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Probabilistic Multimodel Ensemble Prediction of Decadal Variability of East Asian Surface Air Temperature Based on IPCC-AR5 Near-term Climate Simulations

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Advances in Atmospheric Sciences 2013年第4期30卷 1129-1142页

作者：王佳智协飞陈钰文 Key Laboratory of Meteorological Disaster of Ministry of Education Nanjing University of Information Science and Technology Climate center of jiangsu province

Based on near-term climate simulations for IPCC-AR5 （The Fifth Assessment Report）, probabilistic multimodel ensemble prediction （PMME） of decadal variability of surface air temperature in East Asia （20°-50°N, 100°- 145°E） was conducted using the multivariate Gaussian ensemble kernel dressing （GED） methodology. The ensemble system exhibited high performance in hindcasting the deeadal （1981-2010） mean and trend of temperature anomalies with respect to 1961-90, with a RPS of 0.94 and 0.88 respectively. The interpretation of PMME for future decades （2006-35） over East Asia was made on the basis of the bivariate probability density of the mean and trend. The results showed that, under the RCP4.5 （Representative Concentration Pathway 4.5 W m-2） scenario, the annual mean temperature increases on average by about 1.1-1.2 K and the temperature trend reaches 0.6-0.7 K （30 yr）-1. The pattern for both quantities was found to be that the temperature increase will be less intense in the south. While the temperature increase in terms of the 30-yr mean was found to be virtually certain, the results for the 30-yr trend showed an almost 25% chance of a negative value. This indicated that, using a multimodel ensemble system, even if a longer-term warming exists for 2006-35 over East Asia, the trend for temperature may produce a negative value. Temperature was found to be more affected by seasonal variability, with the increase in temperature over East Asia more intense in autumn （mainly）, faster in summer to the west of 115°E, and faster still in autumn to the east of 115°E.

关键词： decadal climate prediction PMME GED surface air temperature East Asia

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Transcriptomic analysis reveals essential microRNAs after peripheral nerve injury

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Neural Regeneration Research 2021年第9期16卷 1865-1870页

作者： Yu Wang Shu Wang Jiang-Hong He Key Laboratory for Neuroregeneration of jiangsu province and Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina

Studies have shown that microRNAs(miRNAs) mediate posttranscriptional regulation of target genes and participate in various physiological and pathological processes, including peripheral nerve injury. However, it is hard to select key miRNAs with essential biological functions among a large number of differentially expressed miRNAs. Previously, we collected injured sciatic nerve stumps at multiple time points after nerve crush injury, examined gene changes at different stages(acute, sub-acute, and post-acute), and obtained mRNA expression profiles. Here, we jointly analyzed mRNAs and miRNAs, and investigated upstream miRNAs of differentially expressed mRNAs using Ingenuity Pathway Analysis bioinformatic software. A total of 31, 42, 30, and 23 upstream miRNAs were identified at 1, 4, 7, and 14 days after rat sciatic nerve injury, respectively. Temporal expression patterns and biological involvement of commonly involved upstream miRNAs(miR-21, let-7, miR-223, miR-10 b, miR-132, miR-15 b, miR-127, miR-29 a, miR-29 b, and miR-9) were then determined at multiple time points. Expression levels of miR-21, miR-132, miR-29 a, and miR-29 b were robustly increased after sciatic nerve injury. Biological processes involving these miRNAs include multicellular organismal response to stress, positive regulation of the epidermal growth factor receptor signaling pathway, negative regulation of epithelial cell differentiation, and regulation of myocardial tissue growth. Moreover, we constructed mechanistic networks of let-7, miR-21, and miR-223, the most significantly involved upstream miRNAs. Our findings reveal that multiple upstream miRNAs(i.e., let-7, miR-21, and miR-223) were associated with gene expression changes in rat sciatic nerve stumps after nerve injury, and these miRNAs play an important role in peripheral nerve regeneration. This study was approved by the Experimental Animal Ethics Committee of jiangsu province of China(approval No. 20190303-18) on March 3, 2019.

关键词： bioinformatic analysis Ingenuity Pathway Analysis mechanistic network microRNA peripheral nerve injury peripheral nerve regeneration RNA sequencing sciatic nerve crush

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Spatial and Temporal Characteristics of Rice Potential Productivity and Potential Yield Increment in Main Production Regions of China

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Journal of Integrative Agriculture 2013年第1期12卷 45-56页

作者： JIANG Xiao-jian TANG Liang LIU Xiao-jun CAO Wei-xing ZHU Yan National Engineering and Technology center for information Agriculture Ministry of Industry and Information Technology/Key Laboratory for Information AgricultureScience and Technology Department of Jiangsu Province/College of AgricultureNanjing Agricultural University

The vast area and marked variation of China make it difficult to predict the impact of climate changes on rice productivity in different ***,analyzing the spatial and temporal characteristics of rice potential productivity and predicting the possible yield increment in main rice production regions of China is important for guiding rice production and ensuring food *** meteorological data of main rice production regions from 1961 to 1970（the 1960s） and from 1996 to 2005（the 2000s） provided by 333 stations,the potential photosynthetic,photo-thermal and climatic productivities in rice crop of the 1960s and 2000s in main rice production regions of China were predicted,and differences in the spatial and temporal distribution characteristics between two decades were ***,the potential yield increment based on the high yield target and actual yield of rice in the 2000s were *** with the 1960s,the potential photosynthetic productivity of the 2000s was seen to have decreased by 5.40%,with rates in northeastern and southwestern China found to be lower than those in central and southern *** potential photo-thermal productivity was generally seen to decrease（2.56%） throughout main rice production regions,decreasing most in central and southern ***,an increase was seen in northeastern and southwestern *** potential climatic productivity was observed to be lower（7.44%） in the 2000s compared to the 1960s,but increased in parts of central and southern *** potential yield increment from the actual yield to high yield target in the 2000s were no more than 6×103 kg ha-1 and ranged from 6×103 to 12×103 kg ha-1 in most of the single-and double-cropping rice growing regions,*** yield increasing potential from the high yield target to the potential photo-thermal productivity in 2000s were less than 10×103 kg ha-1 and ranged from 10×103 to 30×103 kg ha-1 in most of the single-and double-croppi

关键词： rice photosynthetic productivity photo-thermal productivity climatic productivity yield increment spatial and temporal distribution China

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NOVA1 promotes SMN2 exon 7 splicing by binding the UCAC motif and increases SMN protein expression

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Neural Regeneration Research 2022年第11期17卷 2530-2536页

作者： Li-Li Du Jun-Jie Sun Zhi-Heng Chen Yi-Xiang Shao Liu-Cheng Wu Institute of Comparative Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of jiangsu and Ministry of Education Co-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Laboratory Animal center Nanjing University of Chinese MedicineNanjingJiangsu ProvinceChina Institute of Neuroscience Soochow UniversitySuzhouJiangsu ProvinceChina

Spinal muscular atrophy(SMA)is a rare hereditary neuromuscular disease with a high lethality rate in *** in the homologous genes survival of motor neuron(SMN)1 and SMN2 have been reported to be SMA pathogenic *** studies showed that a highinclusion rate of SMN2 exon 7 increased SMN expression,which in turn reduced the severity of *** inclusion rate of SMN2 exon 7 was higher in neural tissues than in non-neural ***-oncological ventral antigen(NOVA)is a splicing factor that is specifically and highly expressed in *** plays a key role in nervous system development and in the induction of nervous system *** r,it remains unclear whether this splicing factor affects *** this study,we analyzed the inclusion of SMN2 exon 7 in different tissues in a mouse model of SMA(genotype smn^(-/-)SMN2^(2 tg/0))and litter mate controls(genotype smn^(+/-)SMN2^(2 tg/0)).We found that inclusion level of SMN2 exon 7 was high in the brain and spinal co rd tissue,and that NOVA1 was also highly expressed in nervous system *** addition,SMN2 exon 7 and NOVA1 were expressed synchronously in the central nervous *** further investigated the effects of NOVA1 on disease and found that the number of neurons in the anterior horn of spinal cord decreased in the mouse model of SMA during postnatal days 1-7,and that NOVA1 expression levels in motor neurons decreased simultaneously as spinal muscular atrophy *** also found that in vitro expression of NOVA1 increased the inclusion of SMN2 exon 7 and expression ofthe SMN2 protein in the U87 MG cell line,whereas the opposite was observed when NOVA1 was knocked ***,point mutation and RNA pull-down showed that the UCAC motif in SMN2 exon 7 plays a critical role in NOVA1 binding and promoting the inclusion of exon *** r,CA was more essential for the inclusion of exon 7 than the order of Y residues in the ***,these findings indicate that NOVA1 intera

关键词： exon 7 inclusion motor neuron neuro-oncological ventral antigen 1 SMN2 splicing spinal cord spinal muscular atrophy splicing factors UCAC motif

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Common Spectral Bands and Optimum Vegetation Indices for Monitoring Leaf Nitrogen Accumulation in Rice and Wheat

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Journal of Integrative Agriculture 2012年第12期11卷 2001-2012页

作者： WANG Wei YAO Xia TIAN Yong-chao LIU Xiao-jun NI Jun CAO Wei-xing ZHU Yan National Engineering and Technology center for information Agriculture Ministry of Industry and Information Technology/Key Laboratory for Information AgricultureScience and Technology Department of Jiangsu Province/College of AgricultureNanjing Agricultural University

Real-time monitoring of nitrogen status in rice and wheat plant is of significant importance for nitrogen diagnosis, fertilization recommendation, and productivity prediction. With 11 field experiments involving different cultivars, nitrogen rates, and water regimes, time-course measurements were taken of canopy hyperspeetral reflectance between 350-2 500 nm and leaf nitrogen accumulation （LNA） in rice and wheat. A new spectral analysis method through the consideration of characteristics of canopy components and plant growth status varied with phenological growth stages was designed to explore the common central bands in rice and wheat. Comprehensive analyses were made on the quantitative relationships of LNA to soil adjusted vegetation index （SAVI） and ratio vegetation index （RVI） composed of any two bands between 350-2 500 nm in rice and wheat. The results showed that the ranges of indicative spectral reflectance were largely located in 770-913 and 729-742 nm in both rice and wheat. The optimum spectral vegetation index for estimating LNA was SAVI （R822, R738） during the early-mid period （from jointing to booting）, and it was RVI （Rs22, R73s） during the mid-late period （from heading to filling） with the common central bands of 822 and 738 nm in rice and wheat. Comparison of the present spectral vegetation indices with previously reported vegetation indices gave a satisfactory performance in estimating LNA. It is concluded that the spectral bands of 822 and 738 nm can be used as common reflectance indicators for monitoring leaf nitrogen accumulation in rice and wheat.

关键词： spectral band vegetation index leaf nitrogen accumulation (LNA) rice wheat

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The interaction effect of grip strength and lung function (especially FVC) on cardiovascular diseases: a prospective cohort study in jiangsu province, China

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Journal of Geriatric Cardiology 2022年第9期19卷 651-659页

作者： Jia-Li LIU Jia-Qi WANG Dan WANG Yu QIN Yong-Qing ZHANG Quan-Yong XIANG School of Public Health Southeast UniversityNanjingJiangsu ProvinceChina Department of Chronic Non-com-municable Disease Control Jiangsu Province Center for Disease Control and PreventionNanjingJiangsu ProvinceChina

OBJECTIVE Lung function and grip strength(GS)are associated with cardiovascular disease(CVD),but whether these risk factors interact to affect CVD is *** study aimed to explore the interactions between lung function and GS with major CVD(defined as fatal/non-fatal myocardial infarction,stroke,and heart failure)*** We conducted a prospective cohort study on the Chinese population in jiangsu *** proportional haz-ards models were used to explore the associations between GS,lung function,and major CVD *** A total of 5967 participants were included in our study;among them,182 participants developed major ***-cipants with low forced vital capacity(FVC)had a higher risk of major CVD(hazard ratio(HR)=1.45;95%confidence interval(CI):1.05-2.01;P<0.05)compared with normal *** risk of major CVD incidence(HR=0.54;95%CI:0.35-0.83;P<0.01)was significantly lower in participants with high GS than in individuals with low *** interaction between FVC and GS for major CVD incidence(P=0.006)was statistically *** with normal FVC participants with high GS,low FVC parti-cipants with low GS had the highest risk of major CVD incidence(HR=2.50;95%CI:1.43-4.36;P<0.01).CONCLUSION Among people with low FVC,the risk of major CVD is lower with high *** with low FVC and low GS have the highest risk of major ***,more attention should be paid to the incidence of major CVD in individu-als with low FVC,especially those who have lower GS.

关键词： function strength interaction

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Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou Qian Lu Mingcong Tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu Xiaomin Xu Xiao Zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

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Profile of the RNA in exosomes from astrocytes and microglia using deep sequencing:implications for neurodegeneration mechanisms

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Neural Regeneration Research 2022年第3期17卷 608-617页

作者： Hui-Min Xie Xing Su Feng-Yuan Zhang Chao-Lun Dai Rong-Hua Wu Yan Li Xiao-Xiao Han Xing-Mei Feng Bin Yu Shun-Xing Zhu Song-Lin Zhou Key Laboratory of Neuroregeneration of jiangsu and Ministry of Education Co-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Stomatology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Medical College of Nantong University NantongJiangsu ProvinceChina Laboratory Animals center Nantong UniversityNantongJiangsu ProvinceChina

Glial cells play an important role in signal transduction,energy metabolism,extracellular ion homeostasis and neuroprotection of the central nervous ***,few studies have explained the potential effects of exosomes from glial cells on central nervous system health and *** this study,the genes expressed in exosomes from astrocytes and microglia were identified by deep RNA *** Encyclopedia of Genes and Genomes analysis indicated that several pathways in these exosomes are responsible for promoting neurodegenerative diseases,including Alzheimer's disease,Parkinson's disease and Huntington's *** ontology analysis showed that extracellular exosome,mitochondrion and growth factor activity were enriched in exosomes from the unique astrocyte group,while extracellular exosome and mitochondrion were enriched in exosomes from the unique microglia ***,combined with the screening of hub genes,the protein-protein interaction network analysis showed that exosomes from astrocytes influence neurodegenerative diseases through metabolic balance and ubiquitin-dependent protein balance,whereas exosomes from microglia influence neurodegenerative diseases through immune inflammation and oxidative *** there were differences in RNA expression between exosomes from astrocytes and microglia,the groups were related by the hub genes,ubiquitin B and heat shock protein family A(Hsp70) member *** B appeared to be involved in pleiotropic regulatory functions,including immune regulation,inflammation inhibition,protein catabolism,intracellular protein transport,exosomes and oxidative *** results revealed the clinical significance of exosomes from glia in neurodegenerative *** study was approved by the Animal Ethics Committee of Nantong University,China(approval No.S20180102-152) on January 2,2018.

关键词： astrocyte bioinformatics analysis central nervous system exosomes microglia neurodegenerative disease RNA transcriptomics UBB

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Physiological mechanism underlying spikelet degeneration in rice

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Journal of Integrative Agriculture 2018年第7期17卷 1475-1481页

作者： WANG Zhi-qin ZHANG Wei-yang YANG Jian-chang Key Laboratory of Crop Genetics and Physiology of jiangsu province/Innovation center for Modern Production Technology of Grain Crops of jiangsu province Yangzhou University

The phenomenon of degenerated spikelets is very common in cereals, and considered as a serious physiological defect and a main constraint to grain production. Understanding the physiological mechanism in which spikelet degeneration occurs would have great significance in enhancing yield potential in grain crops. Taking rice as an example, the paper reviewed the physiological mechanism underlying spikelet degeneration, with focus on the roles of phytohormones in regulating the process. There are several hypotheses for the spikelet degeneration, such as resource limitation, self-organization, and primigenic dominance. However, convincing evidences are not enough to support the assumptions. Phytohormones including auxins, cytokinins, gibberellins, abscisic acid, and ethylene are involved in regulating spikelet degeneration in cereals. The new phytohormones of brassinosteroids and polyamines have been observed to suppress spikelet degeneration in rice. The interactions among or between plant hormones may play a more important role in regulating spikelet degeneration. However, the information on such interactions is very limited. Some agronomic practices, especially proper water and nitrogen management, could reduce spikelet degeneration but the mechanism underlying remains unclear. Further research is needed to understand the cross-talk among/between phytohormones on spikelet degeneration, to reveal the physiological and molecular mechanism in which phytohormones and their interactions regulate the degeneration of spikelets, to exploit approaches to decrease spikelet degeneration and to elucidate their mechanism.

关键词： rice(Oryza safiva) spikelet degeneration phytohormones brassinosteroids polyamines

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Reliability Evaluation of IEEE 802.11p-Based Vehicle-to-Vehicle Communication in an Urban Expressway

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Tsinghua Science and Technology 2015年第4期20卷 417-428页

作者： Yizhi Wang Jianming Hu Yi Zhang Chao Xu Department of Automation Tsinghua National Laboratory for Information Science and Technology (TNList) Tsinghua University jiangsu province Collaborative Innovation center of Modern Urban Traffic Technologies

IEEE 802.11p/DSRC （Dedicated Short Range Communication） is considered to be a promising wireless communication standard for enhancing transportation safety and efficiency. However, IEEE 802.11p-based Vehicle- to-Vehicle （V2V） communication is still unreliable because of the complicating factors of high vehicle speed and complex radio environments. In this paper, we performed a data-based evaluation of V2V communication reliability, using real-world measurements in a typical urban expressway in Beijing. With respect to the characteristics of the urban expressway and our experimental data, we found road slope and traffic density to be the major environmental factors having a significant impact on the V2V communication＇s Line-Of-Sight （LOS） conditions. On the basis of these two factors, we propose a fuzzy classification method for the LOS conditions, and separate the real- time communication environments into different LOS cases. For each LOS case, we quantify the metrics as received signal strength indication, packet delivery rate, and communication latency. The results reveal that the communication reliability in urban expressways is very unstable because of the changing LOS conditions. This study provides a useful reference for the IEEE 802.11 p-based cooperative systems in urban expressways.

关键词： IEEE 802.11p V2V communication empirical measurement urban expressway line-of-sight condition

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