to a more detailed study of these *** diseases also caused by dysfunctions of mast cells have been examined in many *** instance,mast cell activation syndrome is known as an augmented number of cells due to decreased cell death,resulting in clinical symptoms affecting many *** main common symptoms include flushing,hypotension,urticaria,angioedema,headache,vomiting and *** the underlying mechanism is not yet clearly known,we aim to review the literature in a broad perspective and bring together the existing knowledge in the light of the literature due to the diversity of its involvement in the body and the fact that it is a little known syndrome.

关键词： Mast cell Mast cell activation syndrome tryptase Histamine

Risk Factors in Surgical Site Infections

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Surgical Science 2024年第2期15卷 64-80页

作者： Atilla Duran Hüseyin Gülay Mustafa Cem terzi Department of General Surgery Mersin City Training and Research Hospital Mersin Türkiye Department of General Surgery Baskent University Ankara Türkiye Department of General Surgery Acibadem Kent Hastanesi Izmir Türkiye

Purpose of the Research: Our study aimed to determine and understand the risk factors of surgical site infections in patients operated on in general surgery wards. Method of Research: Between May 2008 and November 2008, 422 consecutive patients who underwent emergency and elective surgeries, excluding breast, goitre and laparoscopic surgeries, were included in the study to determine surgical site infections and risk factors. the patients’ risk factors were selected in the preoperative period, and postoperative 3rd, 7th, and 30th days were checked by the physician responsible for conducting the study regarding surgical site infection. Results and Conclusion: Surgical site infections were defined as incisional and organ/space based on NNIS data. Gender, diabetes mellitus, malignancy, degree of contamination, ASA score ≥ 3, preoperative skin cleansing, duration of intensive care unit stay, duration of hospital stay, growth in wound culture, duration of surgery and incision length were determined as risk factors increasing CAI rates. Especially the degree of contamination, duration of intensive care unit stay, hospitalisation, duration of operation, and growth in wound culture were decisive factors in the development of CAI. As a result of our study, in the light of these data, we concluded that to prevent the development of CAI can be modified, interventions to foreseeable factors can be assessed.

关键词： Infection CAI Risk Patient

Customized scaffolds for large bone defects using 3D‑printed modular blocks from 2D‑medical images

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Bio-Design and Manufacturing 2024年第1期7卷 74-87页

作者： Anil AAcar Evangelos Daskalakis Paulo Bartolo Andrew Weightman Glen Cooper Gordon Blunn Bahattin Koc Faculty of Engineering and Natural Sciences Sabanci UniversityIstanbul 34956Türkiye D Bioprinting Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye School of Mechanical Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12UPUK

Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or *** algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based AM *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

关键词： Additive manufacturing Modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds