The interaction effect of grip strength and lung function (especially FVC) on cardiovascular diseases: a prospective cohort study in Jiangsu Province, China

作     者：Jia-Li LIU Jia-Qi WANG Dan WANG Yu QIN Yong-Qing ZHANG Quan-Yong XIANG Jia-Li LIU;Jia-Qi WANG;Dan WANG;Yu QIN;Yong-Qing ZHANG;Quan-Yong XIANG

作者机构：School of Public HealthSoutheast UniversityNanjingJiangsu ProvinceChina Department of Chronic Non-com-municable Disease ControlJiangsu Province Center for Disease Control and PreventionNanjingJiangsu ProvinceChina 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2022年第19卷第9期

页      面：651-659页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by the Natural Science Foundations of China(81973005) the Natural Science Foundation of Jiangsu Province(BK20151593) 

主　　题：function strength interaction 

摘      要：OBJECTIVE Lung function and grip strength(GS)are associated with cardiovascular disease(CVD),but whether these risk factors interact to affect CVD is *** study aimed to explore the interactions between lung function and GS with major CVD(defined as fatal/non-fatal myocardial infarction,stroke,and heart failure)*** We conducted a prospective cohort study on the Chinese population in Jiangsu *** proportional haz-ards models were used to explore the associations between GS,lung function,and major CVD *** A total of 5967 participants were included in our study;among them,182 participants developed major ***-cipants with low forced vital capacity(FVC)had a higher risk of major CVD(hazard ratio(HR)=1.45;95%confidence interval(CI):1.05-2.01;P0.05)compared with normal *** risk of major CVD incidence(HR=0.54;95%CI:0.35-0.83;P0.01)was significantly lower in participants with high GS than in individuals with low *** interaction between FVC and GS for major CVD incidence(P=0.006)was statistically *** with normal FVC participants with high GS,low FVC parti-cipants with low GS had the highest risk of major CVD incidence(HR=2.50;95%CI:1.43-4.36;P0.01).CONCLUSION Among people with low FVC,the risk of major CVD is lower with high *** with low FVC and low GS have the highest risk of major ***,more attention should be paid to the incidence of major CVD in individu-als with low FVC,especially those who have lower GS.